BackgroundVirtual patients (VPs) have long been used in health care education. However, their high cost restricts their widespread use, and personal use of VPs has not yet been achieved. In addition, the quality of VPs, such as validity and accuracy, has rarely been reported, although the effects of VPs have been widely discussed. “Sun Yat-sen University Nursing Education Platform” (SYSU-NEP) is a software program designed for use on WeChat that provides VPs for nursing history-taking sessions. SYSU-NEP is characterized by ease of use, accessibility, and capacity to facilitate autonomous learning. This study aimed to examine the quality of the 13 VPs in SYSU-NEP based on content completeness and accuracy. MethodThis was a retrospective data analysis study. The data were derived from 570 history-taking sessions involving conversations generated by 57 baccalaureate nursing students and 13 VPs. Among the conversations, the students' queries without a response and the queries with an incorrect response were analyzed. The content completeness of each VP was defined as the percentage of queries with a response. The accuracy was defined as the percentage of queries with a correct response. ResultsThere were 13,312 student queries. The content completeness of each VP ranged from 73.7% to 97.3% (median: 83%; interquartile range: 78.1%–88.3%). The content accuracy of each VP ranged from 85.7% to 98.8% (median: 97.7%; interquartile range: 95.7%–98%). The Present Conditions part had the highest rate of queries without a response and with an incorrect response. ConclusionsThe content completeness and accuracy of the VPs were satisfactory but had room for improvement. The queries without a response and with an incorrect response were also identified, which is helpful for the continuous improvement of the VPs.