You have accessJournal of UrologyStone Disease: SWL, Ureteroscopic or Percutaneous Stone Removal IV1 Apr 20101888 CHANGING STONE COMPOSITION IN RECURRENT STONE FORMERS Kashif Alvi, Mohummad Siddiqui, Ahmad Sharif-Tabrizi, Stephen Dretler, and Dianne Sacco Kashif AlviKashif Alvi More articles by this author , Mohummad SiddiquiMohummad Siddiqui More articles by this author , Ahmad Sharif-TabriziAhmad Sharif-Tabrizi More articles by this author , Stephen DretlerStephen Dretler More articles by this author , and Dianne SaccoDianne Sacco More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1842AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Nephrolithiasis is a recurrent condition in which approximately 50-70% of all stone formers have a risk of subsequent stone formation. Preventative treatment is based on the stone type as well as serum and urinary metabolic factors. The possibility that a recurrent stone former can make more than one stone type over time was evaluated. METHODS A medical record review was performed on 302 patients who had repeat stone analysis between 1988 and 2008. Stone analyses were performed on stones retrieved either after ureteroscopy/laser lithotripsy, percutaneous ultrasonic lithotripsy or from voided specimens. The same stone laboratory analyzed all these stones by x-ray crystallography. The stones were noted to be of following types: Calcium phosphate- Carbonate, Calcium oxalate monohydrate, Calcium oxalate dihydrate, Ammonium Urate, Brushite (Calcium hydrogen phosphate dihydrate), Struvite, Uric Acid, Cystine, Ammonium Urate, and Xanthine stones. RESULTS A total of 302 patients and 736 stone analyses were reviewed. Out of the 302 patients, 173 patients had change in their stone analyses over a certain period of time. A total of 193 stone analyses had changed from one mixed type to a different mixed type, 41 stone analyses changed from a pure stone type to a mixed stone type, 40 analyses changed from a mixed stone type to a pure stone type and 10 stone analyses had changed from one pure stone type to another pure stone type. Among 10 pure stone type changes, 5 stone analyses had a change from uric acid stone into calcium oxalate monohydrate & 2 analysis had changed from uric acid stone to calcium oxalate monohydrate stone. Hence, stone composition changed in 173 (57%) patients in this study upon repeat stone analysis. The most common stone composition change was calcium oxalate monohydrate. CONCLUSIONS Stone composition may change in recurrent stone formers with subsequent stone analysis. It is especillay important when one pure stone type is completely replaced by a totally different stone. These findings suggest that a solitary stone analysis may not be reliable in long term management of recurrent stone formers. Boston, MA© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e734 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kashif Alvi More articles by this author Mohummad Siddiqui More articles by this author Ahmad Sharif-Tabrizi More articles by this author Stephen Dretler More articles by this author Dianne Sacco More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...