Part 3A Research Articles

A Comprehensive Formal Specification of ARINC 653 With Conformity Proof

ABSTRACTAs the predominant standard for partitioning operating systems, ARINC 653 has been applied in many critical domains. However, its reliance on informal textual languages presents challenges for ensuring both the correctness of the standard itself and the conformity of a specification or an OS to this standard. This paper addresses the gap through formal work on the ARINC 653 standard. We provide a comprehensive formal specification of multi‐core ARINC 653 Part 1–5 using Isabelle/HOL that encompasses all the 68 services and covers all components outlined in the standard, then conduct a formal proof of conformity of the specification according to ARINC 653 Part 3A. Our work marks the first comprehensive multi‐core ARINC 653 specification with a formal conformity proof. Notably, we identify and address three defects in the standard document during the formal specification and proof.

1185TiP First-in-human phase I study of ABBV-637 as monotherapy and in combination in patients with relapsed and refractory solid tumors

The epidermal growth factor receptor (EGFR) is a potent oncogene overexpressed and/or mutated in various solid tumors including non-small cell lung cancer (NSCLC). ABBV-637 is an investigational agent that targets EGFR on tumor cells and delivers a targeted payload that specifically inhibits the pro-survival factor Bcl-xL. This first-in-human trial evaluates the safety and efficacy of ABBV-637 as a monotherapy and in combination with docetaxel (DTX) or osimertinib (Osi) in patients (pts) with advanced or relapsed and refractory (RR) solid tumors. This phase I, open-label trial (NCT04721015) consists of 3 parts (Table). Eligible pts are aged ≥18 years, have measurable disease per RECIST v1.1, and Eastern Cooperative Oncology Group performance status ≤1. Additional criteria for each part are presented in Table. Primary endpoints are: adverse events (including dose-limiting toxicities); recommended phase II dose of ABBV-637 alone; maximum tolerated or administered dose of ABBV-637 plus DTX or Osi; and objective response rate (ORR) of ABBV-637 plus DTX or Osi. Secondary endpoints include: ORR of ABBV-637 alone; duration of response and pharmacokinetics of ABBV-637 alone and combined with DTX or Osi; and progression-free survival and overall survival of ABBV-637 plus DTX or Osi. ABBV-637 is administered intravenously (IV) in 28-day (D) cycles. In Part 2, pts receive an IV infusion of DTX (35 mg/m2 D1, D8, D15) plus IV ABBV-637 (at dose determined in part 2a) in 28-D cycles. In Part 3, pts receive daily oral Osi (80 mg) plus IV ABBV-637 (at dose determined in part 3a). Planned enrollment will be approximately 109 pts (Part 1, n=11; Parts 2 and 3, n=49 each [dose escalation, n=9; expansion, n=9]). Enrollment initiated in March 2021, with Part 1 dose escalation completed. Enrollment for Parts 2/3 combination dose escalation began in January 2022.Table: 1185TiPStudy partTreatmentEligibilityPart 1 Dose escalationABBV-637RR solid tumors Progressed on standard-of-care chemotherapy, radiation, immunotherapy, or targeted therapyPart 2 2a: dose escalation 2b: dose expansionABBV-637 + DTXEGFR*-expressing RR NSCLC Progressed on platinum-based chemotherapy and an immune checkpoint inhibitor or targeted therapy Has not received single-agent chemotherapyPart 3 3a: dose escalation 3b: dose expansionABBV-637 + OsiMutated EGFR-expressing RR NSCLC Progressed on Osi*Per central laboratory testing by immunohistochemistry. Open table in a new tab NCT04721015. AbbVie funded this study and participated in the study design, research, analysis, data collection, interpretation of data, reviewing, and approval of the abstract. All authors had access to relevant data and participated in the drafting, review, and approval of this abstract. No honoraria or payments were made for authorship. AbbVie Inc.

Sound in the landscape, a study of the historical literature. Part 3a: the sixteenth century onwards

ABSTRACT The sixteenth century witnesses a renewed interest in the sounds issuing from the country pursuits of ordinary folk of the countryside. It will not be until the nineteenth century that the systematic recording of folk songs was to begin but a number of writers were already including mentions of countryside sounds and songs of country folk into their works. The sound of birdsong, however, continues to reign supreme among ‘natural’ sounds, with weather, trees and water also playing a role. These themes continue in poetry and literature throughout the succeeding centuries. A selection of quotations from poetry and other literary sources are given here.

