Partial Vision Research Articles

Purtscher retinopathy following isolated chest compression: a case report.

This case report describes the case of a 56-year-old man who developed Purtscher retinopathy following compressive chest trauma. During the tertiary survey, the patient was found to have a unilateral partial vision decline despite sustaining only mild rib fractures. The patient was diagnosed with a rare complication of Purtscher retinopathy. At a 2-week follow-up outpatient examination, improved visual acuity was observed. This case highlights the importance of conducting a tertiary survey not only on the directly impacted site, but also comprehensively across all sites, while attentively listening to and addressing the patient's complaints.

Future Strategies for Optic Nerve Protection and Repair

Disorders in the function of the optic nerve are defined as optic neuropathy. Etiologically, they can be classified into different groups including glaucomatous, inflammatory (infectious/demyelinating), traumatic, ischemic, infiltrative, toxic, and hereditary. Treatment approaches and disease prognoses vary significantly. Retinal ganglion cells lack the capacity for self-renewal and have limited self-repair capabilities; Therefore, optic neuropathies can lead to irreversible partial or complete vision loss by causing axonal damage and subsequent death of retinal ganglion cells. This review aims to discuss the known mechanisms and limitations of regeneration, as well as to summarize current approaches and future strategies for optic nerve neuroprotection and neuroregeneration.

Seasickness and partial peripheral vision obstruction with versus without an artificial horizon

Motion sickness (MS) is common when subjects are exposed to unfamiliar motion and affect individuals during travel. This study examines the immediate effect of two visual devices, in the form of glasses, on MS symptoms and associated physiological effects. The hypothesis is that peripheral vision obstruction reduces MS and that an additional beneficial effect could be observed when it is combined with an artificial horizon. Fifteen subjects with moderate to severe susceptibility to MS were exposed to a boat simulator in three conditions. Symptoms were assessed immediately after exposure. Time spent in the simulator, heart rate, and temperature were also recorded. The intensity of symptoms at the end of the experience did not differ, but time spent in the simulator before the onset of symptoms was significantly longer with peripheral vision obstruction (+36 %) and with both techniques combined (+40 %) than in the control condition. No difference was observed between the combined condition and peripheral vision obstruction alone. The glasses device used in this study (with or without an artificial horizon) delays the onset of symptoms. Further research is needed to confirm the mechanism that explains the benefits and to evaluate these effects during prolonged exposure to MS-inducing stimuli or after a period of familiarization with the device.

Lack of visual experience leads to severe distortions in the hand representation of the body model

This study investigates the impact of vision on the maintenance of hand representation in the implicit body model, particularly focusing on congenitally blind individuals. To address this, we performed a hand landmark localization task on blind individuals who lacked visual experience of their bodies and compared their performance to normally sighted and normally sighted but blindfolded participants. Through measurements of finger lengths, hand width, and shape index, we demonstrate that blind participants exhibit significantly greater distortions in their hand representation compared to sighted and blindfolded controls. Notably, blind individuals displayed a marked overestimation of hand width and an underestimation of finger lengths, particularly in digits D2, D3, and D4. Surprisingly, blind subjects with partial vision displayed more severe distortions than those with no residual vision. Furthermore, our findings reveal that late-blind participants exhibit similar levels of distortion as congenitally blind individuals, suggesting an extended period of susceptibility to the lack of visual input in shaping body representations. The Reverse Distortion (RD) hypothesis provides a plausible explanation for these distortions, suggesting that compensatory mechanisms occur within the body model to counteract the anisotropic cortical representations. Our results support this hypothesis: blind individuals have expanded cortical representations processing tactile information, so this could lead to more pronounced distortions in their hand representation of the body model. This underscores the importance of visual input in modulating body representations. Overall, our study highlights the malleability of body representations and the intricate interplay between sensory inputs and cortical processing in shaping the implicit body model.

