Introduction. Recent years have been a challenge for the Ukrainian economy. The full-scale war caused significant destruction, interrupted production chains and led to massive migration of the population. In such circumstances, the issues of economic recovery and increasing its competitiveness are particularly acute. The cluster approach, as a proven tool for economic development, can be an effective mechanism for overcoming the consequences of war and ensuring sustainable growth. In the developed countries of the world, there is an increase in cluster formations, where the organizational and functional structures do not change, but the process of joint interaction intensifies, which creates favorable conditions for the development of cluster partnerships based on integrated and quasi-integrated relationships and the economy of the territories where they are based. Problem Statement. The effectiveness of cluster partnerships has been proven theoretically by foreign scientists and confirmed by foreign examples. However, modern approaches to the development of cluster partnership systems of the national economy and the implementation of cluster policy in Ukraine do not consider military consequences, the specifics of the territories, the features of cluster partnership as a network interaction of integrated and quasi-integrated business structures, government and scientific institutions, synergistic links between them, regional, sectoral and other aspects. The purpose is to study the features and formulate directions for ensuring the innovative development of the national economy based on the realization of the economic interests of participants in cluster partnership systems in the face of new challenges. Methods. The study used general scientific and special methods, in particular, description, analysis, theoretical generalization, synthesis. Results. The directions of state support for the innovative development of the national economy based on the realization of the interests of participants in cluster partnership systems, which are implemented by intensifying the policy of cluster partnership in the innovation sector and are an alternative option for the formation and support of initiatives in the implementation of innovative projects. A characteristic of cluster partnership systems is the acquisition of forms of mutual assistance through cooperation in the regulatory policy of innovative development of the country's economy. The private sector is responsible for increasing the amount of funding for the innovation process, directly implements and ensures the commercialization of innovations. The state, first of all, provides legislative, financial, and informational support, and undertakes the training of highly qualified personnel. Conclusions. State support is the driving force behind the development of cluster partnership systems, which are implemented through the intensification of cluster partnership policy in the innovation sector and is the only alternative option for the formation and support of initiatives in the implementation of innovative projects for the development of the national economy in the post-war period.