Cystic Peritoneal Mesothelioma Research Articles

870 Benign Cystic Mesothelioma- a Rare Intra-Abdominal Tumour

Abstract Introduction Benign cystic mesothelioma is a rare intra-abdominal tumour affects primarily women who are in reproductive. Since this pathology has a rare occurrence, a similar presentation, and similar imaging features, the diagnosis is based on histologic findings and there is no current standard treatment for this condition. Presentation of case In this case report, a 40-year-old female patient presented in the Emergency Department with a five-day history of right-sided, migratory, abdominal pain. She was systemically well, and her inflammatory markers were unremarkable. The patient was investigated for appendicitis, with a CT scan showing a multi-loculated cystic structure below the liver. Her case was discussed with the Basingstoke Peritoneal Malignancy Institute who felt this may demonstrate benign cystic peritoneal mesothelioma. As per their advice, and the thoughts of the local MDT team, the patient underwent a diagnostic laparoscopy, and the cystic mass was removed. The diagnosis of benign cystic peritoneal mesothelioma was then confirmed by histology. Discussion Based on literature, this is a rare and asymptomatic form of mesothelioma.Imaging is able to provide suspicion of this type of benign mesothelium, but only histological examination can provide a definitive diagnosis. Additionally, on review there are no guidelines regarding management and no standard treatment for this condition. The only effective treatment for a benign cystic mesothelioma is surgery, but no evidence-based strategies exist. Conclusions It is critical to publish more case reports on this condition once it is diagnosed in order to formulate guidelines and to advance towards a possible effective treatment solution.

Management of an Uncommun Giant Ovarian Hydatid Cyst

We report the case of a 52-year-old patient. She was overweight and thought at first she was gaining weight. She presented to our department with a gradually increasing huge abdomen after 11 months of clinical evolution. She was not febrile and had normal vital signs on general assessment. No icterus or edema was present. On examination of the abdomen, there was widespread distension and a dull tone on percussion. The liver and spleen could not be felt. A large abdominal echogenic tumor filled the whole abdomen and pelvic cavity, according to the CT scan (Figure 1). Despite their rarity, peritoneal cystic mesothelioma and abdominal cystic lymphangioma should be suspected in the presence of such a pelvic mass. The huge cyst was confirmed on an abdomino-pelvic Magnetic Resonance Imaging (MRI) and measured 65 x 52 cm, supero-laterally displacing the liver and spleen. The kidneys were located in the back, and the bowel loops were located in the front. The ovaries were not visible. There was fluid in the peritoneal cavity (Figures 2 and 3). Tumor markers (CEA, a-fetoprotein and CA-125) were within normal limits. The hydatid cyst serology was positive.

Benign cystic Mesothelioma of Peritoneum: A Case Report and Review of Literature

Benign cystic peritoneal mesothelioma (BCPM) is an uncommon clinical condition with diverse presentations. Its abstruse pathogenesis and association with diverse intra- abdominal conditions make an explicit diagnosis arduous. Diagnostic veracity and conscientious followup are essential because, though benign nature, it recurs locally with potentials for malignant transformation. Hence a definitive diagnostic and surgical strategy needs to be formulated.Bangladesh J Obstet Gynaecol, 2014; Vol. 29(2) : 120-122

Mesotelioma peritoneal quístico benigno. Reporte de caso

El mesotelioma peritoneal quístico benigno es un raro tumor abdominal que ocurre en mujeres en edad reproductiva. La aparición aguda es más rara y las opciones de manejo aún no están establecidas. Se presenta un caso de paciente de 25 años con múltiples episodios de dolor hipogástrico y dismenorrea. El ultrasonido transvaginal mostró tumoración quística desde el flanco izquierdo hasta la pelvis. Durante la laparoscopia, el útero y anexos estaban congestivos. Ambos ovarios, fondo de saco de Douglas y epiplón tenían quistes de paredes finas en forma de racimo de uva. La paciente fue tratada con omentectomía total y resección quirúrgica de los quistes. El análisis histológico de la lesión confirmó el diagnóstico de mesotelioma peritoneal quístico benigno.

Benign Cystic Peritoneal Mesothelioma Revealed by Small Bowel Obstruction.

Benign cystic peritoneal mesothelioma is a rare tumor which frequently occurs in women of reproductive age. Abdominal pain associated with pelvic or abdominal mass is the common clinical presentation. We report the case of a 22-year-old woman with a pathological proved benign cystic mesothelioma of the peritoneum revealed by a small bowel obstruction and a painful left-sided pelvic mass with signs of psoitis. Contrast enhanced abdominal CT-scan demonstrated a large pelvic cystic mass with mass effect on rectosigmoid and pelvic organs. The patient underwent surgical removal of the tumor. Pathological examination revealed the diagnosis of benign cystic mesothelioma of the peritoneum. The outcome was excellent with a 12-month recoil.

