Peels In Treatment Research Articles

Evaluation of fractional erbium: YAG laser and glycolic acid 70% peeling in melasma improvement

Melasma is an acquired chronic hyperpigmentation which mainly affects women on sun-exposed areas of the body, especially on the face in Fitzpatrick skin types III-V. The study setting is at the Dermatology Clinic at NILES, Cairo University, Egypt. This study aims to evaluate the clinical efficacy and safety of fractional ablative erbium:YAG Laser therapy versus chemical peeling in treatment of melasma. This study included 30 patients with melasma on their face aged 20-50 years. The patients were divided into two groups. In group I, 15 patients were treated by four sessions of fractional erbium YAG laser at 4 weeks interval. In group II, 15 patients were treated by four sessions of chemical peeling with glycolic acid 70%.The percentage of improvement in patients treated by fractional erbium YAG laser was 20 – 80% with amean 54.33 ± 18.01 and the percentage of improvement in patients treated by chemical peeling was 30 – 85 % with a mean 53.33 ± 18.09. So, there was no significant difference in the percentage of improvement in both groups (P- value = 0.881). It was observed that fractional erbium YAG is as effective as 70% glycolic acid peel in patients with melasma.

Combined chemical peels versus trichloroacetic acid (TCA) for treating melasma: a split face study

Melasma is common skin condition presenting with hyperpigmentation. To evaluate the efficacy, tolerance, and complications of one session of combined chemical peels compared to traditional serial sessions of trichloroacetic acid (TCA) peeling in treating melasma. One session of combined chemical peels was carried out at the left side of the face, while six sessions of TCA 15% peel were carried out at the right side of the face every 10 days. The Modified Melasma Area and Severity Index (MASI) score was calculated at baseline (before starting peeling sessions), after one month (at the fourth TCA peeling session), and after three months (one month after the last TCA peeling session). Both sides of the face showed gradual reduction in modified MASI score throughout sessions. By the end of the study, the TCA-treated side showed slightly lower mean modified MASI score than the combined chemical peels-treated side of the face; however this difference was not statistically significant, (p = .405). A single session of combined chemical peels is as effective as six sessions of TCA peel in treatment of melasma. Combined chemical peels can be used as a convenient, tolerable and time saving safe procedure for treating melasma.

Comparative Study on Fractional Ablative Erbium: YAG Laser Versus Chemical Peeling in Treatment of Melasma -

Introduction: Melasma is an acquired chronic hyperpigmentation which mainly affects women on sun-exposed areas of the body, especially on the face in Fitzpatrick skin types III-V. The study setting is at the Dermatology Clinic at NILES, Cairo University, Egypt. The aim: This study aims to evaluate the clinical efficacy and safety of fractional ablative erbium:YAG Laser therapy versus chemical peeling in treatment of melasma. Patients, materials and methods: This study included 30 patients with melasma on their face aged 20-50 years. The patients were divided into two groups. In group I, 15 patients were treated by four sessions of fractional erbium YAG laser at 4 weeks interval. In group II, 15 patients were treated by four sessions of chemical peeling with glycolic acid 70%. Results: The percentage of improvement in patients treated by fractional erbium YAG laser was 20 – 80% with amean 54.33 ± 18.01 and the percentage of improvement in patients treated by chemical peeling was 30 – 85 % with a mean 53.33 ± 18.09. So, there was no significant difference in the percentage of improvement in both groups (P- value = 0.881). Conclusion: It was observed that fractional erbium YAG is as effective as 70% glycolic acid peel in patients with melasma.

Clinical and trichoscopic evaluation of trichloroacetic acid 35% vs phenol 88% peels in treatment of alopecia areata

Among alopecia areata (AA) treatments, contact irritants (anthralin) and topical immunotherapies (diphenylcyclopropenone) have been successfully used. Chemoexfoliation can potentially be utilized, acting as irritants and consecutively immunomodulators. Peels via therapeutic wounding provoke growth factors and cytokines that may induce hair regrowth. To evaluate and compare trichloroacetic acid (TCA) 35% and phenol 88% peels effectiveness and tolerability in patchy AA. This comparative, randomized, double-blind study included 20 patients with multifocal patchy AA. In each patient, 2 patches were selected and randomized into group I (20 patches: TCA 35%) and group II (20 patches: phenol 88%). A session was performed every 3weeks for 9weeks. Response was assessed by two blinded observers as regards percentage of clinical improvement, severity of alopecia tool (SALT), and trichoscopic scaled scores for dystrophic and terminal hairs, respectively. Patients were scheduled for follow-up visits over 6months past treatment cessation. A total of 19 patients completed the study and showed significant reduction in SALT score. TCA- and phenol-treated patches demonstrated significant improvement in the percentage of clinical improvement, trichoscopic scale of dystrophic and terminal hairs. However, TCA was superior to phenol as it showed significant more reduction in trichoscopic score of dystrophic hairs and significant higher increase in terminal hairs. Phenol yielded significant higher discomfort than TCA. No relapse was detected. Trichloroacetic acid 35% and phenol 88% peels can be considered effective therapeutic modalities for patchy AA. TCA 35% represents a treatment of choice in terms of the efficacy and tolerability.

