Permethrin Group Research Articles

Adjunctive Agent for Treating Scabies: In vitro Killing Activity of Permethrin and Tea Tree Oil on Sarcoptes scabiei Collected from Patients

Recently, there has been a serious increase in cases of scabies. The number of patients who do not benefit from the current treatment agents is also quite high. There are publications showing that scabies mites are permethrin-resistant and ivermectin. The treatment with scabicides usually lasts for several hours and usually the treatment is repeated for at least another time, which reduces the patient's compliance with the treatment, especially in pediatric patients where the toxic effects of the products are more pronounced. Therefore there is a need for treatment modalities that are less toxic to humans. To observe the in vitro effect of tea tree oil (TTO) on S. scabiei and to compare it with those of permethrin. Scabies specimens were removed from the patient and examined using a digital microscope. Parasites that were not damaged during sampling, and showed full motion were included in the study. No treatment was applied to the patients before removal of the mites. A total of 40 parasites were included in the study, with 10 parasites in each group. Immersion oil was applied to the control group, 5% permethrin to the first treatment group, while 5% and 25% TTO were used for the second and third study groups. The mean survival time (ST) of scabies mites in the 5% permethrin group was 350±31.3 min, while this for 5% TTO group 180±15.1 min and 120±13.3 min in the 25% TTO group. The mean ST of the sarcoptes in the control group was 2.820±90 min. The mean ST between the control, permethrin and TTO groups was statistically significant (p=0.03). ST between 5% and 25% TTO groups was also statistically significant (p=0.04). There were no statistical differences between permethrin and 5% or 25% TTO. TTO has an acaricidal effect on S. scabiei. Although not used as the treatment of choise, it can be used as a supportive agent. Since it shows an acaricidal effect within a short time, it could be used as a shampoo or shower gel to enhance the acaricidal activity of another scabicide.

Susceptibility and fecundity of Bedbugs (Cimex hemipterus) from Yaba College of Technology Lagos exposed to Selected Classes of Insecticides: A short report

Background: Tropical bed bug, Cimex hemipterus, is a nocturnal obligate blood-sucking ectoparasite of humans that is highly prevalent in Nigeria. Bed bug controls heavily rely on the application of several insecticide-based formulations. Insecticide resistance in bed bug populations has been widely reported. In this study, we assessed the mortality of bed bugs following exposure to different classes of insecticides. Methodology: Active adult female bed bugs were collected from students’ halls of residence and exposed to DDT (4%), permethrin (0.75), bendiocarb (0.1) and malathion (4%) insecticide-impregnated papers. Mortality and number of eggs laid by each exposed group were recorded at 90 minutes, 24hrs, 48hrs and 72hrs. Results: The impact of the different assays on bugs mortality revealed DDT to produce a time-dependent outcome with the highest mortality rate [(36.7% (Cl 32.7±38.9)], this was followed by Bendiocarb [31.6% (CI 27.2±35.1)]. In comparison, permethrin and malathion produced the same effect [26.7% (CI 23±30.5)] 24 hours post-exposure. In contrast, malathion and bendiocarb impacted the most mortality [53.3% (49.3±58.7) and 46.6%(42.2±49.5)], followed by permethrin [18.9% (CI 44.6±56.8) after 72 hours. The relative numbers of eggs produced by bedbugs in the DDT, bendiocarb and malathion assays were lower than what was observed in the control and permethrin group 24 hours after exposure. The highest reduction in egg production was observed in the malathion exposed group 48- and 72-hours post-exposure compared to the other insecticides and the control group. Conclusion: This study revealed suspected insecticide resistance to all classes of insecticide used on bed bug populations in Lagos State, Nigeria.

Comparison of the in vitro Demodex folliculorum killing activity of azelaic acid and permethrin

