Perchlorate Hexahydrate Research Articles

Alternating Cu(II) chains with bridging pyrazine, oxy- and halo-ligands

Two new Cu(II)-based structures containing alternating chains and their magnetic properties are reported. Reaction of CuBr2 and 2-aminopyridine in methanol yielded [(2-aminopyridine)μ-Br(μ-OMe)Cu]n (1) which crystallizes in the triclinic space group P-1. Cu(II) ions are linked alternately by bibromide and bi-methoxide bridges into chains parallel to the a-axis. Reaction of copper perchlorate hexahydrate with 4-pyridone and pyrazine in methanol yielded [(μ-pz)(μ-κ-O-4-pyridone)2(μ-OH)2Cu2]n(ClO4)2n (2). The Cu(II) ions are alternately linked by bihydroxide and bi-κ-O-4-pyridone species parallel to the a-axis. Those chains are further linked by bridging pyrazine molecules ∼ parallel to the b-axis, with the pyrazine molecules and bi-hydroxide bridges alternating. The net effect is a rectangular lattice where each side of the rectangle is an alternating chain. The layers are separated by perchlorate ions. Both compounds are diamagnetic at room temperature.

Synthesis of HER-capable cobalt metal organic framework using a straightforward reflux method and a thorough spectroscopic and theoretical analysis

A Cobalt MOF was obtained under reflux using aqueous methanol. The Cobalt MOF was synthesized using Cobalt (II) perchlorate hexahydrate and 1,3,5-Benzenetricarboxylic Acid (BTC) in a methanol mixed with double distilled water as a solvent under reflux condition for 2–3 h at 60–65 °C. The reddish solution obtained was filtered and kept in the refrigerator for almost 24 h. A crystal suitable for SC-XRD was obtained and the XRD analysis confirmed the polymeric structure of the Co-BTC. All the other analysis such as FTIR, Thermal analysis and FESEM of Co-BTC was carried out. Further, the efficacy of it as a potential catalyst towards HER was explored. The theoretical study assisted, and the data suggests that low band gap of the MOF possibly favors its efficacy in the Hydrogen Evolution Reaction (HER).

Cobalt perchlorate hexahydrate catalyzed one‐pot synthesis of dihydropyrimidin‐ones/‐thiones through sonochemistry and its mechanistic study using density functional theory calculations

AbstractA cobalt(II) perchlorate hexahydrate coordinated synthesis of dihydropyrimidin‐ones and ‐thiones through sonochemistry is developed. Herein, the reaction was demonstrated as a simple, efficient, and one‐pot method for synthesizing a series of interesting 3,4‐dihydropyrimidin‐2(1H)‐ones. Further, the reaction mechanism was investigated using mass spectrometry and density functional theory calculations suggesting that a Lewis acid character of cobalt(II) perchlorate hexahydrate plays a crucial role in coordinating carbonyl functionalities and stabilizing the polar intermediates like imine–enamine which further led to cyclized dihydropyrimidin‐ones and ‐thiones. This methodology was further explored to synthesize a gram‐scale synthesis of monastrol drug, a kinase inhibitor.

A copper(II) coordination polymer of formate-bridged dimers: an alternating S = ½ antiferromagnetic chain

Reaction of 1,3-propanediamine with copper(II) perchlorate hexahydrate in basic solution in the presence of trimethyl orthoformate and o-iodophenol serendipitously formed sodium [triformato-diperchlorato-di-1,3-propanediaminodicopper(II)], Na[Cu2(HCO2)3(1,3-pn)2](ClO4)2 (1). Single-crystal X-ray diffraction measurements show the compound to be a coordination polymer with the Cu(II) ions alternately bridged in μ1,1- and μ1,3-fashion by the formate ions. The sodium ions are coordinated to both formate ions and perchlorate ions in the lattice. Magnetic measurements were made over the range 1.8-310 K and show the presence of a singlet ground state at low temperature, the µ1,1-bridged copper ions being strongly antiferromagnetically coupled. The data were modeled equally well, within experimental error, by the alternating chain model and the dimer model with a Curie-Weiss correction for weak inter-dimer interactions, yielding C = 0.432(2) emu-K/mol-Oe, J/kB = −94.3(9) K and J’ = −2.4(1.5) K ().

