Patterns Of Psychotropic Drugs Research Articles

Prescription pattern of psychotropic drugs among patients attending outpatient department of psychiatry: A cross-sectional study

Background: The rational use of the drug is so much important in the present-days because the consequences of irrational prescribing may lead to adverse events which are avoidable and can save the available sources. Thus, to estimate the number of patients who are given the drugs for a specific time in a certain area, drug utilization research can be done. One of the important public health priorities which include long-term treatment is psychiatric disorders. Thus, it is important to study prescribing practices of the drugs used for psychiatric disorders. Aim and Objective: The objective of our study was to assess the prescription pattern as the WHO International Network of Rational Use of Drugs drug use indicators. Materials and Methods: This was the prospective observational study. After approval from the Institutional Ethics Committee, the patients of both sexes and all ages, suffering from a psychiatric illness and started on at least one psychotropic drug, were selected from the outpatient Department of Psychiatry, GMCH, Jalgaon, in the duration of February 21–April 21. The data were collected in Microsoft Excel and an appropriate statistical test was applied for analysis. Results: Analysis of 513 prescriptions was done which shows that men received more psychotropic prescriptions than female and antipsychotics were the most commonly prescribed class of psychotropic drugs. The percentage of drugs prescribed by generic name was 82.75% and the percentage of prescription containing fixed-dose combinations was 74.7%. Conclusion: Prescription pattern at Government Medical College, Jalgaon, shows male preponderance in psychiatric illnesses. The most common class of drug prescribed was antipsychotics.

P.529 Prescription patterns of psychotropic drugs in patients who were receiving steroidal anti-inflammatory drugs: analysis of Japanese national prescription data

P.529 Prescription patterns of psychotropic drugs in patients who were receiving steroidal anti-inflammatory drugs: analysis of Japanese national prescription data

Profile and use of licit psychotropic substances in the former Rabat-Sale-Zemmour-Zaër Region (Morocco): the case of tiflet city.

IntroductionPsychopharmacology today faces serious challenges, especially related inappropriate drug choices, abuse and resulting side effects. The aim of this pharmacy based study in the City of Tiflet was to profile the prescription and usage patterns of psychotropic drugs.MethodsThis study was conducted in the pharmacies of the City of Tiflet (Morocco). Descriptive statistics of 5125 prescriptions collected from 21 pharmacies were analysed, and summarized as means, percentages and proportions where appropriate.ResultsThe patterns of psychotropic drugs use were similar, compared to Western Countries, especially for anxiolytics/hypnotics, neuroleptics and anti-depressants. A poor monitoring of the treatment, and the lack of control of its side effects were major concerns. General practitioners ranked first among doctors who prescribed psychotropic drugs (48.5%), followed by psychiatrists (41.7%), and the rest of the prescriptions come from other specialists (neurologists, cardiologists, gynaecologists…). Among psychotropic drugs, anxiolytics dominated prescriptions (52.0%), followed by neuroleptics (29.0%) and anti-depressants (19.0%). Men consumed more psychotropic drugs than women (51.8% against 48.2% respectively).ConclusionAnxiolytics/hypnotics constitute the main class of psychotropic drugs prescribed in the Tiflet City, followed by neuroleptics and anti-depressants. Nearly half of the population currently receive prescribed psychotropic drugs from general practitioners. Psychiatrists are less involved in the prescription and monitoring of these patients. This could predispose the population to addiction, drug misuse, intoxication, and at times, misdiagnosis of serious psychiatric illnesses. Our study highlights the urgency of reinforcing psychotropic prescription regulation and monitoring in Tiflet city.

