Penetration Characteristics Research Articles

Fluid wetting and penetration characteristics in T-shaped microchannels

A thorough understanding of media tightness in automotive electronics is crucial for ensuring more reliable and compact product designs, ultimately improving product quality. Concerning the fundamental characteristics of fluid leakage issues, the dynamic wetting and penetration behavior on small scales is of special interest and importance. In this work, four T-shaped microchannels with one inlet and two outlets are experimentally investigated in terms of contact angle dynamics and interface movement over time, generating novel insight into the wetting mechanisms and fluid distribution. With a main channel width of 1 mm, a crevice width of w=0.3mm,0.4mm\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$w = {0.3}\\,\\hbox {mm}, {0.4}\\,\\hbox {mm}$$\\end{document} and a rounding edge radius of r=0.1mm,0.2mm\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$r = {0.1}\\,\\hbox {mm}, {0.2}\\,\\hbox {mm}$$\\end{document}, the geometrical effects on the fluid penetration depth in the crevice and the interface edge pinning effect are analyzed quantitatively using an automated image processing procedure. It is found that the measured dynamic contact angles in all parts can be well described by molecular kinetic theory using local contact line velocities, even with local surface effects and abrupt geometry changes. Moreover, a smaller crevice width, a sharper edge and a larger flow velocity tend to enhance the interface pinning effect and prevent fluid penetration into the crevice. The rounding radius has a more significant effect on the interface pinning compared with crevice width. The experimental data and image processing algorithm are made publicly available.

Analysis of Nirmatrelvir Entry into Pulmonary Lining Fluid in Patients with COVID-19: A Unique Perspective to Explore and Understand the Target Plasma Concentration of 292 ng/mL in Antiviral Activity.

Currently, the applicant has chosen a target plasma trough concentration for nirmatrelvir, which is adjusted to 292 ng/mL based on the drug's molecular weight (499.54 Daltons), its binding to human plasma proteins (69%), and the in vitro antiviral EC90 value (181 nM). However, the current exposure-effect relationships (ER) analysis of viral load in patients enrolled in the EPIC-HR study has not revealed clinically significant trends in the ER. Given that the lungs are the primary site of COVID-19 infection, we aim to further understand this exposure relationship by exploring and analyzing the penetration characteristics of nirmatrelvir in the lungs. To explore and understand the target plasma concentration of 292 ng/mL in antiviral activity. We identified all critically ill patients with coronavirus disease 2019 who received nirmatrelvir/ritonavir treatment in the respiratory intensive care unit of Changhai hospital between January 2023 and October 2023. Samples of plasma and bronchoalveolar lavage fluid were obtained at pre-dose trough concentrations after administration of nirmatrelvir (NMV). The relationship between NMV levels in plasma and the epithelial lining fluid (ELF) was assessed by determining concentrations of NMV. There was a significant relationship between NMV levels in plasma and ELF (ELF = 0.4976*PLASMA- 204; R = 0.96), with a correlation whose slope (0.4976) suggested that the blood-to-ELF ratio of drug penetration was 2:1. A negative value from the equation indicates that NMV requires to reach baseline concentration to penetrate the ELF. The relationship between NMV levels in plasma and ELF with low permeability and a negative baseline value suggests that the target plasma concentration of 292 ng/mL is insufficient for antiviral activity. This study provides a unique perspective to explore and understand no clinically meaningful trend of exposure-response relationships in patients enrolled in EPIC-HR.

Research on Practical Curriculum of Vocational and Technical Education From the Perspective of Science and Technology Integration

Theory is the navigation of practice, and practice is the wing of theory. Modern vocational and technical education is increasingly showing the characteristics of technology penetration, practice traction, system support and so on, and its dependence on the correct path and scientific methods is more prominent. Exploring the integration of theory and practice, and adhering to the combination of theory and technology to design courses have become a new window to break through the traditional curriculum model research and teaching, which has far-reaching significance and value.

