Perfect Skin Research Articles

AGING MANAGEMENT WITH THE USE OF EXOSOMES, PRP/PRF WITH ALBUMIN GEL (PLASMA GEL) AND ASSOCIATED TECHNIQUES IN OROFACIAL HARMONIZATION TREATMENT

Aging, it is a physiological process that involves a progressive decline in the function of the organs, with loss of homeostasis and increased likelihood of disease disease and death. This account focuses on the classic perspectives on the biogenesis of exosomes, and age-related associated changes. Due to its ability to transmit biological information between cells, this work also discusses the interaction of mesenchymal cell exosomes, as a potent adjuvant in the treatment of association of orofacial harmonization techniques. The demand for aesthetic and rejuvenating treatments is increasing in society, thus, each day, the demand for orofacial harmonization increases exponentially in order to slow aging. Orofacial harmonization is a set of procedures performed by the dentist, which aims at the aesthetic and functional balance of the face. Exosomes are membranous extracellular vesicles ranging from 30 to 200 nm in diameter. Exosomes has been found to be secreted by most cell types, including immune cells (B cells, T cells, mastocytes, dendritic cells), neuronal cells, epithelial cells, endothelial cells, embryonic cells, cancer cells and cells mesenchymal trunk (mscs). The search for youth and perfect skin is a natural desire for the human being. And in this way, collagen biostimulation stands out as a safe and effective option to rejuvenate the skin, fighting the signs of aging and promoting a firmer, toned and radiant appearance. Research in exosomes therapies continues to prosper. Subsequent data on indications, dose response, safety, effectiveness and ability to combine therapy with exosomes as a “skin primer” for biostimulation techniques, such as calcium hydroxylapatite (CAHA), platelet rich plaketers (PRP) and fibrin matrix Platelet plasma, (PRFM) is growing rapidly.

The synergy of skin and science – A comprehensive review of artificial intelligence’s impact on dermatology

Artificial intelligence (AI) has become an omnipresent area in modern culture. Every industry in the world has been greatly impacted by the development of technology, which has improved people’s quality of life. With the advent of AI, even 10 years old can now use smartphones to conquer the world by simplifying complex jobs. AI has made a substantial contribution to the health-care industry as well, sparking debates about whether robots may or may not eventually replace doctors in the medical field. Interestingly, AI additionally has made important advances in the field of dermatology. Through its discovery of applications that can predict a person’s skin type and the products they should use to achieve “perfect skin,” AI has greatly targeted its audience in the esthetics space, where people are most concerned with the health of their bodies and hair. AI has also developed strong relationships with these people and provided excellent advice for skin-related concerns. However, the question of whether individuals are mistreating their skin or relying too much on AI to address their skin troubles remains. Certain applications use the beauty calculator based on face symmetry, which can have a drastic impact on one’s self-confidence. These commercials may also instill false hope, and they may even be an advertising strategy used by the gods of the metaverse. Applications that give predictions regarding skin health can also create a state of anxiety in people who use them. This article examines whether AI has had a discernible effect on skin health, how it may influence cosmetic dermatology in the future, how accurate AI is in diagnosing conditions and recommending treatments, and whether we should rely on AI in the future for dermatological issues.

Exploration of Young Adult’s Perception of Skin Colour and Mental Health Deterioration: A Qualitative Study

Objective: To explore the perception regarding skin colour and decline in mental health due to an increased obsession with fair complexion among young adults, specifically in Pakistan. Study Design: Exploratory study. Place and Duration of Study: Public and Private Universities of Islamabad/Rawalpindi Pakistan, from Jun to Aug 2022. Methodology: Three independent focus group discussions were carried out with young adults (aged 18-35). Focus group discussions were recorded and transcribed by keeping in mind the ethical consideration. Moreover, two interviews, one with the dermatologist and the other with the beautician, were also conducted to gain more information. The data was gathered and transcribed and then, themes emerged by using Thematic Analysis. Inter-rater reliability of themes was computed by four independent raters which were found to be substantial for focus groups and each interview. Results: The results reveal major themes that emerged from the present study, which influenced young adults' perception regarding skin colour and damaged their mental health. New dimensions were revealed in which both males and females were studied, which had not previously been explored in Pakistan. Conclusion: This study identifies those factors contributing to the deteriorating mental health of a person related to skin colour and mental health professionals. The Young adults of Pakistan are dissatisfied and preoccupied with the notion of perfect skin colour, which leads them to opt for different unhealthy means to beautify themselves and damaging their mental health.

