Life Of People Research Articles

Post-Diagnosis HCV RNA Testing Rates Prior to HCV Treatment Among People Living With HIV With HCV Antibody Positivity in the Asia-Pacific Region.

HCV RNA test determines current active infection and is a requirement prior to initiating HCV treatment. We investigated trends and factors associated with post-diagnosis HCV RNA testing rates prior to HCV treatment, and risk factors for first positive HCV RNA among people living with HIV (PLHIV) with HCV in the Asia-Pacific region. PLHIV with positive HCV antibody and in follow-up after 2010 were included. Patients were considered HCV-antibody positive if they ever tested positive for HCV antibody (HCVAb). Repeated measures Poisson regression model was used to analyse factors associated with post-diagnosis HCV RNA testing rates from positive HCVAb test. Factors associated with time to first positive HCV RNA from positive HCVAb test were analysed using Cox regression model. There were 767 HCVAb positive participants included (87% from LMICs) of whom 11% had HCV RNA tests. With 163 HCV RNA tests post positive HCVAb test, the overall testing rate was 5.05 per 100 person-years. Factors associated with increased testing rates included later calendar years of follow-up, HIV viral load ≥1000 copies/mL and higher income countries. Later calendar years of follow-up, ALT >5 times its upper limit of normal, and higher income countries were associated with shorter time to first positive HCV RNA test. Testing patterns indicated that uptake was predominantly in high income countries possibly due to different strategies used to determine testing in LMICs. Expanding access to HCV RNA, such as through lower-cost point of care assays, will be required to achieve elimination of HCV as a public health issue.

New consumption trends in the use of social networks and video games, problematic consumption, and the phenomenon of online gambling.

The inappropriate use of electronic devices can affect the psychological and physical health of children and adolescents. Therefore, it is essential to accompany them and promote media literacy to ensure a healthy and responsible use of technology. On occasions that depend on a multifactorial complex, the inappropriate use of networks can trigger problematic consumption and seriously affect the lives of young people. In 2022, the World Health Organization recognized, through ICD-11, the addiction to video games and used the term "problematic use" for the Internet and social networks. This article attempts to update professionals on new trends in the consumption of social networks, video games, and online gambling platforms and their consequences on the psychophysical well-being of children and adolescents.

Social impacts arising from road infrastructure projects in Sub-Saharan Africa: better management of social issues is needed in road construction, upgrading and rehabilitation

ABSTRACT Despite the use of environmental and social impact assessments for road projects, severe social impacts continue to occur. We discuss the social impacts associated with the construction, upgrading, widening and/or rehabilitation of roads in Sub-Saharan Africa. In addition to a literature review, we analysed 10 road projects in Uganda by examining project planning documents, and undertaking in-depth interviews, group interviews and field visits. While there were some benefits from these road projects, especially dust reduction where roads became sealed, the significant land acquisition necessary for these linear projects has led to physical displacement, economic displacement, and disruption to the livelihoods of local people. Other issues included: inadequate community engagement; delayed payment of compensation and inadequate compensation; gender-based violence; poor road construction practice causing community safety concerns; project-induced in-migration or influx; sexual harassment; impacts on children; and issues around sex work. The lack of local community acceptance (social licence to operate) of the projects resulted in construction delays and increased costs. For more acceptable road projects, better community engagement, improved planning and management, and adequate funding for resettlement and compensation are essential.

Fifty years of research on psychosocial working conditions and health: From promise to practice.

This paper presents an overview of 50 years of research on psychosocial working conditions and health with regards to conceptualization, interventions and policy. We reflect on the promise of past and current research on psychosocial working conditions and, in addition, discuss current progress in translating this research into workplace practice and improvements in people's working lives. We conducted a narrative review of meta-reviews and key publications on psychosocial working conditions and health. The review covers a historical overview of theories of the past 50 years, measurement of psychosocial working conditions, health effects, intervention research, and policy development on psychosocial working conditions. Psychosocial working conditions are conceptualized in different ways, with increasing complexity in the understanding developing over time. Exposures related to psychosocial working conditions are associated with a wide range of health outcomes, in particular cardiovascular disease and mental health conditions. In response to growing evidence on associations between psychosocial working conditions and health outcomes, intervention research has expanded rapidly, but for various reasons the evidence base is stronger and more extensive for individual- than organizational-level interventions. This individual/organizational imbalance is reflected in practice, and may partly explain why policy interventions have yet to show reductions in exposures to psychosocial work factors and associated adverse outcomes. Pressing needs for advancing the field include improvements in capturing exposure dynamics, developing objective measures of exposure, methodologic advancements to optimize causal inference in etiologic studies, and alternatives to randomized controlled trials for intervention evaluation.

