This article is focused on the design of an output tracking control scheme for a class of continuous-time periodic piecewise time-varying systems (PPTVSs) with actuator saturation and nonlinear perturbations. The energy-to-peak tracking performance is studied based on an equivalent condition on the definiteness property of matrix polynomials. Considering the actuator saturation and nonlinear perturbation, matrix polynomial-based sufficient conditions are derived through the Lyapunov method using periodic matrix functions. From a perspective of subinterval segmentation aimed at PPTVSs, the proposed conditions can achieve less conservatism for tracking the output of a periodic time-varying reference system, while the controller gains can be computed using convex optimization. Moreover, a heuristic algorithm is constructed to simultaneously guarantee the closed-loop state convergence and the output tracking performance. The reduction in conservatism and the effectiveness of algorithm are demonstrated by illustrative case studies.