Effect of Electroslag Remelting on the Microstructure and Ballistic Penetration Characteristics of an Austenite‐Based Lightweight Steel

Herein, the effects of electroslag remelting (ESR) and impurities in ESR slag on the composition, microstructure, and properties of lightweight steel with a nominal composition in wt% of Fe‐20Mn‐10Al‐1.5C are studied. These results can provide a reference for the production of such steels using ESR and the design of the composition of such steels. The results show that ESR can make the contents of Si increase and that of S decrease, make the grain size decrease, make the phase transformation of austenite at about 540 °C change from spinodal decomposition to ordered transformation, make the contents of MnS and SiO2 and inclusions greater than 5 μm decrease, make the distribution of inclusions homogenize, and make the shape of inclusions change from long strip with sharp corners to spherical shape. ESR can improve its strength, plasticity, and antiballistic penetration properties.

Experimental studies on penetration process of high-speed water-jet into ballistic gelatin

To reveal the penetration mechanism and present the penetration characteristics of high-speed micro-jet with injection volume larger than 0.3mL into soft tissue, the present study conducted experimental research on high-speed water-jet penetration into ballistic gelatin. The free jet dynamics of an air-powered needle-free injector that can emit up to 1.27mL of liquid at once and the penetration dynamics were visualized to reveal the details of the penetration process. In the early unstable stage, the jet is emitted in the form of pulses, and the first jet pulse can rapidly generate an initial slender channel in gelatin in a very short time. In the subsequent stable stage, energy input produces dispersion and further increases the penetration depth slowly. Changing the driving pressure by the power source mainly changes the penetration depth increment by dispersion; while changing the nozzle diameter mainly affects the penetration depth in the initial stage. The central position of the dispersion area in the injection direction was firstly defined in the present work and it was found that an approximate linear relationship between this position and the maximum penetration depth exits for different nozzle diameters and driving pressures when injecting the same liquid dose. These research results can provide a basis for a thorough understanding of the penetration characteristics of high-speed micro-jet with injection volume larger than 0.3mL into soft tissue, as well as the design and operation of the air-powered needle-free injector.

Large-scale penetration model tests of bucket foundations of different structural types in clay

Clarifying penetration characteristics and accurately predicting penetration resistance of bucket foundations is crucial to ensure their smooth penetration. This study performed large-scale model tests on nearshore seven-compartment (SC) bucket foundations and novel deep-sea five-connected (FC) bucket foundations to systematically explore the penetration attitude, development of soil plugs, flow rates, bucket-soil interactions, and required suction of these two structures in clay. The good penetrability was identified for the new FC bucket foundation. The development of soil plugs due to bucket wall replacement as well as the mechanism of drag reduction of the inner wall and bucket end were revealed. The experiments demonstrated that the penetration flow rate was almost equal to the volume of bucket body entering the soil and accounted for approximately 95% of the total flow rate. A formula for calculating penetration resistance in clay that considers the effect of suction on the reduction in resistance of the inner wall and bucket end was proposed and validated by field tests. The research results improve the safety of bucket foundation penetration in clay and provide significant guidance for the installation of deep-sea FC bucket foundations.

Effects of different types of starches on heat penetration and physicochemical characteristics in alfredo sauce

Corn starch is frequently used as a thickening agent in food products because of its stability under thermal processing conditions. However, with fluctuating raw material costs due to weather conditions, disruptions in supply chains, and geopolitical challenges, there is an increasing need to explore alternative sources of starch. This study examines the effect of retort processing on the heat penetration and physicochemical aspects of modified corn, tapioca, and potato starches in Alfredo sauce. Modified corn starch, commonly used in commercial sauces, was compared with tapioca and potato starches to evaluate their effects on viscosity, color, and processing times required to achieve a F0 = 6 for Clostridium botulinum. Using the reference starch concentration of 1.90%, modified corn starch showed a significant increase in viscosity from 3,328 cP to 13,296 cP with a processing time of 31.33 min. Modified tapioca starch, at the same concentration, increased from 3440 cP to 8176 cP over 38.38 min, indicating superior thermal stability being the longest cooking time evaluated between all samples. For modified potato starch, using the reference concentration, viscosity increased from 1,200 cP to 4,656 cP, with a processing time of 31.93 min. Adjusting the starch concentration to 3% for modified tapioca starch and 2.38% for modified potato starch increased viscosity to 14,400 cP and 16,336 cP, respectively. These adjustments resulted in a darker Alfredo sauce, with the L value decreasing from 92.27 to 83.67 due to the longer cooking time. Heat penetration findings suggest that modified potato starch can replace modified corn starch safely using the reference concentration (1.90%) without altering the process holding time but requiring further adjustments to match commercial viscosity standards, while modified tapioca starch, although requiring higher concentrations and longer processing times, was tested for retention time at 3.00% and to be a feasible alternative. This study offers valuable insights to the food industry in selecting appropriate starches to maintain the quality and safety of thermally processed Alfredo sauce.