A study of drug utilization pattern of psychotropic drugs among female patients with psychotic disorders: a prospective study

A study of drug utilization pattern of psychotropic drugs among female patients with psychotic disorders: a prospective study

Monotherapy Ot Polypharmacy ? Prevalent Prescription Patterns in a Big General Hospital

Introduction In general, monotherapy is advocated. However, a proportion of the treatment regimens contains two or more drugs from the same class (i.e. polypharmacy) or a combination of drugs from different classes. Objectives To investigate the prevalence of prescription patterns of psychotropic drugs to our outpatients with schizophrenia, unipolar depression or bipolar disorder. Methods Files of 510 outpatients were studied. A retrograde examination was done spanning for 6 months. Demographics, details of diagnosis, hospitalizations and a chart of the drugs administered were collected. A comparison was done between various characteristics of patients under polypharmacy and monotherapy. Results Polypharmacy as well as combination therapy was more prevalent than monotherapy in all groups. Patients with a history of previous hospitalizations were not prone to be under polypharmacy, excluding depressives . Antidepressant prescription in schizophrenics was unusually high reflecting the easiness of use of new agents for negative symptomatology . The most commonly prescribed antipsychotics were quetiapine, olanzapine and risperidone. Classical antipsychotics had medium proportion of the treatment, mainly as combined therapy. Mirtazapine, Venlafaxine and Sertraline were the most commonly prescribed antidepressants Tricyclics were prescribed also Conclusions .. Greek clinicians' attitude for polypharmacy, regardless of the diagnosis, is prevalent. The recent changes in reimbursement policies of the healthcare System in Greece, did little to affect antipsychotics, but had an effect in the prescribing patterns of antidepressants

Prescribing pattern of psychotropic drugs used in non-psychiatric patients among outpatient department of two teaching hospitals in Bangladesh

The objectives were to evaluate the prevalence, pattern and rational of psychotropic drugs prescribing by general physicians in two teaching hospitals in Bangladesh in non-psychiatric patient. 320 patients from Sir Salimullah Medical College Hospitals and 240 patients from Holy Family Red Crescent Medical College Hospitals who visited other than psychiatry ward, received psychotropic drugs between July 2012 to June 2013 were analyzed. The rate of psychotropic drugs prescribing was 8.3% and 11.2% in SSMC and HFRCMCH respectively which was found to increase with increasing age and female patient. Benzodiazepines were the most commonly prescribed drugs followed by antidepressant and psychotropic drugs. The psychotropic drugs use was found more in different physical disorder.

Longitudinal prescribing patterns of psychotropic drugs in nursing home residents.

Longitudinal prescribing patterns of psychotropic drugs in nursing home residents.

Metabolism, Distribution and Excretion of the Thiophthalane Lu 5‐003, a Bicyclic Thymoleptic

The metabolism of orally administered Lu 5‐003 has been studied in the rat, dog and man. Urine and faeces were studied by thin layer chromatography of basic and acidic extracts. The metabolic degradation was shown to proceed partly by sulphoxidation and partly by demethylation followed by deamination of the side chain. Seven metabolites were found. The pattern was the same in the three species investigated. A semiquantitative determination showed Lu 5‐003 and the demethylated metabolite to be the main excretion products in the faeces, while the more water soluble sulphoxides of these compounds and propionic acid derivatives were dominant in the urine. 14C‐labelled Lu 5‐003, given intravenously to rats, was used for distribution and excretion studies. Groups of three rats were killed at different times after administration and the amount of radioactivity was determined in the blood and tissues. The distribution was shown to follow the well known pattern of psychotropic drugs i. e. high concentrations in the lungs, liver, kidneys and heart, while the brain concentration was considerably lower. Lu 5‐003 and its demethyl derivative constituted the main part of radioactivity in the organs as shown by thin layer chromatography of basic extracts. Up to 1 hour after administration Lu 5‐003 was the main compound in the brain, but this was exceeded later by the demethylated metabolite. The half‐life of radioactivity in the blood and brain was calculated to be about 2 hours. After a single dose 60 % and 23 % of the radioactivity was excreted in the faeces and urine respectively in 7 days, while 1 % remained in the body. During the first 24 hours 72.6 % was excreted. There was evidence of an enterohepatic circulation. Expired CO2 showed minute amounts of radioactivity shortly after administration, probably originating from impurities.