Real-world smartphone data can trace the behavioural impact of epilepsy: A case study.

Neurobehavioural comorbidities have a detrimental effect on the quality of life of people with epilepsy, yet tracking their impact is challenging as behaviour may vary with seizures and anti-seizure medication (ASM) side effects. Smartphones have the potential to monitor day-to-day neurobehavioural patterns objectively. We present the case of a man in his late twenties with drug-resistant focal epilepsy in whom we ascertained the effects of ASM withdrawal and a convulsive seizure on his touchscreen interactions. Using a dedicated app, we recorded over 185 days the timestamps of 718,357 interactions. We divided the various smartphone behaviours according to the next-interval dynamics of the interactions by using a joint interval distribution (JID). During two ASM load transitions, namely before versus during tapering and tapering versus restarting medication, we used cluster-based permutation tests to compare the JIDs. We also compared the JID of the seizure day to the average of the previous 3 days. The cluster-based permutation tests revealed significant differences, with accelerated next-interval dynamics during tapering and a reversal upon medication restart. The day of the convulsion exhibited a marked slowing of next-interval dynamics compared to the preceding 3 days. Our findings suggest that the temporal dynamics of smartphone touchscreen interactions may help monitor neurobehavioural comorbidities in neurological care.

Sero-Kinship: How Young People Living With HIV/AIDS Survive in Southeast Nigeria.

Research on the lived experiences of HIV survivors, including young people living with HIV, has primarily emphasized broader sociocultural concerns, such as stigmatization and cultural attitudes toward sexuality and gender, while giving less attention to the interconnectedness of these issues with the mental well-being of those affected by the illness. This study, drawing on relational ethnography including observations and interviews at four antiretroviral-administering healthcare facilities in Enugu State, southeast Nigeria, explores how young people living with HIV strive toward viral suppression and how they develop collaborative psychosocial support along with the global efforts in eradicating the HIV epidemic. We found that, in and between themselves, young people living with HIV weave for themselves a network of relationships, though discreetly, to foster and encourage survivorship. Such relatedness, where mutual trust and support have emerged and rebuilt HIV survivors' faith in a livable life, forms what we conceptualize as "sero-kinship." That is, sero-kinship, which focuses on how people create and change meanings in their everyday lives that ultimately contribute to controlling HIV and treatment management, forms an essential foundation on which a life with HIV becomes thinkable, bearable, then manageable, and acceptable.

Do Sex and Gender Have Separate Identities?

The largely binary nature of biological sex and its conflation with the socially constructed concept of gender has created much strife in the last few years. The notion of gender identity and its differences and similarities with sex have fostered much scientific and legal confusion and disagreement. Settling the debate can have significant repercussions for science, medicine, legislation, and people's lives. The present review addresses this debate though different levels of analysis (i.e., genetic, anatomical, physiological, behavioral, and sociocultural), and their implications and interactions. We propose a rationale where both perspectives coexist, where diversity is the default, establishing a delimitation to the conflation between sex and gender, while acknowledging their interaction. Whereas sex in humans and other mammals is a biological reality that is largely binary and based on genes, chromosomes, anatomy, and physiology, gender is a sociocultural construct that is often, but not always, concordant with a person' sex, and can span a multitude of expressions.

