Periorbital Hyperpigmentation Research Articles

Madhu Kumari Lepa in Management of Periorbital Hyperpigmentation - Randomized Controlled Clinical Study

Madhu Kumari Lepa in Management of Periorbital Hyperpigmentation - Randomized Controlled Clinical Study

A clinico-epidemiological study of different dermoscopic patterns in hyperpigmented facial lesions in a tertiary care centre.

Facial pigmentation is a common presentation of patients attending dermatology out patient department (OPD) and is of great concern to patients. Facial pigmentation may be multifactorial and is only rarely diagnosed accurately by a detailed history and clinical examination. Pigmentary disorders cause psychological distress and negatively impact the quality of life of an individual. (1) To study different dermoscopic patterns in facial melanosis. (2) To estimate the frequency of different dermoscopic patterns. Patients with facial hyperpigmentation attending the dermatology OPD were recruited after taking their written consent. A detailed history was taken to collect demographic data. Clinical examination and dermoscopy were done in all patients. Biopsy was done as and when required. Descriptive statistics has been used to describe the quantitative data. Qualitative data were presented as frequency and percentage for clinical and dermoscopic patterns. The study included 100 patients with 15 different facial melanoses. The most common age group affected was 21-40 years in 53 (53%) cases. The female-to-male ratio was 1.63:1. Melasma was reported as the most common cause of facial melanosis constituting 49 (49%) of the total cases. Out of the total melasma cases, epidermal melasma constituted 22 (45%) cases, dermal melasma constituted four (4%) cases and mixed melasma constituted 23 (47%) cases. Other cases included were lichen planus pigmentosus (14; 14%), facial acanthosis nigricans (14; 14%), periorbital hyperpigmentation (7; 7%), post-inflammatory hyperpigmentation (4; 4%), exogenous ochronosis (2; 2%), lentigines (2; 2%), frictional melanosis (2;2%), and one case each of Becker's nevus, nevus of Ota, olanzapine-induced hyperpigmentation, Riehl's melanosis, macular amyloidosis, and tanning. Melasma was reported as the most common cause of facial melanosis. The most common dermoscopic feature was accentuated pseudopigment network. The study is beneficial in understanding the different clinical and dermoscopic patterns of facial melanosis, thus helping the physician to effectively manage the conditions and reduce the need of biopsy. (1) A small sample size. (2) Histopathological correlation was not done in all cases.

Vitamin K (Menadione)-incorporated chitosan/alginate hydrogel as a novel product for periorbital hyperpigmentation

The possibility of controlling periorbital hyperpigmentation disorders is one of the most important research goals in cosmetic preparations. In the current investigation, 1% vitamin K (Vit K) was incorporated into a Chitosan/alginate hydrogel which aimed to increase the dermal delivery and anti-pigmentation effect. The Vit K-hydrogel was evaluated using several different tests, including volume expansion/contraction analysis, differential scanning calorimetry (DSC), scanning electron microscopy (SEM), ultraviolet (UV) absorbance spectroscopy, and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Vit K hydrogel’s drug release profile showed a steady increase over time. Furthermore, the modified Vit K hydrogel formulations showed no harmful effects in an in vitro cytotoxicity study. The Vit K hydrogel was tested for dermal irritation on Wistar rats, and the hydrogel was found to be non-irritating. Furthermore, Vit K-hydrogel inhibited melanin formation (31.76 ± 1.14%) and was remarkably higher than free Vit K. In addition, Vit K-hydrogel inhibited L-dopa auto-oxidation to a greater extent (94.80 ± 2.41%) in comparison with Vit K solution (73.95 ± 1.62%). Vit K-hydrogel enhanced percutaneous transport of Vit K, according to in vitro percutaneous absorption findings, suggesting that this innovative formulation may provide new therapeutic options for periorbital hyperpigmentation.

Treatment of periorbital hyperpigmentation using sublative fractional radiofrequency (SFR).