The Elements of a Nursing Malpractice Case, Part 3A: Causation.

A plaintiff must prove not only that a provider departed from acceptable standards of practice-but that this departure caused an injury.

(2703) Proposal to conserve the name Tontelea attenuata against Maytenus amygdalina (Celastraceae)

(2703) Proposal to conserve the name <i>Tontelea attenuata</i> against <i>Maytenus amygdalina</i> (<i>Celastraceae</i>)

Series 5, Chronic Wounds, Part 3a. Best practice for the holistic management of venous leg ulceration: developing best practice and introduction

British Journal of Healthcare AssistantsVol. 13, No. 3 ClinicalSeries 5, Chronic Wounds, Part 3a. Best practice for the holistic management of venous leg ulceration: developing best practice and introductionMenna Lloyd JonesMenna Lloyd JonesConsultant Editor, BJHCASearch for more papers by this authorMenna Lloyd JonesPublished Online:10 Apr 2019https://doi.org/10.12968/bjha.2019.13.3.117AboutSectionsView articleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareShare onFacebookTwitterLinked InEmail View article References Franks P, Barker J, Collier M et al.. Management of patients with venous leg ulcer: challenges and current best practice. J Wound Care. 2016 Jun; 25(Suppl 6):S1–S67 Link, Google ScholarGuest JF, Ayoub N, McIlwraith T et al. (2015). Health economic burden that wounds impose on the National Health Service in the UK. BMJ Open. 2015 Dec 7; 5(12):e009283. doi: https://doi.org/10.1136/bmjopen-2015-009283 Crossref, Google ScholarHarding K, Dowsett C, Flas L et al.. Simplifying venous leg ulcer management. Consensus recommendations. Wounds International. 2015. https://www.woundsinternational.com/resources/details/simplifying-venous-leg-ulcer-management-consensus-recommendations (accessed 8 February 2019) Google ScholarJones ML. Series 5; Chronic Wounds. Part 2.1. Leg ulcers: anatomy and physiology. British Journal of Healthcare Assistants. 2019; 13(1):11–13 Link, Google ScholarMilne J, Jones L. Evaluation of the sequential use of products embedded into a structured care pathway for leg ulcer management. Wounds UK. 2018; 14(5):98–104 Google ScholarNazarko L. Simplifying the management of venous leg ulcers: choosing appropriate and acceptable compression therapy. Br J Community Nurs. 2017 Jun; 2(22)(Sup6):S6–S12. doi: https://doi.org/10.12968/bjcn.2017.22.Sup6.S6 Link, Google ScholarNational Institute for Health and Care Excellence. Clinical knowledge summaries: leg ulcer—venous. 2017. https://cks.nice.org.uk/leg-ulcer-venous#!scenario (accessed 8 February 2019) Google ScholarTolmine EP, Rice AM. Best-practice statements; should we use them? Nurs Times. 2015 Oct 14–20; 111(42):12–14 Google ScholarVuolo J. Wound care, made incredibly easy. 1st UK edn. London: Lippincott Williams & Wilkins; 2009 Google ScholarWounds UK. Best Practice Statement: holistic management of venous leg ulceration. 2016. https://lohmann-rauscher.co.uk/downloads/VLU_BPS_Web.pdf (accessed 8 February 2019) Google Scholar FiguresReferencesRelatedDetailsCited bySeries 5, Chronic Wounds, Part 3b. Best practice statement, Holistic assessment of Venous Leg Ulceration. Section 1: assessmentMenna Lloyd Jones10 April 2019 | British Journal of Healthcare Assistants, Vol. 13, No. 4 2 March 2019Volume 13Issue 3ISSN (print): 1753-1586ISSN (online): 2052-4420 Metrics History Published online 10 April 2019 Published in print 2 March 2019 Information© MA Healthcare LimitedPDF download