One-pot hydrothermal synthesis of a mononuclear cobalt(II) complex and an organic-inorganic supramolecular adduct: Structures, properties and hirshfeld surface analyses

Through the hydrothermal reaction of cobalt(II) perchlorate hexahydrate with 5-bromo-6-methyl-pyridine-2-carboxylic acid (5-Br-6-Me-Hpyc) and 1,4-bis(4-pyridyl)benzene (1,4-bpb) coligands, a cobalt(II) complex [Co(5-Br-6-Me-pyc)2(H2O)]·2H2O (1) and an organic-inorganic adduct [H2(1,4-bpb)]·2ClO4 (2) have been co-synthesized in the same medium. Structural analyses indicated that the cobalt(II) ion in 1 is penta-coordinated by one water and two bidentate chelate 5-Br-6-Me-pyc anionic ligands to obtain an asymmetric mononuclear species. While in 2, the two pyridyl groups of 1,4-bpb acquire two protons forming a bivalent cation pyridinium, which combine two perchlorate anions via N–H⋯O hydrogen bonds to fabricate an interesting anion-cation supramolecular adduct 2. The magnetism for 1, fluorescence for 2 as well as the hirshfeld surface structures for them have been carefully described and discussed.

Achieving High-Performance Molecular Rectification through Fast Screening Alkanethiol Carboxylate-Metal Complexes Electroactive Units

Achieving High-Performance Molecular Rectification through Fast Screening Alkanethiol Carboxylate-Metal Complexes Electroactive Units

Bio functional molecular complexes, ferrocenyl hydrazone based binuclear Cu (II) derivatives: Synthesis, spectral, DNA/BSA binding &in-silico analyses

As a first stage intermediate, designing mononuclear complexes of amine-based phenolic derivatives employing Cu (II) acetate as a central metal ion in a 1:2:1 ratio. In a methanolic solution treated with 1,1′-diacetyl ferrocene dihydrazone and Cu (II) perchlorate hexahydrate to generate a new group of ferrocene based macrocyclic binuclear Cu (II) complexes. To characterize the macrocyclic complexes, physico-chemical studies such as FT-IR, UV–vis, and photoluminescence were used. The binuclear Cu(II) complex [Cu2L1] exhibits two quasi-reversible reduction waves in the potential range The binuclear complex [Cu2L1]hastwowaves of virtually reversible reductionin the potential range of E1pc = −1.01 V and E2pc = −1.37 V in the electrochemical investigation. They show a reduction process that involves two one-electron reductions in steps. The ferrocenyl group of the complexes shows one-electron ferrocene/ferrocenium redox activity, although with differing peak potentials. CT-DNA was used to study DNA binding utilizing spectroscopic techniques such as Circular Dichroism, UV–vis, and Fluorescence. The binding constant (Kb) values for the series of complexes range from 1.3x105 to 5.8 × 105 M−1. The metal complexes all interacted with CT-DNA by an intercalative form of binding, according to fluorescence spectrum analyses. BSA protein binding, on the other hand, indicates a quenching manner of interaction with the binuclear complex system, with binding constants of 1.77 × 106, 1.65 × 106, 2 × 106, 4.8 × 106 and 5.12 × 106 M−1. Molecular docking analysis was used to support and augment the experimental biological studies. Intercalation was seen during the docking of 1BNA with a metal complex due to multiple hydrogen bonding interactions. The ferrocene heterocyclic ring and the naphthyl group of complexes interacted with the BSA protein's ARG and TYR systems.

