Partial Solubility Parameters Research Articles

Solubility data and solubility parameters of barnidipine in different pure solvents

Introduction: Solubility studies and obtaining physicochemical data on drugs in pure solvents belonging to different chemical classes are key to developing new drug formulations. In this work, Hansen partial solubility parameters (HSP) were calculated to assess the miscibility and intermolecular interactions of barnidipine in seventeen pure solvents. The comparison of the results obtained with the theoretical values ​​calculated according to the structure of barnidipine, were valuable to analyse the influence of the solute-solute, solute-solvent relationships of the additive contribution groups, on the chemical and physical properties of this molecule with the solvents of different polarity tested, to provide relevant information highly useful in the pharmaceutical industry. Method: Equilibrium barnidipine solubilities in mono-solvents was determined using the classical shake-flask method, followed by UV-spectrophotometric analysis at 298.15 K. The partial solubility parameters were calculated by applying theoretical group contribution methods, proposed by Hoftyzer-Van Krevelen and Fedors. The KAT-LSER model was used to investigate the effect of solvent based on the concept of linear solvation energy relationships. The mole fraction was obtained from the densities of the solutions. Solid-phase analyses were made by calorimetry differential scanning. Results: The modification introduced in the extended Hansen method, that is, the use of lnX2 as the dependent variable, provided excellent results. The highest solubility values have been found in polar solvents. It is observed that solvent-solvent and solute-solvent intermolecular interactions through hydrogen bonds and van der Waals forces, significantly influence drug solubility. Conclusions: The affinity between barnidipine and each one of the selected solvent was evaluated by using HSP. Results showed that HSP could be well used to analyse drug solubility in particular solvents. Barnidipine is easier to dissolve in solvents with shorter carbon chains and higher polarity.

Impact of molecular weight on the solubility parameters of poly(3‐hexylthiophene)

AbstractThe solubilities of three P3HT samples of similar regioregularity (rr ≈ 96%) but varying molecular weight (Mn = 14 kDa, 32 kDa, and 49 kDa) are measured in 23 organic solvents. The solubility data is used to calculate the partial solubility parameters (δD, δP, δH) using the functional solubility parameter (FSP) method. The results reveal a monotonic decrease in the polar and hydrogen‐bonding parameters, δP and δH, respectively, with increasing molecular weight of the polymer. The observed trends are consistent with recent experimental and computational results and are rationalized in terms of increasing torsional and conformational disorder of higher molecular weight P3HT following dissolution in solvents of decreasing P3HT solubility. The results indicate that the structural attributes of the P3HT chains in the solutions impact the nature and strength of the polymer‐solvent interactions, and that these structural effects are registered by the observed solubility parameters.

Precise heteroatom doping determines aqueous solubility and self-assembly behaviors for polycyclic aromatic skeletons

Developing effective strategies to improve the hydrophilicity or aqueous solubility of hydrophobic molecular scaffolds is meaningful for both academic research and industrial applications. Herein, we demonstrate that stepwise and precise N/O heteroatoms doping on a polycyclic aromatic skeleton can gradually alter these structures from hydrophobic to hydrophilic, even resulting in excellent aqueous solubility. The Hansen solubility parameters (HSP) method shows that the three partial solubility parameters are closely related to N/O doping species, numbers and positions on the molecular panel. The hydrogen bonding solubility parameter indicates that the hydrogen bonding interactions between N/O doped molecules and water play a key role in enhancing hydrophilicity. Moreover, three optimized water-soluble molecules underwent a self-assembly process to form stable nanoparticles in water, thus facilitating better hydrogen bonding interactions disclosed by HSP calculations, NMR and single crystal X-ray analysis. These ensembles even show quasi-solid properties in water from NMR and luminescence perspectives.

Impact of regioregularity on the solubility parameters of poly(3‐hexylthiophene)

The solubilities of four P3HT samples of varying regioregularity (rr = 58%, 86%, 93%, and 96%) are measured in 18 organic solvents, and the solubility data are used to calculate the partial solubility parameters (SPs) (δD, δP, δH) of the samples using the functional solubility parameter (FSP) approach. The FSP results show that the δP and δH parameters increase with increasing regioregularity. The results reveal that the anomalously large δP and δH SPs regioregular P3HT previously reported in the literature are attributable to the microstructure (regioregularity) of the P3HT polymer, and that as that as the regioregularity of P3HT increases the polymer can engage in stronger associative interactions with the solvent. Complementary computational analyses of hexamer model systems using Gaussian16 and AIMll software, reveal variations in electronic characteristics and topological parameters consistent with the regioregular-dependent increases in δP and δH. This research may aid in modifying the fundamental and/or practical framework of SP theory to account for the effects of polymer microstructure and polymorphism.

