Background: The “echocardiographic Pulmonary to Left Atrial Ratio” (ePLAR) is a new non-invasive parameter describing the physiologic relationship between pulmonary arterial pressure and left atrial pressure. It is derived using Doppler echocardiography and calculated from peak tricuspid regurgitation velocity (TR Vmax) divided by the transmitral E wave: medial DTI E’ wave ratio (E/E’). We sought to establish normal ePLAR values for an ‘athlete’ population. Methods: A retrospective analysis of patients undergoing treadmill stress echocardiogram between 2013 and 2014 was conducted. Patients who achieved high workload (greater than 17 METs) on treadmill exercise stress test were identified and the recorded resting TR Vmax, E/E’ ratio and ePLAR values were compared to established population normal ePLAR reference values. Results: The stress echocardiograms of 120 patients (average age 45±13.5 years; 88% male) were evaluated. The mean achieved METs was 18±1.6. The mean TR Vmax was 2.2±0.3 m/s, the mean E/E’ ratio was 7.4±1.9, and the mean ePLAR was 0.32±0.09 m/s. No statistically significant difference was found between age-stratified mean ePLAR values for athletes compared to normal population group. Conclusions: ePLAR is a novel echocardiographic parameter that is easily obtained during routine stress echocardiogram. In this cohort of ‘athlete’ population, their trans-pulmonary physiology as measured by ePLAR did not appear to differ significantly compared to normal population.