Ligand mediated structural diversity of copper(II)-azido moiety: Synthesis, structure and magnetic study

Two copper azido complexes [Cu4(L1)4(µ1,1-N3)3(N3)] (1) and [{Cu2(L2)(N-benzylen)(µ1,1-N3)3(µ1,1,3-N3(N3)]n (2) have been synthesized by the reaction of aqueous solution of sodium azide to a methanolic solution of copper perchlorate hexahydrate and corresponding Schiff-base ligands. Schiff bases HL1 and HL2 act as blocking coligands are derived from the 1:1 condensation of N-benzyl ethylenediamine with Salicyldehyde and 2-hydroxy-5-chloroacetophenone respectively (N-benzylen is the N-benzyl ethylenediamine). These two complexes are characterized by the elemental analysis, FT-IR, single crystal X-ray diffraction, powder XRD and also TGA. Single crystal X-ray structural study reveals that complex 1 is the only single μ1,1- azido bridged chain tetramer to the best of our knowledge and complex 2 is a mixed ligand azido bridged one dimensional chain which also represents the unique example containing three types of azido bonding modes µ1,1-N3, µ1,1,3-N3 and terminal N3 present simultaneously. Magnetic susceptibility measurements between 4.5 K and 300 K showed that complex 1 and complex 2 are antiferromagnetic and ferromagnetic in nature, respectively.

Nickel(II), copper(II) and zinc(II) complexes with an N-pendent dimethyl derivative of an octamethyl macrocyclic ligand: synthesis, characterization and antimicrobial studies

Interaction of CH3I with L (3,10-C-meso-Me8[14]diene) in the ratio of 4:1 in ethanolic solution at room temperature yielded N-pendent dimethyl derivative [(L-2H)(–CH3)2] denoted by LZ. Interaction of nickel(II) acetate tetrahydrate with LZ and subsequent addition of NaClO4·6H2O produced square planar orange-yellow product, [NiLZ](ClO4)2. The reaction of copper(II) perchlorate hexahydrate with LZ afforded four coordinated square planar red [CuLZ](ClO4)2. However, on the reaction of zinc(II) nitrate hexahydrate with LZ furnished white six coordinated two distereoisomeric complexes [ZnLZα(NO3)2] and [ZnLZβ(NO3)2]. Axial addition reactions on four coordinated square planar [NiLZ](ClO4)2 with KX (X= SCN, NO3, Cl, Br or I) and NaNO2 resulted in six coordinated octahedral and square pyramidal axial addition products, such as [NiLZ(NCS)2], [NiLZ(NO3)(ClO4)], [NiLZCl(ClO4)], [NiLZBr2], [NiLZI2] and [NiLZ(NO2)](ClO4), respectively. However axial substitution reactions on [ZnLZα(NO3)2] with KY (Y= SCN, Cl or Br) and NaNO2 produced six coordinated octahedral axial substitution products [ZnLZα(NCS)2], [ZnLZαCl2], [ZnLZαBr2] and [ZnLZα(NO2)2]. Similarly, the axial substitution reactions on [ZnLZβ(NO3)2] with KI and NaClO4.6H2O resulted in six coordinated octahedral axial substitution products [ZnLZβI2] and [ZnLZβ(H2O)2](ClO4)2, respectively. The compounds have been characterized by analytical, spectroscopic, magnetochemical and conductivity data. The antimicrobial activities of the new ligand and its complexes have been tested against different micro pathogens. Nickel(II), copper(II) and zinc(II) complexes with an N-pendent dimethyl derivative ligand LZ of an octamethyl tetraazmacrocyclic ligand were prepared. The compounds were characterized by different analytical and spectroscopic methods. Antibacterial and antifungal activities of these compounds against some bacteria and fungi were also investigated.

Ultrastable Zinc Anodes Enabled by Anti-Dehydration Ionic Liquid Polymer Electrolyte for Aqueous Zn Batteries.

