The adsorption technology plays a significant role in the carbon capture domain for mitigating the CO2 emissions, whereas the heterogeneous character is presented in practical adsorption process. In this study, a multi-node thermodynamic model is established for temperature-vacuum swing adsorption (TVSA) considering the end non-uniform adsorption. It shows superior performance for the assessment of practical TVSA cycle compared with lumped model. Through the influence analysis of different operation parameters based on multi-node model, specific exergy consumption increases from 41.6 to 62.4 kJ/mol caused by simultaneous drop of heat consumption and lift of work consumption as feed pressure raises from 1.0 to 3.0 bar. Exergy efficiency ranges between 13.8 % and 15.0 % as CO2 concentration increases from 10 % to 20 %. However, those under ppm-level are below 0.86 %, presenting the higher exergy consumption but lower desorption capacity represented for direct air capture. The heat consumption of front half part of adsorption bed is 39.7 % higher than the latter one, proving the potential cascaded desorption of subzone heating is superior for reducing the energy consumption. Furthermore, exergy consumption is lifted due to enhancement of work consumption of vacuum pump as vacuum pressure reduces from 1.0 to 0.02 bar, resulting exergy efficiency drops from 19.6 % to 13.4 %.