Children living with HIV face unique challenges that significantly impact their health and development, with anemia being one of the most prevalent complications. Blood transfusions have emerged as a vital therapeutic intervention for managing anemia in pediatric HIV patients, providing immediate correction of hemoglobin levels and alleviating debilitating symptoms. This review explores the role of blood transfusions in preventing complications associated with HIV, emphasizing their importance in improving health outcomes and enhancing the quality of life for affected children. The mechanisms through which blood transfusions confer benefits include enhanced oxygen delivery to tissues, improved immune function, and support for growth and development. Clinical evidence highlights the effectiveness of transfusions in reducing hospitalization rates and promoting adherence to antiretroviral therapy (ART). Furthermore, integrating blood transfusions into comprehensive care models fosters a multidisciplinary approach that addresses the medical, nutritional, and psychosocial needs of pediatric patients, ensuring a holistic management strategy. Keywords: Pediatrics, HIV, blood transfusions, anemia, immune function, HIV management