The side reaction and dendrite of a zinc anode in an aqueous electrolyte represent a huge obstacle for the development of rechargeable aqueous Zn batteries. An electrolyte with confined water is recognized to fundamentally stabilize the zinc anode. This work proposes acetamide/zinc perchlorate hexahydrate (AA/ZPH) ionic liquid (IL)-polyacrylamide (PAM) polymer electrolytes, here defined as IL-PAM. The novel Zn2+-conducting IL is able to accommodate trace water and can achieve both high conductivity (15.02 mS cm-1) and alleviation of side reactions (>90% reduction). Cross-linked PAM acts as the three-dimensional framework to suppress dendrites and obtain flexibility. As a result, the Zn anode with IL-PAM can cycle stably over 2000 h with a record highest cumulative capacity of 3000 mAh cm-2 and well-preserved morphology. Based on IL-PAM, the flexible LFP|Zn hybrid batteries can be successfully assembled and operate normally in series and parallel conditions. Moreover, the low volatility of IL and binding forces exerted by the PAM network endues IL-PAM with an anti-dehydration property. In a 50 °C unsealed environment, the weight loss of IL-PAM is about two-fifths of PAM hydrogel and an aqueous electrolyte, and the corresponding hybrid battery with IL-PAM can also prolong a 4 times longer lifespan.

Copper(II) and nickel(II) complexes of an N-pendent bis-(cyanoethyl) derivative of an isomeric hexamethyl tetraazamarocyclic ligand: Synthesis, characterization, electrolytic behavior and antimicrobial studies

Hexamethyl derivative salt of the fourteen membered tetraazamacrocycle, Me6[14]diene.2HClO4 (L.2HClO4) has been synthesized by the condensation of ethylenediamine with acetone in presence of quantitative amount of perchloric acid. This diene ligand salt on reduction with NaBH4 followed by extraction with CHCl3 at pH above 12 resulted in a mixture of isomeric ligands, Me6[14]anes which were separated by fractional crystallization from xylene and designated by ‘tet-a’ and ‘tet-b’. Interaction of ‘tet-b’ with excess of acrylonitrile yielded an N-pendent derivative ‘tet-bx’ in which two cyanoethyl groups were attached on less crowded two trans-N atoms. Interactions of nickel(II) acetate tetrahydrate and copper(II) perchlorate hexahydrate with ‘tet-bx’ followed by subsequent addition of NaClO4·6H2O and HClO4 in case of nickel(II) produced square planar orange [Ni(‘tet-bx’)](ClO4)2 and six coordinated octahedral reddish purple [Cu(‘tet-bx’)(ClO4)2] complex respectively. The axial addition reactions on [Ni(‘tet-bx’)](ClO4)2 with NCS, NO3, NO2, Cl, Br and I afforded different colored six coordinated octahedral axial addition products: violet [Ni(‘tet-bx’)(NCS)2]; violet [Ni(‘tet-bx’)(NO3)(ClO4)]; green [Ni(‘tet-bx’)(NO2)(H2O)](ClO4); brown [Ni(‘tet-bx’)(ClO4)Cl]; brown [Ni(‘tet-bx’)(H2O)Br](ClO4) and pink [Ni(‘tet-bx’)(ClO4)I] respectively. All compounds have been characterized by different analytical and spectroscopic parameters. The antimicrobial activities of the concerned ligand and its complexes have been investigated against different bacteria and fungi.

Synthesis and characterization of a double oximato bridged dimeric copper(II) complex and its use in oxidative dimerisation of o-aminophenol

A dinuclear copper(II) complex, [(CH3CN)Cu(L)2Cu](ClO4)2, has been synthesized by reacting an oxime-based tridentate Schiff base ligand, 3-[2-(dimethylamino)-ethylimino] butan-2-one oxime (HL), with copper(II) perchlorate hexahydrate. The complex has been characterized by elemental and spectral analyses. Structure of the complex has been confirmed by single crystal X-ray diffraction technique. The complex may be used as moderate catalyst for the oxidation of o-aminophenol to 2-aminophenoxazine-3-one.

