We describe a patient who had both a left ventricular myxoma and left ventricular hypertrophy; the myxoma was subsequently excised and revealed to produce interleukin-6. The combination of left ventricular myxoma and ventricular hypertrophy is uncommon. Interleukin-6 secreted from the myxoma may be an important factor in the pathogenesis of ventricular hypertrophy in this patient.