Series 5; Chronic Wounds. Part 2.1. Leg ulcers: anatomy and physiology

British Journal of Healthcare AssistantsVol. 13, No. 1 ClinicalSeries 5; Chronic Wounds. Part 2.1. Leg ulcers: anatomy and physiologyMenna Lloyd JonesMenna Lloyd JonesSearch for more papers by this authorMenna Lloyd JonesPublished Online:8 Jan 2019https://doi.org/10.12968/bjha.2019.13.1.11AboutSectionsView articleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareShare onFacebookTwitterLinked InEmail View article References Agale SV. Chronic leg ulcers: epidemiology, aetiopathogenesis, and management. Ulcers. 1-9. 2013. https://doi.org/10.1155/2013/413604 (accessed 10 December 2018). Crossref, Google ScholarChamanga ET. Understanding venous leg ulcers. Br J Community Nurs. 2018 Sep 1; 23(Sup9):S6–S15. doi: https://doi.org/10.12968/bjcn.2018.23.Sup9.S6 Link, Google ScholarJefferies PM. Ballière's Nurses' Dictionary. London: Ballière Tindall; 1979 Google ScholarGuest JF, Ayoub N, McIlwraith T et al. (2015). Health economic burden that wounds impose on the National Health Service in the UK. BMJ Open. 2015 Dec 7;5(12). e009283. doi: https://doi.org/10.1136/bmjopen-2015-009283 Crossref, Google ScholarNHS RightCare. NHS RightCare scenario: the variation between sub-optimal and optimal pathways. Betty's story: wound care. 2017. https://www.england.nhs.uk/rightcare/wp-content/uploads/sites/40/2017/02/nhs-rightcare-bettys-story-app1.pdf (accessed 10 December 2018) Google ScholarScottish Intercollegiate Guidelines Network (SIGN) 120. Management of chronic venous leg ulcers. A national clinical guideline. 2010. https://www.sign.ac.uk/assets/sign120.pdf (accessed 10 December 2018) Google ScholarTortora GJ, Grabowski SR. Principles of anatomy and physiology. 9th edn. London: Harper and Row; 1999 Google ScholarVuolo J. Wound care, made incredibly easy. 1st UK edn. London: Lippincott; 2009 Google Scholar FiguresReferencesRelatedDetailsCited bySeries 5, Chronic Wounds, Part 3a. Best practice for the holistic management of venous leg ulceration: developing best practice and introductionMenna Lloyd Jones10 April 2019 | British Journal of Healthcare Assistants, Vol. 13, No. 3 2 January 2019Volume 13Issue 1ISSN (print): 1753-1586ISSN (online): 2052-4420 Metrics History Published online 8 January 2019 Published in print 2 January 2019 Information© MA Healthcare LimitedPDF download

Pharmacology, Part 3A: Interventional Medications in Renal and Biliary Imaging.

Pharmacology principles provide key understanding that underpins the clinical and research roles of nuclear medicine practitioners. Indeed, the scope of practice of the nuclear medicine technologist demands knowledge and understanding of indications, contraindications, warnings, precautions, proper use, drug interactions, and adverse reactions for each medication to be used. This article is the third in a series of articles that aims to enhance the understanding of pharmacologic principles relevant to nuclear medicine. This article will build on the introductory concepts, terminology, and principles of pharmacology explored in the first 2 articles in the series. Specifically, this article will focus on the pharmacologic principles associated with interventional medications encountered in renal and biliary imaging. A companion article (part 3B) will examine the less commonly used interventional medications in general nuclear medicine and prototype adjunctive medications. Future articles will address the pharmacology related to nuclear cardiology, the emergency crash cart, and contrast media associated with CT and MRI.

Yet more on a stochastic economic model: Part 3C: stochastic bridging for share yields and dividends and interest rates

AbstractThis is the third and last subpart of a long paper in which we consider stochastic interpolation for the Wilkie asset model, considering both Brownian bridges and Ornstein–Uhlenbeck (OU) bridges. In Part 3A, we developed certain properties for both these types of stochastic bridge, and in Part 3B we investigated retail prices and wages. In this paper, we investigate the remainder of many of our data series, relating to shares and interest rates. We conclude that, regardless of the form of the annual model, the monthly data within each year can be modelled by Brownian bridges, usually on the logarithm of the principal variable. But in no case is a simple Brownian bridge enough, and all series have their own peculiarities. Overall, however, our modelling produces simulations that are realistic in comparison with the known data. Many of our findings would apply to any similar model used for simulation over time. Our results have considerable importance for financial economics. We reconcile the conflict between the long-term mean-reverting modelling of Schiller and the short-term random walk modelling of Fama. This conclusion therefore has very wide significance.

