The relevance of research in Entrepreneurship is undeniable, especially for the Republic of Moldova. Almost all enterprises are small and medium. In the previous two years, only one percent of enterprises were large. During making decisions, forecasts are needed at the micro level (enterprise) and the macro level (country). The subject of this study is the methods of forecasting the entrepreneurship development, including small and medium-sized enterprises. The purpose of the research is to develop a new forecasting model for the key indicators that reflect the entrepreneurship activities in the Republic of Moldova, and one of the tasks is to analyze the forecasting methods to identify the advantages and disadvantages of these methods. The EViews program was used in developing the model and calculating medium-term forecasts. According to the results, in the next three years 2024-2026, the percentage of growth in income from sales of small and medium-sized enterprises varies in the range of 6.7-7.9% annually, and financial results before tax — 6.8-8.0%.