Perception Of Pharmacovigilance Research Articles

Knowledge, Attitude and Perception of Pharmacovigilance Science in Ayurveda among Ayurved pharmacy undergraduates - A Cross Sectional Study

Background: India is known for its traditional medicinal systems. Ayurveda, Siddha and Unani systems are being practised since ages and their use have accepted in other countries in era of globalisation. There is a wide spread misconception that all drugs of “natural” origin are “safe”. Many drugs not only of allopathy but homeopathy as well Ayurved, having undesirable unwanted effects beyond therapeutic action called Adverse Drug Reaction (ADR). Ministry of AYUSH, Government of India, New Delhi has initiated the Pharmacovigilance Program for Ayurved, Siddha, Unani & Homeopathy drugs (ASU & H drugs). Aim and Objectives: To evaluate knowledge, attitude and perception of Pharmacovigilance among Ayurved pharmacy undergraduates. Materials and Methods: It was a prospective, cross-sectional study conducted among Ayurved pharmacy undergraduates perusing their study at government Ayurved College during 2022. The questionnaire was designed to test knowledge, attitude and perception of Pharmacovigilance. Basic and study data was entered in Microsoft Office Excel 2016 and descriptive statistics was used. Result: Majority students had knowledge about “ADR’ and “Pharmacovigilance” and “ADR” reporting Centre” but where and to whom and how to report was lacking as there have not been exposed to any practical training and awareness session. Majority participants were agreed that all the drugs including ASU & H has adverse drug reaction and need to report and should be mandatory. Conclusion: There is a need of more awareness and practical/ hand to hand training programme related to Pharmacovigilance and ADR reporting to Undergraduate Ayurved Pharmacy Students to sensitise them and to strengthen the reporting culture for ASU & H drugs form early stage.

Knowledge and perception of pharmacovigilance among pharmacy students and pharmacy professional students

Background: Adverse Drug Reaction (ADR) contributes to high morbidity and mortality rate worldwide. This can be minimised through pharmacovigilance. It is important to evaluate the level of knowledge and perception of pharmacovigilance among pharmacy students. Objective: To describe the level of knowledge and perceptions of final-year pharmacy students and students of pharmacy professional programs in Yogyakarta regarding pharmacovigilance. Method: A cross-sectional study involved 437 pharmacy students from five different universities in Yogyakarta, who were selected using a convenience sampling technique. Data were analysed to describe the characteristics of the respondents and their level of knowledge and perceptions about pharmacovigilance. Result: The majority of final year students in pharmacy and pharmacy professional programs had acquired a high level of knowledge about pharmacovigilance with a percentage of 54.0%. They also shared a positive perception of the implementation of pharmacovigilance with a percentage of 55.6%. Conclusion: Final-year pharmacy students and students of the pharmacy professional program have good knowledge and perceptions towards pharmacovigilance.

The impact of educational interventional session on healthcare providers knowledge about pharmacovigilance at a tertiary Jordanian teaching hospital

ObjectiveA limited number of educational interventions among health care providers and students have been made in Jordan concerning the pharmacovigilance. Therefore, the main aim of this study was to evaluate how an educational workshop affected the understanding of and attitudes toward pharmacovigilance among healthcare students and professionals in a Jordanian institution.MethodsA questionnaire was used before and after an educational event to evaluate the pre- and post-knowledge and perception of pharmacovigilance and reporting of adverse drug reactions (ADRs) among a variety of students and healthcare professionals at Jordan University Hospital.ResultsThe educational workshop was attended by 85 of the 120 invited healthcare professionals and students (a response rate of 70.8%). The majority of respondents were capable of defining ADRs (n = 78, 91.8%) and pharmacovigilance accurately (n = 74, 87.1%) in terms of their prior understanding of the topic. Around 54.1% of the participants (n = 46) knew the definition of type A ADRs while 48.2% of them (n = 41) knew the definition of type B ADRs. Additionally, around 72% of the participants' believed that only serious and unexpected ADRs should be reported (n = 61, 71.8%), also, 43.5% of them (n = 37) believed that ADRs should not be reported until the specific medication that caused it is known. The majority of them (n = 73, 85.9%) agreed that reporting of ADRs was their responsibility. The interventional educational session has significantly and positively impacted participants' perceptions (p value ≤ 0.05). The most reason for not reporting ADRs as stated by the study participants was the lack of information provided by patients (n = 52, 61.2%) and the lack of enough time to report (n = 10, 11.8%).ConclusionParticipants’ perspectives have been greatly and favorably impacted by the interventional educational session. Thus, ongoing efforts and suitable training programs are required to assess the effect of bettering knowledge and perception on the practice of ADRs reporting.

