Simulated round-robin tournaments are used (1) to assess the relative performance of non-defecting, conditionally cooperative programs in a three-person PD setting where exit is possible (PDEs) and (2) to assess the importance of sanctions for the success of joint enterprises. We find that the possibility of exit allows individuals to escape from dysfunctional teams which increases the potential benefits of cooperation while reducing those associated with free-riding. We also find that punishment, especially targeted punishment, is critical to the success of shorter term enterprises. Similar results held in evolutionary settings where successful behavioral programs can be imitated, or propagated by non-rational biological or social processes. Our results suggest that non-defecting programs of conditional cooperation can be rational, average payoff maximizing, strategies for participating in small multilateral settings where individuals can choose to participate in a PD game or not.