Fors≥2, a set {a(i,j):1 ≤j≤s+1 −i≤s} wherea(1,j), 1≤ j≤s, are some prescribed integers anda(i+1,j) =|a(i,j) −a(i,j+1)|, for 1≤i<sand 1≤j≤s−i, is called a set of iterated differences. Such a set has sizesand is full if it containss(s+1)/2 distinct integers. Kreweras and Loeb suggested the problem of partitioning a run ofms(s+1)/2 integers starting withcintomfull sets of iterated differences of sizes. We show that necessary conditions for this are that 2≤s≤9, and thatmbe sufficiently large in comparison withc. In particular, a single set of iterated differences of sizescontains the integers 1 tos(s+1)/2 (inclusive) iff 2 ≤s≤5. We also discuss connections between this problem and the theory of perfect systems of difference sets.