Aim: Demodex parasites have been linked to dermatological disorders, especially rosacea, without a proven mechanism. Moreover, some anti-Demodex agents demonstrate a dual therapeutic effect related to a direct effect on the skin disorder along with a decreased number of Demodex mites. Despite being considered a first-line treatment approach for rosacea, azelaic acid's efficacy against Demodex mites has not been investigated. In the current study, mites were continuously observed after exposure to the test agents to evaluate the potential anti-Demodex efficacy of azelaic acid. The efficacy of azelaic acid was compared to that of a positive control agent (permethrin).
 Material and Method: The wastes of diagnostic standardized skin surface biopsy samples of rosacea patients were collected for the trial. To four active treatment groups were administered 10% azelaic acid, 20% azelaic acid, 30% azelaic acid, and 5% permethrin. In addition, there was a control group, and 20 Demodex mites were included in each of the five groups. The authors conducted the real-time observation of the study groups through a digital microscope. The survival times of the mites were recorded and compared between the groups.
 Results: The mean survival time was 12.2±1.5 minutes in the 5% permethrin group. The mean survival times in the 10%, 20%, and 30% azelaic acid groups were 15.8±1.6, 14±1.5, and 12±1.2 minutes, respectively. The differences between the four active treatment groups did not reach statistical significance (p>0.05).
 Discussion: The present study’s results revealed that all three concentrations of azelaic acid had anti-Demodex efficacy comparable to that of 5% permethrin.

Evaluation of surface versus total permethrin content in permethrin-treated clothing: Implications for protection against mosquitoes

ABSTRACT Permethrin is a synthetic pyrethroid insecticide used to treat uniforms (e.g. military, foresters) and other clothing to protect people against pests (e.g., mosquitoes, ticks). Pests contacting the surface of permethrin-treated clothing (PTC) are repelled and/or killed, depending on the dose and duration of exposure. Hence, it is important to assess the amount of permethrin on the surface of clothing. Fabric swatches prepared using two commercially available permethrin treatments (Insect Shield® & Sawyer Repellant) and one laboratory created treatment (4g permethrin/L) were tested. A Martindale Abrasion and Pilling Tester (MAPT) and gas chromatography were used to assess surface permethrin content (SPC) and total permethrin content (TPC). Sawyer PTC had the highest SPC (mean ± standard error) (32.68±14.55µg/g), followed by Insect Shield® (23.35±2.71µg/g) and lab-created 4g/L permethrin (8.7±0.78µg/g). SPC (after 1000 rubs on MAPT) for Insect Shield®, Sawyer, and 4g/L permethrin groups was significantly lower than TPC (P=0.011, P<0.001, and P=0.001, respectively). The SPC/TPC relationship varied widely between permethrin treatment methods and practical implications for this are discussed. Mosquito repellency tests indicate that Insect Shield®, Sawyer, and lab-created (4g/L) permethrin-treated fabrics showed a significantly higher repellency rate than control (untreated) fabrics (P=0.001, P<0.0001, P<0.0001, respectively). While Insect Shield® had the highest repellency rate against susceptible (53%) and exposed (48%) mosquitoes, differences between groups were not significant. Repellency rates indicate SPC plus other factors (e.g. treatment method) may contribute to mosquito repellency and should be considered in risk assessments for protection against pests.

Is there a really resistance to scabies treatment with permethrin? In vitro killing activity of permethrin on Sarcoptes scabiei from patients with resistant scabies.

Recently, there have been increased scabies infestations but many patients do not respond to treatment. Clinicians are hesitant to use permethrin despite the fact that treatment failure may be due to noncompliance with the treatment rather than permethrin resistance. We aimed to investigate the permethrin resistance of mites collected from patients who have endured scabies for at least 3months despite permethrin treatment. Parasites in patients who had scabies for at least 3months despite permethrin treatment were collected. Only parasites that were not damaged during sampling, not fragmented and had full motion were included. Parasites were divided into four groups, each with 15 parasites. Immersion oil was dripped on the control group and 5%, 7%, and 10% permethrin was added to the study groups. The responses of the parasites to the applied agents were examined using a digital microscope. All solutions, except the control group, killed the scabies mite. The mean survival time (ST) in the 5%, 7%, and 10% permethrin groups was 360 ± 33.2, 340 ± 31.4, and 320 ± 30.2min, respectively. There was no statistically significant difference in the mean ST in the permethrin groups. The mean ST in the control group was 46 ± 1.5h. The mean ST difference between the control and permethrin-treated groups was significant (p= 0.03). There was no resistance to permethrin, which should maintain its place as first line treatment of scabies. Treatment noncompliance, rather than permethrin resistance, seems to be the underlying factor in the chronicity of scabies.