The detrimental effect of socio-economic factors on cotton productivity in the tribal region of Odisha

Cotton is a crucial cash crop in the tribal belt of Odisha. It has a significant effect on the livelihood of the tribal people. The volatile socio-economic background of the tribal farmers is a major hindrance to the proper development of the agriculture sector. In this regard, it is important to study the possible factors affecting cotton productivity in the tribal region to boost the policy effectiveness for the development of this cash crop in the area. More precisely, how is their socio-economic condition reflected in their crop productivity? So, the development of the tribal farmers can develop this crop in the region. This study analyses the detrimental effect of socio-economic factors on cotton productivity in the tribal area of Odisha. The data are collected using a structured questionnaire and a multiple-sampling technique. To understand the effect of socioeconomic factors on productivity, the ordinary least square (OLS) method has been employed in this paper. The result shows that most of the farmers are illiterate for which productivity is degrading. The age and gender of the head of the household are significant contributors to the cotton productivity of the study area. Male-headed households are more productive than female-headed households. Per capita monthly income and proportion of irrigated land are also important factors to affect cotton productivity positively. However, the social group of the family has no significant effect on the cotton productivity in the study area. Policymakers and agriculturists should emphasize farmer literacy, farmer income and land irrigation facilities to boost the productivity of this crop in the studied region.

Development of a Smart Home Modification Program: A Delphi Survey of Multidisciplinary Health Care Experts.

There is a critical gap between the potential of smart home technologies to enhance the lives of people with physical disabilities (PwPD) and their limited use because of complex interfaces, high costs, technical issues, and insufficient institutional support. To bridge this gap and ensure that PwPD can fully benefit from smart home advancements to improve their daily living and quality of life by developing a smart home modification program. A Delphi survey involving three rounds was conducted with experts in disability and smart home technologies. Online survey. Thirty multidisciplinary health care experts. Experts rated the level of relevance in smart home modification with each survey. Consensus was set at ≥75%, content validity (CVR) was ≥.33, and convergence was ≤.5. The first Delphi result selected 26 items, and the second included 59 items after adjusting for values that fell below a CVR of .33. In the third Delphi survey, 59 items were selected. The final Delphi study had an average CVR of .96 and a coefficient of variation of .10. The last survey's consensus point was .92, indicating a high level of agreement among participants. On the basis of expert consensus, the study provides a validated framework for smart home modifications to aid PwPD. Plain-Language Summary: This research highlights the role of smart home adaptations to promote responsible, independent living for people with physical disabilities. There is a critical gap between the potential of smart home technologies to improve the lives of people with physical disabilities and their limited use because of complex interfaces, high costs, technical issues, and insufficient institutional support. The study authors developed a smart home modification program with the goal of closing this gap and to ensure that people with physical disabilities can fully benefit from smart home advancements to improve their daily living and quality of life. Based on expert ratings, the study findings provide a validated framework that occupational therapists can use to recommend smart home modifications to help people with physical disabilities. The framework can also be used by occupational therapists to identify people who may need more extensive environmental modifications and interventions.

Factors influencing recommendation intentions for autonomous vehicles: A path analysis in a pilot study

Over the past decade, the rapid development of artificial intelligence has propelled the transition of autonomous vehicles from laboratories to real-world applications. However, autonomous vehicles are a long way from fully integrating into most people's lives. Previous studies indicate that the word-of-mouth effect is often used by consumers to determine the quality of innovative technologies. Word-of-mouth recommendation can not only increase the income of enterprises by attracting new customers, but also greatly reduce the promotion and publicity expenses of enterprises. Through the word-of-mouth effect, the intention to recommend can contribute to the growth of the autonomous driving market. Therefore, current research explores the mechanisms among the perceived risk of privacy safety, perceived defect, perceived behavioral control, intention to use, and intention to recommend through path analysis. Our findings, based on 433 online questionnaires, indicate that the perceived risk of privacy safety, perceived defects, and perceived behavioral control influence the intention to recommend. Notably, perceived risk of privacy safety and perceived defect directly affects the intention to recommend and also correlates with perceived behavioral control. These findings provide some empirical evidence for the recommendation of autonomous vehicles and the expansion of consumer groups.

People, places, systems and society. A qualitative exploration of socio-cultural factors in head and neck cancer survivorship.