Equilibrium solubility of amrinone in aqueous co-solvent solutions reconsidered: Quantitative molecular surface, inter/intra-molecular interactions and solvation thermodynamics analysis

Two powerful tools of quantum-chemical parameters, minimum negative surface electrostatic potential together with minimum surface average local ionization energy, were employed in this communication to illustrate the electrostatic characteristics of acidity and basicity from a microscopic point of view, correspondingly. The -N = and > NH groups of amrinone molecule are primary sites of electrophilic and nucleophilic attacks. With the help of the famous method of inverse Kirkwood–Buff integrals, preferential solvation analysis was executed based on the reported amrinone solubility in four solution systems of EG (1) + water (2), ethanol (1) + water (2), DMF (1) + water (2) and methanol (1) + water (2). In rich water concentrations, amrinone was surrounded preferentially by water; while in intermediate and rich EG/ethanol/DMF/methanol compositions, EG/ethanol/DMF/methanol solvated preferentially amrinone. High basicity of EG/ethanol/DMF/methanol that favored interactions with the acidic groups of amrinone resulted in selective solvation of amrinone by the co-solvent. Deep investigation on the amrinone solubility behavior was done by the partial Hansen solubility parameters. The inspection of molecular interactions on amrinone solubility variation was made in the light of the well-known linear solvation energy relationships, identifying the solubility parameter, hydrogen-bond acidity and dipolarity-polarizability of solutions presented dominant contributions to the solubility variation. The transfer and thermodynamic dissolution properties including entropy, enthalpy and Gibbs free energy change were also derived and deeply discussed. Thermodynamic enthalpy–entropy compensation analysis validated a shift of prevailing mechanism of dissolution from entropy-driven (in rich water compositions) to enthalpy-driven (in rich co-solvent compositions).

Equilibrium solubility, inter- and intra-molecular interactions and solvation performance of flutamide in some aqueous blended co-solvents

The current research was devoted to the solubility profile and its computational methodologies, partial Hansen solubility parameter, inter- and intra-molecular interactions, and solvation performance for the systems formed by crystalline flutamide dissolved in water and cosolvent, i.e. ethanol/isopropanol/acetonitrile/1,4-dioxane. All solubility experimentations were done via a common shake-flask saturation method at a pressure of atmosphere (p = 101.2 kPa) and the temperature range from 278.15 to 323.15 K. The solubility in magnitudes of flutamide were recorded as the lowest in pure water at 278.15 K; and the highest in pure co-solvent at 323.15 K. The three-dimensional Hansen solubility parameters were utilized here to illustrate the solubility profile. The quantifiable explanation of solvent effect was carried out via modelling the flutamide solubility using linear solvation energy relationships. Satisfactory outcomes for correlating the solubility magnitudes were realized by means of modified van’t Hoff–Jouyban–Acree, modified Wilson and Jouyban–Acree models with the relative average errors of < 6. 67 %. The observed solubility data at 298.15 K were further studied by the extended Hildebrand solubility approach, acquiring the relative average deviations of < 1.54 %. The preferential solvation investigation of flutamide was further performed through quantitation by inverse Kirkwood–Buff integrals. The positive values of preferential solvation parameters in co-solvent-rich and middle composition blends point to that the drug flutamide is preferentially solvated by the co-solvent. In these composition ranges, flutamide is possibly acting as Lewis acid performance with 1,4-dioxane/ethanol/isopropanol molecules; while for the aqueous acetonitrile solutions, the solvation behavior is responsible for the polarization effect.

