Pattern Of Coronary Artery Disease Research Articles

Influence of Pathophysiological Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes.

Diffuse coronary artery disease (CAD) impacts the safety and efficacy of percutaneous coronary intervention (PCI). Pathophysiological CAD patterns can be quantified using fractional flow reserve (FFR) pullbacks incorporating the pullback pressure gradient (PPG) calculation. This study aimed to establish the capacity of PPG to predict optimal revascularisation and procedural outcomes. This prospective, investigator-initiated, single-arm, multicentre study enrolled patients with at least one epicardial lesion with an FFR ≤ 0.80 scheduled for PCI. Manual FFR pullbacks were employed to calculate PPG. The primary outcome of optimal revascularisation was defined as a post-PCI FFR ≥ 0.88. 993 patients with 1044 vessels were included. The mean FFR was 0.68 ± 0.12, PPG 0.62 ± 0.17, and post-PCI FFR 0.87 ± 0.07. PPG was significantly correlated with the change in FFR after PCI (r=0.65, 95% CI 0.61-0.69, p<0.001) and demonstrated excellent predicted capacity for optimal revascularisation (AUC 0.82, 95% CI 0.79-0.84, p<0.001). Conversely, FFR alone did not predict revascularisation outcomes (AUC 0.54, 95% CI 0.50-0.57). PPG influenced treatment decisions in 14% of patients, redirecting them from PCI to alternative treatment modalities. Periprocedural myocardial infarction occurred more frequently in patients with low PPG (<0.62) compared to those with focal disease (OR 1.71, 95% CI: 1.00-2.97). Pathophysiological CAD patterns distinctly affect the safety and effectiveness of PCI. The PPG showed an excellent predictive capacity for optimal revascularisation and demonstrated added value compared to a FFR measurement.

Patterns of coronary artery disease trends in patients with nephrotic syndrome: A national inpatient study

BackgroundIndividuals with nephrotic syndrome (NS) are thought to have elevated cardiovascular risk because of a known association with hyperlipidemia. Unfortunately, no studies have compared the cardiovascular risk profiles of individual nephrotic syndromes. This study explores the prevalence and patterns of coronary artery disease (CAD) in patients with different types of NS, which may aid in developing risk reduction strategies. MethodsThis retrospective study queried data from the National Inpatient Sample database spanning 2016–2020 and included patients over the age of 18 years with minimal change disease (MCD), membranous nephropathy (MN), and focal segmental glomerulosclerosis (FSGS). We analyzed the prevalence and trends of hyperlipidemia and CAD in the study population. ResultsOf the 15,025 cohort, there were 3625 (24.1%) MCD, 4160 (27.7%) MN, and 7315 (48.7%) FSGS. Patients with MN were found to be older with a higher prevalence of hyperlipidemia and CAD compared to other groups. The odds of developing CAD when adjusting for confounding factors were increased in FSGS (adjusted odds [aOR] 1.570, 95% CI 1.406–1.753, p < 0.001) while reduced in MCD (aOR 0.671, 95% CI 0.580–0.777, p < 0.001) and MN (aOR 0.782, 95% CI 0.698–0.876, p < 0.001). ConclusionsThe divergent results of the different NS types highlight the need for targeted research to better understand and characterize the distinct cardiovascular risk profiles inherent in each type of nephrotic disease for risk stratification.

Geographic disparity of pathophysiological coronary artery disease characteristics: Insights from ASET trials

