You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Female Incontinence - Therapy I1 Apr 2015PD27-12 MIRABEGRON DOES NOT DECREASE URINARY NEUROTROPHINS' LEVELS IN OVERACTIVE BLADDER PATIENTS DESPITE SYMPTOMATIC IMPROVEMENT Tiago Antunes-Lopes, Ana Ferreira, Carvalho-Barros Sérgio, Daniel Costa, Rui Pinto, João Silva, Silva Carlos, and Francisco Cruz Tiago Antunes-LopesTiago Antunes-Lopes More articles by this author , Ana FerreiraAna Ferreira More articles by this author , Carvalho-Barros SérgioCarvalho-Barros Sérgio More articles by this author , Daniel CostaDaniel Costa More articles by this author , Rui PintoRui Pinto More articles by this author , João SilvaJoão Silva More articles by this author , Silva CarlosSilva Carlos More articles by this author , and Francisco CruzFrancisco Cruz More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.456AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Neurotrophins play a role in sensory neuron sensitization. High levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were measured in the urine of OAB patients, and decreased after successful treatment with antimuscarinics. Mirabegron, a β3-adrenoceptor agonist recently approved for OAB, has a distinct mechanism of action. In this study we investigated, for the first time, urinary levels of NGF and BDNF in OAB patients treated with mirabegron. METHODS Twenty-two female OAB patients were enrolled. Those medicated with antimuscarinics and not satisfied with the treatment completed a washout period of 4 weeks. A group of 15 women without LUTS was used as control. At baseline urine samples were collected from all participants. Simultaneously, King's Health (KHQ) and Patient Perception of Bladder Condition (PPBC) questionnaires were completed. OAB patients were treated with mirabegron 50 mg once daily and reevaluated at 4 and 12 weeks. At these time points, urine sampling and completion of the same questionnaires were carried out. Urine samples were processed for ELISA analysis of NGF and BDNF and the values were normalized against creatinine (Cr) concentration. Neurotrophin concentration values were logarithmized to improve distribution characteristics. RESULTS At baseline, urinary NGF/Cr and BDNF/Cr were significantly higher in OAB patients compared to healthy controls (NGF/Cr: 3.3±0.6 vs. 2.4±0.5, p<0.01; BDNF/Cr: 2.9±0.5 vs. 2.6±0.4, p=0.028). After treatment with mirabegron there was a decrease in urinary NGF/Cr and BDNF/Cr, which however did not reach statistical significance. Eighteen out of 22 patients reported marked symptomatic improvement, reflected in the variations of KHQ and PPBC scores. Data are summarized in the table. CONCLUSIONS Mirabegron does not change urinary neurotrophins' levels in OAB patients, despite symptomatic improvement. A possible explanation for this finding might be the fact that mirabegron primarily acts on bladder smooth muscle, with a reduced effect on the urothelium, which is believed to release most of urinary neutrophins. Actually, up to now, functional β3-adrenoceptors have not been demonstrated in the human urothelium. Baseline (n=22) 4 weeks (n=21) p 12 weeks (n=20) p NGF/Cr pg/mg 3.3 ± 0.6 3.2 ± 0.5 >0.05 3.0 ± 0.8 >0.05 BDNF/Cr pg/mg 2.9 ± 0.5 2.7 ± 0.6 >0.05 2.7 ± 0.5 >0.05 PPBC Severity scale: 1 – 6 3.6 ± 0.9 2.4 ± 1.0 <0.05 2.4 ± 1.4 <0.05 Data is expressed as the mean ± standard deviation. Higher PPBC score indicates more severe bladder problems © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e576 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Tiago Antunes-Lopes More articles by this author Ana Ferreira More articles by this author Carvalho-Barros Sérgio More articles by this author Daniel Costa More articles by this author Rui Pinto More articles by this author João Silva More articles by this author Silva Carlos More articles by this author Francisco Cruz More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...