Yet more on a stochastic economic model: Part 3B: stochastic bridging for retail prices and wages

AbstractThis is the second subpart of three in a long paper in which we consider stochastic interpolation for the Wilkie asset model, considering both Brownian bridges and Ornstein–Uhlenbeck (OU) bridges. In Part 3A, we developed certain properties for both these types of stochastic bridge, and we investigate the properties of many of our data series on the same lines. We have several economic or investment series, which all have their own peculiarities. In this paper, we cover only retail prices and wages. The other series are dealt with in Part 3C. We find that, although the annual series for the rate of inflation is generated by an AR(1) model, which is the discrete time equivalent of an OU process, an OU bridge is not suitable. We need to use a Brownian bridge on the logarithm of the Price Index. Further, the standard deviation of the monthly increments in any year is, as we find empirically from the data, a function of the change in the annual value, and further there is correlation between the monthly increments in successive years.

Yet more on a stochastic economic model: Part 3A: stochastic interpolation: Brownian and Ornstein–Uhlenbeck (OU) bridges

AbstractIn this paper, we develop certain properties for discrete Brownian bridges and Ornstein–Uhlenbeck bridges, which we use in the successor papers Part 3B and Part 3C to analyse real economic data series, with a view to constructing stochastic interpolation models for the Wilkie asset model.

Cultural Competency in Health Care and Its Implications for Pharmacy Part 3A: Emphasis on Pharmacy Education, Curriculums, and Future Directions

Culture influences patients' beliefs and behaviors toward health and illness. As the U.S. population becomes more diverse, a critical need exists for pharmacy education to incorporate patient-centered culturally sensitive health care knowledge and skills into the curriculum. Nursing was the first profession to incorporate this type of learning and training into its curriculums, followed by medicine. Pharmacy has also made great progress to revise curriculums, but inconsistency exists in depth, breadth, and methods across pharmacy colleges. This article addresses important aspects of pharmacy education such as curriculum development, incorporation of educational innovations and techniques into the teaching of patient-centered culturally sensitive health care across the curriculum from didactic to experiential learning, assessment tools, and global education. A preliminary model curriculum with objectives and examples of teaching methods is proposed. Future directions in pharmacy education, teaching and learning scholarship, postgraduate education, licensure, and continuing education are also presented.

Synthesis and Structure of Optically Active Polyesters Containing C2 Chiral Spirobifluorene Moieties in the Main Chain

Three optically active polyesters possessing C2 chiral spirobifluorene moieties in the main chains were prepared and their structural feature was discussed mainly by the UV-vis and CD spectral characteristics. Polycondensation of optically active (R)-(+)-2,2′-dihydroxy-9,9′-spirobifluorene 1 and terephthaloyl dichloride 2a in THF in the presence of triethylamine yielded the corresponding polyester as methanol-insoluble part (3a, 89%, Mw 5400, Mw/Mn 3.5). The polymerizations with 2,6-naphthaloyl dichloride 2b and 4,4′-azodibenzoyl dichloride 2c also afforded polyesters 3b (95%, Mw 20000, Mw/Mn 2.3) and 3c (95%, Mw 6200, Mw/Mn 2.2), respectively. In the solvent-free polymerization, the corresponding polyester 3a was obtained in 40% yield (Mw 16000). In the case of racemic 1rac, similar yield and molecular weight for 3a were achieved. Although no clear glass transition point was observed in all three polymers, these polymers had high thermal decomposition temperature over 480 °C. In the UV-vis and CD spectra of the polymers 3, bisignate Cotton effect was observed in the UV-vis absorption region of optically inactive diacid part of the repeating unit in all three polymers. Further, CD intensity of 3 depended upon temperature: the temperature increase corresponded to the decrease in CD intensity. Both the results obtained and the structure simulation of 3 suggested their helical conformation.