BackgroundThe geographical disparity in the pathophysiological pattern of coronary artery disease (CAD) among patients undergoing percutaneous coronary intervention (PCI) is unknown. ObjectivesTo elucidate the geographical variance in the pathophysiological characteristics of CAD. MethodsPhysiological indices derived from angiography-based fractional flow reserve pullbacks from patients with chronic coronary syndrome enrolled in the ASET Japan (n = 206) and ASET Brazil (n = 201) studies, which shared the same eligibility criteria, were analysed.The pathophysiological patterns of CAD were characterised using Murray law-based quantitative flow ratio (μQFR)-derived indices acquired from pre-PCI angiograms. The diffuseness of CAD was defined by the μQFR pullback pressure gradient index. ResultsSignificant functional stenoses pre-PCI (μQFR ≤0.80) were more frequent in ASET Japan compared to ASET Brazil (89.9% vs. 67.5%, p < 0.001), as were rates of a post-PCI μQFR <0.91 (22.1% vs. 12.9%, p = 0.013). In the multivariable analysis, pre-procedural μQFR and diffuse disease were independent factors for predicting a post-PCI μQFR <0.91, which contributed to the different rates of post-PCI μQFR ≥0.91 between the studies. Among vessels with a post-PCI μQFR <0.91, a consistent diffuse pattern of CAD pre- and post-PCI occurred in 78.3% and 76.7% of patients in ASET Japan and Brazil, respectively; only 6.3% (Japan) and 10.0% (Brazil) of vessels had a major residual gradient. Independent risk factors for diffuse disease were diabetes mellitus in ASET Japan, and age and male gender in Brazil. ConclusionsThere was geographic disparity in pre-procedural angiography-based pathophysiological characteristics. The combined pre-procedural physiological assessment of vessel μQFR and diffuseness of CAD may potentially identify patients who will benefit most from PCI.

Pattern of Coronary Artery Disease in Young Patients with Acute Coronary Syndrome

Background: Coronary artery disease (CAD), historically considered a malady of the elderly, has increasingly emerged as a significant health concern among young adults, including individuals in their third or fourth decade of life. Objective: The primary aim of the study is to identify the pattern of coronary artery disease in young patients with acute coronary syndrome (ACS). Methods: This retrospective observational study was conducted at a tertiary cardiac care center in Rawalpindi from July 2023 to November 2023. The study included a cohort of 180 young patients aged less than 45 years who were diagnosed with ACS. These patients were identified from medical records and databases over a defined time period. Detailed demographic data, including age, gender, and pertinent medical history, were extracted from the medical records of each patient. This information facilitated a comprehensive understanding of the patient population under investigation. Results: Data were collected from 180 patients. The analysis of clinical profiles and demographics revealed a diverse patient population. The study cohort comprised individuals with a mean age of 39 years. Male patients predominated, constituting approximately 65% of the cohort. Among the study participants, 40% had a documented history of smoking, while 20% reported a family history of CAD. Hypertension was the most prevalent risk factor, affecting nearly 50% of the patients, followed by hyperlipidemia (30%) and diabetes (20%). Conclusion: It is concluded that coronary artery disease (CAD) is not confined to older age groups but can significantly impact young individuals aged less than 45 years presenting with acute coronary syndrome (ACS). The prevalence of traditional risk factors and genetic predisposition among these patients underscores the multifactorial nature of CAD in this demographic.

Pattern of coronary artery disease in Non-ST-Elevation myocardial infarction patients in diabetic and non-diabetic patients.

Objective: To compare the coronary artery disease pattern in patients with and without diabetes presenting with Non-ST-Elevation Myocardial Infarction (NSTEMI). Study Design: Retrospective, Hospital Based, Observational Comparative study. Setting: Punjab Institute of Cardiology, Lahore. Period: January 2022 to December 2022. Material &amp; Methods: 180 Non-ST-Elevation Myocardial Infarction (NSTEMI) patients who were separated into two groups on the basis of Diabetes mellitus being absent or present and each group comprised of 90 individuals. All data was analyzed, and comparison was made among the two study groups. Results: Hypertension and smoking status was found to have significant differences among the two study groups. Significant number of individuals in the diabetic group were found to be smokers (46.6 % vs. 31.1 %; p = 0.03). The commonest risk factor in the diabetic group was noted to be hypertension. Single vessel disease was found to be significantly higher in the non-diabetic group in comparison with the diabetic group (25.5% vs 11.1%; p = 0.01) whereas diabetics showed significantly higher number of multivessel disease individuals. Coronary artery disease was more severe in the patients with Diabetes mellitus and grade was significantly higher along with LM being affected at a significantly greater rate in diabetic patients. Conclusion: Non-ST-Elevation Myocardial Infarction (NSTEMI) patients presented with Diabetes are more likely to have extensive and more severe coronary artery disease than the non-diabetic individuals.

