The Direct Sequence Code Division Multiple Access (DS-CDMA) system faces several disruptions, this is most crucial of which is the Multi Access Interference (MAI) caused by its users. The efficiency of the system gradually declines as every quantity rises, and the MAI rises, especially in faded environments. This work proposes a multiple-phase multiuser identification approach called Differencing Partial Parallel Interference Cancellation (DPPIC), which improves the overall efficiency. The methods known as Differencing Parallel Interference Cancellation (DPIC) and Partial Parallel Interference Cancellation (PPIC) are combined in this methodology. Current solutions for Parallel Interference Cancellation (PIC) and PPIC have enhanced overall effectiveness; however, this has come at the expense of increasing the complexity of computation. As the variety of consecutive stages grows, the MAI falls. Using the DPIC approach may reduce the computational burden without improving system functionality. The use of the Partial Differencing Parallel Interference Cancellation (PDPIC) technique can enhance system performance while lowering the level of complexity. According to the simulation findings, Bit Error Rate (BER) vs normalized signal strength (i.e., Eb / N0) performs more effectively for the suggested DPPIC approach than for PIC, the PPIC, and PDPIC.