BackgroundPeople living with head and neck cancer (HNC) often endure permanent and life changing adverse effects of treatment and reduced health-related quality of life. Study of post-traumatic growth (PTG), is gaining traction to understand why some people living with cancer have better psychosocial outcomes than others.Current theoretical models on PTG point to the importance of ‘socio-cultural influences’ but do not provide insight into how such socio-cultural factors influence survivorship outcomes. This research aimed to illuminate pathways to PTG following HNC by exploring socio-cultural factors in experiences of living with, and moving on from, HNC. MethodSemi-structured interviews with people living with HNC (up to 5 years post-treatment) on experiences of diagnosis, treatment and recovery. Qualitative framework analysis using the environmental factors codes from the International Classification of Functioning, Disability and Health (ICF) HNC core set. Results20 people living with HNC were interviewed (11 male, 9 female; aged 46-83 years). Four inter-related themes described socio-cultural factors that influence (positively and/or negatively) the experience of living with HNC: (1) people and places; (2) healthcare systems and support services; (3) societal attitudes to cancer; (4) work and finances. ConclusionSupport from family, friends and healthcare professionals, as well as societal attitudes, financial and work security and personal experiences all appear to contribute to an individuals’ ability to navigate the HNC experience. These findings could inform development of interventions targeting the socio-cultural factors in the lives of people living with HNC, particularly for those at risk for poorer psycho-social outcomes.

"Being Queer, It Was Really Isolating": Stigma and Mental Health Among Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ+) Young People During COVID-19.

Lesbian, Gay, Bisexual, Transgender, Queer, and other sexual and gender minority (LGBTQ+) youth and young adults (YYAs) have poorer mental health outcomes than their cisgender, heterosexual peers in large part due to multilevel stigmatization and minority stress. This was exacerbated by psychological stressors stemming from the COVID-19 pandemic; these experiences intersected with YYA unique developmental stage. Here we explored LGBTQ+ YYA's pandemic-related experiences, focusing on intersections between stigma and belonging, developmental processes, and their relationship to mental health. We conducted qualitative interviews from August to November 2021 with 34 LGBTQ+ YYA ages 14 to 24; interviews were nested within a quantitative study on YYA experiences during COVID-19. Interviews were transcribed and coded using thematic analysis. YYA described how pandemic impacts like quarantine and isolation directly impacted their mental health; these coalesced around four types of thematic shifts: shifts in (1) time, (2) living situations, (3) community supports, and (4) social and political climate. Multilevel stigmatization also created new mechanisms of norm enforcement for LGBTQ+ YYA. Interviews demonstrated how the pandemic also impacted key developmental processes including identity formation and autonomy seeking. The potential consequences of these pandemic-related shifts largely depended on YYA's experiences of stigma and/or belonging throughout the pandemic. Findings suggested that isolation from the COVID-19 pandemic intersected with existing socio-ecological structures in LGBTQ+ young people's lives. Efforts to investigate longitudinal impacts of the pandemic, as well as to intervene to reduce the stigmatization experienced by LGBTQ+ YYA, remain urgent.

A Collective Fantasia of the Financial Age in Early 1990s China: Erotic-Speculative Sensation, Neoliberal Labor Heroine, and Presentist Worldly Wisdom

Abstract When the notion of “finance” reentered ordinary Chinese people's lives since the “Reform and Opening Up,” how were “finance and economics” (caijing) perceived and felt? This essay focuses on the mainland critics’ reviews of the “finance-themed” novels by the Hong Kong entrepreneur-cum-writer Leung Fung Yee (b. 1949) and discusses how “Leung fever” (1992 – 93) provided a medium for a collective imagination of the financial age. Leung's fiction introduced “sensuous and lively” financial knowledge particularly attractive to a financially uneducated mainland readership who nonetheless desired to engage in adventurous economic activities. This essay is situated in the intersection of finance and literary practice and highlights the ways these critics’ interpretations of Leung's novels helped instruct readers in how to feel, experience, and survive the financial age and legitimize the new economic behaviors in everyday life. This new age was first and foremost experienced as an “erotic-speculative sensation” in which an erotic adventure was experienced similar to the financial behavior of speculation. The mainland critics envisioned the figure of “the neoliberal labor heroine,” one who creatively utilizes the intervals to maximize productive value and who performs “presentist worldly wisdom” to strategically navigate life and achieve optimal outputs and success in a disorienting world.