Does the pre-procedural pathophysiological pattern impact post-procedural hemodynamic outcomes and vessel prognosis in multivessel coronary artery disease?

Abstract Aim The pathophysiological pattern of coronary artery disease (CAD) pre-procedure may affect the physiological response to percutaneous coronary intervention (PCI). The aim of this study was to evaluate whether the pathophysiological pattern of CAD, derived from virtual pullbacks of angiography-based fractional flow reserve, impacted the immediate hemodynamic outcome post-PCI. Methods and results Among 503 consecutive patients with chronic coronary syndrome and non-ST elevated acute coronary syndrome treated at least 1 vessel in the Multivessel TALENT trial, 826 quantitative flow ratio (QFR) analysable vessels were enrolled. Pre-procedural pathophysiological patterns in CAD were characterized by the physiological distribution and local severity of coronary atherosclerosis using QFR-derived indexes acquired from pre-PCI angiograms. The physiological distribution of CAD was defined as "predominant diffuse" or "focal" according to a QFR pullback pressure gradient (PPG) index &amp;lt;0.78 and ≥0.78, respectively. Physiological local severity was assessed using QFR gradient per 1 mm (dQFR/ds), with a value ≥ 0.025/mm defining the presence of a "major gradient". The optimal post-PCI QFR value was defined as QFR ≥0.91. Among the 826 vessels, 673 vessels were analysed (excluding vessels which have total occlusions, ostial lesions, and paired QFR not analysable). Mean pre-PCI PPG index was 0.70 with a nadir in the distribution curve. As per the definition, "focal" lesions were 30% of the total analysed vessels and 88% had a "major gradient". The majority of the vessels belong to predominantly diffuse disease with a major gradient (62.7%, Figure 1). Compared to predominantly focal disease with a major gradient, predominantly diffuse disease had a higher risk of a post-PCI QFR &amp;lt;0.91 (OR 1.78, 95%CI 1.23-2.58). The scatterplot between pre-procedural PPGI and post-procedural QFR showed positive correlation (Piason’s R=0.163, p&amp;lt;0.001, Figure 2). The correlation suggested that the vessels with focal lesions more frequently achieved optimal post-PCI QFR values compared to that with diffuse lesions. In multivariable analysis, low QFR PPG index (diffuse disease) was an independent factor for predicting a post-PCI QFR&amp;lt;0.91 (per 0.1 decreases of QFR PPG index, OR:10.3, 95% CI 1.7-63.3, p=0.012). The estimated 2-year VOCE, the powered secondary endpoint of this study, estimated by the post-QFR is 5.9% in treated vessels with predominant diffuse lesion, while 4.9% in that with predominant focal lesion based on the previous substudy of SYNTAX II trial.[1] Conclusions A physiological pattern of diffuse CAD pre-procedure was an independent factor in predicting an unfavourable immediate hemodynamic outcome post-PCI. Pre-procedural PPG index can be the predictor of not only post-PCI physiological value but also vessel base prognosis.pre-PCI pathophysiological patternScatterplot and correlation

Association between pre-procedural pathophysiological pattern of coronary disease and immediate hemodynamic outcome post-percutaneous coronary intervention