Assessment of pharmacovigilance activities among pharmacist interns in Nigeria: a cross-sectional study

BackgroundPharmacovigilance (PV) and adverse drug reaction (ADR) reporting is at the core of the services and functions of a pharmacist. Pharmacist interns undergoing their one-year mandatory internship program are expected to be armed with this tool kit in order to provide adequate pharmaceutical services in all areas of pharmacy practice.ObjectivesThis study sought to assess the knowledge and perception of pharmacovigilance and adverse drug reaction reporting among pharmacist interns in Nigeria.MethodsThis study was a cross-sectional study among pharmacist interns in their one-year mandatory internship program across Nigeria. The 32-item semi-structured questionnaires were administered online using simple random sampling with the snowballing technique to recruit the participants in the study. The results were analyzed with IBM SPSS version 25. Descriptive statistics were used to summarize the data. The Chi-square test and contingency coefficient were used to determine the association between knowledge of PV and the demographics of the participants.ResultsA total of 450 pharmacist interns participated in this study. The participants' knowledge of pharmacovigilance and ADR is 92.5%. About 96.2% of respondents feel that responses to newly released pharmaceuticals must be recorded, compared to 79.1% for older drugs already on the market. There is a high correlation between the duration of the internship program and understanding of PV and ADR reporting among participants. More than fifty percent of respondents concur that ADR reporting is critical, while more than eighty percent concur that ADR reporting is required for pharmacists, the most significant health professionals in ADR reporting. The participants' length of participation in an internship program and their internship location significantly impact their opinion of ADR reporting. Seventy-four percent (74%) of respondents from tertiary hospitals say their internship center encourages ADR reporting.ConclusionMost participants have a solid understanding of PV and ADR reporting, but perceptions of PV and ADR reporting are substantially correlated with internship location and program length. Active measures should be implemented to ensure that all pharmacy interns comprehend and embrace PV and ADR reporting as their exclusive duty.

Perception of Pharmacovigilance: A survey of pharmacists at the city of Casablanca, Morocco#

Perception of Pharmacovigilance: A survey of pharmacists at the city of Casablanca, Morocco#

Exploration of Perception, Need and Barriers against Pharmacovigilance and Adverse Drug Reactions Reporting: Healthcare Professionals’ Insight

Objective: The present study was designed to assess the perception, need and the barriers of PV and ADRs reporting in the hospital settings of Karachi, Pakistan.
 Methods: A cross-sectional survey was conducted from October 2019 to February 2020 by the random sampling in the healthcare professionals including physicians, pharmacists and nurses. Questionnaire was distributed to 525 participants (n=175 from each group) being serving for one or more year in hospitals and clinics. Overall, 425 participants were responded having 138 physicians, 143 pharmacists and 145 nurses.
 Results: Perception of pharmacovigilance was found to be 81.02%, 73.40% and 35.17% respectively in physicians, pharmacists and nurses. Overall, 80.70% of respondents were felt the need of drug monitoring system in each hospital to improve patients’ responses against treatment. The main hindrance for PV in our society was the lacking/ absence of the ADRs monitoring and reporting system marked by the physicians and pharmacists.
 Conclusion: ADRs reporting and pharmacovigilance are not practiced properly in our region. It’s a time to pay attention to this neglected area not only to strengthen the infra structure of healthcare units but also to increase the patient compliance and to avoid any drug associated disaster in future.

Healthcare students' knowledge, attitude and perception of pharmacovigilance: A systematic review.