Periorbital hyperpigmentation (POH) is a common cosmetic concern. Numerous techniques of treatment have been assessed with variable results. The purpose of this research is to assess the efficacy of non-ablative radiofrequency, Sublative fractional Radiofrequency (SFR) on POH treatment. In this research study, nine patients with POH and the age range of 25-57 years, were enrolled. The patients were treated by non-ablative radiofrequency SRF. The outcomes were assessed by biometric assessment. The skin lightness and melanin content of the periorbital skin were assessed by colorimeter and Mexameter. Skin elasticity was assessed by Cutometer. The skin ultrasound imaging system was used to evaluate the diameter and density of the epidermis and dermis. Visioface was used to evaluate the skin color and wrinkles. Also, patient's satisfaction and physician's assessment were assessed. The results showed that the lightness and elasticity of the periorbital skin were significantly increased after treatment. Also, the melanin content of the skin was decreased. The denser skin layers were seen in both dermis and epidermis. The Visioface results displayed the reduction in the percent change of the skin color and wrinkle (p<0.05). Similarly, the physician and patients' assessment confirmed the outcomes. No serious adverse effect was reported. In conclusion, the SFR technique is an effective and satisfactory therapeutic choice for treatment of POH.

Aetiological Factors of Periorbital Hyperpigmentation in Patients Presenting to the Hospital

Objective: To know the aetiological factors of periorbital hyperpigmentation in patients presenting to the Outpatient Department of Combined Military Hospital, Kharian Pakistan.&#x0D; Study Design: Cross-sectional study.&#x0D; Place and Duration of Study: Combined Military Hospital, Kharian Pakistan, from Nov 2020 to Sep 2021.&#x0D; Methodology: We conducted a study of sixty patients with periorbital hyperpigmentation periorbital hyperpigmentation presenting to Skin OPD. A detailed history, clinical examination, and lab investigations like complete blood counts, thyroid function tests, and vitamin B12 and D levels were advised.&#x0D; Results: Out of 60 patients, 2(3.33%) were male, and 58(96.66%) were females. The mean age of patients was 24.95 years ±6.48. 10(16.66%) had a family history of periorbital hyperpigmentation. Lack of adequate sleep was found in 18(30%) patients, and prolonged daily bright screen exposure was found in 28(46.66%). History of atopy was present in 18(30%). History of seasonal allergies was present in 17(28.33) % of individuals. Other associated pigmented conditions like melasma in 14(23.33%) and post-inflammatory hyperpigmentation were noted in 2(3.33%) patients. 8(13.33%) patients had anaemia, 4(6.66%) had subclinical Hypothyroidism, and low vitamin D levels were found in 6(10%). None of our patients had vitamin B12 deficiency.&#x0D; Conclusion: Periorbital hyperpigmentation has multiple aetiological factors and associations. Correctable factors need to be addressed for better treatment outcomes. The presence of anaemia, subclinical Hypothyroidism, and low serum vitamin D levels indicate the need to screen periorbital hyperpigmentation patients for these conditions.

Microneedle fractional radiofrequency in the treatment of periorbital dark circles.

Periorbital hyperpigmentation (POH) is a common disorder in the patients. Women are more upset with POH in compare to males. Several methods have been used to the POH, with different efficacy and adverse reactions. The aim of the present study is to evaluate the efficacy of microneedle fractional radiofrequency (MRF) in treating POH. So, nine patients with POH and the age range of 25-57 years, were treated by microneedle fractional radiofrequency (MRF). The outcome was evaluated via biometric assessment. The colorimeter was used to assess the skin lightness. Mexameter was used for evaluated the amount of Melanin in the periorbital skin. Cutometer was used for skin elasticity assessment. The skin ultrasound imaging system was utilized to estimate the epidermis and dermis diameter and density. Furthermore, Visioface was applied to assessed the skin color and wrinkles. Also patient's satisfaction and physician's assessment were evaluated. The results displayed that the periorbital skin lightness 32.38% ± 5.67 and elasticity of the R2: 40.29% ± 8.18, R5: 39.03 ± 5.38 and R7: 42.03% ± 14.16 were significantly improved after treatment (p < 0.05). Also the melanin content of the skin was decreased (49.41% ± 9.12). The skin layers were denser in the dermis and also in the epidermis (skin density: 30.21% ± 10.16 and skin thickness: 41.12% ± 13.21) (p < 0.05). The results revealed the decrease in the percent change of the skin color (30.34% ± 9.30) and wrinkle (area: 25.84% ± 6.43 and volume: 30.66% ± 8.12) (p < 0.05). Similarly, the physician and patient's assessment were confirmed the obtained outcomes. In conclusion, the microneedle RF technique is practicable, effective and safe method for periorbital dark circles treatment.