The dissolution behavior and thermodynamic properties of amlodipine in mixtures of n-propanol/isopropanol + water

Improving the solubility of poorly water-soluble drugs is one of the biggest problems. In this study, the dissolution behavior of amlodipine in aqueous mixtures of co-solvents including n-propanol and isopropanol within the temperature range from 273.15 K to 313.15 K was investigated and presented by Jouyban-Acree model. In n-propanol (1) + water (2) binary mixtures, the maximum mole fraction solubility of amlodipine (3.546 × 10-2) was observed at 313.15 K when the mass fraction of n-propanol was 0.80. The corresponding data (2.714 × 10-2) for isopropanol (1) + water (2) systems was obtained with the mass fraction of 0.60 for isopropanol at 313.15 K. The maximum data for water was (2.245 × 10-5) at 313.15 K, an about 1.580 × 103 fold increase in n-propanol + water binary mixtures, and 1.209 × 103 fold increase in isopropanol + water systems. The co-solvency behavior of amlodipine in two aqueous solutions was analyzed by acidic partial solubility parameter (δ1a), basic partial solubility parameter (δ1b) and Hildebrand solubility parameter (δ1). The positive coefficient of δ1 and δ1a related to favorable nonspecific and specific interactions, respectively. Moreover, amlodipine behaves as Lewis base toward n-propanol + water and isopropanol + water binary mixtures. Besides, the outcomes of the “apparent thermodynamic analysis” showed that the dissolution of amlodipine was endothermic and entropy-driven in all composition of n-propanol + water and isopropanol + water binary mixtures.

Predictability of drug encapsulation and release from propylene carbonate/PLGA microparticles.

Key parameters for microparticle-based parenteral depot formulation development are entrapment efficiency and sustained drug release, which both depend on the intermolecular affinity of the components. Here, partial solubility parameters were evaluated as descriptors for 21 drug substances and 3 polymers in propylene carbonate (PC). Out of these 21 drug substances, eight BCS class II substances (celecoxib, clotrimazole, erythromycin, ibuprofen, indomethacin, itraconazole, lopinavir and ritonavir) were encapsulated using PLGA (Poly(DL-lactide-co-glycolide)) as polymer matrix and PC as a polar aprotic solvent in order to assign microparticle properties to potential affinity-related interactions using partial solubility parameters. Microparticle morphology was highly dependant on the specific glass transition temperature (Tg) of the encapsulated drug substance. A strong correlation (R=0.912) between the encapsulation efficiency and the difference in total solubility parameter (Δδt API-PLGA) underlined the encapsulation predictability. Moreover, in drug release, a significant impact of Δδt API-PLGA on initial burst was observed and even more pronounced on the release rate of the encapsulated drug substance. The possibility to predict these important microparticle properties underline the value of including solubility descriptors such as partial solubility parameters into microparticle formulation development.

Characterization of the thermodynamic properties of ionic liquid 1-allyl-3-vinylimidazolium bis((trifluorompropyl)sulfonyl)imide by inverse gas chromatography

The thermodynamic parameters at infinite dilution for twenty-six organic solutes in 1-allyl-3-vinylimidazolium bis((trifluorompropyl)sulfonyl)imide ([AVIM][NTf2]) ionic liquid were determined by the inverse gas chromatography (IGC). The parameters encompassed the Flory-Huggins interaction parameter (γ12∞), the activity coefficient at infinite dilution (γ12∞), the thermodynamic functions (ΔH1E,∞,ΔS1E,∞) and the Hildebrand solubility parameter (δ2) in the temperature range of 313.15 K − 343.15 K. The values of selectivity and capacity for four separation problems as heptane (1)/benzene (2), cyclohexane (1)/benzene(2), benzene(1)/ methanol(2) , hexane(1) /1-hexene(2) were calculated from γ12∞ and compared to literature values for bis((trifluorompropyl)sulfonyl)imide-based ionic liquids (ILs) for the same separation problems. The Hansen solubility parameter (δT) and its partial solubility parameters (δd, δp, δh) were also determined based on the method proposed by Voelkel and Janas. It was found that for tested solutes, the value of χ12∞was less than 4 and γ12∞value was less than 25 except for the n-alkanes. The five types of solubility parameters showed a linear decrease trend with the increase of temperature and the solubility parameters at room temperature were obtained as δ2 = 23.27, δT = 23.21, δd = 22.78, δp = 3.366, δh = 2.486 (MPa)1/2 by the extrapolation.