The objective of this review is to evaluate the existing evidence about the knowledge, attitude, and perceptions (KAP) of healthcare students towards pharmacovigilance and adverse drug reactions reporting (ADRs). A systematic literature search was conducted using MEDLINE, CINAHL, EMBASE, ERIC, and Cochrane Database of Systematic Reviews via OVID. This review restricted the search to studies published in English from inception until December 2019. The primary outcome was healthcare students' knowledge, attitude, and perceptions of pharmacovigilance. Of the 664 articles identified, twenty-nine studies were included in the review. Overall, healthcare students vary in their knowledge and attitude towards pharmacovigilance and ADRs reporting. There was inconsistency in measuring KAP between the studies and the main drawback in the literature is lacking validated KAP measures. In summation, optimal KAP assessment can be achieved through developing a standard validated measure. Our future healthcare providers should have basics pharmacovigilance knowledge in order to rationally reporting ADRs and preventing serious health problems.

The short and long-term impact of educational intervention on pharmacovigilance awareness in second year MBBS students: a questionnaire-based survey

Background: Under-reporting of adverse drug reactions (ADRs) is a burning issue globally. Sensitizing medical students to the concepts of pharmacovigilance in their early years through regular training holds the key for successfully perpetuating ADR reporting culture. This study attempted to assess the short and long-term impact of interventional training programs on the knowledge and perception of Pharmacovigilance amongst II MBBS students.Methods: It was a Cross-sectional, interventional, questionnaire‑based study. Second MBBS, new entrants (n=127) were tested for their awareness regarding pharmacovigilance knowledge using pre-validated questionnaires at entry point and following regular training sessions, at 1 week (short-term) and at 1 year (long-term). Students’ perceptions towards ADR monitoring were also recorded. Descriptive statistics, Chi-square test, Independent t-test/Mann-Whitney-U test for identifying mean difference and paired-t-test/Wilcoxon signed rank test for paired data was used for quantitative and qualitative data analysis accordingly.Results: Significant improvement in scores following training was seen at both short (10.8±1.914) and long term (11.63±1.516) compared to base-line scores (6.07±2.036). There was significant increase in long-term scores compared to short-term scores (<0.001). Female students performed better than their male counterparts. Majority of students positively perceived the need for ADR monitoring and reporting.Conclusions: Pharmacovigilance training increases students’ knowledge significantly. Strengthening the existing pharmacovigilance activities through regular refresher training programs and adequate sequencing in curriculum not only maintains but improves students’ knowledge significantly.

Pharmacist's Perception of Pharmacovigilance and Reporting of Adverse Drug Reactions in Saudi Arabia

Pharmacist's Perception of Pharmacovigilance and Reporting of Adverse Drug Reactions in Saudi Arabia

Comparative Perception of Pharmacovigilance by Physicians versus Paramedical Professions in Ivory Coast

Objective: To assess the perception of pharmacovigilance by healthcare professionals practicing at the University Teaching Hospital of Cocody (Ivory Coast) in 2017. Methodology: A descriptive and analytic cross-sectional survey has been conducted in 2017 at the University Teaching Hospital of Cocody. This survey involved a sample of healthcare professionals practicing in 17 services who are prescribing medications and gave their oral consent. Results: A response rate of 54.08% (106/196) among physicians versus 43.87% (86/196) for the nurses and 27.61% (21/76) for the mid-wives. 57.94% (62/107) of paramedics versus 94.33% (100/106) of physicians had already heard about pharmacovigilance, during their basic training (40.18% of paramedics versus 73.58% of doctors). However, the main obstacles to the practice of pharmacovigilance were it teaching hours considered insufficient (94.39% of paramedics versus 75.47% of physicians), the lack of knowledge on the location of the pharmacovigilance unit (80.37% of paramedics versus, 40% of physicians) and the reporting of the adverse drug reactions to a hierarchical supervisor (60.60% of paramedics versus 37.25% of physicians). A regular visit of pharmacovigilance monitors in the hospital services (34.57% of paramedics versus 29.24% of physicians) and the availability of reporting forms (30.84% of paramedics versus 27.35% of physicians) could improve the perception of pharmacovigilance by the healthcare professionals. Conclusion: Our investigational survey has highlighted some factors that may influence the perception of pharmacovigilance by the healthcare professionals in Ivory Coast.