Effect of Pyrethroid on Fertility of Adult Rats

Sixty&nbsp; Adult female albino rats&nbsp; were randomly divided into seven groups as fellow group (1) normal control, Inductive group (1) in this group animals received low dose&nbsp; 12 mg/kg) from permethrin,&nbsp; Inductive group (2),in this group animals received high dose ( 75mg/kg.) from permethrin, group 4: treated group, animals received Vit E. (500 mg/ mg/Kg.) and then received low dose of permethrin (12 mg/k.) after half hour, group 5: treated group, animals received Vit E. (500 mg/ mg/Kg.) and then received high dose of permethrin (75 mg/k.) after half hour,Group 6: treated group, animals received Vit E. (250 mg/ mg/Kg) and then received low dose of permethrin (12 mg/k. ) after half hour and group 7: treated group, animals received Vit E. (250 mg/ mg/Kg.) and then received low dose of permethrin (75 mg/k. ) after half every doses received daily. At the end of the experimental period Blood samples were withdrawn,we determine triglyceride (TG), total cholesterol (TC), blood urea and creatinine. Also Estradiol and progesterone, total T3 , T4 and TSH levels&nbsp; in plasma of female were measured. The excised ovary in each group used to measure MDA, as a marker for lipid peroxidation (LPO) and GSH content in ovary tissue . In the same time the ovarian tissue which were&nbsp; removed after sacrifice,&nbsp; it was used for histological examination for the evaluation and assessment of the d fibrous formation, in injuries tissue. permethrin with different doses (12 and 75 mg/kg &nbsp;respectively) significantly (p≤ 0.05) increased the MDA &nbsp;and significantly decreased (p&lt; 0.05) in GSH content in ovary tissue versus control animal. Though treatment with vitamin E after permethrin with different dose (250 and 500 mg/kg respectively) significantly deceased the MDA content versus permethrin group (12 and 75 mg/kg&nbsp; respectively) and Vit E treatment increased GSH content in a group treated with (permethrin 75 mg/kg b.w). The level of both serum estrogen (E2) and progesterone were significantly (p&lt;0.05) decreased in a permethrin group in both doses (12 and 75 mg/kg ) when compared to control group. While, treatment with Vit E ameliorate the level of E2 and progesterone. Treating rats with permethrin led to a significant decrease in triiodothyronine (T3) and thyroxine (T4) as well as a significant increase of thyroid-stimulating hormone (TSH) when compared to control group. Administration of Vitamin E and permethrin caused an improvement in the levels ofT3 and T4 and TSH. This study was designed to elucidate premethrin effects at doses (12and75mg\kgw b) for 30 days, causing reproductive toxicity through several biotransformation metabolites processes. Focusing on ovarian injures and reproductive efficacy. treated ovarian tissue showed histological alterations represented by reduction number of different follicles, with absent mature follicles in high dose premethrin, or follicles without oocytes&nbsp; and zone granulose residual with vacuolar change finally necrotic areas. Special stain for connective tissue fibersMasson's&nbsp; trichrome, showed accumulation of fibrous proportional to the dose. while the Immuno- reactive of TNF-ᾳ assayment many necrotic area evidence of premethrin toxicity, also its dwindling effect on proliferating cell nuclear antigen (PCNA)which affected the efficiency of DNA, and consequently on the cell proliferative activity. In contrast, evaluate the effective therapeutic role of Vitamin E at doses (250 and 500 mg \kg bw),as an antioxidant clarified, which is explained by the&nbsp; histological in the results.&nbsp; This study reveals that chronic exposure to premerthin even&nbsp;&nbsp; low dose alters ovarian cycle&nbsp; activity . Hence, Premethrin exposure threat&nbsp; fertility of humans and&nbsp; animals.it is speculate that the positive effect of the Vitamin E by its antioxidant activity able to protect ovarian tissues the premerthin toxicicity

Comparison of safety and cost-effectiveness of topical 5% permethrin and topical 1% ivermectin in patients of uncomplicated scabies