Abstract Background The pathophysiological pattern of coronary artery disease (CAD) pre-procedure may affect the physiological response to percutaneous coronary intervention (PCI). Purpose The aim of this study was to evaluate whether the pathophysiological pattern of CAD, derived from virtual pullbacks of angiography-based fractional flow reserve, was predictive of the immediate hemodynamic outcome post-PCI. Methods Data from 206 patients with chronic coronary syndrome enrolled in the ASET (Acetyl Salicylic Elimination Trial) JAPAN study were analyzed. The ASET JAPAN study is a multi-center, single-arm, open-label, proof-of-concept trial to demonstrate the feasibility and safety of "aspirin-free" therapy with low-dose prasugrel (3.75 mg) monotherapy following PCI, Pre-procedural pathophysiological patterns in CAD were characterized by the physiological distribution and local severity of coronary atherosclerosis using Murray law-based quantitative flow ratio (µQFR)-derived indexes acquired from pre-PCI angiograms. The physiological distribution of CAD was defined as "predominant diffuse" or "focal" according to a µQFR pullback pressure gradient (PPG) index &amp;lt;0.78 or ≥0.78, respectively. Physiological local severity was assessed using µQFR gradient per 1 mm (dµQFR/ds), with a value ≥ 0.025/mm defining the presence of a "major gradient". The statistical association of preprocedural pathophysiological pattern of CAD with post-PCI µQFR &amp;lt;0.91 was investigated. Results Out of 207 vessels, 26.6% (n=55) were classified as predominantly focal (µQFR PPG index ≥0.78) with a major gradient (dµQFR/ds ≥0.025/mm, Group 1), 1.0% (n=2) predominantly focal without a major gradient (Group 2), 53.6% (n=111) predominantly diffuse (µQFR PPG index &amp;lt;0.78) with a major gradient (Group 3), and 18.8% (n=39) predominantly diffuse with no major gradient (Group 4)(Figure 1). Vessels with predominantly diffuse disease and no major gradient (Group 4) had significantly higher pre-PCI µQFR (mean difference, -0.163; 95%CI, -0.211 to -0.118) and lower post-PCI µQFR (mean difference, 0.031; 95% CI, 0.014 to 0.487; by bootstrapping using 2000 replications) than those with predominantly focal disease and major gradients (Group 1). Low pre-PCI µQFR values were significantly associated with an increased risk of a post-PCI µQFR &amp;lt;0.91 (Figure 2A). Similarly, low µQFR PPG index showed a significantly higher risk of a post-PCI µQFR &amp;lt;0.91 (Figure 2B). The highest dµQFR/ds had no significant impact on the risk of a post-PCI µQFR &amp;lt;0.91 (Figure 2C). In multivariable analysis, low µQFR PPG index (diffuse disease) was an independent factor for predicting a post-PCI µQFR &amp;lt;0.91 (per 0.1 decrease of µQFR PPG index, OR:1.68, 95% CI 1.17-2.46, p=0.005). Conclusions A physiological pattern of diffuse CAD pre-procedure was an independent factor in predicting an unfavorable immediate hemodynamic outcome post-PCI.

TCT-271 Characterizing Pathophysiological Patterns of Coronary Artery Disease Among Individuals With Elevated Lipoprotein(a)

TCT-271 Characterizing Pathophysiological Patterns of Coronary Artery Disease Among Individuals With Elevated Lipoprotein(a)

TCT-440 Physiological Patterns of Coronary Artery Disease and Percutaneous Coronary Intervention With Bioresorbable Vascular Scaffolds

TCT-440 Physiological Patterns of Coronary Artery Disease and Percutaneous Coronary Intervention With Bioresorbable Vascular Scaffolds

Clinical and Angiographic Profile of Patients with Coronary Artery disease among Nigerians and Indians

Background: Coronary Artery Disease (CAD) in young and old individuals represents a special subsets that clinical profile and angiographic findings are different from older population. Better understanding of CAD in these groups of population would lead to further improvement in prevention and management. However, there are no data regarding coronary artery disease in Nigerian and Indian population. So this study was aimed to analyze the clinical profile and angiographic pattern of coronary artery disease among Nigerian and Indian patients.