How to have perfect skin and an even better workshop – our experience with organizing a cricothyrotomy workshop

How to have perfect skin and an even better workshop – our experience with organizing a cricothyrotomy workshop

The Characteristics of the Skin Physiological Parameters and Facial Microbiome of "Ideal Skin" in Shanghai Women.

Everyone pursues perfect skin, but there exist significant differences between cultures, and no commonly accepted standards have been established. Therefore, our study attempted to define the "ideal skin" of oriental women and analyze the relationship between different skin physiological parameters and microbiomes. Based on our customized grading standard, the VISIA CR photos of 111 young women aged from 18 to 25 in Shanghai were collected and scored by the severity of pores, acne, spots, and wrinkles. The volunteers were then divided into "ideal skin" (W1), "normal skin" (W2), and "undesirable skin" (W3) groups. The physiological parameters of facial skin were measured by non-invasive instrumental methods, and the skin microbiome was analyzed by 16S rRNA and ITS high-throughput sequencing. From "ideal skin" to "undesirable skin", the skin physiological parameters, α-diversity, and composition of the facial microbiome showed noticeable regular changes. Compared with the "normal skin" (W2) and "undesirable skin" (W3), the "ideal skin" (W1) group had lower sebum content, TEWL, melanin, hemoglobin, and roughness but higher hydration content and skin pH value. Furthermore, the Shannon index of skin bacteria was significantly increased in W1 (P = 0.004), suggesting that the ideal skin had higher species diversity. From W1 to W3, the species composition was changed significantly. The abundance of Actinobacteria was increased, while Proteobacteria and Bacteroidetes were decreased. Correspondingly, the abundances of lipophilic Propionibacterium and Malassezia were increased, while the abundances of Stenotrophomonas, Pseudomonas, Ralstonia, and Streptococcus, were significantly decreased. Additionally, Spearman correlation analysis revealed strong correlations between the physiological parameters and the microbiota. Notably, the Shannon index of skin bacteria was significantly positively correlated with skin hydration (P = 0.03) but negatively correlated with the abundance of Cutibacterium (P = 0.000), hemoglobin content (P = 0.025), and sebum content (P = 0.5). Therefore, the skin hydration content and the abundance of Cutibacterium played an important role in maintaining the α-diversity and skin homeostasis. Ideal skin had better water-oil balance and barrier function, higher microbial diversity, and more reasonable species distribution. Therefore, daily skincare needs to control skin oil and maintain skin microecological balance to achieve ideal skin conditions for young women aged 18-25 years old.

Prospective cohort study in evaluation of risk factors for infection during and after coronary graft operations

Introduction: There is a strong suggestion that an impairment of vascular supply of the sternum may be one of the most important factors influencing the incidence of deep sternal wound infection (DSWI). Several studies have studied the risk factors for SSIs including DSWI in cardiac surgery. Methods: All patients who are presented to Assiut University Heart Hospital in need of Coronary artery Bypass Grafting from 1st of January, 2018 to 30th june, 2021 were included in the study prospectively. Exclusion criteria included patients who were diagnosed with infective endocarditis, have undergone open heart surgery before or had sternotomy been done for any other reason- redo surgery is excluded-, and where other surgical accesses were used other than sternotomy. Results: During the study duration, we included 99 pateinets. Our patients were followed for 1 week post-operative and then on day 30 post-operative. 81 patients showed perfect skin healing at 1 week post-operative follow-up with very nice and neat scar at 1 month follow-up. 5 patients showed wound breakdown with subcutaneous being exposed (Type I SWIs). 3 patients suffered type I SWI with exposed subcutaneous but with severe infection and loss of skin.

Challenging the Selfie: Perfect Skin by Chatonsky

In the series Perfect Skin launched in 2015, Gregory Chatonsky, a French Canadian artist, ran an AI programme on the more than 5000 Tumblr and Instagram selfies posted by Kim Kardashian, to create distorted and serial representations of the celebrity which were then reproduced through a series of media: photo, video, textiles, ceramics, VR. Chatonsky challenges the genre of the selfie on several accounts. He highlights issues such as scale and exposure within the infoglut. Using algorithms also enables him to trigger cognitive and artistic shifts: from the visual arts to mathematics, from representation to data, from creative control to chance, from recognition to perceptual aporia, from social media to the gallery. These distorted and serialised images, “organes sans corps” to take up Deleuze’s famous concept, may pertain to a regime of meaning based on affect, as defined by Brian Massoumi, rather than on mimesis.