Perception of Pharmacovigilance by Nurses and Midwives of the Cocody University Teaching Hospital in Abidjan

Objective: To assess the perception on pharmacovigilance by the nurses and midwives at the University Teaching Hospital (CHU) of Cocody in 2017. Methodology: Descriptive and analytic cross-sectional study conducted in 17 services of the University Teaching Hospital (CHU) of Cocody using an anonymized and standardized questionnaire. Results: The response rate was 39.33% for the 86 nurses and 21 midwives with at least 10 years of professional experience (50.6%). 57.94% of the respondents (n = 62) have already heard about pharmacovigilance during their basic training (40.18%, n = 43). However, only 19.63% (21/107) of the respondents knew about the existence of a pharmacovigilance unit which they wrongly located to the pharmacy (11/21) of the CHU of Cocody. 40.18% of respondents (n = 43) had previously experienced an adverse drug reaction that was reported (76.74%, n = 33) to a hierarchical supervisor (60.60%, n = 20). The causes of non-reporting were either the frequent occurence (4/10) or the benign nature (2/10) of the adverse drug reaction. Specific actions to be taken (37.38%, n = 40) and a feedback (28.97%, n = 31) were the respondents’ main expectations for the stimulation of the reporting system. They also wanted the pharmacovigilance monitors to regularly visit their services (34.57%, n = 37) and to provide them with the reporting forms (30.84%, n = 33). Conclusion: Our study has allowed us to highlight the lack of knowledge of the pharmacovigilance and to identify certain factors that could improve the perception of the pharmacovigilance by the nurses and the midwives in Ivory Coast.

Comparison of the Knowledge and Perception of Pharmacovigilance Among Pharmacy, Dental and Medical Students in Aden-Yemen

Background: Adverse drug reactions (ADRs) represent a serious health problem. Despite all the benefits of modern medicines, evidence continues to mount that ADRs to them are common, yet often preventable cause of illness, disability and even death. ADRs are responsible for a significant number of hospital admissions. Healthcare professionals have an important role to play in reducing ADRs. Purpose: The goal of this study was to compare the knowledge and attitudes of pharmacy, dental and medical students regard¬ing adverse drug reactions (ADRs), as well as their perceptions of barriers to ADR reporting, in Aden University, Yemen. Methods A cross-sectional study was conducted among final-year students. A total of 130 pharmacy students, 101 medical and 69 dental students completed the self-administered questionnaire. The study was conducted from July 1 to October 31, 2016. The responses of pharmacy students were compared to those of dental and medical students. Results: The mean ages of the pharmacy, medical and dental students were 25.13 ± 1.90 years. A non-significant gender difference (P Key words: Aden; dental; Pharmacy; Medical; Students; Pharmacovigilance; Comparison; Yemen.

Health care professionals knowledge and perception of pharmacovigilance in a tertiary care teaching hospital in Amman, Jordan.

Underreporting of adverse drug reactions (ADRs) by health care professionals is a common inherent health problem encountered in many countries. This could be explained by the lack of awareness and knowledge about the guidelines to follow to identify and report ADRs. Thus, this study aimed to evaluate the awareness, knowledge, and perceptions among medical doctors and nurses regarding their role as ADRs reporters in Jordan. A cross-sectional study was conducted between September 2015 to January 2016 at the Jordan University Hospital in Amman. During the study period, a total of 670 validated questionnaires were distributed to medical doctors and nurses in different departments. Most of health care professionals were not aware of the concept of pharmacovigilance. Medical doctors showed a better overall knowledge compared with nurses (P<.05). Interestingly, despite the low level of awareness, the majority of respondents believed in the necessity of reporting ADRs. Although there is a low level of awareness among health care professionals regarding pharmacovigilance, there is strong agreement among them about the necessity of reporting ADRs and attending educational sessions about pharmacovigilance which will help them to improve the quality of services they provide.

Assessment of knowledge, attitude, and practice of pharmacovigilance among private practitioners in Southern India: A questionnaire-based study

