Adult men, particularly those in the millennial generation (age 25-40) and younger, are increasingly targeted by direct-to-consumer (DTC) companies offering diagnosis and treatment of men’s health conditions, including home semen testing. However, perceptions of infertility among adult men not actively attempting to conceive and their willingness to undergo semen analysis are not well understood. We hypothesized that men proactive about their health are more likely to be concerned about infertility and undergo semen analysis without a healthcare provider recommendation. Online survey study conducted via ResearchMatch.com. We surveyed men age 18 and older without children (n=634). Sociodemographic data (age, education, income, insurance, relationship status) were collected. Survey questions included 5-point Likert items assessing level of concern and likelihood of performing a particular action, such as discussing infertility with a physician or conducting a semen analysis test without a physician recommendation. Responses were dichotomized and logistic regression estimated the association between participant characteristics and outcomes of interest. The majority of men (54.7%) were aged 18-39 and in a romantic relationship (55.2%). Only 186 (29.3%) men expressed concern about infertility, whereas 391 (62%) expressed concern about low testosterone. Among men concerned about infertility, 23.4% were unlikely to discuss infertility concerns with a health care provider. On multivariable analysis, factors associated with infertility concern included younger age (age 18-39: OR 4.48, 95% CI 2.23-9.03, p<0.001), being single (OR 0.65, 95% CI 0.43-0.97, p=0.037), and concern about low testosterone (OR 5.28, 95% CI 3.32-8.40, p<0.001). Of all respondents, 10.4% would obtain a semen analysis without a health care provider recommendation. This increased to 14.2% if the test could be performed at home (p=0.04). Factors associated with likelihood to pursue semen analysis included post-graduate degree (OR 0.28, 95% CI 0.11-0.72, p=0.009), frequency of doctor visits (1-2 in last year: OR 4.05, 95% CI 1.11-14.83, p=0.034), concern about low testosterone (OR 2.30, 95% CI 1.12-4.74, p=0.023), and concern about infertility (OR 3.91, 95% CI 2.14-7.15, p<0.001). Regular exercise, fitness tracker use, and use of DTC services such as Hims®, Roman®, or 23andMe® were not associated with increased likelihood. Millennial and younger men were more concerned about infertility than older men, but many were unlikely to discuss infertility concerns with a healthcare provider. These men were not more inclined to pursue a semen analysis without a health care provider recommendation, even after accounting for use of other DTC health care services. Concerns about low testosterone were pervasive and are strongly associated with both infertility concern and likelihood of self-initiating a semen analysis.
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