A prospective observational study based on angiographic profile in coronary artery disease patients with coronary intervention

Background: An enlargement of the coronary artery that restricts optimal blood flow to the heart tissue is called coronary artery disease. The most common cause is arteriosclerosis. Platelet aggregation inhibition is the mainstay of primary and secondary prevention of ischemic events associated with coronary artery atherosclerosis.&#x0D; Objective: Study of the angiographic profile of patients with coronary artery disease undergoing percutaneous coronary intervention, coronary artery bypass graft and medical management.&#x0D; Methods: This prospective observational study included all patients who underwent PCI, CABG and medical treatment at a tertiary hospital between August 2021 and February 2022. Demographic and angiographic data were collected for all patients. The details of the procedure, clinical symptoms, comorbidities, diagnostic tests such as coronary angiography, 2D echocardiography, and treatment, including anticoagulant therapy, of these patients were reviewed.&#x0D; Results and discussion: A total of 100 patients (mean age - 58 years) with 71% males and 29% females were included in the study. Hypertension and Diabetes were the most common risk factors, present in 60% and 35% patients respectively. Smokers were observed in 16% patients respectively. Single vessel disease (SVD) was most common angiographic pattern, observed in 57% patients. Anterior wall MI was the most common mode of presentation (75%). Chest Pain was most common symptom, observed in 95% patients; PTCA was the most frequently employed procedure (71%) followed by CABG (10%) and Medical Management (19%); and Among 100 patients in 2DEcho Mild LV Dysfunction (Grade-1) were most prevalent (32%). The most commonly affected vessel was the right coronary artery (RCA) (51%). Drug-eluting stents were used in 71% of cases. Out of 100 patients, 51 patients received 1 stent and 20 patients received 2 stents.&#x0D; Conclusion: This prospective study of percutaneous coronary intervention provides insight into the patterns of coronary artery disease with angiographic features. Our aim was to profile patients undergoing percutaneous coronary intervention to alleviate symptoms and improve survival in patients with coronary artery disease

Modes of Presentation and Patterns of Coronary Artery Disease in Patients Undergoing Percutaneous Intervention at Birat Medical College Teaching Hospital

Background and Aims: Percutaneous coronary interventions have been provided in various hospitals of Nepal for more than two decades. Hence, we aimed to study the percutaneous coronary intervention revascularization status in patients with coronary artery disease at a tertiary center of eastern Nepal.&#x0D; Methods: A cross sectional study was conducted at Birat Medical College Teaching Hospital from 1st Aug to 30th Feb 2023. Ninety seven coronary artery disease patients (Unstable angina, Non ST elevated Myocardial Infarction ST elevated Myocardial Infarction and Stable Angina) requiring percutaneous coronary interventions were enrolled. Patient socio-demography and findings of percutaneous coronary intervention were recorded, entered in Microsoft Excel and analyzed by SPSS 23.&#x0D; Results: Majority 30(31.3%) had unstable angina. Left main coronary artery was normal in all patients. Severe stenosis was found in 58(59.7%) of left anterior descending artery, 32(32.9%) of right coronary artery and 29(29.8%) of left circumflex artery. Total occlusion was found in 10(10.3%) of left anterior descending artery, 8(8.2%) of right coronary artery and 6(6.2%) of left circumflex artery. Majority 68(70.1%) of patients had elective percutaneous coronary intervention.&#x0D; Conclusion: The most common mode of presentation of coronary artery disease was unstable angina and majority have severe stenosis. The preferred intervention was elective percutaneous coronary intervention.