Numerical simulation of the dynamic interaction characteristics between Wood’s metal and water under coolant injection mode

The accident of the steam generator tube rupture in the lead-bismuth-cooled fast reactor or the core meltdown in the light water reactor may cause violent heat and mass transfer between the melt and the coolant, potentially further damaging the reactor. Therefore, it is essential to study the corresponding mechanisms. In this study, numerical simulations are utilized to investigate the dynamic interactions between Wood’s metal and subcooled water in the coolant injection (CI) mode, focusing on jet behavior and critical cavity parameter changes. By analyzing these factors, this research aims to clarify the interfacial evolution and interaction mechanisms between the melt, water, and air, thereby tackling the problem of inadequate observation in experiments. A user-defined function (UDF) was employed to simulate the flow characteristics of the melt during the solidification process. This approach effectively addressed the limitation of Fluent’s inherent solidification model, where the fluid no longer participates in turbulent velocity calculations after solidification. In addition, an equivalence method was proposed according to the characteristics of two-dimensional simulations in Fluent. Comparisons with Cheng’s experimental results show that the equivalent model can accurately predict jet penetration characteristics while significantly reducing the demand for computational resources. According to this equivalence method, this research developed a new correlation for predicting the maximum jet penetration depth in the CI mode. The above results provide new perspectives for understanding the dynamic interactions between metals and coolants, which is significant for the application and optimization of technologies in the nuclear field.

NIR-II-Responsive Hybrid System Achieves Cascade-Augmented Antitumor Immunity via Genetic Engineering of Both Bacteria and Tumor Cells.

The combination of nanoparticles and tumor-targeting bacteria for cancer immunotherapy can overcome the shortcomings of poor nanoparticle accumulation, limited penetration, and restricted distribution. However, it remains a great challenge for the hybrid system to improve therapeutic efficacy through the simultaneous and controllable regulation of immune cells and tumor cells. Herein, a hybrid therapeutic platform is rationally designed to achieve immune cascade-augmented cancer immunotherapy. To construct the hybrids, photothermal nanoparticles responsive to light in the second near-infrared (NIR-II) region are conjugated onto the surface of engineered bacteria through pH-responsive Schiff base bonds. Taking advantage of the hypoxia targeting and deep penetration characteristics of the bacteria, the hybrids can accumulate at tumor sites. Then nanoparticles detach from the bacteria to realize genetic engineering of tumor cells, which induces tumor cell apoptosis and down-regulate the expression of programmed cell death ligand 1 to alleviate immunosuppressive tumor microenvironment. The mild photothermal heating can not only induce tumor-associated antigen release, but also trigger sustainable expression of cytokine interleukin-2. Notably, a synergistic antitumor effect is achieved between the process of p53 transfection and NIR-II light-activated genetic engineering of bacteria. This work proposes a facile strategy for the construction of hybrid system to achieve cascade-augmented cancer immunotherapy.