Solubility Parameter for Copolymer used Additives for Lubricating Oil

Obiectives: In this article I have been looking at the determination of the solubility parameter by two methods for an additive hydrogenated poly (isoprene-co-styrene) used in lubricating oils. To determine the solubility parameter, it is necessary to know the intrinsic viscosities of the polymer hydrogenated poly (isoprene-co-styrene) in as many solvents with different solubility parameters. Methods: The viscosities of the dilute solutions copolymer hydrogenated poly (isoprene-co-styrene) were determined using Oa and I viscosimeters of the Ubbelodhe Schott capillary-type Viscosimeter set with the 0.04887 and 0.00976 constants at 25°C±0,1°C. From the values obtained for intrinsic viscosities it is concluded that the best solvent for this copolymer is cyclohexane, followed by trichlorethylene, carbon tetrachloride and SAE 10 W oil, and benzene is the weakest. Huggins constants, calculated from the intrinsic viscosity values obtained by extrapolating the reduced viscosities to the zero concentration of the copolymer, have values less than 0.4 for all four solvents. Findings: The value of the overall solubility parameter is comparable to the previous copolymer, which reflects its lack of polarity, and those due to polar interactions and hydrogen bonds are also very small: 1.2 (MPa)1/2 for those obtained by the Hansen method and between 1.4 and 2.4 (MPa)1/2 if the improved one is used. Analyzing the values determined by the two methods it is found that for the partial solubility parameters differences between 0.2 and 1.2 (MPa)1/2 are obtained, due to the intrinsic viscosity intake and the method of determination used. The difference between the global solubility parameters determined by the two methods is 0.4 (MPa)1/2. A larger difference also occurs in the sphere of solubility sphere: the obtained with the improved method is almost 30% lower, which means that fewer solvents are found in the sphere of solubility. The improved method applied to the studied copolymer used as an additive for lubricating oils is much more precise than the Hansen method. The solvents used are mostly included within the scope of the action sphere in the improved method. Application: Determination of the partial and global solubility parameters hydrogenated poly (isoprene-co-styrene) was done, first, using the Hansen method, then by an improved method. The improved method for determining the solubility parameter is much more precise than the Hansen method. Keywords: Additives, Copolymer, Lubricating Oil, Solubility Parameter

Solubility parameter of lenalidomide for predicting the type of solubility profile and application of thermodynamic model

The dissolving capacity of lenalidomide in pure and mixed solvents is limited. The purpose of this work is to enhance the solubility and study the solubility parameter of pure and mixtures (δ1) to characterize different types of solubility profiles. The solubility of lenalidomide in acetonitrile (MeCN), methanol (MT), ethanol (EA), ethyl acetate (EAC) and isopropanol (IPA) was experimentally determined at T = 293.15–333.15 K. Its solubility in binary mixtures of EA and EAC was also investigated. The polarity of lenalidomide is related to the tendency of the solubility data against the solubility parameter δ1 of pure and binary solvent mixtures. Consequently, the method of linear solvation energy relationships introduced by Kamlet, Abboud and Taft (KAT-LSER) was applied to analyze the effect of the solute-solvent intermolecular interactions on the solubility in pure solvents. In order to estimate maximum solubility in a specific co-solvent ratio, we also attempt to calculate the Hansen solubility parameter (HSP) of lenalidomide and to compare it with HSP of solvent mixture. Based on the experimental solubility data, two thermodynamic models including modified Apelblat equation and Jouyban-Acree model were then assessed. Meanwhile, a modification of the extended Hildebrand solubility approach (EHSA) including the Hildebrand solubility parameter (δ1) and the acidic and basic partial solubility parameters (δ1a and δ1b) of the solvent mixtures was used to simulate lenalidomide solubility in pure and binary mixture compositions.

Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review

Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work addresses the need to review solubility parameter applications in pharmaceutics of poorly water-soluble drugs. An overview of the different experimental and calculation methods to determine solubility parameters is provided, which covers from classical to modern approaches. In the pharmaceutical field, solubility parameters are primarily used to guide organic solvent selection, cocrystals and salt screening, lipid-based delivery, solid dispersions and nano- or microparticulate drug delivery systems. Solubility parameters have been applied for a quantitative assessment of mixtures, or they are simply used to rank excipients for a given drug. In particular, partial solubility parameters hold great promise for aiding the development of poorly soluble drug delivery systems. This is particularly true in early-stage development, where compound availability and resources are limited. The experimental determination of solubility parameters has its merits despite being rather labour-intensive because further data can be used to continuously improve in silico predictions. Such improvements will ensure that solubility parameters will also in future guide scientists in finding suitable drug formulations.