Electrothermal-Assisted Photothermal Lubrication Surfaces for Continuous Anti-Icing/Deicing in Multiple Low-Temperature Environments.

Solving the problem of ice accumulation on solid surfaces is of great significance to the economic development of the country and the safety of people's lives. In this work, a coating with multifunctional photothermal/electrothermal solid-state lubrication (PEL) for anti-icing/deicing was prepared in layers based on the intrinsic properties of silicone oil and paraffin wax in combination with conductive graphite and multiwalled carbon nanotubes. Silicone oils and paraffins are used as lubricating media giving the coating excellent lubricity, which results in a water sliding angle (SA) of only 12° on the PEL surface. Meanwhile, PEL shows favorable static and dynamic ice resistance at low temperatures; at -10 °C, the freezing time of water droplets on the PEL surface is extended by at least 4 times compared to the bare substrate. Furthermore, PEL also offers highly efficient photothermal and electrothermal deicing performance, which can effectively remove the accumulated ice at a light intensity of 0.6 kW/m2 or an EPD of 0.1 W/cm2. Meanwhile, the synergistic deicing mechanism of photothermal and electrothermal was verified at -20 °C. Interestingly, the coating shows heat-assisted healing ability due to the phase change characteristic of paraffin wax, which allows the coating to regain lubricating properties after mechanical abrasion. Therefore, this work provides a reliable way for the design of stable all-weather anti-icing/deicing strategies at low temperatures.

Did COVID-19 discriminate in the global South? Revealing heterogeneity of urban households’ livelihood resilience based on evidence from Bangladesh, China, India and Philippines

“Lives or livelihoods” is a hard trade-off when confronting COVID-19, especially for cities in the Global South. Countermeasures to protect people's lives may exert negative impacts on urban households and test their livelihood resilience. Did COVID-19 discriminate? Did livelihood resilience vary among different urban households within and across different countries and cities? Established studies focused on rural households' livelihood resilience under climate change or natural hazard based on single country context. Little is known about the variety of urban households' livelihood resilience under COVID-19 across countries and cities. This study aims to fill this gap by revealing heterogeneity of livelihood resilience at both individual urban household level and country level. First-hand questionnaire survey data (N ​= ​4374) were collected from seven cities from Bangladesh, China, India, and Philippines. Using a combination of quantitative and qualitative analytical methods, it's found that: COVID-19 did discriminate. Urban households with larger household size, no home ownership, no financial assets, and household heads with low education level, informal employed and no flexibility to transfer to work from home, were vulnerable groups. COVID-19 also discriminated across cities. Cities with a high ratio of informal workers, no effective economic relief policies and long stringent mobility restriction measures performed worse.

Brief Report: Evaluating the Efficacy of Psychobehavioral Interventions for Cardiovascular Risk Among People Living With HIV: A Systematic Review and Meta-Synthesis of Randomized Controlled Trials

Abstract: People with HIV (PWH) are disproportionately affected by cardiovascular disease (CVD). Psychobehavioral therapies are capable of targeting the pathophysiology underlying HIV-CVD comorbidity. This study synthesized findings from randomized controlled trials of psychobehavioral therapies for reducing CVD risk among PWH following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Inclusion criteria were as follows: (1) used a randomized controlled trial design, (2) evaluated a cognitive–behavioral or mindfulness-based therapy, (3) sampled adults (age ≥18 years) with HIV, (4) measured a behavioral (eg, diet) or biological (eg, immune functioning) CVD risk factor, and (5) published in an English-language peer-reviewed journal. Electronic searches were conducted in 6 databases (eg, MEDLINE) using controlled vocabulary and free-text synonyms for HIV, psychobehavioral therapy, and CVD risk. Data were independently extracted with consensus reached. Outcomes were immune activation, tobacco smoking, stress, inflammation, and physical activity from 33 studies. There were stronger effects for psychobehavioral interventions compared with controls on CD4 [Hedge g = 0.262, 95% confidence interval (CI) = 0.127 to 0.396] and tobacco-smoking abstinence (Hedge g = 0.537, 95% CI = 0.215 to 0.86). There were no differences or insufficient data for stress, inflammation, or physical activity. No eligible studies examined psychobehavioral interventions on blood pressure, lipids, or weight in PWH. There is increasing importance to further invest in broader CVD risk reduction effort for PWH that include psychobehavioral intervention strategies.