Skin Wound Healing of the Adult Newt, Cynops pyrrhogaster: A Unique Re-Epithelialization and Scarless Model.

In surgical and cosmetic studies, scarless regeneration is an ideal method to heal skin wounds. To study the technologies that enable scarless skin wound healing in medicine, animal models are useful. However, four-limbed vertebrates, including humans, generally lose their competency of scarless regeneration as they transit to their terrestrial life-stages through metamorphosis, hatching or birth. Therefore, animals that serve as a model for postnatal humans must be an exception to this rule, such as the newt. Here, we evaluated the adult newt in detail for the first time. Using a Japanese fire-bellied newt, Cynops pyrrhogaster, we excised the full-thickness skin at various locations on the body, and surveyed their re-epithelialization, granulation or dermal fibrosis, and recovery of texture and appendages as well as color (hue, tone and pattern) for more than two years. We found that the skin of adult newts eventually regenerated exceptionally well through unique processes of re-epithelialization and the absence of fibrotic scar formation, except for the dorsal-lateral to ventral skin whose unique color patterns never recovered. Color pattern is species-specific. Consequently, the adult C. pyrrhogaster provides an ideal model system for studies aimed at perfect skin wound healing and regeneration in postnatal humans.

Demolishing the “Ideal” Concept of Beauty: How Pore Hero’s Instagram Campaign Challenges Other Skincare Advertisements

Skincare companies purposely combine textual and visual features to create a compelling sign that can be correlated with beauty. In their ads, people are frequently depicted as having bright, white, and flawless skin. These exaggerated and repetitive representations eventually built a certain concept of beauty. In this paper, a preparatory approach is employed to investigate how an Indonesian beauty brand, Pore Hero, employs diverse promotional strategies. The analysis focuses on the textual aspects and discursive features of the posts, and how the campaign challenges the “ideological” concept of beauty. Data were collected from the brand’s Instagram account then analyzed with Fairclough’s three-dimensional model (1989) and van Leeuwen’s word-image links (2005b). Results indicated that Pore Hero uses five distinctive techniques to promote the brand’s values and offerings: 1) exposition of existing ingredients 2) inspiring campaign 3) emotive contents 4) realistic representations 5) reviews by Instagram users. It is concluded that the Instagram promotional posts of the brand strive to change people's minds to respect and accept themselves by changing the goal of having perfect skin to healthy skin.

Herbal Lepa Formulation Preparation and its Evaluation

The concept of beauty is as old as humanity itself. It is the natural desire of every human being to look beautiful and glamorous. The beauty and glamour are because of perfect skin. Herbs have been used for beautification from historic times and have also been described in Ayurvedic literature. Herbs as whole or herbal extracts have been used to treat the various ailments of the skin, hair, body odor, and overall beautification. The demand for Ayurveda in cosmetology is established because it is effective, cheaper, and long-lasting without any side effects. The present study aimed to formulate and evaluate the beneficial effect of herbal Lepa formulation for beautification. Beautification in terms of skin lightening, removal of scars and pigmentation, dark circles, and ultimately healthy glowing skin. The advantage of herbal cosmetics compared to chemical products is they are non-toxic in nature. The Lepa formulation is the suitable dosage form prepared using various natural components in the appropriate and desired quantity for better effectiveness. The formulation has shown significant improvement in various skin problems, including skin pigmentation, melasma, acne marks, and skin lightening effect with no further moisturizing cream requirements.

Use of micro-grafts in a chronic infected open wound after limb amputation in a cat

In human medicine, skin grafting is an innovative surgical technique widely used in reconstructive surgery to repair skin loss. This case evaluated the effectiveness of a treatment with dermal micro-grafting obtained through the Rigenera<sup>®</sup> technology in a chronic open wound resulting from a suture dehiscence of a limb amputation in a cat. Significant differences were observed between the aesthetic aspects of the injury using traditional treatments (cleaning and curettage) and the regenerative technology. The results showed that the healing periods were significantly reduced after the Rigenera<sup>®</sup> treatment and that, moreover, a perfect skin status and a complete reduction in the wound area (100%) were achieved in one month. Given these results, Rigenera<sup>®</sup> has proven to be a simple yet highly effective method in the treatment of inactivated chronic wounds.

Recognition and development of customized cosmetics for military trainees in 20s and 30s in Republic of Korea.