Effect of nature of chemical crosslinker on swelling and solubility parameter of a new stimuli-responsive cationic poly(N-acryloyl-N′-propyl piperazine) hydrogel

New stimuli-responsive cationic hydrogels based on N-acryloyl-N′-propyl piperazine (AcrNPP) were prepared using two types of chemical crosslinkers, viz., N,N-methylene bisacrylamide (Mba) and 1,4-butanediol diacrylate (Bda), respectively. The solubility parameter of the hydrogels was evaluated by equilibrium swelling experiment in a series of twelve solvents with well-distributed range of solubility parameters. The hydrogels exhibited maximum equilibrium swelling ratio in 1-butanol. The experimental swelling data were analyzed by two methods, (1) non-linear curve fitting and (2) least-square regression to determine the solubility parameter of the hydrogels. The solubility parameter determined by the two methods was in the range 11.45–11.85 (cal cm−3)1/2. The solubility parameter of the hydrogel containing the hydrophilic crosslinker (Mba) was higher than the hydrogel with a hydrophobic crosslinker (Bda), in all cases. This showed that the nature of chemical crosslinker influences the swelling and thus the solubility parameter of the hydrogels. The partial solubility parameter of the hydrogels related to the cohesive energy was evaluated by plotting the equilibrium swelling data against dispersion forces, polar forces, and hydrogen bonding. It was observed that both polar forces and hydrogen bonding play an important role in the swelling of these cationic hydrogels. The solubility parameter and the related forces were also estimated theoretically using group contribution methods and compared with the experimental results.

Predicting miscibility in polymer blends using the Bagley plot: Blends with poly(ethylene oxide)

This paper explores the different methods currently available to obtain the partial solubility parameters of polymers in order to apply them for the prediction of miscibility in polymer/polymer blends. Blends based on poly(ethylene oxide) (PEO) have been chosen because its miscibility has been reported with a large number of polymeric counterparts (miscible or not), allowing the representation of its miscibility map with the required detail. The solubility parameters of PEO and 55 blending partners have been obtained using the most widely used group contribution (GC) methods, namely the ones proposed by Hoy, Hoftyzer-Van Krevelen, Stefanis-Panayiotou and Yamamoto (Y-MB), and have been used to build a Bagley plot. In addition, the miscibility map based on experimental data obtained from solubility tests has been also obtained and compared with the calculated ones. The clouds of points obtained around the point corresponding to PEO show different shapes, that can be used to obtain conclusions about the coherence and the accuracy of each of the different methods used to obtain the solubility parameters of polymers.

Homogeneous Grafting of New Amido Groups onto Hydroxyethyl Cellulose Acetate Microfibrils: Solubility Study

Attempts to modify the surface of hydroxyethyl cellulose acetate (HECA-DS AC ~1.5) microfibrils were made using amine terminated molecules. First, the amine compounds were reacted with sebacoyl chloride in nonstoichiometry ratio in order to obtain a monoadduct chloride such as ClCO-(CH 2 ) 8 -CONHR. Then the resulted derivatives were coupled with hydrophobic hydroxyethyl cellulose acetate (HECA) by a condensation reaction in homogenous medium using triethyl amine (N(C 2 H 5 ) 3 ) in THF. The products were characterized by FTIR, 1 H NMR, 13 C NMR, and DRX, and thermal proprieties were also determined. The X-ray diffraction showed that the crystallinity of the amido esters obtained depends on both the degree of substitution and the nature of the graft moiety. The solubility study was based on the determination of the Flory–Huggins interaction parameters (χ) using the partial Hansen solubility parameters (HSP) and that were calculated from the Van Krevlen–Hoftyze (VKH) method and the T. Lindvig approximation. Keywords: cellulose; microfibrils; amidation; Hansen solubility; Flory–Huggins parameters.