Background: Scabies is an infestation of the skin by the mite Sarcoptes scabiei that causes a pruritic skin eruption. Scabies is a relatively common infestation that can affect individuals of any age and socioeconomic status. The worldwide prevalence is estimated to be 100 million people, with wide variation in prevalence among individual geographic regions.Worldwide, an estimated 300 million cases occur annually.The burden of the disease is highest in developing countries where the disease is endemic. Many studies were conducted on scabies using different therapies to compare the efficacy. However, only some studies were conducted by comparing the safety and cost-effectiveness. Our country is a developing country. Hence, cost is an essential factor in the individual and public health sector. Aims and Objectives: This study aims to provide better and improved treatment options for scabies based on efficacy, safety, and cost-effectiveness profile with objective to compare the efficacy, cost-effectiveness, and safety profile of 5% permethrin and 1% ivermectin in uncomplicated scabies patients. Materials and Methods: This was a randomized, prospective, open-label, comparative, parallel study. After taking Institutional Ethics Committee permission, the study was conducted from May 2019 to June 2019, on 95 patients who came to RVMIMS hospital dermatology outpatient department, Laxmakkapally, Mulugu Mandal, Siddipet district in Telangana state, and diagnosed scabies is randomly allocated to two groups. One group received permethrin 5% cream as a single application, and the other group received ivermectin 1% lotion as a single application. Results:A total of 93 patients were enrolled in the study and randomly allocated into two treatment groups, permethrin group having 48 patients and ivermectin group having 45 patients. Conclusion: Although topical 5% permethrin is as effective as topical 1% ivermectin, permethrin is considered as superior drug compared to topical ivermectin regarding safety andcost-effectiveness. There were two dropouts of patients during the study in ivermectin intervention. At the end of the study, we concluded that topical 5% permethrin is safer and cost-effective drug compared to topical 1%ivermectin.

Comparative efficacy of permethrin 1%, lindane 1%, and dimeticone 4% for the treatment of head louse infestation in Iran.

Pediculosis capitis occurs worldwide. Children in the age group of 5-13years are the ordinary victims. Population-based studies show that the prevalence of pediculosis is 1.6-13.4% in various regions of Iran. In this observer-blinded trial, we conducted a study to evaluate the comparative efficacy and safety of permethrin 1% and lindane 1% shampoos and dimeticone 4% lotion to cure head lice infestation in children aged 7-13years in female primary schools in Ahvaz City, Iran. Children with head lice were randomized to receive each treatment. Two applications of permethrin 1% or dimeticone 4% were done, 1week apart. However, lindane 1% was used just once for treatment cases. Data analysis was done using SPSS software. Recovery differences between the groups were tested using the chi-squared test. Four hundred forty-four louse-infested schoolgirls were randomly treated with them. Permethrin, lindane, dimeticone, and placebo produced the recovery rates 56.8, 31.5, 51.4, and 10.8% on day 2 post-treatment, respectively. Cure rates were in the permethrin group on days 8 and 15, respectively, 69.4 and 90.1%. The success rates were in the lindane group on days 8 and 15, respectively, 73 and 86.5%. The success rates were in the dimeticone group on days 8 and 15, respectively, 60.4 and 94.6%. It is recommended dimeticone lotion (4%) as a very effective and safe pediculicide for pediculosis control. With proper application, dimethicone can rapidly cure head lice infestation with minimal reinfestation.

Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson's disease.

There is growing awareness within the scientific community of the strong connection between the inflammation in the intestine and the pathogenesis of Parkinson’s disease (PD). In previous studies we developed a PD animal model exposing pup rats to permethrin (PERM) pesticide. Here, we intended to explore whether in our animal model there were changes in gut permeability, fecal microbiota and hepatic injury. Moreover, we tested if the co-treatment with an electrolyzed reduced (ERW) was effective to protect against alterations induced by PERM. Rats (from postnatal day 6 to 21) were gavaged daily with PERM, PERM+ERW or vehicle and gut, liver and feces were analyzed in 2-months-old rats. Increased gut permeability, measured by FITC-dextran assay, was detected in PERM group compared to control and PERM+ERW groups. In duodenum and ileum, concentration of occludin was higher in control group than those measured in PERM group, whereas only in duodenum ZO-1 was higher in control than those measured in PERM and PERM+ERW groups. Number of inflammatory focis and neutrophils as well as iNOS protein levels were higher in livers of PERM-treated rats than in those of PERM+ERW and control rats. Fecal microbiota analysis revealed that Lachnospira was less abundant and Defluviitaleaceae more abundant in the PERM group, whereas the co-treatment with ERW was protective against PERM treatment since the abundances in Lachnospira and Defluviitaleaceae were similar to those in the control group. Higher abundances of butyrate- producing bacteria such as Blautia, U.m. of Lachnospiraceae family, U.m. of Ruminococcaceae family, Papillibacter, Roseburia, Intestinimonas, Shuttleworthia together with higher butyric acid levels were detected in PERM+ERW group compared to the other groups. In conclusion, the PD animal model showed increased intestinal permeability together with hepatic inflammation correlated with altered gut microbiota. The positive effects of ERW co-treatment observed in gut, liver and brain of rats were linked to changes on gut microbiota.

Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice.

Permethrin, a pyrethroid chemical, is widely used as a pesticide because of its rapid insecticidal activity. Although permethrin is considered to exert very low toxicity in mammals, the effects of early, low-level, chronic exposure on the adult central nervous system are unclear. In this study, we investigated the effects of low-level, chronic permethrin exposure in early life on the brain functions of adult mice, using environmentally relevant concentrations. We exposed mice to the acceptable daily intake level of permethrin (0.3ppm) in drinking water during the prenatal and postnatal periods. We then examined the effects on the central nervous system in adult male offspring. In the permethrin group, we detected behavior that displayed incomplete adaptation to a novel environment, as well as an impairment in learning and memory. In addition, immunohistochemical analysis revealed an increase in doublecortin- (an immature neuron marker) positive cells in the hippocampal dentate gyrus in the permethrin exposure group compared with the control group. Additionally, in the permethrin exposure group there was a decrease in astrocyte number in the hilus of the dentate gyrus, and remaining astrocytes were often irregularly shaped. These results suggest that exposure to permethrin at low levels in early life affects the formation of the neural circuit base and behavior after maturation. Therefore, in the central nervous system of male mice, low-level, chronic permethrin exposure during the prenatal and postnatal periods has effects that were not expected based on the known effects of permethrin exposure in mature animals.

A comparison of the efficacy and tolerability of topical agents used in facial Demodex treatment.

Demodex spp. is the most common ectoparasite in humans. This parasite is believed to play a role in the etiology of many dermatological and ocular disorders. The aim of this study was to compare the efficacy and tolerability of the sulfur-sodium sulfacetamide combination, crotamiton, and permethrin, which are three topical agents commonly used in Demodex treatment. A total of 28 patients with primary demodicosis and 44 patients with Rosacea+Demodex were included in the study. The pretreatment and post-treatment Demodex spp. counts, patient satisfaction, and erythema decrease rates were compared. Analysis of the efficacy of these topical agents on Demodex revealed that all three significantly decreased the number of parasites. The patient satisfaction was higher in the sodium acetamide group than the 10% crotamiton and 5% permethrin groups, and clinical evaluation (erythema/ papulopustules and white plugs) was better in the sodium acetamide group than the other groups but no statistically significant difference was found in terms of patient satisfaction and clinical evaluation. The sulfur-sodium combination, crotamiton, and permethrin are the three agents commonly used in the treatment of Demodex spp. and all significantly decreased the Demodex count. The three agents were similar in terms of tolerability. Our study needs to be supported with others on larger patient series.

EFFECTIVENESS OF WET COMBING COMPARED WITH 1% PERMETHRIN LOTION FOR THE TREATMENT OF PEDICULOSIS CAPITIS

Objective: Pediculus humanus capitis is an ectoparasite that sucks blood from the patient’s scalp. Gamma-hexachlorocyclohexane is an effective treatment but its use has been discontinued because of its neurotoxicity. Although the replacement pediculicide is permethrin, this is not affordable for everyone, and thus the recommended treatment is wet combing. The aim of this study is to evaluate the effectiveness of permethrin compared with wet combing for eliminating pediculosis.&#x0D; Methods: This study was a randomized controlled trial (RCT) conducted in a boarding school in Bogor District; the data were collected in July–August, 2018. Subjects were regarded as infested if lice were found during examination. Infested subjects were divided into two groups. In the permethrin group, the hair was wetted with permethrin lotion and left for 10 min. Afterwards, a fine-toothed comb was used to remove lice, and then the subjects were instructed to wash their hair with shampoo. On day 14, each subject’s head was reexamined to determine the cure rate. The wet-combing group was treated similarly but using conditioner instead of permethrin.&#x0D; Results: Of 121 subjects, 88.4% were infested with head lice. The cure rate after one week of treatment was 66% in the permethrin group and 63% in the wet-combing group. After a two-week course of treatment, the cure rate increased to 94% in permethrin group and 89% in the wet-combing group. There was no significant difference in cure rate between permethrin and wet combing after a one-(P = 0.740) or two-week (P = 0.507) course of treatment.&#x0D; Conclusion: The prevalence of pediculosis capitis in a boarding school in Bogor District was 88.4%. Wet combing treatment was as effective as permethrin for treating pediculosis capitis.

