A tuned liquid column damper (TLCD) is widely used in offshore structures as a passive energy dissipation device to reduce the harm of wind, wave, and current loads to the safety of offshore platforms. This investigation explores the dynamic response and interaction mechanism of a photovoltaic support structural platform (SSP) equipped with a TLCD by experimental and numerical analysis. The vibration mitigation performance of the TLCD under varying liquid depth ratios, external excitation frequencies, and amplitudes is systematically evaluated. The experiments focus on assessing the structural dynamic response and wall pressure to determine the vibration reduction efficiency of the TLCD for structures with fundamental frequencies more than 2 Hz. The experimental results indicate that the TLCD can reduce the structural response maximally near the natural frequency (2.52 Hz) of the structure, with vibration reduction effectiveness ranging from 42.0% to 85.1%. Additionally, one develops a two-way fluid-structure interaction (FSI) model to investigate further the impact of hydrodynamic pressure caused by sloshing inside the TLCD on the SSP motion response, which providing a more detailed explanation for the different phenomena observed in the experimental results.