Synthesis and catalysis of hydrolysis of phosphate esters by Zn(II), Cu(II), and Ni(II) Schiff base complexes

The Schiff base ligand 2-(((2-(pyridin-2-yl)ethyl)imino)methyl)phenol (Salpea) was derived from the condensation reaction of 2-(2-pyridyl)ethylamine and salicylaldehyde. Three Schiff base complexes of the ligand were synthesized by reacting the Salpea ligand with Zn(II), Cu(II), and Ni(II) perchlorate hexahydrate salts. The compounds were analyzed by H-NMR, FT-IR, and UV–visible spectroscopies. CHN elemental analysis and x-ray crystallography were also employed for characterization in this research. Kinetic studies were performed on these complexes to evaluate their efficiency as catalysts for the hydrolysis of 4-nitrophenylphosphate (4NPP) in DMSO:H2O (1:1) solvent mixture using a TRIS buffer solution. It was determined experimentally that the complexes are catalytically active in hydrolysis of the phosphate ester studied (4NPP). Second order rate constants on the order of 10−3 M−1 s−1 were observed for the complexes studied.

Synthesis, characterization and theoretical calculations of Cu(I) complex of trithiocyanuric acid [Cu(ttc)3

A new Cu(I) complex constructed by reaction of trithiocyanuric acid (ttc) and copper (II) perchlorate hexahydrate has been successfully synthesized by a slow sedimentation method in a DMF solvent at room temperature. The molecular structure of the compound was elucidated by MALDI-TOFMS, UV Vis and FTIR spectroscopy, DSC-TGA analysis and magnetic susceptibility measurement. The proposed structure was corroborated by a computational study carried out with the Gaussian09 and AIMAII programs using the RB3LYP hybrid DFT functional with both 6-31G and Alhrich-TZV basis sets. The calculated vibrational frequencies values were compared with experimental FTIR values. Photophysical properties of the synthesized complex were evaluated by UV-Visible spectroscopy and compared with computed vertical excitation obtained from TDDFT. The theoretical vibrational frequencies and the UV Vis spectra are in good agreement with the experimental values. Additionally, the Frontier Molecular Orbitals (HOMO-LUMO) and the Molecular Electrostatic Potential of the complex was calculated using same theoretical approximation. The results showed the interaction between three coordinatedl igand atoms and the Cu(I) ion.

DNA/Protein Binding, Molecular Docking and Cytotoxicity Studies of Piperazinyl‐Moiety‐Based Copper(II) Complexes

AbstractCopper(II) complexes {[Cu(HL)(ClO4)(H2O)](ClO4)⋅3H2O} (1), {[Cu(HL)(m‐phth)]⋅5H2O} (2) and {[Cu(HL)(NCS)]2(ClO4)2⋅2H2O} (3) (HL=2‐{[2‐(1‐piperazinyl)ethylimino]methyl}phenol; m‐phth=1,3‐benzenedicarboxylate] have been synthesized and characterized by structural determination and spectroscopic studies. The mononuclear square pyramidal complex 1 resulted from the reaction of HL with copper perchlorate hexahydrate. Then mononuclear square planar complex 2 and dinuclear thiocyanato bridged complex 3 were obtained by reacting 1 with disodium 1,3‐benzenedicarboxylate (Na2(m‐phth)) and potassium thiocyanate, respectively. The interactions of 1–3 with CT‐DNA / serum albumins were investigated by UV‐visible absorption and fluorescence spectroscopy. The intrinsic binding constants of 1, 2 and 3 with CT‐DNA were calculated as 1.44 (±0.13) × 105, 4.86 (±0.11) × 105 and 4.51 (±0.16) × 105 L mol−1, respectively. Study of the interactions of 1–3 with human serum albumin (HSA) / bovine serum albumin (BSA) showed that all the complexes could quench intrinsic fluorescence of HSA and BSA through a static quenching process. Molecular docking technique was utilised to confirm the mode of interaction of complexes with CT‐DNA / serum albumin. Anticancer activities of the complexes have been tested using human breast cancer cell lines MCF7 and MBA‐MB‐231. Among the complexes studied 3 shows the higher cytotoxic activity and growth inhibition of cancer cells via induction of apoptotic cell death.

