We numerically investigate negative mobility of an inertial Brownian particle moving in a periodic double-well substrate potential in the presence of a time-periodic force and a constant bias. For the deterministic case, we find from the average velocity that the varying shape parameter and driving forces can cause negative mobility, differential negative mobility, and giant positive mobility. We analyze these findings via the bifurcation diagram and maximal Lyapunov exponent and find that certain chaos can give rise to negative mobility. For the presence of a Gaussian color noise, the results suggest that the noise intensity can enhance or result in negative and positive mobilities, whereas correlation time can enhance, weaken, or even eliminate them. On the basis of the time series, phase-space map, and power spectrum of various attractors, we unveil how these mobilities connect to strong chaotic attractors (SCAs), including both stable attractor and unstable attractors, and propose an underlying mechanism that SCAs can result in the negative mobility, whereas other attractors do not. Our findings may be potentially useful for research on anomalous transports of the particles and on designs of various devices, such as atomic chains, crystals with dislocations, and superconducting nanowires, etc.