Introduction and Aim: Perifocal edema are the cause of the severity of patients, increasing intracranial pressure and dislocation syndrome. The objective of this study is to plan an adequate approach to the area of perifocal edema in the treatment of patients with glial brain tumors by studying the pathogenesis and consequences.
 
 Methods: 720 patients with glial tumors with varying degrees of malignancy and a zone of perifocal edema were operated and of these, 281 patients with GRADE I-IV astrocytoma, 147 patients with GRADE I-III oligodendroglioma, 115 patients with GRADE I-III ependymoma, and 177 patients with GRADE IV glioblastoma. The zone of perifocal edema was assessed by a point system from 1–5 points.
 
 Results: The glial tumor was significantly more common in the age group of 45-59 years (44.9 ± 2.1 cases per 100 patients). In the zone of perifocal edema at a distance from the tumor up to 1.5-2.0 cm, there was a site of apoptosis, demyelination, and destruction of nerve fibers.
 
 Conclusion: The surgical approach proposed by us with the removal of the apoptosis zone and the zone of perifocal inflammation is the key to the successful recovery of patients, without or with minimal postoperative complications.