Percutaneous Biopsy For Diagnosis Research Articles

CT guided biopsy of lung lesions

Introduction: Computed Tomography (CT) Biopsy is a corrigible coruscate procedure that corrected the discrepancy of the results between final biopsy and unguided Biopsy. CT guidance permits biopsy of nearly all lesions regardless of size and position. Recognition of the accuracy of biopsy and simple methods of treating pneumothorax has brought this method within the reach of most radiologist and pathologist. Infections and other neoplastic process may be proven by this method. In cases of malignancy of the lungs, cytopathological examination of material obtained by CT guided biopsy offers a quick and specific diagnosis which help clinicians implement appropriate anticancer measures like chemotherapy and radiotherapy. The present study is undertaken to determine the accuracy and efficacy of percutaneous biopsy in diagnosis of various lung lesions, and correlate the concordance with available results and available other methods. An interest to analyse the age, gender, topographic distribution and cytopathological diagnosis of thoracic mass lesions using CT guided biopsy is specially stepped in the current study. Aim: To assess the role of Computed tomography (CT) guided biopsy in the diagnosis of thoracic mass lesion and to analyse and compare the results with other studies. To evaluate the diagnostic accuracy and complication of Computed tomography (CT) guided biopsy in thoracic masses. To know the pathological spectrum of thoracic mass lesions and to correlate CT findings with cytopathological report. Methods: This Prospective study was done at Nizam’s Institute of medical sciences, Hyderabad, surrounded by thickly populated districts which provide surplus material for doing research work and is also fully equipped with all the required modes and means for researches and health care. This study was conducted totally at indoor site including both OPD and IPD males and females from both urban and rural exclusively adults. Fifty one cases having Lung masses both malignant and benign were selected and subjected to CT guided biopsy. Statistical analysis was carried out by Using SPSS soft ware version 12. Results: Majority of the patients with lung masses in present study were males who constituted 66.6% and the females were 33.4%. Minimum age was of 22yrs and maximum age was of 92 yrs from the patients of this study. The mean age is 57 yrs. The chief etiological factor for the initiation of the pathogenesis of lung masses was found to be smoking. Out of the total cases included for the study 49% were malignant and 37% were benign lung masses. The complications observed were very few only in 8 cases (15.8%) in total of 51 cases selected for the study. The pneumothorax was noticed in 13.7% and haemoptysis in 1.9%. Conclusion: This CT guided biopsy stands as fruitful topic for study will be to elucidate the diagnostic and prognostic procedures in chest. This procedure of diagnosis with prosaic complications like Pneumothorax or Haemothorax or Haemoptysis and with its mosaic results outstands and extends its scope of study.

PET/CT-guided percutaneous biopsy for diagnosis of MPNST in Neufibromatosis Type 1 (NF1).

e21513 Background: MPNST (Malignant Peripheral Nerve Sheath Tumor) is one of the most frequent causes of death in patients (pts) with NF1. Early detection is crucial, as complete surgical resection is the only curative treatment. However, diagnosis between BPNST (Benign Peripheral Nerve Sheath Tumor) and MPNST by clinical symptoms or conventional CT and MRI (including whole-body MRI protocol) is difficult. PET/CT, with a T/L (Tumor/Liver) SUVmax ratio > 1.5, provides a high negative predictive value but it is not specific enough for NF1-related MPNST diagnosis. Thus, a formal proof of malignant transformation by histological analysis is necessary before surgical excision, which could be mutilating. We aimed to investigate the effectiveness and complications of PET/CT-guided percutaneous biopsy (PET/CT GPB) technique for MPNST NF1-related diagnosis. Methods: PET/CT GPB procedures performed on 26 NF1 pts with a clinical suspicion of MPNST and a suspect lesion on PET/CT (T/L SUVmaxratio > 1.5) were retrospec...

Imaging of Primary and Secondary Renal Lymphoma

This article reviews the CT and MRI patterns of primary and secondary renal lymphomas and discusses the role of percutaneous biopsy in diagnosis and management. Renal lymphoma has a variable imaging spectrum and may mimic renal cell carcinoma. An awareness of the typical and atypical imaging features of both primary and secondary renal lymphomas can help the radiologist to suggest these diagnoses and recommend biopsy when appropriate.

The emerging role of percutaneous biopsy in diagnosis and management of small renal masses

Percutaneous biopsy has an emerging role in the diagnosis and management of small renal masses. The increasing importance of percutaneous biopsy is related to both a better understanding of the natural history of these tumors as well as new developments in treatment strategies. We discuss the emerging role of biopsy in the current practice setting. Additionally, we review recent data regarding its diagnostic accuracy, important technical considerations, and possible complications. Finally, we speculate on its future role in managing these patients. The role of percutaneous renal biopsy in the management of small renal masses continues to evolve. It is critically important at this juncture to evaluate the benefits and shortcomings of such an approach.

Variation in the Use of Percutaneous Biopsy for Diagnosis of Breast Abnormalities in Ontario

Preoperative diagnosis of breast abnormalities is currently the standard of care. A population-based study to determine the use of percutaneous needle biopsy for breast diagnosis in Ontario was performed. A total of 17,068 women undergoing breast tissue sampling (percutaneous needle biopsy or surgical excision) for diagnosis between April 1, 2002, and December 31, 2002, and without a previous cancer diagnosis were identified. Univariate and multivariate analyses examined the association of age, residence in a particular local health integration network (LHIN), income quintile, urban or rural residence, primary care provider, any prior mammogram, and prior regular screening mammography, as well as whether the biopsy was initiated by a screening mammogram with different methods of tissue diagnosis. A total of 10,459 women (61%) underwent percutaneous biopsy for diagnosis. A total of 10,131 women underwent surgery, of whom 6,637 received a benign diagnosis and 3,494 had cancer, for a benign-to-malignant ratio of 1.9:1. Women with cancer were slightly more likely to undergo percutaneous biopsy than women without (64.7% vs. 60.3%). There was variation among LHINs in the use of percutaneous biopsy (range, 24%-72%). Women with the highest incomes, urban residence, a primary care provider, or history of any prior mammography were more likely to receive percutaneous biopsy. On multivariate analysis, age 50 to 69 years, LHIN, urban residence, primary care provider, and screen-initiated evaluation were associated with percutaneous biopsy. Variation in the use of percutaneous biopsy by factors unrelated to indications for biopsy indicate that strategies to identify and overcome barriers to its use are needed.