Damage To Pelvic Organs Research Articles

P-729 The cumulative clinical pregnancy and live birth rates of IVF in women treated for genital tuberculosis are similar to those in other infertility etiologies

Abstract Study question Is cumulative clinical pregnancy rate (CPR) and live birth rate (LBR) in infertile patients with treated genital tuberculosis similar to other infertility etiologies undergoing IVF? Summary answer There is no significant difference in cumulative CPR and LBR in women adequately treated for genital tuberculosis undergoing IVF compared to other etiology of infertility. What is known already Female genital tuberculosis (FGTB) is an important cause of infertility in high tuberculosis prevalent countries. The uterine endometrial environment is an important cradle for embryo development. Once violated with infection, the damage to the endometrial blood flow and uterine cavity morphology is likely to be irreversible leading to infertility even after cure with anti-tuberculosis therapy (ATT). Adequate treatment of FGTB involves medical therapy with ATT and surgical treatment of hydrosalpinges and endometrial adhesions. The cumulative CPR and LBR are reported to be lower in the treated endometrial tuberculosis than in non-tuberculosis infertile patients undergoing IVF. Study design, size, duration This is a retrospective analysis of women who underwent IVF with self-oocytes over a period of 4 years from 2015 to 2018. All patients were divided into two groups as: Group-1: All women treated with ATT for FGTB before IVF with all presentations including women who underwent surgery for hydrosalpinges or intrauterine synechiae except with severe intrauterine adhesions and unfit for embryo transfer (ET) Group-2: Patients undergoing IVF other infertility etiologies. Participants/materials, setting, methods Women undergoing ovum pickup along with subsequent fresh and frozen embryo transfer attempts until attained a live birth or all the embryos were used. Exclusion criteria: Main results and the role of chance A total of 948 women underwent OPU during the study period. 171 were excluded from analysis for following reasons: Total of 775 women were included for analysis and results are summarized as: The mean number of embryos per OPU was 7.04 in Group-1 while 6.97 in Group-2. A total of 195 ET procedures were done in Group-1 while 1035 in Group-2. The mean number of ET procedures required for one clinical pregnancy in Group-1 was 3.15 and 2.81 in Group-2.The mean number of ET procedures required for one live birth in Group-1 was 3.42 and 3.02 in Group-2. CPR per ET procedure in Group-I was 31.79% while 35.55% in Group-2. All these differences were statistically insignificant. Limitations, reasons for caution The FGTB has a wide spectrum of presentation from a very early sub-clinical disease to an advanced stage with pelvic organ damage. The prognosis of IVF varies with the extent of disease. This study analyzed overall result while sub categories of FGTB were not analyzed. Wider implications of the findings Infertility after ATT treated FGTB has good IVF outcome. IVF outcome in these patients need to be studied based upon the extent of damage. We recommend undertaking an early IVF with good hope of live birth in ATT treated FGTB. Trial registration number Not applicable

Impact of Surgeon Annual Volume on Short-term Maternal Outcome in Cesarean Delivery

(Am J Obstet Gynecol. 2016;215(1):85.e1–85.e8) Surgeon volume is known to be associated directly with morbidity and mortality rates in surgical procedures. Cesarean delivery (CD) is correlated to increased maternal morbidity including hemorrhage, infection, pelvic organ damage, and increased number of hospital readmissions. This study aimed to investigate whether annual surgeon volumes had an impact on outcomes in CDs.

Impact of Surgeon Annual Volume on Short-term Maternal Outcome in Cesarean Delivery

(Abstracted from Am J Obstet Gynecol 2016;215:85.e1–85.e8) Surgical volume is known to be associated directly with morbidity and mortality rates in surgical procedures. Cesarean delivery (CD) is associated with increased maternal morbidity, including hemorrhage, infection, pelvic organ damage, and increased number of hospital readmissions.

Complex Organ Injuries After Mid-Trimester Termination of Pregnancy: Pushing Boundaries in Laparoscopic Management

Surgical termination of pregnancy is one of the most often performed gynecologic procedures in the United Kingdom and worldwide. Although complications are rare, they can be devastating because they include hemorrhage and pelvic organ damage often necessitating hysterectomy. Traditionally, these complications have been managed via laparotomy; however, with increasing technological advances and surgical expertise, it is now possible to manage extreme complications of these procedures via operative laparoscopy. Herein is reported successful laparoscopic management of 3 cases of complex uterine perforation in young women after mid-trimester surgical termination of pregnancy.

751 CORPORAL SMOOTH MUSCLE RELAXATION IS AFFECTED BY ABNORMAL LIPIDS METABOLISM RELATED DOWN-REGULATING OF ATP SYNTHASE

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research1 Apr 2011751 CORPORAL SMOOTH MUSCLE RELAXATION IS AFFECTED BY ABNORMAL LIPIDS METABOLISM RELATED DOWN-REGULATING OF ATP SYNTHASE Tao Xu and Jing li Tao XuTao Xu Beijing, China, People's Republic of More articles by this author and Jing liJing li Beijing, China, People's Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1776AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Primary risk factors of ED include: hypertension, hyperlipidemia, diabetes, coronary and peripheral vascular disease, pelvic organ damage or spinal cord injury or surgery. Our preliminary study found that as society changes in lifestyle and the popularity of metabolism disorders, in addition to the traditional view on ED that the nerve damage and vascular factors caused erectile dysfunction, the metabolic factors play more and more important roles in ED. The purpose of this article is to figure out the dysfunction of corporal smooth muscle itself with aging and metabolic disorders. Whether diastolic dysfunction and fibrosis of corporal smooth muscle cells also caused the erectile dysfunction and the possible target for intervention. METHODS leptin receptor knockout mice (db/dblepr−/−) and high-fat diet for 16 weeks mice model and it°−s control were using in our expetiments, we tested the erectile corpus cavernosum smooth muscle impulse conduction, and the key factor on energy generation were detected on the molecular biological level. RESULTS In vivo the ICP of HFD induced hyperglycemia mouse model are lower. The energy related protein ATP F1 subunit has a significant decrease compared with its control, cell cycle related protein cyclinD1 and akt has also decreased while the fatty acid synthase (FAS) upregulated. In the primary cultured human Corporal smooth muscle cell study, a 24h FFA treated significantly induced fatty acid accumulation in the cell as the oil red O staining showed, the energy and cell survival related protein decrease and the fatty acid oxidation decreased while inflammatory marker protein NFκB increased. CONCLUSIONS Diabetic mice models has erectile dysfunction, the corporal smooth muscle itself, as the impact of hyperglycimia and hyperinsulindimia appeared to decline in ATP synthase protein levels and promote corporal smooth muscle to be in inflammatory state may affect the cavernous smooth muscle structure and downregulate the energy generation which might cause erectile dysfunction. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e302 Peer Review Report Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Tao Xu Beijing, China, People's Republic of More articles by this author Jing li Beijing, China, People's Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...