Influences of bit button wear on performance of rotary-percussive drilling: MBD-DEM coupling simulation and verification

This paper focuses on the use of rotary-percussive drilling for hard rocks. In order to improve efficiency and reduce costs, it is essential to understand how operational parameters, bit wear, and drilling performance are related. A model is presented therein that combines multibody dynamics and discrete element method (DEM) to investigate the influences of operational parameters and bit wear on the rate of penetration and wear characteristics. The model accurately captures the motion of the bit and recreates rock using the cutting sieving result. Field experimental results validate the rod dynamic behavior, rock recreating model, and coupling model in the simulation. The findings indicate that hammer pressure significantly influences the rate of penetration and wear depth of the bit, and there is an optimal range for economical hammer pressure. The wear coefficient has a major effect on the rate of penetration, when wear coefficient is between 1/3 and 2/3. Increasing the wear coefficient can reduce drill bit button pressure and wear depth at the same drill distance. Gauge button loss increases the rate of penetration due to higher pressure on the remaining buttons, which also accelerates destruction of the bit. Furthermore, a more evenly distributed button on the bit enhances the rate of penetration (ROP) when the same number of buttons is lost.

Study of rooftop PV hosting capacity in 20 kV systems in facing distributed generation penetration

---With the increasing request for integrating rooftop photovoltaic (PV) systems into the distribution grid, it is crucial to prevent the potential negative impacts of high PV penetration. Considering the uncertainty and variability characteristics of high rooftop PV penetration, a stochastic approach for determining PV hosting capacity (HC)—the maximum capacity of a PV system to receive electricity from the power distribution network before the network reaches an operating limit violation—is necessary. Therefore, this study proposes calculating PV hosting capacity using the Monte Carlo simulation. Unlike previous works, this paper uses real feeders as case studies, representing both urban and rural areas. The feeder representing an urban area with many industrial and business customers has a higher hosting capacity, 31 % of full load, compared to the feeder representing rural areas, which has 18 % of full load. By using actual feeders that represent urban and rural areas, more representative results for specific problems can be achieved without assuming urban and rural feeders have the same specific problems.

Experimental study on the penetration and evaporation characteristics of a liquid kerosene jet in the supersonic crossflow

The penetration and evaporation characteristics of a liquid kerosene jet in the supersonic crossflow were experimentally investigated in this study. The experiments were carried out in both cold and high-enthalpy inflows. Detailed spray images were obtained using planar laser scattering techniques. The structures of the spray field were further analyzed on the basis of high spatial and temporal resolution images. The results show that the atomization and evaporation characteristics of a liquid kerosene jet are related to the crossflow temperature, liquid–gas momentum flux ratio, and injection distance. It is found that the breakup process of a liquid jet is accelerated in the high-enthalpy inflow. To accurately describe the maximum flow distance along the direction that kerosene can reach in the state of droplets, the survival distance is defined. It is revealed that the penetration depth and survival distance of the liquid kerosene jet decrease clearly with increase in the crossflow temperature. For the cavity-based combustor, the liquid kerosene jet can mix more sufficiently in the cavity region by reducing the injection distance and liquid–gas momentum flux ratio.

Research on adaptive penetration characteristics of space harpoon based on aluminum honeycomb buffer

To address the issues of high impact and limited adaptability in capturing space debris with space harpoons, a novel harpoon capture device based on aluminum honeycomb buffering was proposed. The issue of excessive impact force for harpoons could be effectively addressed by the excellent energy-absorbing characteristics of aluminum honeycomb. A simulation model was established to analyze the penetration of space harpoons into aluminum alloy target plates using Johnson-Cook’s dynamic constitutive model and fracture failure criteria. Ground experiments were conducted to validate the correctness of the simulation model. The impact of aluminum honeycomb was investigated by analyzing the simulation results of harpoons with and without aluminum honeycomb. With the introduction of aluminum honeycomb as a buffering component, the rebound velocity of the harpoon decreased by 76.2 %, and the impact force reduced by 78.6 %. Then the model was used to study the influence of different launching angles and different targets on the penetration characteristics of the space harpoon. The research findings indicate that space harpoons could successfully penetrate and capture aluminum alloy targets at a launch velocity of 53.1 m/s to 58.5 m/s, as determined through ground experiments and simulation analysis. The error in the crushing height of the aluminum honeycomb was found to be 2.19 %, while the error in the harpoon penetration depth was 9.02 %. Moreover, within a launch angle error of 10°, space harpoons also demonstrate the capability for adaptive capture of both aluminum alloy plates and aluminum honeycomb sandwich panels, with average correction capabilities of 92.5 % and 95.5 %. In conclusion, the analysis of the adaptive penetration characteristics of space harpoons provides a solid theoretical foundation and technical support for the design of harpoon capture systems.