Assistive products in pharmacy practice to optimize medications use for visually impaired patients: Focus groups to explore community pharmacists' opinions and expectations

BackgroundVisual impairment can significantly affect a person's ability to take medications safely. Therefore, pharmacists need to ensure safe and effective access to medication information, particularly through the use of assistive products, which are devices that compensate for partial or total vision loss. Although assistive products are used by visually impaired patients for activities of daily living, their use in medication management needs to be more widespread. ObjectiveThe study aimed to investigate community pharmacists' opinions and excpectations on the use of assistive products in pharmacy practice to optimize and secure medications use for visually impaired patients. The goal is to transfer these assistive products to pharmacy practice. MethodsFocus groups were conducted with 6 French-speaking community pharmacists via videoconference in Belgium, following the principle of participatory action-research. The participants were recruited voluntarily, and moderator's guides were developed to lead the discussion. The focus groups were recorded, transcribed verbatim, and analyzed in a double-blind fashion using thematic analysis. The data were organized by NVivo software. ResultsFour themes were identified: easy-to-use assistive products according to pharmacists, usefulness of assistive products in pharmacy practice, barriers to the use of assistive products, and potential solutions. According to community pharmacists, certain assistive products were deemed easy-to-use and transferable to pharmacy practice. ConclusionsThis qualitative study demonstrates the transferability of assistive products to pharmacy practice for visually impaired patients in medications use. The study taken into account the patient's profile and the multidisciplinary approach, which community pharmacists consider essential.

Amelioration of Fibrosis via S1P Inhibition Is Regulated by Inactivation of TGF-β and SPL Pathways in the Human Cornea.

Human corneal fibrosis can lead to opacity and ultimately partial or complete vision loss. Currently, corneal transplantation is the only treatment for severe corneal fibrosis and comes with the risk of rejection and donor shortages. Sphingolipids (SPLs) are known to modulate fibrosis in various tissues and organs, including the cornea. We previously reported that SPLs are tightly related to both, transforming growth factor beta (TGF-β) signaling and corneal fibrogenesis. The aim of this study was to investigate the effects of sphingosine-1-phosphate (S1P) and S1P inhibition on specific TGF-β and SPL family members in corneal fibrosis. Healthy human corneal fibroblasts (HCFs) were isolated and cultured in EMEM + FBS + VitC (construct medium) on 3D transwells for 4 weeks. The following treatments were prepared in a construct medium: 0.1 ng/mL TGF-β1 (β1), 1 μM sphingosine-1-phosphate (S1P), and 5 μM Sphingosine kinase inhibitor 2 (I2). Five groups were tested: (1) control (no treatment); rescue groups; (2) β1/S1P; (3) β1/I2; prevention groups; (4) S1P/β1; and (5) I2/β1. Each treatment was administered for 2 weeks with one treatment and switched to another for 2 weeks. Using Western blot analysis, the 3D constructs were examined for the expression of fibrotic markers, SPL, and TGF-β signaling pathway members. Scratch assays from 2D cultures were also utilized to evaluate cell migration We observed reduced fibrotic expression and inactivation of latent TGF-β binding proteins (LTBPs), TGF-β receptors, Suppressor of Mothers Against Decapentaplegic homologs (SMADs), and SPL signaling following treatment with I2 prevention and rescue compared to S1P prevention and rescue, respectively. Furthermore, we observed increased cell migration following stimulation with I2 prevention and rescue groups, with decreased cell migration following stimulation with S1P prevention and rescue groups after 12 h and 18 h post-scratch. We have demonstrated that I2 treatment reduced fibrosis and modulated the inactivation of LTBPs, TGF-β receptors, SPLs, and the canonical downstream SMAD pathway. Further investigations are warranted in order to fully uncover the potential of utilizing SphK I2 as a novel therapy for corneal fibrosis.

Evaluating Visual Dependence in Postural Stability Using Smartphone and Stroboscopic Glasses

This study explores the efficacy of integrating stroboscopic glasses with smartphone-based applications to evaluate postural control, offering a cost-effective alternative to traditional forceplate technology. Athletes, particularly those with visual and visuo-oculomotor enhancements due to sports, often suffer from injuries that necessitate reliance on visual inputs for balance—conditions that can be simulated and studied using visual perturbation methods such as stroboscopic glasses. These glasses intermittently occlude vision, mimicking visual impairments that are crucial in assessing dependency on visual information for postural stability. Participants performed these tasks under three visual conditions: full vision, partial vision occlusion via stroboscopic glasses, and no vision (eyes closed), on foam surfaces to induce postural instability. The use of a smartphone app to measure postural sway was validated against traditional force plate measurements, providing a comparative analysis of both tools under varied sensory conditions. We investigated postural parameters like anterior–posterior and medial–lateral sway ranges, root mean square values, 95% confidence ellipse area, and sway velocity and median dominant sway frequency from both the smartphone and the force plates. Our findings indicate that force plates exhibit high sensitivity to various visual conditions, as evidenced by significant differences observed in certain postural parameters, which were not detected by smartphone-based measurements. Overall, our findings indicate that smartphones show promise as a cost-effective alternative to force plate measurements for routine monitoring of postural control in sports, although they may not achieve the same level of accuracy as force plates. The integration of stroboscopic glasses further refined the assessment by effectively simulating visual impairments, thereby allowing precise evaluation of an individual’s ability to maintain balance under visually perturbed conditions.

