Purpose – The purpose of this paper is to assess the changing pattern and direction of sex segregation of occupation as a measure of unbalanced distribution of occupation by sex in Ghana between 1960 and 2010, identify the sources of the changes and show whether female-male earnings difference has changed in line with the changes in occupational segregation. Design/methodology/approach – The paper applies two segregation indices to data from population censuses and household surveys in the empirical analysis Findings – The outcome of the segregation measure indicates a generally modest to high but declining occupational sex segregation in Ghana over a period of five decades. Sex composition and occupational mix effects are found to be the underlying drivers of the declining segregation with the former coming up strongly during the initial 40 years. This has, however, not translated into narrowing female-male earnings gap. Practical implications – The paper recommends measures towards economic transformation for a change in occupational structure backed by implementation of education policy to enhance female access to male-dominated science and engineering programmes and employment in high-skill occupations. Originality/value – The strength of the paper is seen from its originality as it is the first attempt to assess changing pattern of occupational segregation over a long period of five decades with consistent and comparable data sources.