Comparison of the cohesion-adhesion balance approach to colloidal probe atomic force microscopy and the measurement of Hansen partial solubility parameters by inverse gas chromatography for the prediction of dry powder inhalation performance

The abilities of the cohesive-adhesive balance approach to atomic force microscopy (AFM) and the measurement of Hansen partial solubility parameters by inverse gas chromatography (IGC) to predict the performance of carrier-based dry powder inhaler (DPI) formulations were compared. Five model drugs (beclometasone dipropionate, budesonide, salbutamol sulphate, terbutaline sulphate and triamcinolone acetonide) and three model carriers (erythritol, α-lactose monohydrate and d-mannitol) were chosen, giving fifteen drug-carrier combinations. Comparison of the AFM and IGC interparticulate adhesion data suggested that they did not produce equivalent results. Comparison of the AFM data with the in vitro fine particle delivery of appropriate DPI formulations normalised to account for particle size differences revealed a previously observed pattern for the AFM measurements, with a slightly cohesive AFM CAB ratio being associated with the highest fine particle fraction. However, no consistent relationship between formulation performance and the IGC data was observed. The results as a whole highlight the complexity of the many interacting variables that can affect the behaviour of DPIs and suggest that the prediction of their performance from a single measurement is unlikely to be successful in every case.

Total and partial solubility parameters of supercritical methanol

Supercritical methanol (above 513K and 8.1MPa) is applicable to many processes, including biodiesel production from oils. Its total (Hildebrand) and the partial (Hansen) solubility parameters, the latter pertaining to dispersion, polarity, and hydrogen bonding interactions, are useful quantities, related to the solubilities of various solutes. They have been determined at the relevant thermodynamic states for the applications of supercritical methanol: temperatures in the range 525–675K and pressures in the range 10–40MPa.

Determination of Solubility Parameters of Ibuprofen and Ibuprofen Lysinate.

In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable problem by these dispersions is drug-carrier (in)solubility. Here we focus on solubility parameters as a tool for predicting the solubility of a drug in certain carriers. Solubility parameters were determined in two different ways: solely by using calculation methods, and by experimental approaches. Six different calculation methods were applied in order to calculate the solubility parameters of the drug ibuprofen and several excipients. However, we were not able to do so in the case of ibuprofen lysinate, as calculation models for salts are still not defined. Therefore, the extended Hansen’s approach and inverse gas chromatography (IGC) were used for evaluating of solubility parameters for ibuprofen lysinate. The obtained values of the total solubility parameter did not differ much between the two methods: by the extended Hansen’s approach it was δt = 31.15 MPa0.5 and with IGC it was δt = 35.17 MPa0.5. However, the values of partial solubility parameters, i.e., δd, δp and δh, did differ from each other, what might be due to the complex behaviour of a salt in the presence of various solvents.

Solubility of Naproxen in Polyethylene Glycol 200 + Water Mixtures at Various Temperatures.

The solubility of naproxen in binary mixtures of polyethylene glycol 200 (PEG 200) + water at the temperature range from 298.0 K to 318.0 K were reported. The combinations of Jouyban-Acree model + van't Hoff and Jouyban-Acree model + partial solubility parameters were used to predict the solubility of naproxen in PEG 200 + water mixtures at different temperatures. Combination of Jouyban-Acree model with van't Hoff equation can be used to predict solubility in PEG 200 + water with only four solubility data in mono-solvents. The obtained solubility calculation errors vary from ~ 17 % up to 35 % depend on the number of required input data. Non-linear enthalpy-entropy compensation was found for naproxen in the investigated solvent system and the Jouyban-Acree model provides reasonably accurate mathematical descriptions of the thermodynamic data of naproxen in the investigated binary solvent systems.

Chemometric and Experimental Investigations of Organogelation Based on β-Cyclodextrin

The evaluation of PEG as a gelation solvent for an organogel based on β-cyclodextrin (β-CyD) was investigated using principal component analysis (PCA). The test tube tilting method was performed to examine the gel formation experimentally. The important descriptors used in the PCA included the Hansen partial solubility parameters. LogP may be able to be used as an additional descriptor for this system. According to PCA analysis, PEG was in a cluster of gelation solvents. Subsequently, various PEG liquid state grades were tested for their ability to gel the system and PEG400 was found to be able to produce a gel. This verifies that PCA can be successfully used to evaluate the role of PEG. Accordingly, this PCA method may be an effective tool to evaluate the role of any solvent for other low molecular weight gelators (LMWGs). Afterwards, the optimal components in the system were explored, and it was found to be 0.1M β-CyD, 0.5M K2CO3 in PEG400. Based on WAXS, the gel fiber of this organogel was demonstrated to be amorphous. This forming organogel will be further characterized in details and investigated for use in a drug delivery system.