CORONARY ARTERY DISEASE IN YOUNG PAKISTANIS: RISK FACTORS AND PATTERN OF DISEASE

Objectives: To determine the distribution of risk factors and pattern of coronary artery disease among young Pakistanis presenting with acute coronary artery syndrome. A cross sectional study conducted from August 2018 to October 2019 at Department of Cardiology Jinnah Hospital Lahore.&#x0D; Methodology: Total of 150 young patients up to 40 years of age with acute coronary syndrome (ACS) was included in this study. Risk factors were evaluated on patient’s current medication history for diabetes mellitus, hypertension, lipid lowering drugs and recent reports HbA1c, total body lipids. Data was entered and analyzed in SPSS version 21.0. Socio-demographic, clinical profile and risk factors were evaluated and presented as frequency and percentages. Cross tabulation was for ACS and risk factors. Statistical significance was assessed using Chi-square test with significant value of p &lt; 0.05.&#x0D; Results: Among 150 subjects mean age was 34.20 + 4.246 with minimum age of 23 years and maximum age of 39 years. 92.0 % were male and 56.0% were having acute anterior wall STEMI, 36.0% had acute inferior Wall STEMI, 2.0% suffered from acute lateral wall STEMI, 2.7% had acute inferoposterior wall STEMI and 3.3% had NSTE-ACS. Risk factor analysis shows that 22.0% had diabetes mellitus, 20.7% had hypertension, 33.7% had a positive history of IHD in family, 71.3% were smokers, 44.0% had obesity, 66.0% had reduced HDL and 44.0 % had elevated LDL levels. Regarding pattern of coronary artery disease, 70.7% patients were having one vessel CAD, 28.0% two vessels CAD and 1.3% had three vessels CAD.&#x0D; Conclusion: Mean age of acute coronary syndrome is low amongst young Pakistani population with male predominance and acute anterior and inferior wall STEMI being most frequent diagnosis. Smoking, dyslipidemia particularly low HDL, positive family history of ischemic heart disease, hypertension, diabetes mellitus, obesity, was identified as important risk factors. Most of the patients had one vessel CAD.

Glomerular hyperfiltration: An independent risk factor and predictor of advanced coronary artery disease.

Objective: To determine frequency and patterns of coronary artery disease in patients with glomerular hyper filtration (GHF), presented with acute coronary syndrome (ACS). Study Design: Cross Sectional, Retrospective study. Setting: Tertiary Healthcare Centre, Karachi. Period: July 2018 to July 2021. Material &amp; Methods: Twelve hundred and sixty seven patients undergone Coronary angiography (CAG) for ACS having estimated glomerular filtration rate (eGFR) calculated through Cockcroft-Gault equation &gt;90ml/min were selected. They were divided into two groups on the basis of eGFR, group A with normal eGFR (90-120ml/min) and B with eGFR i-e &gt;120ml/min with glomerular hyper filtration (GHF). Variables like age, gender, BMI, Diabetes mellitus (DM), Hypertension, Smoking, history of previous cardiovascular diseases (CVD) and family history of CVD and obesity were studied. Findings of CAG results from Cath lab were also noted down. All the relevant data was analyzed through SPSS 16. Results: Out of 1267 patients 807 patients had normal eGFR and 460 had GHF. Mean age in two groups was 45± 8.5years and 45.6± 7.8years, mean eGFR 102ml/min and 146ml/min and mean B.P was 110/80 and 135/90 mmHg respectively. Association of GHF with younger age, mean B.P, BMI, and family history of obesity was significant P value &lt;0.05. Patients with GHF had significant Coronary artery disease (CAD) P-0.036. Patients with eGFR between 145-175ml/mid had worst angiographic results, 80% of those had CAD. Conclusion: GHF has strong association with CVD and is a predictor of severity of disease.

Angiographic patterns of coronary artery disease in young patients presenting at a tertiary cardiac center.