Effect of early versus late onset of partial visual loss on judgments of auditory distance.

It is important to know whether early-onset vision loss and late-onset vision loss are associated with differences in the estimation of distances of sound sources within the environment. People with vision loss rely heavily on auditory cues for path planning, safe navigation, avoiding collisions, and activities of daily living. Loss of vision can lead to substantial changes in auditory abilities. It is unclear whether differences in sound distance estimation exist in people with early-onset partial vision loss, late-onset partial vision loss, and normal vision. We investigated distance estimates for a range of sound sources and auditory environments in groups of participants with early- or late-onset partial visual loss and sighted controls. Fifty-two participants heard static sounds with virtual distances ranging from 1.2 to 13.8 m within a simulated room. The room simulated either anechoic (no echoes) or reverberant environments. Stimuli were speech, music, or noise. Single sounds were presented, and participants reported the estimated distance of the sound source. Each participant took part in 480 trials. Analysis of variance showed significant main effects of visual status (p<0.05) environment (reverberant vs. anechoic, p<0.05) and also of the stimulus (p<0.05). Significant differences (p<0.05) were shown in the estimation of distances of sound sources between early-onset visually impaired participants and sighted controls for closer distances for all conditions except the anechoic speech condition and at middle distances for all conditions except the reverberant speech and music conditions. Late-onset visually impaired participants and sighted controls showed similar performance (p>0.05). The findings suggest that early-onset partial vision loss results in significant changes in judged auditory distance in different environments, especially for close and middle distances. Late-onset partial visual loss has less of an impact on the ability to estimate the distance of sound sources. The findings are consistent with a theoretical framework, the perceptual restructuring hypothesis, which was recently proposed to account for the effects of vision loss on audition.

Possibilities for Faithfulness in a Partial Vision

Possibilities for Faithfulness in a Partial Vision

Global Transcriptomic Profiling of Innate and Adaptive Immunity During Aspergillus flavus Endophthalmitis in a Murine Model.

Fungal endophthalmitis is characterized by chronic inflammation leading to the partial or complete vision loss. Herein, we analyzed the transcriptomic landscape of Aspergillus flavus (A. flavus) endophthalmitis in C57BL/6 mice to understand the host-pathogen interactions. Endophthalmitis was induced by intravitreal injection of A. flavus spores in C57BL/6 mice and monitored for disease progression up to 72hours. The enucleated eyeballs were subjected to histopathological analysis and mRNA sequencing using the Illumina Nextseq 2000. Pathway enrichment analysis was performed to further annotate the functions of differentially expressed genes (DEGs) and validation of cytokines was performed in vitreous of patients with fungal endophthalmitis using multiplex ELISA. Transcriptomic landscape of A. flavus endophthalmitis revealed upregulated T-cell receptor signaling, PI3K-AKT, MAPK, NF-κB, JAK-STAT, and NOD like receptor signaling pathways. We observed significant increase in the T-cells during infection especially at 72 hours infection along with elevated expression levels of IL-6, IL-10, IL-12, IL-18, IL-19, IL-23, CCR3, and CCR7. Furthermore, host-immune response associated genes, such as T-cell interacting activating receptor, TNF receptor-associated factor 1, TLR1, TLR9, and bradykinin receptor beta 1, were enriched. Histopathological assessment validated the significant increase in inflammatory cells, especially T-cells at 72 hours post-infection along with increased disruption in the retinal architecture. Additionally, IL-6, IL-8, IL-17, TNF-α, and IL-1β were also significantly elevated, whereas IL-10 was downregulated in vitreous of patients with Aspergillus endophthalmitis. Regulating T-cell influx could be a potential strategy to modulate the excessive inflammation in the retina and potentially aid in better vision recovery in fungal endophthalmitis.