The Effect of Mars‐Relevant Soil Analogs on the Water Uptake of Magnesium Perchlorate and Implications for the Near‐Surface of Mars

AbstractThe water uptake and release by perchlorate salts have been well studied since the first in situ identification of such salts in the Martian soil by the Phoenix mission in 2008. However, there have been few studies on the effect of the insoluble regolith minerals on the interaction of perchlorate with water vapor. In this work, we investigate the impact of a Mars‐relevant mineral, montmorillonite, and a Mars soil analog, Mojave Mars Simulant (MMS), on the deliquescence (transition from dry crystalline to aqueous via water vapor absorption), ice formation, and efflorescence (transition from aqueous to dry crystalline via loss of water) of pure magnesium perchlorate. We studied mixtures of magnesium perchlorate hexahydrate with either montmorillonite or MMS. Although montmorillonite and MMS are materials that may serve as nuclei for either ice nucleation or salt efflorescence, we find that these soil analogs did not affect the phase transitions of magnesium perchlorate. The salt‐mineral mixture behaved similarly, within estimated uncertainties, to pure magnesium perchlorate in all cases. Experiments were performed in both N2 and CO2 atmospheres, with no detectable difference. We use data from the Mars Science Laboratory Rover Environmental Monitoring Station instrument and the Phoenix Thermal and Electrical Conductivity Probe, as well as modeling of the shallow subsurface, to determine the likelihood of these perchlorate phase transitions occurring at Gale Crater and the northern arctic plains (Vastitas Borealis). We find that aqueous solutions are predicted in the shallow subsurface of the Phoenix landing site, but not predicted at Gale Crater.

Investigation on biomolecular interactions of nickel(II) complexes with monoanionic bidentate ligands

Reactions of monoanionic bidentate ligands 5-methylsalicylaldehyde (5-msal), 5-bromosalicylaldehyde (5-brsal), 5-nitrosalicylaldehyde (5-nsal) and 2-hydroxy-1-naphthaldehyde (2-hnap) with nickel perchlorate hexahydrate produced nickel(II) complexes 1–4, respectively. Single crystal X-ray analyses of complexes 1 and 2 confirmed bidentate mode of the ligands with O˄O coordination to give square planar geometry around nickel atoms. Complexes 1–4 showed one quasi-reversible redox peak at cathodic region (−0.67 to −0.80 V) and one redox peak at anodic region (+1.08 to +1.44 V) assignable to the Ni(II)/Ni(I) and Ni(II)/Ni(III) redox couples, respectively. The complexes exhibited good bovine serum albumin (BSA) binding abilities with a maximum binding constant of 1.96 × 105 M−1. The binding of complexes with calf thymus DNA (ctDNA) showed that the binding affinity is consistent with an increase in steric bulk of the ligands. The nuclease activity of the complexes showed efficient oxidative cleavage in the presence of hydrogen peroxide as an oxidizing agent. The complexes showed higher zone of inhibition when screened for antimicrobial activity against bacteria and human pathogenic fungi.

Can perchlorates be transformed to hydrogen peroxide (H2O2) products by cosmic rays on the Martian surface?

