Particulate matter (PM) from the road resuspension dust of vehicles driving can deteriorate urban air quality. The goal of our study was to develop a discrete phase model and sliding grid technology to simulate the distribution characteristics of resuspension PM2.5 from vehicle road dust, and to analyze PM2.5 exposure of drivers and pedestrians caused by resuspension dust. The results indicated that the maximum height of PM2.5 concentration at the XZ section at 1-10 s varied in a zigzag pattern, with the lowest at 3.37 m at 1 s and the highest at 5.85 m at 2 s. PM2.5 concentration diffusion presented a "two lungs within one bracket" shape at Z=-0.03 m section and PM2.5 was gradually diffused from the tire to the two sides of the vehicle at 1-10 s. PM2.5 concentration at y=5.5 m line of X=-15 m section gradually decreased with ground height increasing. The average PM2.5 concentration at Z=1.25 m section at 1-10 s was 1.86, 3.17, 6.85, 8.85, 12.78, 14.69, 16.64, 18.96, 21.50, and 22.98 μg/m3, respectively. The average PM2.5 concentration was directly proportional to the change in road dust mass flow rate. The range of PM2.5 concentration of points a (left driver), b (right driver), c1 (pedestrian standing still for 3 m on right side of right vehicle) and c2 (pedestrian walking at a speed of 1.5 m/s) were 0-49.8, 0-183.0, 0-16.5, and 0-59.8 μg/m3, and the time of the maximum PM2.5 concentration for a, b, c1, and c2 was 5, 6.5, 4.5 and 5 s, respectively. These results indicated that the driver of point b had the highest exposure concentration within 1-10 s, which was 5.8 times that of the driver of point a, 7.7, and 2.9 times that of pedestrians of points c1 and c2. These results can provide basic data for road dust emissions and population exposure risk management.