Pathology Of Pneumonia Research Articles

Pathological and molecular investigations on post-mortem lung samples of goats from Akola region, India

Pneumonia is one of the important causes of morbidity and mortality in caprines. Although bacterial organisms play important role in the pathology of pneumonia in goats, it has a multifactorial etiology. In the present investigation 480 goat carcasses in Akola, Maharashtra, India, were examined during April to December 2022, for pneumonic lesions and the occurrence was found to be 6.66% (32/480). Pathological and molecular studies were conducted on pneumonic lungs of goat carcasses, these pneumonic lung samples revealed gross lesions like hepatization, consolidation, congestion, and bronchial froth. Histopathologically, pneumonia was categorized as bronchopneumonia (59.375%, 19/32), interstitial pneumonia (28.125%, 9/32), bronchointerstitial pneumonia (9.375%, 3/32), and hydatidosis (3.125%, 1/32). Bronchopneumonia was further subtyped into suppurative (acute) bronchopneumonia (34.375%, 11/32), chronic bronchopneumonia (15.625%, 5/32) and fibrinous bronchopneumonia (9.375%, 3/32). PCR assays identified Mycoplasma spp. (40.62%), C. pseudotuberculosis (9.37%), P. multocida (21.87%), and M. haemolytica (25%) as bacterial etiologies. This study provides novel insights into the occurrence, histopathological classification, and associated bacterial causes of goat pneumonia in the Akola region.

Effect of Poor Nutritional Status and Comorbidities on the Occurrence and Outcome of Pneumonia in Elderly Adults.

Background: Malnutrition and comorbidity are two common geriatric syndromes. The pathology of pneumonia is multifactorial, making its diagnosis and management a great challenge. Hospital-acquired pneumonia (HAP) and community-acquired pneumonia (CAP) are two main types of pneumonia. However, the effect of geriatric syndromes on pneumonia and its prognosis have not been clearly explored.Methods: We collected the relevant electronic data of inpatients aged over 65 years and diagnosed with pneumonia in the Geriatrics Department Building of the First Affiliated Hospital with Nanjing Medical University between December 2018 and December 2019, and further divided them into HAP group and CAP group. The correlations of age, age-adjusted Charlson Comorbidity Index (aCCI), basic diseases and nutritional indexes (i.e., albumin, electrolyte, hemoglobin) with pneumonia and prognosis were analyzed. We analyzed the associations between infection prognosis/infection level and age, nutritional status, aCCI and underlying diseases, using linear regression model. The box plot was applied to present infection outcome, and the nomogram was built for predicting infection outcomes. We utilized the heat map to show the associations between nutritional status and infection level/outcome in all infected patients, HAP, and CAP.Results: The final study comprised samples of 669 pneumonia patients divided into HAP group (n = 517) and CAP group (n = 152). In all patients, the infection outcome was negatively correlated with age (P = 0.013). The level of albumin was negatively correlated with infection prognosis in all patients (P = 0.03), and negatively correlated with neutrophil count and CRP (P = 0.008, P < 0.001). ACCI was positively correlated with CRP (P = 0.003). The prognosis was negatively associated with age and albumin level. In the patients with basic dementia/Alzheimer's disease and chronic obstructive pulmonary disease/asthma, the prognosis was worse.Conclusion: There was a correlation between poor nutritional status-related indexes and inflammatory indexes. A poor nutritional status might predict a high risk of pneumonia in elderly adults. Advanced age and comorbidities were risk factors for the occurrence and poor prognosis of pneumonia. Therefore, comorbidities should be well-treated in the elderly with pneumonia.

Mothers Awareness of Pneumonia and the Toddler Breastfeeding Duration Affect Pneumonia Incidence

This study aims to determine the relationship between the mother's level of awareness about the pathology of pneumonia and the duration of breastfeeding under five with the incidence of pneumonia in DR. M.A. Hospital Hanafiah. This research is a retrospective analytic descriptive study with a cross-sectional design. The results showed that mothers' awareness of pneumonia was lower by 71.8%, they breastfed their babies for less than six months (71.8%), and more than two-thirds of children under five (76.9%) were diagnosed with pneumonia. Furthermore, statistical analysis significantly correlated the mothers' awareness of pneumonia and the duration of breastfeeding they performed on their children with pneumonia. The conclusion is that the mother's understanding of pneumonia has a linear effect on the incidence of pneumonia in infants and toddlers. The duration of breastfeeding has a significant impact. We assume that non-exclusive breastfeeding in infants stimulates underweight and immunological disorders that accelerate the incidence of pneumonia.&#x0D; &#x0D; Keywords: Mother's Awareness, Length of Breastfeeding, Toddler Pneumonia