Dermatological Findings in Children’s Films

Introduction: Filmmakers use dermatologic findings to help the audiences decipher between ‘good’ and ‘bad’ characters by portraying villains with recognizable skin findings. The objective of this study was to analyze 18 Disney live-action movies in relation to their earlier animated releases to determine whether there were changes or correlation about how the industry portrayed certain characters based on their roles as heroes or villains. Methods: To better understand how the use of dermatological findings are changing in the film industry, eighteen Disney live-action movies in relation to their earlier animated releases were compared for changes or correlation on how the industry portrays certain characters based on their roles as heroes or villains. Results: Film antagonists were depicted with significantly more dermatologic findings than protagonists (p&lt;0.0001). In addition, the frequency of periorbital hyperpigmentation (p=0.02) and nasolabial folds (p=0.05) were significantly higher in antagonists verses protagonists. Conclusion: These findings have important implications about the dermatological content of movies directed toward children. Findings of this study suggest filmmakers are continuing to use common dermatological findings to indirectly portray characters as ‘good’ or ‘bad.’

CLINICO DERMOSCOPIC STUDY OF PATTERNS OF PERIORBITAL HYPERMELANOSIS

Background:Periorbital hyperpigmentation (POH) is a routinely encountered condition in dermatology practice. Studying the clinical features and its correlation with dermoscopy will help in better understanding of patterns of periorbital pigmentation and its evolution. 2POH is a condition characterised by bilateral homogenous, hyperchromicmacules and patches, primarily involving the upper and the lower eyelids. 3It is a common problem with multifactorial etiology, is evident on the face and can affect patients quality of life (QoL). 7 Aim: To study dermoscopic patterns of periorbital hyper melanosis in patients presenting to dermatology, venereology,leprosy OPD in Bhaskar General Hospital from January 2022 to June 2022. Methods: 50 patients with periorbitalhypermelanosiswere included in the study.Dermilite 4 Dermoscope (10X magnification) with polarised light was employed in the study. Results:Out of 50 patientsondermoscopy mixed type was 76.4%, pigmented 11%, vascular 10.6%, structural 2%. Conclusion:Periorbital melanosis presents as multifactorial entity with constitutional type being the most common. The most common pattern seen on dermoscopy is mixed.It is essentially a clinical diagnosis, but dermoscopy might aid in further classification of the disease. Also, it might give us a clue regarding the etiology and help in the treatment, as different types of POH respond to varying treatments.7

Do we need to worry for metabolic syndrome in patients of periorbital melanosis? A case report of a middle-aged female

Background: In today's world, periorbital melanosis (PM), frequently referred to as dark circles, is of great cosmetic importance. This condition not only has a huge psychological impact but, it could also possibly be an indication of acanthosis nigricans (AN). Recently, it has been recognized as a distinct manifestation of metabolic syndrome. Methods: We studied one case of a middle aged female who came with a complaint of periorbital darkening. Relevant clinical and laboratory investigations were carried out. Results: Along with periorbital hyperpigmentation, she was also found to have axillary darkening consistent with AN. Further evaluation revealed abnormal electrocardiogram findings and she fulfilled the criteria of metabolic syndrome. Conclusion: We emphasize the need for evaluating such patients of PM for underlying metabolic syndrome.

Extended Overview of Ocular Phenotype with Recent Advances in Hypohidrotic Ectodermal Dysplasia.

The term ectodermal dysplasias (EDs) describes a heterogeneous group of inherited developmental disorders that affect several tissues of ectodermal origin. The most common form of EDs is hypohidrotic ectodermal dysplasia (HED), which is characterized by hypodontia, hypotrichosis, and partial or total eccrine sweat gland deficiency. HED is estimated to affect at least 1 in 17,000 people worldwide. Patients with HED have characteristic facies with periorbital hyperpigmentation, depressed nasal bridge, malar hypoplasia, and absent or sparse eyebrows and eyelashes. The common ocular features of HED include madarosis, trichiasis, and ocular chronic surface disease due to dry eye syndrome, which manifests clinically with discomfort, photophobia, and redness. Dry eye is common in HED and results from a combination of ocular surface defects: mucus abnormalities (abnormal conjunctival mucinous glands), aqueous tear deficiency (abnormalities in the lacrimal gland) and lipid deficiency (due to the partial or total absence of the meibomian glands; modified sebaceous glands with the tarsal plate). Sight-threatening complications result from ocular surface disease, including corneal ulceration and perforation with subsequent corneal scarring and neovascularization. Rare ocular features have been reported and include bilateral or unilateral congenital cataracts, bilateral glaucoma, chorioretinal atrophy and atresia of the nasolacrimal duct. Recognition of the ocular manifestations of HED is required to perform clinical surveillance, instigate supportive and preventative treatment, and manage ocular complications.