Update on Blindness From Filler: Review of Prognostic Factors, Management Approaches, and a Century of Published Cases.

Vision loss secondary to aesthetic filler treatment is a rare but disastrous complication. The aim was to update the published cases of blindness after filler injection that have occurred since our group published reviews of 98 cases in 2015 and an additional 48 cases in 2019. A literature review was performed to identify all cases of visual complications caused by filler injection published between September 2018 and March 2023. The cases were analyzed independently and in combination with previously reviewed cases. Analyses are based on the number of cases with data available. 365 new cases of partial or complete vision loss after filler injection were identified. The sites that were highest risk were the nose (40.6%), forehead (27.7%), and glabella (19.0%). The filler injected was hyaluronic acid in 79.6% of cases. The most common associated signs were ptosis (56.2%), ophthalmoplegia (44.1%), pain (31.2%), and skin changes (73.2%). Stroke-like features were seen in 19.2% of cases. Of the cases reporting visual outcomes (318), 6.0% experienced complete vision recovery, 25.8% had partial improvement in visual acuity, and 68.2% had no vision recovery. Partially preserved visual acuity at onset was a significant predictor of visual improvement (p < .001). The three most common treatments were subcutaneous hyaluronidase at or near the filler site (70.1%), systemic steroids (57.3%), and intra-arterial thrombolytic therapy (56.0%). No treatments were significantly associated with visual improvement (p > .05). Although blindness and stroke from fillers is a rare complication, practitioners who inject filler should have a thorough knowledge of prevention and management strategies.

A Comparative Review of Typical and Atypical Optic Neuritis: Advancements in Treatments, Diagnostics, and Prognosis.

Optic neuritis (ON) is a debilitating condition thatthrough various mechanisms, including inflammation or demyelination of the optic nerve, can result in partial or total permanent vision loss if left untreated. Accurate diagnosis and promptly initiated treatment are imperative related to the potential of permanent loss of vision if left untreated, which can lead to a significant reduction in the quality of life in affected patients. ONis subtyped as "typical" or "atypical" based on underlying causative etiology. The etiology of ON can be differentiated when appropriate diagnostic testing is performed. Using history taking, neuroimaging, and visual testing to localize the underlying pathology of ON in a time-sensitive manner is critical in mitigating these unsatisfactory outcomes. Herein, we examine the differences in presentation, pathophysiology, and treatments of typical ON causes, like multiple sclerosis (MS), and atypical causes such as neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) ON. The present investigation places focus on both neuroimaging and visual imaging in the differentiation of ON. Additionally, this review presents physicians with a better understanding of different presentations, treatments, and prognoses of ON.

Awareness of the Risk of Chronic Use of Steroid Causing Cataract in Al Ahsa City, Saudi Arabia.

Introduction The lens, essential for vision, can be impaired by cataracts, leading to partial or complete reversible vision loss. Common risk factors include aging, diabetes, and steroid use, with significant financial implications. Limited awareness in Saudi Arabia necessitates further research to reduce cataract prevalence and increase knowledge about steroid-induced cataracts. Methodology This was a cross-sectional study in Al Ahsa City, Saudi Arabia that aims to assess awareness of cataracts induced by long-term steroid use. Data was collected via an online survey and analyzed using Statistical Package for Social Sciences (SPSS) version 29 (IBM Corp., Armonk, NY, USA). Results Our study results show that 69.8% (n=291) of participants were female, and 30.2% (n=126) were male, with the majority (62.6%, n=261) having a university education. Notably, 91.1% (n=380) reported no steroid use, while 8.9% (n=37) reported long-term use, and 10.1% (n=42) used steroids topically. There are moderate awareness levels regarding cataract and steroid associations, with 68.1% (n=284) recognizing topical steroids as the common culprits. Logistic regression highlighted the positive correlation between knowledge of cataract risks due to steroid use and actual steroid use, corroborated by a notable 73.0% (n=27) steroid usage among high-awareness individuals. Conclusion Our study underscores moderate awareness regarding steroid-related cataract risks in Al Ahsa City. Educational status significantly influenced understanding, highlighting the importance of targeted health education initiatives.