Benign cystic peritoneal mesothelioma: an abdominal daze

Benign cystic peritoneal mesothelioma (BCPM) is a rare clinical entity with varied presentations. Its obscure etiology and association with various intraabdominal conditions makes a precise diagnosis difficult. Diagnostic accuracy and diligent follow-up are essential because, though benign nature, it recurs locally. Herewith reporting a case of BCPM presenting as acute abdomen.

Giant peritoneal inclusion cyst mimicking ovarian cyst

Benign cystic peritoneal mesothelioma also known as peritoneal inclusion cyst is a rare lesion that usually occurs in women of reproductive age. Giant peritoneal inclusion cysts are extremely rare and to the best of our knowledge only has been reported in man to date. Hereby, a case of a 45-year-old multiparous patient with a giant peritoneal inclusion cyst that mimicks an ovarian cyst is presented. The patient with a complaint of abdominal distention sought out to our outpatient clinic. In her medical history she has had neither prior surgery nor pelvic infection. Physical examination revealed a giant smooth surfaced pelvic mass originating from the left adnexal space. Ultrasonography and computed tomography images supported the pelvic examination. The patient underwent diagnostic laparatomy and frozen section analysis. Histopathological diagnosis revealed a peritoneal inclusion cyst with endometriotic focus. After one year from surgery, the patient has had no recurrences. Although giant masses of pre-menopausal women are usually malignant, clinicians may encounter with rare benign tumors such as peritoneal inclusion cysts and should be aware of them in the differential diagnosis.

Benign cystic peritoneal mesothelioma incorrectly diagnosed as an ovarian borderline mucinous tumor of intestinal type at transvaginal preoperative ultrasound evaluation

Benign cystic peritoneal mesothelioma incorrectly diagnosed as an ovarian borderline mucinous tumor of intestinal type at transvaginal preoperative ultrasound evaluation

Laparoscopic excision of a benign peritoneal cystic mesothelioma

Benign cystic peritoneal mesothelioma is a rare tumor and most commonly occurs in women in the reproductive age group. It is very rare in women of postmenopausal age. We present a rare case of a postmenopausal woman with benign peritoneal cystic mesothelioma removed at laparoscopy.

Benign Peritoneal Cystic Mesothelioma

Benign peritoneal cystic mesothelioma (BPCM) is a rare tumor of unknown origin, most frequently encountered in women of reproductive age. Etiology is unknown; definitions and terminology are confusing, and preoperative diagnosis is difficult. Several differential diagnoses must be considered. Based on our own clinical experience and a review of the relevant literature, we address clinical challenges and controversies of importance. Current literature on BPCM is mostly based on small case reports. Complete surgical resection is recommended if possible. Nevertheless, recurrent disease is not uncommon. Clinical positive effects of various adjuvant medical treatments remain to be shown. Lack of consistent definitions, various treatment approaches, and mostly short follow-up times make it difficult to draw any firm conclusions from published reports. The natural history of this rare disease is less than well clarified. When possible, in an individual patient, surgical resection with curative intent seems to be the treatment of choice.

Peritoneal cystic mesothelioma presenting as a cystic mass in the pelvis: a challenging differential diagnosis

Peritoneal cystic mesothelioma is a relatively rare neoplasm, characterized by cystic lesions of various sizes on both visceral and parietal peritoneal surfaces. When located in the pelvis, a wide spectrum of cystic or multicystic lesions should be included in the differential diagnosis. From an imaging point of view, no definite differential diagnostic suggestions can be made, because reports of peritoneal cystic mesothelioma are few and consist mostly of case reports. The rarity of this disease, as well as its malignant potential, include it among the challenging differential diagnoses of pelvic/peritoneal cystic masses, especially in the case of a paraovarian cyst with identification of ovaries with non-suspect morphology. In this case, repetition of transvaginal ultrasound examination after a few weeks seems to be appropriate. When the findings persist, cystic peritoneal mesothelioma must be included in the differential diagnosis. Nevertheless, it seems that the definitive diagnosis of peritoneal cyst...