Platelet-rich plasma versus carboxytherapy in the treatment of periorbital dark circles: A split-face study.

Periorbital hyperpigmentation is a recurrent problem in dermatologic clinics that affect the patients' quality of life and their psychological status. Platelet-rich plasma (PRP) may serve as a source of different growth factors which may reduce the pigmentation in this problem. Carboxytherapy is carbon dioxide infusion into human tissue for therapeutic purposes. To evaluate and compare the clinical efficacy of PRP and carboxytherapy in the treatment of periorbital dark circles (PODC). Histopathological evaluation was also done. Split-face study of 23 patients with PODC treated with PRP at the right side and carboxytherapy at the left side. Patients received four sessions; one session/week. Final follow-up evaluation was done 3 months after the last session by clinical and histopathological assessment. PRP showed significant better response (p=0.002), shorter downtime, and tolerable side effects than caboxytherapy. Reduction in area percent of melanin after PRP injections showed 46.6% improvement, while after carboxytherapy, it showed only 14.3% improvement. The present study showed that PRP is more effective and tolerable than caboxytherapy in the treatment of PODC.

An updated review on facial hyperpigmention disorder and treatment

Abstract: Skin health is an important aspect of glamour and reflects the overall wellbeing of the whole body. Facial and neck hyperpigmentation have been posing a challenge towards a complete cure in skincare and cosmetology. The root cause of hyperpigmentation is excessive production of melanin induced by the enzyme tyrosinase and also excessive production is related to exogenous factor-like cosmetics and perfumes, and endogenous factor-like hormonal imbalance during pregnancy. There are many types of hyperpigmentation including post-inflammatory hyperpigmentation (PIH), periorbital hyperpigmentation, exogenous ochronosis, which are a few to mention. Though many innovative therapy techniques and newer products have been introduced in cosmetology, nevertheless efficient management of hyperpigmentation continues to be a challenge in health care and hence presents an area of research interest for dermatologists and scientists to develop novel methods. The recent addition in skincare is the sheet masks, which are considered to be the most productive and trending technique of drug delivery for skin rejuvenation. Sheet masks are beneficial because they are toxin-free and are the perfect carrier to our skin. Having realized the scope of innovation in cosmetology, the present review article revisits different types of hyperpigmentation conditions developed due to drug use and/or other causes and potentiality of sheet masks in the management of hyperpigmentation disorder. Also, it is envisaged that this review article may be of interest among dermatologists, other health care researchers, and manufacturing chemists to develop new strategies in skincare.

Carboxytherapy in dermatology: A systematic review.

The overall effects of Carboxytherapy, defined as the administration of carbon dioxide, have been studied for many years. It has been suggested that by improving oxygenation, interacting with the tissue perfusion regulators, and disrupting the adipose cell membranes, the method can lead to notable improvements in different esthetic and pathological conditions. Therefore, we aimed to systematically review the available studies evaluating the potential benefits of carboxytherapy in dermatological conditions and how it objectively stands against scientific scrutiny. We searched the PubMed, Scopus, Embase, and Web of Science databases, including the studies exploring the method's efficacy in managing any dermatological condition. A total 27 of studies were identified (with a pooled sample of over 700 cases), most of which were clinical trials. Facial wrinkles, periorbital hyperpigmentation, skin laxity deficiency, scars, striae distensae, localized lipolysis and cellulite, alopecia, chronic diabetic wounds, and psoriatic plaques comprised the package of the dermatological conditions that were studied. Except for a few studies, the method mainly demonstrated significant improvements on all of the mentioned conditions. The inter- and post-operational adverse events were mild and transient, including erythema, pain, crepitus, and ecchymoses. Carboxytherapy can provide those practicing in the field with sustainably favorable results. However, the numbers of cases on whom the fat-reducing capabilities of the method were studied and experienced varying degrees of recurrence caught our eye. In addition, we observed a notable disparity between the outcome measures utilized in the studies. The modest sample size in each condition also added to the injury, as the conditions on which the method was evaluated are pretty common in the general population. Therefore, for a definite conclusion, more randomized controlled trials with the shortcomings mentioned well addressed need to be conducted.

Efficacy and Safety of Carboxytherapy versus Combined Microneedling with Topical Glutathione in the Treatment of Patients with Periorbital Hyperpigmentation: An Evaluator-Blind, Split-Face, Controlled Pilot Clinical Trial.