Study on the penetration characteristics of conical harpoon on rotating space debris

The purpose of this paper is to study active removal of rotating space debris in space, a conical harpoon was used to carry out penetration experiments on a single-axis rotating 2A12 aluminum alloy target plate at 6° / s, 12° / s and 18° / s, respectively. The velocity change curve and kinetic energy change curve of the harpoon were established. The results show that the rotation velocity of the 2A12 aluminum alloy target has little effect on the velocity change of the harpoon after the harpoon penetrates the 2A12 aluminum alloy target with different rotation speeds. Under the same initial kinetic energy E = 2738.78 J, the velocity of kinetic energy attenuation of harpoons with different initial velocities in the process of penetrating the aluminum alloy target plate is different. According to the research, the velocity of the kinetic energy attenuation of the harpoon can be arranged according to the initial velocity, as follows: 30.73 m/s > 28.38 m/s > 26.50 m/s > 24.95 m/s, which means that the greater the initial velocity, the faster the kinetic energy attenuation of the harpoon.

Penetration Characteristics of a Rock Drill Bit into Rock

Penetration Characteristics of a Rock Drill Bit into Rock

Omnidirectional borehole detector for muography: Design and performance evaluation

Muography using cosmic ray muons is a non-invasive and environmentally friendly imaging technique with comprehensive applicability across various fields such as mineral exploration, archaeology, and engineering, etc. Given characteristics of high penetration and broad energy spectrum of cosmic ray muons, three-dimensional density distribution of objects up to hundreds of meters can be well reconstructed. In mineral exploration and archaeology applications, conventional planar detectors are too large and usually deployed in spacious rooms like tunnels or outdoors, which seriously limits the deeper and broader applications of muography. A type of borehole muon detector is highly desired to address this. In the work, we introduce a novel borehole-type muography detector comprising annular and prismatic plastic scintillators, allowing for its deployment in boreholes. In the paper, the structural design of the detector is described in details and its performance is evaluated numerically and experimentally. Comprehensive investigation on components and on the system as a whole were conducted. According to our commissioning tests, the detector we propose has an omnidirectional field of view without blind spots, with an angular uncertainty of 27.4 mrad and a position uncertainty of 2.29 mm in the azimuthal direction, an angular uncertainty of 20.6 mrad and a position uncertainty of 10.31 mm in the zenithal direction. Detection efficiencies for both annular and prismatic scintillators were measured as 90.3 ± 0.53% and 92.27 ± 0.82%. In addition, an underground location was investigated, survival rate distributions being calculated from above-ground and underground measurements. The results indicate its capability to successfully address muography applications This novel borehole-type detector has the potential to address industry demand for lower-cost, more flexible muography solutions.

Impact of fiber structure on the heat and mass transfer characteristics of medium density fiberboard from fractal-based microstructure reconstruction

Microwave heating can rapidly desorb residual volatile organic compounds (VOCs) such as formaldehyde in medium density fiberboard (MDF) because of its penetration and selective heating characteristics. To further understanding the desorption of formaldehyde from MDF by microwave heating, it’s essential to reveal the relationship between specific fiber structure and the heat and mass transfer characteristics of MDF. The study used scanning electron microscopy (SEM) to acquire the microstructural characteristics of MDF before and after low-temperature (350 ℃) pyrolysis treatment, including porosity and pore size distribution. A reconstruction model of MDF incorporating fractal theory and microstructural information was developed to explore the impacts of fiber structure on the heat and mass transfer parameters. The results indicate that low-temperature pyrolysis has a minimal impact on the pore structure of MDF, the porosity increased to ∼ 45 % from ∼ 40 % after slightly pyrolysis while the average pore diameter is maintained at 7 μm, thus the changes in structure can be disregarded when studying microwave-induced desorption of VOCs in MDF. Further analysis combined with fractal reconstructed structure shows that the inherent fiber organization in MDF introduces anisotropy to the mass transfer parameters, resulting in approximately ∼ 10 % higher mass transfer capability perpendicular to the thickness direction compared to that along the thickness direction. However, the heat transfer parameters of MDF are not significantly affected by the fibre structure, which indicates its isotropy. This study provides a theoretical basis for future research on microwave-induced desorption of VOCs in MDF by offering insights into heat and mass transfer theory.