Safety, Tolerability and Cost Effectiveness of Commercially Available vs. Freshly Prepared Salicylic Scid Peel in Treatment of Acne: An Indian Perspective

Safety, Tolerability and Cost Effectiveness of Commercially Available vs. Freshly Prepared Salicylic Scid Peel in Treatment of Acne: An Indian Perspective

A comparative study to evaluate the efficacy of trichloroacetic acid versus gycolic acid chemical peels in treatment of melasma

A comparative study to evaluate the efficacy of trichloroacetic acid versus gycolic acid chemical peels in treatment of melasma

The effect of internal limiting membrane peeling in treatment of idiopathic epiretinal membrane

The effect of internal limiting membrane peeling in treatment of idiopathic epiretinal membrane

Comparison of efficacy of commercially available vs. freshly prepared salicylic acid peel in treatment of acne: a randomized open-label study

BackgroundChemical peeling is increasingly used in dermatology nowadays. Salicylic acid peels have been widely used in Asian patients since long ago, but very few published literature is there focusing on the efficacy and safety of it in Asian population. This study was planned to compare the efficacy of salicylic acid (SA) peel either commercially available or freshly prepared in treatment of acne.MethodsA prospective, randomized, open-label, parallel-group study was carried out in patients with acne. A total of 126 patients were randomized to receive 30% salicylic acid peel either commercially available (group A, n = 60) or freshly prepared (group B, n = 63). Assessment of acne lesions was done at baseline and at 2, 4, 6, 8, 10, and 12 weeks. Objective assessment was carried out using total acne score and subjective assessment using visual analog scale and were compared.ResultsMean age of patients was 22.4 ± 3.1 years with female predominance. After six sessions with commercially available SA peel, reduction in average number of comedones was 88.45% (P = 0.002), in inflammatory papules 89.16% (P = 0.01), in pustules 31.47% (P = 0.06), and in nodules/cyst 50% (P = 0.5). After six sessions with freshly prepared SA peel, reduction in average number of comedones was 89% (P = 0.0001), in inflammatory papules 90.36% (P = 0.0001), in pustules 28.3% % (P = 0.05), and in nodules 96% (P = 0.05). Significant reduction of both non-inflammatory and inflammatory acne was seen in both groups (P < 0.05). Both of the agents led to a highly significant (P < 0.001) improvement in the total acne score; freshly prepared SA peel showed improvement significantly earlier at 6 weeks onwards. VAS score was significantly high for the freshly prepared SA group (P = 0.05).ConclusionThis study has shown equivalence in therapeutic efficacy of both commercially available and freshly prepared SA peels both in terms of objective and subjective assessments in acne treatment with more patient satisfaction with freshly prepared peel.

Correction to: Comparative study using fractional carbon dioxide laser versus glycolic acid peel in treatment of pseudo-acanthosis nigricans.

The author found small mistakes in scientific content of article. Editor-in-Chief confirmed that mistakes do not change or invalidate conclusions of article.

Efficacy and safety of superficial chemical peeling in treatment of active acne vulgaris.

Acne vulgaris is an extremely common condition affecting the pilosebaceous unit of the skin and characterized by presence of comedones, papules, pustules, nodules, cysts, which might result in permanent scars. Acne vulgaris commonly involve adolescents and young age groups. Active acne vulgaris is usually associated with several complications like hyper or hypopigmentation, scar formation and skin disfigurement. Previous studies have targeted the efficiency and safety of local and systemic agents in the treatment of active acne vulgaris. Superficial chemical peeling is a skin-wounding procedure which might cause some potentially undesirable adverse events. This study was conducted to review the efficacy and safety of superficial chemical peeling in the treatment of active acne vulgaris. It is a structured review of an earlier seven articles meeting the inclusion and exclusion criteria. The clinical assessments were based on pretreatment and post-treatment comparisons and the role of superficial chemical peeling in reduction of papules, pustules and comedones in active acne vulgaris. This study showed that almost all patients tolerated well the chemical peeling procedures despite a mild discomfort, burning, irritation and erythema have been reported; also the incidence of major adverse events was very low and easily manageable. In conclusion, chemical peeling with glycolic acid is a well-tolerated and safe treatment modality in active acne vulgaris while salicylic acid peels is a more convenient for treatment of darker skin patients and it showed significant and earlier improvement than glycolic acid