Comparison of efficiency of 1% permethrin lotion vs. 0.5% ivermectin shampoo in the treatment of pediculosis capitis

&lt;p class="abstract"&gt;&lt;strong&gt;Background:&lt;/strong&gt; Pediculosis or head louse infestation is a common condition and an issue of concern in developing countries. Various treatment options are available for the management of this condition but still needs further research due to drug resistance. This study seeks to compare the efficacy of 1% permethrin lotion and 0.5% ivermectin shampoo in the management of pediculosis capitis.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Methods:&lt;/strong&gt; A prospective longitudinal study was conducted in a tertiary care hospital from September 2013 to June 2015. Patients presenting with pediculosis capitis infestation were divided into two groups of 50 each. They were treated with either topical 1% permethrin lotion or 0.5% ivermectin shampoo. Follow up was done once in 4 weeks on the extent of head lice infestation.&lt;strong&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Results:&lt;/strong&gt; After being treated with either topical 1% permethrin or 0.5% ivermectin shampoo, the presence of nits decreased significantly in the ivermectin group. Number of patients either had no nits or less than 5 dead nits in the permethrin group than in the ivermectin group.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; It is concluded that both 1% permethrin and 0.5% ivermectin have comparable efficacies in managing pediculosis capitis infestation, but permethrin was found to be more effective in treatment. In addition, none of the participants in both the treatment groups experienced any side effects. This is one of the very few studies exploring the treatment efficacy of topical ivermectin and the potential scope for future studies on the treatment options for pediculosis capitis.&lt;/p&gt;

Ivermectin and permethrin for treating scabies.

Ivermectin and permethrin for treating scabies.

Efficacy of fluralaner (Bravecto\u2122 chewable tablets) for the treatment of naturally acquired Linognathus setosus infestations on dogs

BackgroundThe clinical efficacy of fluralaner chewable tablets (Bravecto™, MSD Animal Health) against naturally acquired Linognathus setosus infestations on dogs was evaluated compared with permethrin (Exspot®, MSD Animal Health) treatment.MethodsPrivately-owned dogs naturally infested with L. setosus from 21 different households were randomly allocated to two treatment groups. Fourteen dogs were treated once orally with fluralaner and ten dogs were treated once topically with permethrin, at the recommended label dose. Live L. setosus on all dogs were counted before treatment and 1, 7, 28 (both groups) and 84 (fluralaner group) days post-treatment according to a coat parting technique at pre-specified locations and lice species were confirmed microscopically. At the same time points, a veterinary dermatology severity score and an owner’s perceived pruritus score were recorded.ResultsPercentage reduction in geometric mean L. setosus counts, comparing post- with pre-treatment counts within each group, were 85.7% (day 1), 96.8% (day 7) and 100% (days 28 and 84) for the fluralaner (two-sided two-sample t-test, P ≤ 0.0088 for days 1–84) and 67.5% (day 1), 90.3% (day 7) 99.1% (day 28) for the permethrin group (two-sided two-sample t-test, P ≤ 0.0014 for days 7–28). No lice were seen on fluralaner-treated dogs 28 and 84 days post-treatment. In contrast, two permethrin-treated dogs were re-treated at 7 and 28 days after initial treatment because of observed lice. Owner’s perceived pruritus scores were reduced compared to pre-treatment levels by 23.8% (day 1), 31.1% (day 7), 70.4% (day 28) and 99.5% (day 84) after fluralaner treatment and 21.3% (day 1), 45.8% (day 7), and 78.1% (day 28) after permethrin treatment. Dermatological signs were improved compared to pre-treatment levels in both treatment groups.ConclusionsSingle oral fluralaner treatment eliminated natural L. setosus infestation on dogs within 28 days and led to complete dermatological recovery that was maintained until the study end on day 84. Single topical permethrin treatment reduced the number of L. setosus by 99.1% at day 28 although two animals required unscheduled re-treatment.