Ultrananocrystalline diamond (UNCD™) coating for new-generation implantable medical devices/prostheses

Ultrananocrystalline diamond (UNCD™) coating for new-generation implantable medical devices/prostheses In this materials science piece, Orlando Auciello, describes the development of a unique multifunctional/best biocompatible ultrananocrystalline diamond (UNCDTM) coating for new-generation implantable medical devices and prostheses. Materials’ surfaces of vital medical devices, such as silicon (Si) microchip (artificial retina) implanted on human retina, restoring partial vision to people blinded by genetically induced photoreceptors degeneration, and metallic dental implants, are attacked chemically by eyes’ fluids or oral fluids respectively. Metallic stents/artificial heart valves, inside human blood vessels, activate blood enzymes, inducing coagulation, and fibrinolytic, leading to thrombus formation (i.e., blood clot in blood vessels, obstructing blood flow or loosed clot getting stuck in arteries/veins’ walls, causing life-threatening stroke/heart attack.

Benefits of thermal and distance-filtered imaging for wayfinding with prosthetic vision

Visual prostheses such as the Argus II provide partial vision for individuals with limited or no light perception. However, their effectiveness in daily life situations is limited by scene complexity and variability. We investigated whether additional image processing techniques could improve mobility performance in everyday indoor environments. A mobile system connected to the Argus II provided thermal or distance-filtered video stimulation. Four participants used the thermal camera to locate a person and the distance filter to navigate a hallway with obstacles. The thermal camera allowed for finding a target person in 99% of trials, while unfiltered video led to confusion with other objects and a success rate of only 55% (p<0.01\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$p<0.01$$\\end{document}). Similarly, the distance filter enabled participants to detect and avoid 88% of obstacles by removing background clutter, whereas unfiltered video resulted in a detection rate of only 10% (p<0.01\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$p<0.01$$\\end{document}). For any given elapsed time, the success rate with filtered video was higher than with unfiltered video. After 90 s, participants’ success rate reached above 50% with filtered video and 24% and 3% with normal camera in the first and second tasks, respectively. Despite individual variations, all participants showed significant improvement when using the thermal and distance filters compared to unfiltered video. Adding a thermal and distance filter to a visual prosthesis system can enhance the performance of mobility activities by removing clutter in the background, showing people and warm objects with the thermal camera, or nearby obstacles with the distance filter.

First-in-Human Whole-Eye Transplantation: Ensuring an Ethical Approach to Surgical Innovation

As innovations in the field of vascular composite allotransplantation (VCA) progress, whole-eye transplantation (WET) is poised to transition from non-human mammalian models to living human recipients. Present treatment options for vision loss are generally considered suboptimal, and attendant concerns ranging from aesthetics and prosthesis maintenance to social stigma may be mitigated by WET. Potential benefits to WET recipients may also include partial vision restoration, psychosocial benefits related to identity and social integration, improvements in physical comfort and function, and reduced surgical risk associated with a biologic eye compared to a prosthesis. Perioperative and postoperative risks of WET are expected to be comparable to those of facial transplantation (FT), and may be similarly mitigated by immunosuppressive protocols, adequate psychosocial support, and a thorough selection process for both the recipient and donor. To minimize the risks associated with immunosuppressive medications, the first attempts in human recipients will likely be performed in conjunction with a FT. If first-in-human attempts at combined FT-WET prove successful and the biologic eye survives, this opens the door for further advancement in the field of vision restoration by means of a viable surgical option. This analysis integrates recent innovations in WET research with the existing discourse on the ethics of surgical innovation and offers preliminary guidance to VCA programs considering undertaking WET in human recipients.