Jessner's solution vs. 30% salicylic acid peels: a comparative study of the efficacy and safety in mild‐to‐moderate acne vulgaris

Chemical peeling is a well-identified therapeutic modality for acne vulgaris (AV). Jessner's solution (JS) is a known peeling agent for acne since more than 100 years. Salicylic acid (SA) peel is a well-established peeling agent for acne. There is paucity of literature comparing the current peeling agents of choice, that is, SA with the older peeling agents, that is, JS for acne. To compare the efficacy and safety of 30% SA vs. JS peels in treatment of mild-to-moderate facial acne in Indian patients. A total of 40 patients with mild-to-moderate AV were enrolled for 12 weeks and were randomly divided into two groups: group 1, 30% SA peels and group 2, JS peels were performed 2 weeks apart with total of six peels in 12-week duration. Clinical improvement was assessed objectively using Michaelsson acne scores (MAS) and clinical photographs. Side effects were observed at each visit. At the end of therapy, improvement in MAS and percentage decrease in MAS were significantly higher in group 1 as compared to group 2. Likewise, decrease in mean comedone counts in group 1 was significantly higher as compared to group 2. However, there was no statistically significant difference in the decrease in mean papule and pustule counts between the two groups. Both the groups tolerated the peels well. Thus, 30% SA peels were more effective than JS peels in treatment of noninflammatory lesions, that is, comedones and in overall improvement of mild-to-moderate facial acne vulgaris.

Efficacy of Intradermal Injection of Tranexamic Acid, Topical Silymarin and Glycolic Acid Peeling in Treatment of Melasma: A Comparative Study

Background: Melasma is one of the most common causes of facial hyperpigmentation which causes cosmetic disfigurement and leads to psychological problems. Although various treatments are available for melasma, it remains a difficult condition to treat. Aim of the Work: to evaluate and compare the efficacy of intradermal injection of tranexamic acid, topical silymarin cream and glycolic acid peeling in treatment of melasma. Patients and Methods: Sixty female patients with melasma were divided into 3 groups: group A; 20 patients were treated with intradermal injection of tranexamic acid. Group B; 20 patients were treated with topical silymarin cream and group C; 20 patients were treated with glycolic acid peeling 50%. Dermoscopic examination and clinical assessment (according to the modified Melasma Area and Severity Index) were performed for all patients. Results: There was a statistically significant difference between the studied groups as regard the response to different therapeutic modalities with the best results in group C followed by group B then the least response was in group A. There was statistically significant difference between A and B, A and C; so group B and C showed better response than group A, while there was no statistically significant difference between groups B and C. Conclusion: Silymarin cream was a novel, effective and safe treatment modality for melasma especially in epidermal and mixed types in Fitzpatrick skin phototype III, IV and V as it showed a significant improvement of melasma lesion. It was as effective as 50% glycolic acid peeling in the treatment of melasma without post inflammatory hyperpigmentation that occurred by glycolic acid peeling.

Confocal microscopic evaluation of modified Cook peel for treatment of widespread actinic keratosis in a renal transplant patient

Confocal microscopic evaluation of modified Cook peel for treatment of widespread actinic keratosis in a renal transplant patient

A comparative study of safety and efficacy between 4% hydroquinone and 30% salicylic acid peel in treatment of periorbital hyperpigmentation in dark-skinned patients

A comparative study of safety and efficacy between 4% hydroquinone and 30% salicylic acid peel in treatment of periorbital hyperpigmentation in dark-skinned patients

The Effect of Internal Limiting Membrane Peeling in Treatment of Idiopathic Epiretinal Membrane

Purpose: This study was designed to evaluate the effect of internal limiting membrane (ILM) peeling in the surgical management of idiopathic macular epiretinal membrane (ERM). Method: The records of 36 patients (36 eyes) with idiopathic macular ERM who had undergone pars plana vitrectomy with removal of the ERM were retrospectively reviewed. The patients were divided into two groups: eyes with (18 eyes) or without (18 eyes) ILM peeling. The best corrected visual acuity (BCVA), recurrence of ERM, persistence of retinal wrinkling, as well as the complications and improvement of visual acuity of the two groups were compared. Results: The mean pre-operative BCVA for the two groups was 0.29 in the group with ILM peeling and 0.26 in the group without ILM peeling, while the mean post-operative BCVA was 0.59 and 0.50, respectively. Although the post-operative BCVA significantly improved in both groups (P=0.001), there was no statistically significant difference between the two groups (P>0.05). However, the persistence of retinal wrinkling greatly decreased in the group with ILM peeling, and ERM recurred in two cases in the group without ILM peeling. Conclusion: ILM peeling in the surgical management of idiopathic macular ERM does not affect the postoperative results of visual acuity and complications, except for the persistence of retinal wrinkling and recurrence.