Periorbital hyperpigmentation (POH) is a common skin condition that presents as infraorbital darkening. POH has a multifactorial etiology. Studies evaluating POH treatment are several with varying satisfaction results. To compare carboxytherapy and microneedling (MN) combined with topical glutathione for POH treatment. A split-face pilot clinical trial was conducted on 31 female patients with POH. Carboxytherapy injection was done at the right periorbital area, and MN with topical glutathione (Left periorbital area), for 6 biweekly sessions. Visual analogue scale (VAS), dermoscopic evaluation, patient satisfaction, and patient dermatology life quality index questionnaire (DLQI), safety evaluation were done with 3 months follow up. The trial registry number is NCT04389788. Carboxytherapy showed a higher significant improvement as regards VAS evaluation compared to MN with glutathione during the active treatment phase (P = 0.001) and during the follow-up phase (P = 0.006). Also, the dermoscopic evaluation showed a statistically significant improvement in the Carboxytherapy group. DLQI showed a statistically significant improvement (P <.001). As regards patient satisfaction, carboxytherapy showed in comparison to MN with glutathione (80.6% vs 25.8% in moderate satisfaction) and (3.2% vs 0% in marked satisfaction respectively) (P = .05). As regards the patients' safety, there was no significant difference between both eyes (P = .23). Carboxytherapy showed higher efficacy than MN with glutathione in POH patients. Carboxytherapy improved clinical, dermoscopic, patient satisfaction, and patient DLQI; with a good safety profile.

Combined Therapy with Laser and Autologous Topical Serum for Facial Rejuvenation: A Multiple Case Series Report.

Lasers require several sessions to achieve significant results and may lead to adverse reactions. Platelet-rich plasma (PRP) therapy is a good adjuvant to laser therapies; however, repeated blood extractions and invasive injections are needed. A 100% autologous topical formulation based on the patient's proteins has been recently developed, known as Endoret-Serum (ES). Unlike other PRPs, ES provides a home care, storable, and topical needle-free application. Preliminarily assess the clinical performance of a single session of the combined therapy with nonablative laser and ES in the management of cutaneous pigmented and vasculature lesions. Nine patients with clinical signs of skin aging received a single session of nonablative laser. ES was topically applied twice daily. They were clinically assessed after 1 and 8 weeks. VISIA-CR System was used for high-resolution topographic analysis. Subjects were asked to complete a self-assessment questionnaire and an impression of improvement survey. An investigator's global assessment scale was fulfilled. The combined treatment improved cutaneous spots, wrinkles, and texture after 8 weeks, whereas significant pore reduction was observable at 1 week. Ultraviolet (UV) spots and porphyrins decreased at 1 week, whereas red area improvement was noticeable after 8 weeks. Overall wrinkle amelioration, periorbital hyperpigmentation decrease, softened skin, and tone recovery was observed. Patients referred to be very satisfied and felt that their cutaneous condition was much better. At the end of the study, subjects presented minimal dermatological symptoms like pigmented lesions, redness, or capillaries. No side effects were reported. Results presented herein suggest that one session of laser in combination with ES provides a good clinical outcome.

The conformity between dermoscopy imaging and Wood’s lamp diagnostic on periorbital hyperpigmentation

Introduction: Periorbital hyperpigmentation (POH) is a common skin problem characterized by homogeneous/dark brown hyperchromic/pigmented macules around the lower eyelid and upper eyelid up to the malar area temporal area and the sides of the nose. POH is a multifactorial condition caused by both endogenous factors and exogenous factors, without one aspect dominating. Dermoscopy and Wood's lamp can assist the diagnosis of POH types when the inspection is regarded as weak. The assessment of the suitability of the dermoscopic image and Woods’ lamp diagnosis indicates an alternative supporting test in POH diagnosis. This study aimed to examine the conformity between dermoscopic images and Wood's lamp examination in POH diagnosis.Methods: This observational conformity study was conducted using a cross-sectional design. There were 38 subjects diagnosed with POH who went to the Cosmetics Division of Dermatology and Venereology, Universitas Sumatra Utara Hospital participated as subjects. Assessments regarded the types of POH analyzed based on dermoscopic images and Wood's lamp examination. Data analysed with SPSS version 20 using Kappa test.Results: On dermoscopy examination, the mixed type was the type most obtained, as many as 18 subjects (47,4%), whilst on Wood's lamp examination, the most dominant type obtained was pigment type, as much as 21 subjects (55,3%). Moderate conformity value on POH examination was obtained with dermoscopy and Wood’s lamp.Conclusion: Dermoscopic images and Wood's lamp examination shared a sufficient conformity value in POH diagnosis.

