e22502 Background: Cancer poses a significant health challenge within the military population, impacting both medical and economic aspects, as well as military operations. Despite the potential benefits of early cancer detection, adherence to organized and individual screenings remains below 50%. The pivotal role of military physicians, especially within military forces, in cancer prevention and screening is crucial.The main objective was to investigate the professional practices of military physicians in cancer screening, aiming to understand their perceptions, practices, and the role of screening in their daily routines. Methods: A prospective, observational, non-interventional cohort study was conducted, utilizing anonymous self-assessment questionnaires among military physicians practicing in army or joint military medical centers. Criteria for inclusion involved physicians engaged in patient care, including the performance of medical check-ups. Demographic data, perceptions, declared practices, and primary prevention measures were assessed through secure electronic questionnaires. Results: Between June 1, 2023, and September 30, 2023, 169 practitioners were included, with 51% were female. The median number of visits per practitioner was 400 (range 150-600). The study revealed a heightened concern among military physicians regarding cancer screening, particularly for breast, colon, and testicular cancers, with over 78% of practitioners expressing a significant level of concern (range: 59-90%). However, our investigation exposed disparities in clinical examinations and the prescription of additional tests, specifically within organized screenings among unit physicians. Less than 7% utilized recommendation sheets. Conclusions: Military physicians express a genuine concern for cancer screening, indicating the periodic medical check-up as an opportune moment for imparting screening information. The study highlights limitations such as the need for dedicated training, availability of materials, and optimizing patient care pathways. This research sheds light on the critical role of military physicians in cancer screening and provides insights into the challenges and opportunities for improving screening practices within military healthcare settings. The findings underscore the importance of targeted interventions to enhance adherence to screening guidelines and strengthen cancer prevention efforts within the military healthcare system.