Promoting the Inclusion of Care Partners of People Living With Dementia in Hospital Care Through Workflow Redesign

Abstract Date Presented 03/23/24 This qualitative study outlines the redesign of hospital workflows that can be used to guide OTPs in including care partners of hospitalized people living with dementia. Primary Author and Speaker: Catherine Still Contributing Authors: Andrea Strayer, Nicole Werner, Beth Fields

Policy Targets to Improve Diagnosis and Treatment of Hyperlipidemia Identified by People Living With Hyperlipidemia: Results from a Patient-Led Study

Policy Targets to Improve Diagnosis and Treatment of Hyperlipidemia Identified by People Living With Hyperlipidemia: Results from a Patient-Led Study

Living well with chronic pain: a 12-month randomized controlled trial revealing impact from the digital pain self-management program EPIO.

Chronic pain affects a wide range of physical and psychological aspects of life for those impacted. Psychosocial treatment approaches may be of support, but outreach is still limited. To evaluate the efficacy of EPIO, an evidence-informed, user-centered digital self-management intervention for people with chronic pain, in a 12-month randomized controlled trial. People living with chronic pain (N = 266) were randomized to the EPIO intervention (n = 132) or a usual-care control group (n = 134). The intervention was delivered in a simple blended care model, and outcome measures collected at baseline, 6 months, and 12 months. Generalized linear models for repeated measures were fitted to compare groups over time. Participants were primarily female (81%), median age 49 years (range 22-78), with heterogeneous pain conditions, and had lived with pain >5 years (77.6%). A mixed linear model with all timepoints included revealed no statistically significant group differences for the primary outcome of pain interference. Significant psychological benefits in favor of the intervention group were however detected for depression (P = 0.022), self-regulatory fatigue (P = 0.024), vitality (P = 0.016), and mental health (P = 0.047). Baseline to 12-month changes showed additional favorable effects for anxiety (between-group mean differences [MDs] = 0.79, P = 0.047), depression (MD = 1.08, P = 0.004), self-regulatory fatigue (MD = 2.42, P = 0.021), pain catastrophizing (MD = 2.62, P = 0.009), and health-related quality of life. The EPIO program aims to improve outreach of evidence-based pain self-management interventions. Findings demonstrate how using EPIO can lead to sustainable psychological change, enhancing mental health and health-related quality of life for people suffering from pain, providing a chance to live well with the pain.

Internalized Stigma and Quality of Life in Patients With Alcohol Use Disorder: A Cross-Sectional Study From Gujarat, India

Introduction: Substance use disorders (SUDs) contribute to one-fifth of all disability- adjusted life years caused by psychiatric illnesses. They have a high treatment gap. Stigma affects the lives of people with SUDs and is shown to impede the pursuit of valued life goals and recovery from addiction. We studied stigma and QOL in patients with Alcohol Use disorders (AUD). Methods: Participants between 18 and 65 years with a clinical diagnosis of AUD were included (inpatients and outpatients). Demographic and clinical data were recorded using a semistructured questionnaire. ISMIS & WHOQOL-Bref questionnaires were used to assess internalized stigma and quality of life. Results: Of the 141 participants, 89(63.10%) patients had severe self-stigma, 31(22.10%) patients had moderate self-stigma, and 21(14.90) patients had mild self-stigma. In ISMIS, stigma due to alienation (3.22) was higher than social withdrawal, discrimination, stereotype, and stigma resistance. In the WHOQOL-Bref questionnaire, the mean score of social domain (9.45) was the lowest compared to the other domains of the quality of life scale. A significant association was found between the education and the duration of substance use with ISMI grades with people with up to 10th standard education (p-value - 0.002*), living in urban areas (p-value - 0.022*), and ten or more years of substance use (p-value - 0.00002). Conclusion: The various domains of quality of life generally negatively correlated with the internalized stigma score, suggesting that a greater degree of self-stigma is associated with poorer quality of life.