Polymorphisms in P53 and VEGFA genes in different subtypes of periorbital hyperpigmentation

A black eye circle or periorbital hyperpigmentation affects men and women alike. The periocular area is affected by a poorly defined lesion that appears as round or semicircular brown or dark brown pigmented macules. VEGFA (rs833061) and P53 (rs1042522) polymorphisms were detected in various periorbital hyperpigmentation types. Methods: Thirty patients with periorbital hyperpigmentation were included in this prospective case-control research, along with twenty seemingly healthy control individuals of the same age and gender. The distribution of p53 and VEGFA genotypes in patients and controls did not vary significantly. Cases with POH were more likely to have p53 genotypes Pro/Pro and Arg/Pro+Pro/Pro than controls. A greater frequency of the VEGFA TC, CC, TC+CC genotypes, and the C allele were found in patients compared to the control group with POH risk. The VEGFA TC genotype was associated with the pigmented subtype. Periorbital hyperpigmentation was more likely to occur in those with the p53-pro/pro and arg/pro+pro/pro genotypes, the pro allele, VEGFA-TC, TC+CC, and C allele genotypes. There was a strong association between the VEGFA TC genotype and the pigment subtype. Otherwise. There was no relationship between VEGFA rs833061 and any of the VEGFA variants (p53 rs1042522 or p53 rs1042522). For orbital hyperpigmentation susceptibility, P53 and VEGFA genotypes have been proposed as risk factors.

Efficacy and safety of plasma gel versus platelet-rich plasma in periorbital rejuvenation: a comparative split-face clinical and Antera 3D camera study.

Periorbital skin is the thinnest. That is why, it is the easiest to wrinkle and the most challenging to rejuvenate. Platelet-rich plasma (PRP) as well as plasma gel have been used for skin rejuvenation and considered relatively safe and effective. This split-face study was conducted on forty female patients seeking periorbital rejuvenation where PRP was injected in the right (Rt) side and plasma gel in the left (Lt) side, two treatment sessions 4weeks apart (week 0 and week 4). Patients were followed up 2weeks after each treatment session (week 2 and week 6) as well as 12weeks after the last session (week 16) using both subjective [physician assessment through Global Aesthetic Improvement score (GAIS) and patient's satisfaction (Likert scale)] and objective [Antera 3D camera] assessment methods. Both modalities yielded a significant improvement of periorbital wrinkles after the 2nd session, with significantly better results on the plasma gel injected side; however, the improvement achieved through both modalities could not be maintained for the following 3months. Besides, objective assessment could not prove any improvement in periorbital hyperpigmentation. Two sessions of both PRP and plasma gel are effective for periorbital rejuvenation, with plasma gel showing significantly better results. However, improvement was not maintained for 3months.

Periorbital hyperpigmentation etiology, pathophysiology and clinical features update: A review article.

periorbital hyperpigmentation etiology, pathophysiology and clinical features update: A review article.

Comparing novel versus conventional technique of platelet-rich plasma therapy in periorbital hyperpigmentation: A randomized prospective split-face study.

Platelet-rich plasma (PRP) has been found to be effective in treating periorbital hyperpigmentation (POH). PRP prepared by double-spin (DS) method and activated by calcium has been used conventionally. PRP can be prepared by single spin (SS) and activated at low temperature (novel method), but the evidence is limited. To compare the novel and conventional PRP in the treatment of periorbital hyperpigmentation. We selected 21 patients of POH and randomly divided the face into two halves. One-half of the face (group A) was treated with novel PRP (SS and low-temperature activation). The other half (group B) was treated with conventional PRP (DS and calcium activation). A total of 3 PRP injections were given at 4 weekly intervals. Patients were observed and assessed on 12th week by photography, dermoscopy, visual analog scale (VAS) score, and Dermatology life quality index (DLQI). Platelet counts and growth factors were assessed in PRP. Mean platelet count in novel and conventional PRP was 7.41±1.76 lacs and 8.17±2.23 lacs (p=0.348). Mean photographic and dermoscopic assessment at the end of the study in group A and group B was 52.33±6.468 and 53.14±6.99 (p=0.151). Change in VAS in groups A and B was 3.85±1.27 and 3.90±1.04 (p=0.895). Levels of various growth factors assessed by ELISA did not differ significantly. There was significant decline in DLQI. The novel method is not inferior to conventional method of PRP in the treatment of periorbital hyperpigmentation.