BackgroundPatient’s account of personal experiences of having lived through coronavirus disease 2019 is important for understanding the magnitude of the debilitating impact of the infection. There is increasing recognition that the infection impedes multiple functional domains, but to date the evidence remains scarce. Moreover, to the author’s knowledge, there are no documented cases reporting on research data derived from self-reflective first-person experience.Case presentationThe patient was a 59-year-old female psychologist of White self-ascribed ethnicity who had coronavirus disease 2019. She had no history of medical, neurological, or psychiatric conditions and works in a neurosurgery clinic at a large hospital as a psychologist, specializing in neuropsychology. Using the introspective method, she captured the occurrence of neuropsychological and psychological dysfunctions she experienced in the acute stage of the illness, which took place in December 2020 and lasted for 17 days. Treatment of coronavirus disease 2019 was conducted in the home environment under medical supervision and followed a standardized protocol adopted at the time in the country.ConclusionsThe data derived from the first-person experience indicated that among the most salient cognitive functions impacted by the disease were: executive control, working memory, attention, concentration, and processing speed.Furthermore, emotional instability; mood swings; racing, repetitive, or intrusive thoughts; uncontrolled associations; dizziness; fatigue; disbalance; and sleep disturbances featured consistently throughout the illness. The overall profile of these dysfunctions suggests disruption in the overall operation of the brain and particularly in the functioning of the frontal lobes. Although less tangible than the physical symptoms, the neuropsychological and psychological dysfunctions associated with coronavirus disease 2019 form a distinct cluster that has a highly debilitating impact on a person’s well-being.