In the context of the rapid growth of urbanization and industrialization of Kazakhstan, the air pollution problem in large cities is becoming increasingly urgent. It is essential to assess the impact of economic growth on the environmental situation, as this allows us to develop strategies to improve air quality and ensure sustainable development. Thus, this study examines the impact of urbanization and economic growth on air pollution across four major cities in Kazakhstan from 2016 to 2022. Statistical methods were used to analyze the relationship between pollution levels and economic indicators, including gross regional product (GRP) and industrialization. The study covers the period from 2016 to 2022 and is based on data on concentrations of critical pollutants collected from the National Bureau of Statistics of the Republic of Kazakhstan. National monitoring sources collected air quality data, including PM2.5, PM10, SO2, NO2, and CO concentrations. Statistical analyses, as correlation and regression models, were applied to establish relationships between pollution levels and economic growth indicators. The study found significant correlations between economic activities and air pollution levels. In Almaty, a 10% increase in GRP corresponds to a 5% increase in pollutant concentrations. Almaty experienced the highest average PM2.5 concentration at 42 µg/m³, exceeding permissible norms by 20%. Other cities showed varied levels of pollution influenced by specific economic and industrial profiles. The results underscore the pressing need for effective urban management and strategic policy-making to mitigate the adverse effects of economic development on air quality.