BackgroundFor the health of the skin, social standards have been changed to increase the public's interest in achieving perfect skin. With the diversification of consumer needs, the reorganized core market for demand pursues the attributes of customization that bring the individual ego and product image to match through aggressive consumer needs.ObjectivesTherefore, in this study, we conducted a questionnaire to 450 men in their 20s and 30s, Chuncheon City, Gangwon‐do, Republic of Korea, focused on the fact that customized cosmetics drive individuals and optimization.MethodsStatistical processing of materials collected by the data analysis method is analyzed using the SPSS (Statistical Package for Social Science) WIN25.0 statistical package program through the process of data coding and data cleaning.ResultsAs a result, “I think I need customized cosmetics for me.” 3.91 (SD = 1.19), and it seems that the number of custom cosmetics used will increase in the future. “3.99 (SD = 1.06) It was the highest in terms of points. Also, I would like to use PX's men's custom cosmetics when they are released.” The average was 4.34 (SD = 0.91), which was the highest. Comprehensive research results of P <0 .001 and above suggested the possibility of developing customized cosmetics for men.ConclusionTherefore, this requires continuous research on personalized bespoke cosmetics according to work and usage characteristics, and PX custom products for future soldiers should be developed. In the future, the researcher plans to continue to study the recognition and development potential of customized cosmetics for female military personnel in South Korea in subsequent research.

Organic entities, costume, human body and neo-liberalism

This visual essay presents four of the author’s artistic projects, which respond to prevailing eastern European neo-liberal conceptions of the human body and the subjects it produces. The first project is concerned with the use of human skin as an organic material donated by its ‘owner’ for the manufacture of a corset and belt, which become parts of a new costume. The second project explores the characteristic of the ‘ideal’ neo-liberal human subject by means of the costume produced by manipulating the author’s own blood. The third project highlights the cultural norm according to which one is expected to present oneself to the known and especially unknown others in line with the dominant standards of feminine beauty – erotically attractive, healthy, youthful and slim. The fourth project focuses on the almost obsessive endeavour to preserve or rather achieve ‘the perfect skin’, as evident in countless beauty advertisements and artificially ‘optimized’ selfies.

Health-related domains of quality of life in pyoderma gangrenosum: A qualitative analysis

Health-related domains of quality of life in pyoderma gangrenosum: A qualitative analysis

Engineering immune-responsive biomaterials for skin regeneration.

ABSTRACTThe progress of biomaterials and tissue engineering has led to significant advances in wound healing, but the clinical therapy to regenerate perfect skin remains a great challenge. The implantation of biomaterial scaffolds to heal wounds inevitably leads to a host immune response. Many recent studies revealed that the immune system plays a significant role in both the healing process and the outcome. Immunomodulation or immuno-engineering has thus become a promising approach to develop pro-regenerative scaffolds for perfect skin regeneration. In this paper, we will review recent advancements in immunomodulating biomaterials in the field of skin repair and regeneration, and discuss strategies to modulate the immune response by tailoring the chemical, physical and biological properties of the biomaterials. Understanding the important role of immune responses and manipulating the inherent properties of biomaterials to regulate the immune reaction are approaches to overcome the current bottleneck of skin repair and regeneration.

Destruction, Reconstruction and Resistance: The Skin and the Protean Body in Pedro Almodóvar’s Body Horror The Skin I Live In

The instinct to tame and preserve and the longing for eternal beauty makes skin a crucial element in the genre of the Body Horror. By applying a gendered reading to the art of destruction and reconstruction of an ephemeral body, this paper explores the significant role of skin that clothes a protean body in Almodóvar’s unconventional Body Horror, “The Skin I Live In” (2011). Helpless vulnerable female bodies stretched on beds and close shots of naked perfect skin of those bodies are a frequent feature in Almodóvar films. Skin stained and blotched in “Tie Me Up! Tie Me Down!” (1989), nurtured and replenished in “Talk to Her” (2002), patched up and stitched in “The Skin I Live In”, becomes a key ingredient in Almodóvar’s films that celebrate the fluidity of human anatomy and sexuality. The article situates “The Skin I Live In” in the filmic continuum of Body Horrors that focus primarily on skin, beginning with Alfred Hitchcock’s “Psycho” (1960), and touching on films like Jonathan Demme’s “The Silence of the Lambs” (1991) and Tom Tykwer’s “Perfume: The Story of a Murderer” (2006) and attempts to understand how the exploited bodies that have been culturally and socially subjugated have shaped the course of the history of Body Horrors in cinema. In “The Skin I Live In” the destruction of Vicente’s body and its recreation into Vera follow a mad scientist’s urge to dominate an unattainable body, but this ghastly assault on the body has the onscreen appearance of a routine surgical operation by an expert cosmetologist in a well-lit, sanitized mise-en-scène, suggesting that the uncanny does not need a dungeon to lurk in. The exploited body on the other hand may be seen not as a passive victim, but as a site of alterity and rebellion. Anatomically a complete opposite of Frankenstein’s Creature, Vicente/Vera’s body, perfect, beautiful but beset with a problematized identity, is etched with the history of conversion, suppression, and the eternal quest for an ephemeral object. Yet it also acts as an active site of resistance.

