Healthy living and well-being at all ages are one of the UN Sustainable Development Goals. Active mobility is a must as a basic choice for healthy individuals and communities in sustainable cities. However, commuting by walking presents a critical challenge in the city with rapid urbanization, leading to auto dependency rather than a non-motorized mode of residents’ daily mobility. By employing spatial configurations of urban physical elements, the interaction between its association and active mobility can be unfolded. Bangkok, a megacity in Thailand, is used as a case study for the objective assessments by generating data from on-street images and incorporating it into the analysis through geographic information systems (GIS). The finding based on the results of spatial configurations related to the pedestrian volume can then be quantified. The linkage between the physical environment—both sidewalks and their surrounding context—can demonstrate its significance in term of relationship. This information is useful for promoting compact urban development with consideration of the availability of transportation systems, especially public transport, which can lead to the promotion of healthy cities and environmental protection while solving traffic problems.