Incidental findings of pathological significance in pneumonic lungs of sheep in Al Qassim Area, Kingdom of Saudi Arabia: an abattoir survey

A total of 1425 ovine lungs were grossly examined at the local abattoir during a 6-month survey on the aetiology and pathology of pneumonia in slaughtered sheep at the Al-Qassim region, Kingdom of Saudi Arabia. The results of the survey demonstrated the occurrence of several types of pneumonic and related lesions in 140 specimens of condemned lungs. However, more detailed microscopic examination of the pneumonic lungs incidentally revealed the coexistence of some other significant pathological alterations indicative of sheep pulmonary adenomatosis (Jaagziekte), ovine syncytial virus infection, ovine progressive pneumonia (maedi) and verminous pneumonia. In addition, pulmonary corpora amylacea (PCA) were also detected in the bronchial lumen of some pneumonic lungs initially diagnosed as fibrinous pneumonia. It is worth mentioning that none of the abovementioned cases was previously recognized or diagnosed in the Al-Qassim region or in any other parts of the Saudi Kingdom.

The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus.

Mice were infected intranasally with a serotype 2 pneumococcus, a pneumolysin-negative derivative (PLN-A), or an autolysin-negative derivative (AL-2). Numbers of wild type pneumococci were seen in the lung from approximately 12 h after infection and were first detected in the blood around this time. Immunofluorescent staining of lung sections showed that pneumolysin was produced in vivo. Pneumococcal infection resulted in alteration of the composition of the blood but not the bone marrow. Some of the hematologic changes did not occur after PLN-A. PLN-A had a slower growth rate in the lung and bacteremia was delayed. AL-2 was rapidly cleared from the lungs and was not detected in the blood. These events paralleled the pattern of histology in the lung, with the severity of inflammation reduced with PLN-A and no inflammation or hematologic changes with AL-2.

The Pathology of Pneumonia in Young Lambs Inoculated with Bedsonia

Neonatal lambs were inoculated intratracheally with a strain of Bedsonia (Chlamydia) isolated from a case of ovine atypical pneumonia and were examined 3, 5, 9 and 12 days after inoculation. Clinical signs included a marked rise in temperature, dyspnoea and anorexia. One lamb died 5 days after inoculation. Macroscopic lesions of pneumonia were present in each of the Bedsonia-inoculated lambs. In lambs killed 3 and 5 days after inoculation the histological lung lesions were characterized by foci of necrosis and a sero-cellular exudate in alveoli and bronchioles. The principal lesions in lambs killed 9 and 12 days after inoculation were hyperplasia of the bronchiolar epithelium, pseudo-epithelialization and epithelialization of alveoli and infiltration of the interalveolar septa by macrophages and lymphocytes. Elementary bodies were demonstrated in cryostat sections of lung from each of the infected lambs and Bedsonia organisms were recovered from their lungs. Two control lambs inoculated with Bedsonia-free yolk sac suspension and killed 4 and 9 days later remained healthy. No macroscopic or histological lesions of pneumonia were observed, nor were elementary bodies demonstrated or Bedsonia recovered from their lungs.

Some observations on the pathology of pneumonia of pigs in Kenya.

Some observations on the pathology of pneumonia of pigs in Kenya.

Pathology of pneumonia in intensively-reared calves

During an investigation of pneumonia in intensively-reared calves two morphologically distinct types of pneumonia were encountered. Of 9 cases in the first group 6 had lesions resembling inclusion body pneumonia of calves which, by their histopathological appearance, were considered to be due to parainfluenza 3 virus. The second group consisted of 27 animals and resembled “cuffing” pneumonia of calves. The possibility that this condition was the sequel to a previous bronchopneumonia is discussed.

The Pathology of Pneumonia

The Pathology of Pneumonia

The Croonian Lectures on the Natural History and Pathology of Pneumonia

The Croonian Lectures on the Natural History and Pathology of Pneumonia

The Croonian Lectures on the Natural History and Pathology of Pneumonia

The Croonian Lectures on the Natural History and Pathology of Pneumonia

The Croonian Lectures on the Natural History and Pathology of Pneumonia

The Croonian Lectures on the Natural History and Pathology of Pneumonia

The Croonian Lectures on the Natural History and Pathology of Pneumonia

The Croonian Lectures on the Natural History and Pathology of Pneumonia