Background: Data regarding relative readmission rates following endovascular and surgical revascularization for chronic limb threatening ischemia (CLTI) are conflicting. Understanding comparative readmission rates may inform selection of the most appropriate revascularization modality for these patients. Research Question: What are the differences in 30-day readmission rates between endovascular and surgical interventions for CLTI? Methods: The 2012 to 2021 American College of Surgeons National Surgical Quality Improvement Program's (NSQIP) Targeted Vascular Module was used to identify patients discharged alive after surgical or endovascular revascularization for CLTI. The primary outcome was 30-day readmission following the index procedure; secondary outcomes included survival, major re-intervention of the treated arterial segment, amputation, untreated loss of patency of bypass graft, bleeding requiring transfusion or re-intervention, major adverse cardiovascular events (MACE) and major adverse limb events (MALE). Revascularization modality was related to 30-day readmission using multivariable logistic regression. Results: We identified 30,390 patients (mean age 69±11.5 years, male 62.8%, mean BMI 26.9±8.1 kg/m 2 , 61% Caucasian, 20.2% Black). When compared with endovascular therapy, surgical bypass was associated with higher 30-day readmission (13.3% vs. 8.6%, p = <0.001). After adjusting for demographic, clinical, procedural variables and year of publication, surgical revascularization was independently associated with higher 30-day readmission rates (OR 1.53 95% CI [1.36, 1.71]; p<0.001), mortality and major reintervention rates (Figure). Conclusion: Surgical revascularization was independently associated with higher 30-day readmission rates when compared to endovascular revascularization for patients with CLTI.