Study on blast‐induced cracks penetration characteristics of double water jet slotted boreholes

Study on blast‐induced cracks penetration characteristics of double water jet slotted boreholes

The effect of skin diffusion kinetics of isopropyl ester permeation enhancers on drug permeation: Role of lateral spread and penetration characteristics

The purpose of present work was to study the effects of permeation enhancers’ two kinetic behaviors of simultaneous lateral diffusion and vertical penetration in the skin on its enhancing effect. The skin diffusion kinetics of isopropyl ester permeation enhancers were characterized by the innovative concentric tape peeling study and Raman imaging, which were quantitatively assessed through innovative parameters, namely, lateral-to-vertical penetration amount (CL-V) and lateral-to-vertical penetration distance (DL-V). The enhancement effect of permeation enhancers on drug flurbiprofen (FLU) was assessed by in vitro skin permeation tests, which were confirmed by transdermal water loss and skin resistance study. The relationship between kinetic parameters of permeation enhancers and permeation parameters of FLU was carried out by correlation analysis. The molecular mechanisms of effect of skin diffusion kinetics of permeation enhancers on drug permeation were characterized by molecular docking, modulated-temperature differential scanning calorimetry (MTDSC), Raman spectra, solid-state NMR and molecular dynamic simulation. The results indicated skin diffusion kinetics of short-chain (C8–C12) isopropyl ester permeation enhancers were governed by vertical penetration, while long-chain (C14–C18) ones were characterized by lateral spread. Quadratic correlation between CL-V and enhancement ratio of permeation-retention ratio of FLU (ERQ/R) (R2 = 0.95), DL-V and enhancement ratio of permeation area (ERA) of FLU (R2 = 0.98) indicating that varied skin diffusion kinetics of permeation enhancers directly influenced the barrier function of stratum corneum (SC) and further enhancing drug permeation. In terms of molecular mechanism, long-chain isopropyl ester enhancers had good miscibility with SC, leading to their high CL-V and DL-V, and causing strong interaction strength with SC and resulting in weaker skin barrier function for drug permeation. In summary, in comparison to short-chain isopropyl ester enhancers that relied on penetration, long-chain ones that depended on lateral spread exhibited greater enhancement efficacy, which guided the application of enhancers in transdermal formulations.

MEMS-actuated terahertz metamaterials driven by phase-transition materials

The non-ionizing and penetrative characteristics of terahertz (THz) radiation have recently led to its adoption across a variety of applications. To effectively utilize THz radiation, modulators with precise control are imperative. While most recent THz modulators manipulate the amplitude, frequency, or phase of incident THz radiation, considerably less progress has been made toward THz polarization modulation. Conventional methods for polarization control suffer from high driving voltages, restricted modulation depth, and narrow band capabilities, which hinder device performance and broader applications. Consequently, an ideal THz modulator that offers high modulation depth along with ease of processing and operation is required. In this paper, we propose and realize a THz metamaterial comprised of microelectromechanical systems (MEMS) actuated by the phase-transition material vanadium dioxide (VO2). Simulation and experimental results of the three-dimensional metamaterials show that by leveraging the unique phase-transition attributes of VO2, our THz polarization modulator offers notable advancements over existing designs, including broad operation spectrum, high modulation depth, ease of fabrication, ease of operation condition, and continuous modulation capabilities. These enhanced features make the system a viable candidate for a range of THz applications, including telecommunications, imaging, and radar systems.Graphical