Charles Peirce, the founder of pragmatism and himself a working scientist, was concerned to formulate elements of his pragmatism so as to be of practical benefit to philosophers and scientists alike. This discussion investigates the practical recommendations of Peircean pragmatism, especially as it relates to questions of how we should conduct scientific inquiry. Peirce’s model of inquiry is supposed to demarcate appropriate from specious methods of inquiry. While, as Cheryl Misak points out, Peirce’s explicit account fails, the account can nevertheless be rescued by elements of his own system. Specifically the account provided in this paper draws from Peirce’s corollary to his “first rule of reason,” that one should not block the road to inquiry. Following this corollary, under the guidance of Peirce’s view of reality and the role it plays in inquiry, leads us to conclude that the optimal way to conduct inquiry is to follow the path of greatest resistance. We cannot, however, as Peirce recognized, pursue our researches optimally, since we are limited in time, energy, and other resources. Making the best use of those resources requires a measure of economy. To this end, Peirce developed specific recommendations about the economy of research. The focus here is on his recommendation regarding hypothesis testing, which is that we “begin with that positive prediction . . . which seems least likely to be verified.” According to this suggestion, to test any given hypothesis we should begin by assessing the probability of each of its predictions, given a suitable, contrary hypothesis. Once we note which are the least likely of the predictions, we use other economic factors to determine which tests to perform. The fortified Peircean account developed here maintains that inquiry should be conducted so as to leave open the path to future inquiry. This means taking a particular attitude toward our set of beliefs—being prepared to recognize their limitations and keeping the field of belief susceptible to doubt. In accepting that inquiry is best that serves to maximize resistance, we require of ourselves a constant striving, believing just what we believe, but never resting content with it. This is the attitude of the consummate scientist, accepting the best of the theories available, but never dogmatically, and always on alert for opportunities to recognize the shortcomings of those views and awake to the possibility that other, better theories are on the horizon.