Mobile (m)-learning is a technology-enhanced learning approach utilizing mobile technologies to facilitate learning. Despite significant attention from previous researchers, there is a lack of adequate studies about student’s usage and perceptions of m-learning in Zanzibar’s’ higher learning institutions (HLIs). In this study, the researchers explored the specific activities undertaken by students through the m-learning system, the students’ perceptions on the usefulness and ease of use of m-learning system, and the challenges they faced at the State University of Zanzibar (SUZA). The study used the survey method with descriptive statistical analysis and examined 240 randomly selected participating in the m-learning initiative. The findings indicate that 96.7% of participants easily used the system to navigate learning resources, 92.9% viewed assignments, and 94.6% took quizzes. Additionally, the majority of the respondents showed a positive attitude regarding the usefulness and ease of use of the system. However, 57% of participants experienced challenges, including unreliable internet connectivity and system incompatibility with some of their devices. The findings of this study will help HLIs like SUZA to find better strategies to improve m-learning, especially pedagogical features and awareness among students. Moreover, the study underscores the importance of more research to discover factors that influence m-learning adoption in Africa HLIs.