666 Targeting perfect skin repair markers in a model of induced cellular senescence

666 Targeting perfect skin repair markers in a model of induced cellular senescence

302 Targeting perfect skin repair markers in a model of induced cellular senescence

Skin repair is a multistep process involving both epidermal and dermal compartments. Among the sequential and overlapping events that take place during the skin repair process, the regeneration of the epidermal compartment represents a critical step for a complete and effective repair, described here as “perfect skin repair”. In the present study, we evaluated an extract of Rosa centifolia, prepared using a proprietary extraction progress, that is rich in small RNA and compounds of interest including. This extract was evaluated for its effects on markers associated with skin repair, on normal aged human keratinocytes. MARCKS like protein (MARCKSL1) is a regeneration-initiating protein, discovered in axolotl, an amphibian species known for its scar-free healing capacity. MARCKSL1 is also expressed in human skin. Among the different miRNAs implicated in skin repair, miR-132 has been described as critical to improve skin regeneration, playing a role in the transition between the inflammatory phase and epidermal restoration. In the model of induced cellular senescence, we observed a decrease in MARCKSL1 and miR-132 expressions and a slowdown of cell migration in a scratch test assay. When senescent keratinocytes were treated with the extract of Rosa centifolia, the marker of perfect skin repair MARCKSL1, as well as the level of miR-132, were observed to have increased. The ability of senescent keratinocytes to regenerate a scratched monolayer was also observed to have improved after application of the extract. Some dermal markers associated with skin repair such as collagen I, fibronectin and hyaluronic acid were increased in ex vivo skin biopsies that had been treated with the extract. In conclusion, the extract of Rosa centifolia was shown to act on markers of the early phase of skin repair, associated with epidermal restoration, as well as components of the extracellular matrix. Taken together, these effects are in favor of optimizing skin repair especially in aged or compromised skin.

All VN-graphene architecture derived self-powered wearable sensors for ultrasensitive health monitoring

The booming of wearable electronics has nourished the progress on developing multifunctional energy storage systems with versatile flexibility, which enable the continuous and steady power supply even under various deformed states. In this sense, the synergy of flexible energy and electronic devices to construct integrative wearable microsystems is meaningful but remains quite challenging by far. Herein, we devise an innovative supercapacitor/sensor integrative wearable device that is based upon our designed vanadium nitride-graphene (VN-G) architectures. Flexible quasi-solid-state VN-G supercapacitor with ultralight and binder-free features deliver a specific capacitance of ~ 53 F·g−1 with good cycle stability. On the other hand, VN-G derived pressure sensors fabricated throughout a spray-printing process also manifest favorably high sensitivity (40 kPa−1 at the range of 2–10 kPa), fast response time (~ 130 ms), perfect skin conformability, and outstanding stability under static and dynamic pressure conditions. In turn, their complementary unity into a self-powered wearable sensor enables the precise detection of physiological motions ranging from pulse rate to phonetic recognition, holding promise for in-practical health monitoring applications.

Engineering Pro-Regenerative Hydrogels for Scarless Wound Healing.

Skin and skin appendages protect the body from harmful environment and prevent internal organs from dehydration. Superficial epidermal wounds usually heal without scarring, however, deep dermal wound healing commonly ends up with nonfunctioning scar formation with substantial loss of skin appendage. Wound healing is one of the most complex dynamic biological processes, during which a cascade of biomolecules combine with stem cell influx and matrix synthesis and synergistically contribute to wound healing at all levels. Although many approaches have been investigated to restore complete skin, the clinically effective therapy is still unavailable and the regeneration of perfect skin still remains a significant challenge. The complete mechanism behind scarless skin regeneration still requires further investigation. Fortunately, recent advancement in regenerative medicine empowers us more than ever to restore tissue in a regenerative manner. Many studies have elucidated and reviewed the contribution of stem cells and growth factors to scarless wound healing. This article focuses on recent advances in scarless wound healing, especially strategies to engineer pro-regenerative scaffolds to restore damaged skin in a regenerative manner.