Abstract Adhesives containing large percentages of methylene chloride are commonly utilized in the asbestos abatement industry. The adhesive is used to seal polyethylene sheeting to the underlying surfaces, which in turn is used to contain the work area. When completely contained, the work area is essentially a confined space. During subsequent asbestos removal procedures, High Efficiency Particulate Air filter (HEPA)-equipped exhaust systems provide dilution ventilation to the work area, exhausting 1000 to 2000 cubic feet of air per minute per machine. This study characterizes worker exposure levels to methylene chloride when applying these adhesives during the construction of asbestos abatement containments. Personal samples were collected with both 3M organic vapor monitors and standard SKC charcoal tubes. Analysis of the sampling media was conducted by gas chromatography according to NIOSH Method 1005. Exposure periods, ranging from four to six hours, corresponded to a personal time-weighted average (TWA) of 0.09 to 270 ppm. This corresponded to an eight-hour TWA range from 0.06 to 140 ppm, respectively. Short-term exposure limits (STEL), 15 minutes in duration, ranged in concentration from non-detectable to 1294 ppm. Exposure concentrations greatly varied depending upon dilution ventilation, exposure period, adhesive quantity, and room volume. Sample results revealed that use of large quantities of adhesive in a confined area can result in high concentrations of methylene chloride. It is recommended that the HEPA-equipped exhaust systems, primarily designed to control airborne asbestos fiber levels during subsequent removal procedures, be utilized to provide dilution ventilation to the work area when applying these adhesives. It is a current Environmental Protection Agency and Occupational Safety and Health Administration recommendation to start the HEPA-equipped exhaust systems after the work area is completely sealed off and the decontamination unit has been constructed. If these systems are activated at the beginning of the preparation phase, they will create dilution ventilation that can decrease methylene chloride concentrations by a minimum of fourfold. In addition, air purifying respirators equipped with organic vapor cartridges or supplied air respirators should be worn by the workers to reduce their exposure levels even more. Finally, the aerosol manufacturers should substitute the methylene chloride in these products with a suitable, less toxic replacement.