Background: Pharmacovigilance has constantly gained importance in last 15 years, relating to absolute the amount of adverse drug reactions (ADRs) and to the fact that several hospital admissions are due to ADRs. The success of Pharmacovigilance Programme of India (PVPI) depends on the active involvement of not only the health-care professionals, such as allopathic doctors, dentists, nurses, and pharmacists but also on those doctors who practice alternative systems of medicine. Aims and Objective: To assess the awareness and perception of pharmacovigilance among doctors practicing alternative systems of medicine in Tumkur, Southern India. Materials and Methods: A cross-sectional study was conducted among doctors practicing alternative systems of medicine in Tumkur, Southern India, using a validated questionnaire suitable for assessing the knowledge, attitude, and practice of pharmacovigilance was designed and distributed to the private practitioners. Results: Of 120 doctors who answered the questions, 28.3% reported to have heard the name pharmacovigilance, 14.2% doctors answered that drugs used in alternative systems of medicine cause ADRs whereas 85.8% said they do not. Only 12.5% thought that reporting an ADR with Ayurveda, Siddha and Unani (ASU) drugs is necessary and 9.2% had encountered an ADR with ASU drugs. Only 6.7% have been trained on how to report ADRs, whereas only 1 (0.8%) doctor had reported ADRs. Conclusion: Knowledge of doctors practicing alternative systems of medicine regarding pharmacovigilance is poor as well as their attitude and practice toward it. Sincere efforts should be made to include them under PvPI and to train through continued medical education programs as well as workshops on PvPI.

Assessment of knowledge, attitude, and practice of pharmacovigilance among doctors practicing alternative systems of medicine in Southern India: A questionnaire-based study

Background: Reporting adverse drug reactions (ADRs) are an essence of pharmacovigilance practice. Health-care professionals should know how and where to report an ADR. For Pharmacovigilance Programme of India (PVPI) to be successful, the health-care professionals such as allopathic doctors, nurses, and pharmacists must be actively involved along with the doctors who practice alternative systems of medicine. Aims and Objective: To assess the awareness and perception of pharmacovigilance among doctors practicing alternative systems of medicine in Tumkur, Southern India. Materials and Methods: A cross-sectional study was conducted among doctors practicing alternative systems of medicine in Tumkur, Southern India, using a validated questionnaire suitable for assessing the knowledge, attitude, and practice of pharmacovigilance was designed and distributed to the private practitioners. Results: Of 120 doctors who answered the questions, 28.3% reported to have heard the name pharmacovigilance, 14.2% doctors answered that drugs used in alternative systems of medicine cause ADRs, whereas 85.8% said they do not. Only 12.5% thought that reporting an ADR with Ayurveda, Siddha, and Unani (ASU) drugs is necessary, 9.2% had encountered an ADR with ASU drugs. Only 6.7% have been trained on how to report ADRs, whereas only 1 (0.8%) doctor had reported ADRs. Conclusion: Knowledge of doctors practicing alternative systems of medicine regarding pharmacovigilance is poor as well as their attitude and practice toward it. Sincere efforts should be made to include them under PVPI and to train through continued medical education programs as well as workshops on PVPI.

Pharmacovigilance Awareness among the Community Pharmacists and Pharmacy Students in the Turkish Republic of Northern Cyprus

All healthcare professionals, other healthcare workers, patient caregivers, patients and even their families are all important to the healthcare system and pharmacists in every country are an important part of this system, and have a major duty to maintain and monitor the safety and efficacy of drugs as an integral part of their professional practice. Since pharmacovigilance is an indispensable part of the clinical discipline for detecting, assessing, understanding and prevention of adverse effects or any other possible drug-related problems, the knowledge of pharmacists about spontaneous reporting of adverse drug reactions is the cornerstone of pharmacovigilance for patient care and safety. On the other hand, the worldwide reporting of adverse drug reactions (ADRs) by healthcare professionals, in particular those in developing countries are with poor contribution. Therefore, the knowledge and perception of pharmacovigilance and ADR reporting of 67 community pharmacists and Near East University (NEU) Faculty of Pharmacy students on their 1st (n=83) and 4th (n=79) years were investigated in the Turkish Republic of Northern Cyprus (TRNC). The observed results point out that the standards of training and education need to be improved for pharmacists and undergraduates alike giving rise to the design and implementation of more effective training for drug safety.

