This work is devoted to studying the combined action of periodic in-plane load and tangential subsonic flow on the nonlinear mechanism of the out-plane deformation of the functionally graded composite plate. Three distribution functions are proposed to investigate the distribution of the transverse shear strains and stresses across the thickness of the plates. By using Hamilton’s variational principle, the equations governing the plate instability boundaries are formulated. A nonlinear differential equation describing the first mode of the plate dynamic instability behavior by employing Galerkin’s method. The method of multiple time scales is used to obtain a periodic one-mode solution, which directly leads to the solvability condition. The different resonance cases for the interaction between the frequency of out- plane deformation and the external forces are discussed to discover the extent of the sandwich functionally graded material (FGM) rectangular plate resistance in the presence of external influences. Various bifurcation diagrams for different cases of resonance are obtained versus the basic parameters. In view of this study, we could get a deeper look at the complexity of frequency components in resonance responses of the sandwich FGM rectangular plate. The results could provide some suggestions for the sandwich plate’s vibration reduction design or fault diagnosis field or design fault diagnosis.