AbstractDue to their oxidizing properties, perchlorates (ClO4−) are suggested by the planetary science community to play a vital role in the scarcity of organics on the Martian surface. However, alternative oxidation agents such as hydrogen peroxide (H2O2) have received surprisingly little attention. In this study, samples of magnesium perchlorate hexahydrate (Mg(ClO4)2 · 6H2O) were exposed to monoenergetic electrons and D2+ ions separately, sequentially, and simultaneously to probe the effects of galactic cosmic ray exposure of perchlorates and the potential incorporation of hydrogen (deuterium) into these minerals. The experiments were carried out under ultrahigh‐vacuum conditions at 50 K, after which the samples were slowly heated to 300 K while the subliming products were monitored by a quadrupole mass spectrometer. In all cases, molecular oxygen (O2) was detected upon the onset of irradiation and also during the warmup phase. In case of a simultaneous D2+‐electron exposure, deuterated water (D2O) and deuterium peroxide (D2O2) were also detected in the warmup phase, whereas only small amounts of D2O2 were found after an exclusive D2+ irradiation. These experiments yield the first data identifying hydrogen peroxide as a potential product in the interaction of cosmic rays with perchlorates in the Martian regolith revealing that perchlorates are capable of producing multiple oxidizing agents (O2 and D2O2) that may account for the destruction of organics on the Martian surface.

Synthesis, structure characterization, and anticancer activity of a novel oxygen-bridged tricyclic Biginelli adduct

Herein, we report the one-pot cyclization of Biginelli Adduct, ethyl 4-(2-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (I) to the oxygen-bridged adduct, ethyl 2-methyl-4-thioxo-3,4,5,6-tetrahydro-2H-2,6-methanobenzo[g] [1,3,5]oxadiazocine-11-carboxylate (II) in a high yield and purity under mild reaction condition using zinc(II) perchlorate hexahydrate as a highly efficient catalyst. The cyclic product (II) was characterized both in the solid state and in solution using FT–IR, 1H NMR, and UV–visible spectroscopy. Theoretical calculations using density functional theory with B3LYP/6-311++G(d,p) level were used to further investigate the structure properties. DFT calculations (gas phase) revealed the stability of cyclic compound II (3.45 kcal/mol) than compound I. In addition, the anticancer activity of II was investigated using MCF-7 human breast cell line. The results revealed a moderate activity with 223.55 μg/ml IC50 value.

A Reflectron Time-of-Flight Mass Spectrometric Study on the Degradation Pathways of Glycine on Mars in the Presence of Perchlorates and Ionizing Radiation

Abstract The absence of abundant organics on the Martian surface is a much discussed observation. So far, no explanation is completely satisfactory. In this study we aim for a deeper understanding of the degradation processes of organics in the presence of perchlorates that can take place on the Martian surface. Our primary goal is to study the radiation-induced decomposition process of glycine (H2NCH2COOH) in the absence and presence of an oxidizer relevant to the Martian surface—perchlorate anions ( ClO 4 − ) . Glycine and various samples of glycine-1-13C (+H3NC H 2 13 COO−)–magnesium perchlorate hexahydrate (Mg(ClO4)2 · 6H2O) were exposed to energetic electrons mimicking secondary electrons originating from the interaction of galactic cosmic rays (GCRs) with the Martian regolith. Using isotope-labeled and deuterated pure glycine samples such as glycine-1-13C, glycine-d5 (+D3NCD2COO−), glycine-N,N,N-d3 (+D3NCH2COO−), and glycine-2,2-d2 (+H3NCD2COO−), we can conclude that decarboxylation (carbon dioxide loss) of the glycine molecule is exclusively the first decay step during irradiation regardless of whether perchlorate anions are present or not. In pure glycine samples, the decarboxylation co-product methylamine (CH3NH2) and its radiolytic decay product ammonia could both be detected explicitly for the first time. In the presence of perchlorates, (partial) oxidation of the glycine decarboxylation product CH3NH2 may occur. Because the decarboxylation is an equilibrium reaction and the CH3NH2 is effectively removed from the system by this oxidation, glycine cannot be recycled. Therefore the depletion of the CH3NH2 facilitates the process, resulting in an overall 10-fold increase in the formation rate of carbon dioxide and its elevated concentrations in the perchlorate-containing irradiated samples.