To compare the patterns of coronary artery disease (CAD) between young adults ≤35 years of age and patients >35 years of age. The observational retrospective study was carried out in angiography department of emergency at Punjab Institute of Cardiology, Lahore between January 2020 and October 2020. Patients ≤35 years old were in Group-I whereas patients >35 years who served as controls were in Group-II. Patients with unstable angina, non-ST and ST elevation MI all were included. The patients with previous history of CAD (CABG/PCI) and angiography done for other purposes i.e., before valvular surgery or PPM implantation were excluded. Out of 1268 patients, 552 were in Group-I and 716 were in Group-II. The prevalence of normal coronaries/ mild CAD was higher in Group-I i.e., 224(40.6%) than in Group-II i.e., 64 (8.9%). Single vessel disease (SVD) was comparable in both the groups 185 (33.5%) vs. 216 (30.2%). Double vessel disease and triple vessel disease (TVD) was common in Group-II and left main stem (LMS) involvement was also significantly higher in Group-II i.e., 32 (4.5%) vs. 8 (1.4%). Clot in coronary arteries with or without underlying CAD was seen more frequently in Group-I, 61(11.1%) vs. 34 (4.7%). Presence of clot was seen mostly in those patients who had moderate coronary artery disease. Young patients have different coronary artery disease patterns, so the management strategy must be different in this population. Majority of the young patients have non severe disease. Clot formation is commonly seen in young adults with moderate CAD.

Comparison of Patterns of Coronary Artery Disease in Patients With Heart Failure by Cardiac Sarcoidosis Status

Comparison of Patterns of Coronary Artery Disease in Patients With Heart Failure by Cardiac Sarcoidosis Status

Coronary Artery Disease Patterns in Diabetic Patients

Coronary Artery Disease Patterns in Diabetic Patients

Discordance in the Pattern of Coronary Artery Disease Between Resting and Hyperemic Conditions.

Discordance in the Pattern of Coronary Artery Disease Between Resting and Hyperemic Conditions.

Outcomes of Coronary Artery Disease Patients with Severe Left Ventricular Dysfunction Undergoing Surgical Management.

Surgical revascularization by coronary artery bypass grafting (CABG) is the gold standard treatment for coronary artery disease. But, in patients with severe left ventricular dysfunction (ischemic cardiomyopathy), the result of CABG is different from those with normal left ventricular function. The coronary artery disease pattern in the Indian subconti-nent is different from the western world, due to the diffuse nature of coronary involvement, the smaller size of native vessels, increased prevalence of diabetes mellitus and other risk factors, and more prevalence of severe left ventricular dysfunction. Most of the studies regarding the surgical outcomes in ischemic cardiomyopathy come from western countries. This study attempts to assess the outcomes of surgical management of ischemic cardiomyopathy in the Indian subcontinent. A single-center retrospective cohort study was conducted at Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram. The data of CAD pa-tients, who underwent surgical coronary revascularization for severe LV dysfunction from January 2010 to December 2014, were collected from the hospital records and through tele-phonic interviews in a structured study proforma. A total of 146 patients satisfied the criteria and were followed up for a period of 5 years. The mean age of the study population was 55.6 (8.8) years. Male preponderance was observed (94.52%; N = 138). CABG alone was done in 62.3% (N = 91) of the study partici-pants. CABG with linear plication was done in 23.3% (N = 34), CABG with MV repair in 7.5% (N = 11), and CABG with DORS in 6.8% (N = 10). The majority of patients (N = 54, 37%) received 4 grafts. Thirty-day mortality observed in the study population was 11 (7.5%). The causes documented were cardiac causes in 9 (82%), cerebrovascular events in one (9%), and septicemia in one (9%). The mean of 5-year survival of the study population was 94.2 (3.5) months with 95% CI 87.32, 101.13. There was a substantial improvement in the degree of mitral regurgitation. Ejection fraction (EF) also showed improvement. The mean preoperative EF was 29.51 (4.84%) and that of post-op was 39.92 (9.0%). Despite the challenges of diffusely diseased coronary arteries, severe LV dysfunction, addressing associated significant MR and ventricular aneurysms, the outcome of surgical management of CAD with severe LV dysfunction, in the Indian population can be done with acceptable results. Randomized control studies in this subset can provide more solid evidence in this regard.

CRT-100.85 Comparison of Patterns of Coronary Artery Disease in Patients With Heart Failure by Cardiac Sarcoidosis Status

CRT-100.85 Comparison of Patterns of Coronary Artery Disease in Patients With Heart Failure by Cardiac Sarcoidosis Status