Each storage medium possesses a capacity that is vital to technological progress in supporting internet speed for downloading extensive data. Effective storage media management includes compressing image data to optimize available space utilization for efficient usage. Digital processing of image data for each patient over a specific duration is crucial. This study proposes medical image compression utilizing multi-level thresholding employing the fuzzy entropy and differential evolution (FE-DE) algorithms. The compression results are subsequently assessed using the Peak Signal to Ratio (PSNR), Structural Similarity Index Measure (SSIM), and Feature Similarity Index Measure (FSIM) to appraise the algorithm's performance and the quality of the compressed images. Employing Fuzzy Compression yields increasing PSNR, SSIM, and FSIM values as the threshold level rises, with the highest values achieved at threshold level 40. The increase in value is in line with the visual quality and compressed image produced.
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