The difficulty of recharging the weakly consolidated sandstone geothermal reservoirs (WCSGR) is a macroscopic manifestation of the interplay of multiple factors associated with both fluids and formation properties. However, current studies predominantly focus on the influence mechanisms of individual factors on the reinjection of WCSGR. To address this limitation, a high temperature–pressure core flow experimental platform, combined with an orthogonal experimental design, is employed to investigate the dynamic reinjection process of WCSGR under the combined effects of multiple factors. The research indicates that high temperatures significantly impact the movement of 3 μm microspheres, leading to a rapid decrease in core permeability. Additionally, in experiments conducted at flow rates of 2 mL/min, 3 mL/min, and 4 mL/min, the pH stabilization time of the outflow solution decreased, while both the pH value and turbidity of the outflow solution increased, compared to the experiments conducted at flow rate of 0.5 mL/min and 1 mL/min. The permeability damage rate (%) was used as the experimental evaluation index. The primary and secondary order of influence of each factor on the permeability is: microsphere size > flow rate > turbidity > confining pressure > temperature. The optimal levels for each factor are 5 μm, 4 mL/min, 2 mg/L, 1.4 MPa, and 25 °C, respectively. Consequently, the reinjection technology of GT in WCSGR is optimized.