Assessment of knowledge, attitude and perception of Pharmacovigilance among nurses in a rural tertiary care center

Background: Pharmacovigilance (PV) is an integral and essential part of patient care. PV deals with the science and activities relating to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The aims of PV are to improve patient care, public health and safety in relation to the use of medicines, to contribute to the assessment of benefit, harm, effectiveness and risk of medicines, encouraging their safe, rational and more effective use, to promote understanding, education and clinical training in PV and its effective communication to health professionals and the public. The objective of present study was to assess the knowledge, attitude and perception of PV among nurses in a rural tertiary care center, Adichunchanagiri Institute of Medical Sciences (AIMS), B G Nagar. Methods: A cross-sectional questionnaire-based study was conducted among nurses of AIMS, B G Nagar, Mandya, Karnataka. Results: A total of 94 respondents were analyzed. 75.53% of participants knew the definition of PV, 77.65% participants knew the international PV reporting centers, 81.91% have knowledge about regulatory body responsible for monitoring adverse drug reactions (ADRs), 80.85% have good orientation of specific ADR format, 98.93% of nurses thought ADR reporting is necessary, 86.13% have attitude of encouraging non-medical persons to report ADR and 95.74% of nurses want PV to be taught in detail and 87.23% nurses reported that they came across ADRs. 31.91% participants are not aware about how to report ADR. Lack of knowledge about the reporting procedure is the major reason for under-reporting. Conclusions: The majority of nurses has good knowledge and attitude toward PV and understand the need for reporting in our study, but unfortunately the actual practice of ADR reporting is still deficient among them. Training programs and continued medical education type of interventions periodically can improve the knowledge toward PV.

Assessment of Knowledge, Attitude and Perception of Pharmacovigilance and Adverse Drug Reaction (ADR) Reporting among the Pharmacy Students in South India

The Study entitled Assessment of Knowledge, Attitude and perception of Pharmacovigilance and Adverse Drug Reaction (ADR) Reporting among the Pharmacy Students in South India was designed to assess the awareness of Pharmacovigilance and ADR reporting, and to evaluate the impact of an educational intervention. A validated (pilot study) self administered (KAP) Knowledge, attitude, perception survey questionnaire was used in the study. This prospective knowledge attitude practice (KAP) questionnaire study, of 6 month duration included a total of 225(90%) participants out of 250. An interactive educational intervention was designed for all participants of pre-KAP questionnaire survey. The impact of effectiveness of educational intervention among the pharmacy students was evaluated by means of post-KAP questionnaire survey. The paired t-test and chi-square test in GraphPad InStat was used for statistical calculation. The overall response rates between pre intervention and post intervention was statistically significant (P< 0.001) shows effectiveness of educational intervention for improving awareness of pharmacovigilance and ADR reporting among the participants. The study concluded that imparting the knowledge and awareness of Pharmacovigilance among the pharmacy students by means of continuous educational intervention would bring up updated knowledge and practice in drug safety and rational use.

Perception of pharmacovigilance among doctors in a tertiary care hospital: Influence of an interventional lecture

One of the important pillars of an efficient pharmacovigilance system is contribution by healthcare professionals in the form of spontaneous reporting. This study was aimed at investigating the knowledge, attitude and practice of spontaneous ADR reporting among doctors in a teaching hospital in Pune, and to analyze the effect of an informative lecture about Pharmacovigilance on the same. This was an interventional study conducted among 220 doctors at a tertiary care teaching hospital, Pune. Each participant was explained the purpose of study and asked to fill in a questionnaire about their knowledge, attitude and practice of pharmacovigilance. Only 80 of them attended the interventional lecture on Pharmacovigilance and again filled up the questionnaire after a period of one month from this intervention. Merely 7.5% of the participants knew ADR reporting system in India. Majority of the respondents (95%) knew that, as doctors, they could report ADRs but were unaware about the methodology to report (92.5%) which affected their practice of Pharmacovigilance. All (100%) the participants expressed that proper training should be provided to clinicians for ADR reporting & 81% felt ADR reporting should be made mandatory. Only 80 participants (36.4%) attended the interventional lecture which reflected a poor response. Intervention improved their (96%) knowledge about ADR reporting system and now majority of them (92%) agreed that all sort of ADRs should be reported (p < 0.001). Attitude towards ADR reporting was positive but knowledge about ADR reporting system was inadequate among doctors working in a teaching hospital in Pune. Education helped in improving knowledge and had an impact on attitude of participants regarding pharmacovigilance.

Perception of Pharmacovigilance by Health Professionals: A Survey Conducted in Rabat

Perception of Pharmacovigilance by Health Professionals: A Survey Conducted in Rabat