Efficacy and safety of permethrin 5% topical gel vs. placebo for rosacea: a double-blind randomized controlled clinical trial.

Rosacea is a chronic, multifactorial, dermatological condition. Increased density of Demodex folliculorum mites in the skin of rosacea patients suggests a possible role for these mites in the pathophysiology of rosacea. To evaluate the effects of permethrin 5% topical gel vs. placebo on Demodex density (Dd) and clinical presentations of rosacea patients, and also to further refine the quantitative assessment of Dd in the non-invasive standard skin surface biopsy (SSSB). Twenty patients with bilateral papulopustular rosacea and ≥5 mites/cm2 were enrolled in the study. Participants and physicians were blinded to the group assignments. Each patient applied permethrin on one side and placebo on the other side of the face twice daily for 12 weeks. SSSB and photography and Rosacea Clinical Scorecard of the National Rosacea Society were used to assess the patients at the baseline, 2nd, 5th, 8th, and 12th weeks for both sides of the face. Causality and severity of adverse drug reactions (ADRs) were assessed by WHO Scale and Hartwig Scale, respectively. Dd was not significantly different between the two groups at the baseline. In both groups, Dd significantly decreased after 12 weeks compared to the baseline. At the end of the 12th week, the Dd in the permethrin group was significantly lower than the placebo group. Severity of the clinical presentations decreased in both groups at the end of week 12 in comparison to the baseline, particularly in the permethrin group. ADRs were all mild and in most cases unlikely related to permethrin. Permethrin 5% gel can significantly reduce the Dd and severity of presentations in rosacea patients and can be a safe and effective option in the management of this chronic disorder. This new SSSB technique offers an easy, quick, inexpensive, and non-invasive sampling method proper for quantitative assessment of Dd.

Permethrin-induced oxidative damage in liver of rainbow trout (Oncorhynchus mykiss) and its attenuation by vitamin C.

The objective of this study was to investigate the propensity of permethrin (PTN) to induce oxidative stress and changes in enzyme activities in liver of rainbow trout and its possible attenuation by vitamin C. Forty-eight fish were randomly assigned to 1 of 6 treatment groups and their livers were used for liver perfusion method: control (0 µgL(-1) permethrin and 0 mgL(-1) vitamin C), PTN-0.16 (0.16 µgL(-1) permethrin), PTN-0.32 (0.32 µgL(-1) permethrin), PTN-0.64 (0.64 µgL(-1) permethrin), Vit. C (17.2 mgL(-1) vitamin C), and PTN-0.64 + Vit. C (0.64 µgL(-1) permethrin and 17.2 mgL(-1) vitamin C). Results obtained showed that permethrin significantly (P<0.05) increased ALT, AST and LDH activities in the liver perfusion medium and malondialdehyde (MDA) level in liver tissue. The values of reduced glutathione (GSH) and total antioxidant capacity (FRAP) in the liver tissue were significantly decreased due to permethrin administration. Pearson's correlation analysis revealed a positive correlation between MDA concentration and ALT, AST and LDH activities in the permethrin groups, suggesting that the enhanced lipid peroxidation may be linked to hepatic damage caused by permethrin. On the other hand, treatment with vitamin C in the PTN-0.64 + Vit. C group increased the values of GSH and FRAP, and decreased the level of MDA and the activities of hepatic enzymes, when compared to the PTN-0.64 group. The present study revealed that vitamin C could ameliorate permethrin-induced oxidative damage by decreasing lipid peroxidation and altering antioxidant defense system in liver of rainbow trout.

Mass Drug Administration for Scabies Control in a Population with Endemic Disease