Scalable Industrial Visual Anomaly Detection With Partial Semantics Aggregation Vision Transformer

Scalable Industrial Visual Anomaly Detection With Partial Semantics Aggregation Vision Transformer

Developing gene‐independent approaches for retinal dystrophies

Inherited retinal dystrophies (IRDs) display remarkable genetic heterogeneity, with over 300 retinal disease genes mapped and/or identified. Profound vision loss and blindness, often from birth, is a common occurrence in these clinically heterogeneous disease conditions. The therapeutic options for IRDs are currently very limited but recent advancements in understanding mechanisms of retinal degeneration and technological progress paved the way towards development of novel therapies. Much progress has been made in moving from gene discovery to gene therapy. However, the genetic heterogeneity of IRDs represents a significant challenge for development of gene therapy.Many studies from our group have demonstrated that the survival of cones (responsible for diurnal and high‐resolution vision) depends on the presence of rods (responsible for vision at low light levels) that secrete a diffusible trophic factor identified as rod‐derived cone viability factor (RdCVF). The discovery of RdCVF, of its receptor and mechanism of action, and the demonstration of its mutation‐independent therapeutic potential in several animal models of IRDs paved the way to the development (with the start‐up company Sparing Vision) of RdCVF neuroprotective gene therapy that entered in clinical trial in 2023.IRDs destroy photoreceptors but leave intact and functional a significant number of inner retinal cells. Using viral vectors, light‐sensitive microbial opsins can be expressed in these remaining cells, making possible their conversion into ‘artificial photoreceptors’. Our group in Paris, together with Botond Roska (IOB, Basel) and the biotech company GenSight, demonstrated that this technology, named optogenetics, can restore vision in secondary retinal neurons which can survive years after the degeneration of photoreceptors. Our groups established the foundation for the first‐in‐man clinical trial (NCT03326336) with the photoactivatable optogene ChrimsonR (developed by Ed Boyen at MIT) delivered in the eye via adeno‐associated viral vectors and electronic goggles to intensify the light and provide adaptation. We demonstrated (Nat Med 2021) that optogenetics is a remarkably effective way to restore partial vision and provide useful vision restoration in blind people.Gene‐independent approaches such as neuroprotection and optogenetics would allow for the treatment of a broad spectrum of retinal dystrophies, even at advanced stages of disease, giving hope for vision rescue and vision restoration to approximately 2 million people with IRDs worldwide.

One size fits all: How the “Ethiopian Highlands” made Bale Mountains National Park inscrutable

The categories we use to make sense of a place are never neutral. Scientific classifications can maintain ignorance about some aspects of a landscape, even as they create knowledge about others. This article considers this in the context of Ethiopia's Bale Mountains National Park, a landscape whose hydrologic and socio-cultural characteristics have been made inscrutable through the convergence of imperial legacies, processes of knowledge production, and complex biophysical properties. We use the example to conduct a genealogy of the notion of the “Ethiopian Highlands” and its associated metaphors, tracing the political-economic, biophysical, and epistemic factors by which this category came into use, and how these intersected to maintain a particular yet partial vision of the region. By critically analyzing bibliometric data, historical sources, and chains of reasoning in the scientific literature, we show how a small group of foreign experts erroneously conflated the landscapes, peoples, and environmental concerns of one area with those of another. Together these forces reify imperial gazes, perpetuate degraded wilderness narratives, and overlook significant geologic, (paleo)climatic, sociocultural, and land use differences. The result is a simplistic understanding of a distinct hydrosocial landscape, the perpetuation of conflict and resentment, and poorer conservation outcomes.

Eye Disease Diagnosis and Classification using Deep Convolution Neural Network

Human eye plays a vital role in everyone’s life. If retinal diseases occur it could cause complete or partial vision loss. Objective: To overcome that situation, the fundus images can be utilized by the ophthalmologists to automatically diagnose the retinal diseases. At the same time, the development of latest Artificial Intelligence (AI) techniques, especially Deep Learning (DL) models finds useful for object detection in several application areas, including medical imaging. Methods: In this view, this paper presents an automated DL based multi-retinal disease diagnosis and classification model. The presented technique comprises three processes, such as pre-processing, feature extraction, and classification. For feature extraction purposes, AlexNet and Residual Network (ResNet) models are employed. Besides, Convolutional Neural Network (CNN) and Deep Neural Network (DNN) models are applied to classify the retinal fundus images into different retinal diseases. The incorporation of DL models for feature extraction and classification resulted to enhanced diagnostic performance. Findings: A series of experiments were conducted on benchmark dataset and the experimental results are examined under different aspects. The experimental values exhibited that the ResNet-CNN model has achieved better performance with the accuracy of 98.84%, precision of 98.84%, recall of 98.17%, and F1-score of 98.48%. Novelty: With the help of such methods and techniques those latest findings indicate that some human eye diseases which can be alleviated by pharmacological interventions in an easy manner.