Peritoneal cystic mesothelioma presenting as a cystic mass in the pelvis: a challenging differential diagnosis

Peritoneal cystic mesothelioma presenting as a cystic mass in the pelvis: a challenging differential diagnosis

Imaging benign peritoneal disease

•. Benign diseases of the peritoneum and its reflections may be either diffuse processes or more discrete lesions; the latter may be solid or cystic. •. Diffuse processes, such as infection or inflammation, produce ascites and mesenteric oedema. The clinical presentation and the site of origin of the abnormality may aid diagnosis. •. Discrete solid lesions include sclerosing mesenteritis, mesenteric desmoid tumour, plexiform neurofibromatosis and lipoma. •. Discrete cystic lesions include congenital cysts, such as lymphangioma, duplication, and enteric and mesothelial cysts, but also benign cystic tumours such as cystic teratoma and benign cystic peritoneal mesothelioma. •. Cross‐sectional imaging has an important role in percutaneous abscess drainage and guiding biopsy of solid lesions.

Peritoneal cystic mesothelioma treated with minimally invasive approach

A case of peritoneal cystic mesothelioma in a young woman was treated with a minimally invasive approach. The technique and a review of the literature are presented.

Peritoneal Benign Cystic Mesothelioma

A case of a benign cystic peritoneal mesothelioma is reported. A 25-year-old woman presented a 8-year history of recurrent tumor and five operations because of that. On the basis of this case and of 18 cases proved by electron microscopy reported by others, the clinicopathological features and the problems of differential diagnosis are discussed. The ultrastructural examination is essential for the diagnosis of cystic mesothelioma.

Cystic Mesothelioma of the Peritoneum: A Report of Three Cases

Three cases of peritoneal cystic mesothelioma are reported. All patients were women who had undergone previous abdominal surgery for unrelated conditions. Tumors consisted of solitary and multiple cystic masses involving the abdominal and pelvic peritoneum. The cysts focally infiltrated the muscularis externa of the small intestine in case 1, the outer muscular layer of the uterus in case 2, and the omental tissue in case 3. These findings give morphologic support to the borderline clinical behavior of this tumor that often recurs and support the hypothesis that previous surgery may play a role in its pathogenesis.

Tumors of Serosal Tissue Origin

Primary serosal neoplasms demonstrate a wide spectrum of growth patterns and biologic aggressiveness. The adenomatoid tumor is uniformly benign, whereas the diffuse malignant mesothelioma pursues a downhill clinical course, rapidly leading to fatality. The cystic peritoneal mesothelioma occupies an intermediate position characterized by persistent and/or recurrent disease but without progression to death. The distinction of an epithelial mesothelioma from metastatic adenocarcinoma remains a challenging problem. In the vast majority of cases, this can be accomplished by combining routine histochemistry, immunocytochemistry, and electron microscopy. The absence of epithelial mucins and nonreactivity with antibodies to CEA strongly favor mesothelioma. Ultrastructurally observed long, thin, sinuous surface microvilli without a glycocalix, well-developed desmosomes, and abundant tonofilaments add further support for a primary serosal neoplasm. The sarcomatoid mesothelioma can easily be confused with a chest-wall sarcoma. Despite lacking ultrastructural evidence of "epithelial" differentiation, immunocytochemical studies demonstrate cytokeratin. This distinguishes the sarcomatoid mesothelioma from most soft-tissue sarcomas. There remains a small number of cases, particularly those in the "poorly differentiated" or "transitional" category, in which the distinction between mesothelioma and metastatic carcinoma remains difficult. In this situation, it is imperative that all the clinical information be closely reviewed and a diligent search for a primary site be carried out. There are many parallels between reactive and neoplastic serosal tissue. The desmoplastic/sarcomatoid mesothelioma morphologically and immunocytochemically resembles the reactive multipotential subserosal cell (MSC) of injured serosal tissue, whereas the adenomatoid tumor, cystic peritoneal mesothelioma, and epithelial mesothelioma resemble surface mesothelium. The poorly differentiated mesothelioma resembles a stage of maturation between the two extremes, and thus the term "transitional" mesothelioma is suggested. The localized fibrous tumor of the pleura is unique among all other serosal neoplasms in its failure to express cytokeratin. It more closely resembles the unspecialized connective tissue fibroblast of normal serosal tissue, and thus may be more analogous to a soft-tissue tumor than to the remaining mesothelial-derived neoplasms.

Peritoneal cystic mesothelioma: an electron microscopic and immunohistochemical study of two male patients.

The clinical, pathological, and ultrastructural features of two cases of peritoneal cystic mesothelioma occurring in men were studied. The results of immunohistochemical staining for CAM 5.2, epithelial membrane antigen, carcinoembryonic antigen, and Factor VIII related antigen are reported for the first time and compared with the staining results of two peritoneal cystic lymphangiomas. Although resembling cystic lymphangioma by light microscopy, cystic mesothelioma may have a greater tendency for local recurrence. Staining for CAM 5.2 or epithelial membrane antigen may facilitate the differentiation of these two entities.