BackgroundScabies is an underrecognized cause of illness in many developing countries. It is associated with impetigo, which can lead to serious systemic complications. We conducted a trial of mass drug administration for scabies control in Fiji.MethodsWe randomly assigned three island communities to one of three different interventions for scabies control: standard care involving the administration of permethrin to affected persons and their contacts (standard-care group), mass administration of permethrin (permethrin group), or mass administration of ivermectin (ivermectin group). The primary outcome was the change in the prevalence of scabies and of impetigo from baseline to 12 months.ResultsA total of 2051 participants were enrolled; 803 were in the standard-care group, 532 in the permethrin group, and 716 in the ivermectin group. From baseline to 12 months, the prevalence of scabies declined significantly in all groups, with the greatest reduction seen in the ivermectin group. The prevalence declined from 36.6% to 18.8% in the standard-care group (relative reduction in prevalence, 49%; 95% confidence interval [CI], 37 to 60), from 41.7% to 15.8% in the permethrin group (relative reduction, 62%; 95% CI, 49 to 75), and from 32.1% to 1.9% in the ivermectin group (relative reduction, 94%; 95% CI, 83 to 100). The prevalence of impetigo also declined in all groups, with the greatest reduction seen in the ivermectin group. The prevalence declined from 21.4% to 14.6% in the standard-care group (relative reduction, 32%; 95% CI, 14 to 50), from 24.6% to 11.4% in the permethrin group (relative reduction, 54%; 95% CI, 35 to 73), and from 24.6% to 8.0% in the ivermectin group (relative reduction, 67%; 95% CI, 52 to 83). Adverse events were mild and were reported more frequently in the ivermectin group than in the permethrin group (15.6% vs. 6.8%).ConclusionsMass drug administration, particularly the administration of ivermectin, was efficacious for the control of scabies and impetigo. (Funded by the Australian National Health and Medical Research Council; Australian New Zealand Clinical Trials Registry number, ACTRN12613000474752.)

A Comparative Study of Oral Ivermectin and Topical 5% Permethirn Cream in the Treatment of Scabies in Patient Suffering from Diabetes Mellitus

Scabies is one of the commonest diseases among all age groups. Topical permethrin is a widely used treatment option for scabies. Ivermectin is a newer oral agent for the treatment of scabies. This study was done to compare the efficacy of permithrin and oral Ivermectin in the treatment of Scabies in patient suffering from Diabetes mellitus. This comparative clinical trial was carried out in the outpatient department of Dermatology &amp; Venereology, Diabetic Association Medical College Hospital (DAMCH), Faridpur from January 2012 to December 2012. A total 60 cases were enrolled purposively and divided into 2 groups. Group I received 2 doses oral Ivermectin and group II treated with 5% permethirn cream. Patients were followed up at the 3rd and 4th week. Total 86.6% patients of Ivermectin group and 90% of permethrin group were cured. Though permethrin showed somewhat more effective, the difference was not statistically significant. The study found that both ivermectin and permethrin were similarly effective in the treatment of scabies in patients suffering from Diabetes Mellitus.Faridpur Med. Coll. J. 2014;9(2): 70-72

Effect of Permethrin–Impregnated Underwear on Body Lice in Sheltered Homeless Persons

The control of body lice in homeless persons remains a challenge. To determine whether the use of long-lasting insecticide-treated underwear provides effective long-term protection against body lice in homeless persons. A randomized, double-blind, placebo-controlled trial was conducted in February and December 2011 in 2 homeless shelters (Madrague Ville and Forbin) in Marseille, France. Of the 125 homeless persons screened for eligibility, 73 body lice-infested homeless persons, 18 years or older, were enrolled. Body lice-infested homeless persons were randomly assigned to receive 0.4% permethrin-impregnated underwear or an identical-appearing placebo for 45 days, in a 1:1 ratio, with a permuted block size of 10. Visits were scheduled at days 14 and 45. Data regarding the presence or absence of live body lice were collected. The primary and secondary end points were the proportions of homeless persons free of body lice on days 14 and 45, respectively. Mutations associated with permethrin resistance in the body lice were also identified. Significantly more homeless persons receiving permethrin-impregnated underwear than homeless persons receiving the placebo were free of body lice on day 14 in the intent-to-treat population (28% vs 9%; P = .04), with a between-group difference of 18.4 percentage points (95% CI, 1.4-35.4), and in the per-protocol population (34% vs 11%; P = .03), with a between-group difference of 23.7 percentage points (95% CI, 3.6-43.7). This difference was not sustained on day 45. At baseline, the prevalence of the permethrin-resistant haplotype was 51% in the permethrin group and 44% in the placebo group. On day 45, the permethrin-resistant haplotype was significantly more frequent in the permethrin group than in the placebo group (73% vs 45%, P < .001). Permethrin-impregnated underwear is more efficient than placebo at eliminating body louse infestations by day 14; however, this difference was not sustained on day 45. The use of permethrin may have increased the resistance to permethrin in body lice and thus must be avoided. clinicaltrials.gov Identifier: NCT01287663.