The Development and Institutionalization of Romani Representation and Administration. Part 3b: From National Organizations to International Umbrellas (1945–1970)—the International Level

This article is the fourth in this Nationalities Papers series, following Part 1 which covered the period from the arrival of Gypsies to Europe until the mid-nineteenth century, Part 2 describing the birth of the first modern Romani organizations from the nineteenth century up until the Second World War (WWII) and Part 3a covering the first wave of expansion of Romani activism countrywide after 1945. As mentioned in Part 3a, the period between WWII and 1970 can be distinguished from the previously covered periods by the emergence of the following phenomena: (1) modern Romani political organizations at the national level, (2) their unification through international Romani umbrella organizations, (3) some limited Romani participation in non-Romani mainstream political or administrative structures, (4) an international Romani evangelical movement, (5) reconciliation between Romani political representation and the Catholic Church, (6) national institutions created by various governments to aid the administration of policies on Roma, (7) rapid growth of non-governmental organizations addressing Romani issues, and (8) some limited cooperation between Romani organizations and intergovernmental organizations.

Reforms to the NSW Planning System &amp; Introduction of a New Assessment Process for State Significant Development: A Case Study

This paper examines recent reforms to the New South Wales planning system with a particular focus on the introduction of Part 3A of the Environmental Planning and Assessment Act 1979. Part One of this paper examines the details of all of these reforms which evidence a marked trend towards the streamlining of the New South Wales planning system and an increase in State government and Planning Ministerial powers. A case study of a Major Project currently being assessed under the newly introduced Part 3A of the EPA Act is examined in Part Two, demonstrating the potential advantages and pitfalls of the new system.

The Development and Institutionalization of Romani Representation and Administration. Part 3a: From National Organizations to International Umbrellas (1945–1970)—Romani Mobilization at the National Level

This article is the third in this Nationalities Papers series, following “Part 1: The Legacy of Early Institutionalism: From Gypsy Fiefs to Gypsy Kings,” which covered the period from the arrival of Gypsies to Europe until the mid-nineteenth century (Vol. 32, No. 3), and “Part 2: Beginnings of Modern Institutionalization,” describing the birth of the first modern forms of ethnically-based political and social organizations established by Romani elites from the nineteenth century up until the Second World War (WWII) (Vol. 33, No. 2). The article concentrates on developments between two significant landmarks in the history of Romani mobilization—the end of WWII in 1945 and the institutionalization of a permanent international Romani body in the form of a World Romani Congress, held for the first time in 1971. The time period covered in this article is distinguished from the previously covered periods by the emergence of the following phenomena: (1) modern Romani political organizations at the national level, (2) their unification through international Romani umbrella organizations, (3) some limited Romani participation in non-Romani mainstream political or administrative structures, (4) an international Romani evangelical movement, (5) reconciliation between Romani political representation and the Catholic Church, (6) national institutions created by various governments to aid the administration of policies on Roma, (7) rapid growth of non-governmental organizations addressing Romani issues, and (8) some limited cooperation between Romani organizations and intergovernmental organizations.

Problems in the theory and design of electromagnetic flowmeters for dielectric liquids. Part 3a. Modelling of zero drift due to flux linkage between coil and electrode cables

This paper investigates theoretically the magnitudes of zero offsets and zero drifts originating from magnetic flux linkage between the coils of the electromagnet and the loop formed by the electrode cables in an electromagnetic flowmeter for dielectric liquids. The dependence of such zero offsets on liquid properties, frequency of operation, etc. is explained. The paper gives the results of measurements of the effective electrical conductivity and permittivity of dielectric liquids BP180 and Castrol OX-9 (and mixtures of these) in the frequency range 1 Hz–1 kHz. These are used to predict the zero offsets expected in metering these liquids using phase sensitive detection with the flowmeter tube described in Part 1 of the paper. Precautions needed in flowmeter design to minimise instrument zero offsets and zero drifts are explained. The electromagnetic flowmeter theory was developed at Cranfield and the determination of the electrical properties of the dielectric liquids was carried out at QinetiQ.

Book Review: Practical CNC—Training for Planning and Shop Part 3a

Book Review: Practical CNC—Training for Planning and Shop Part 3a

Seaweeds of the British Isles. Volume 1, Rhodophyta, Part 3A, Ceramiales

Seaweeds of the British Isles. Volume 1, Rhodophyta, Part 3A, Ceramiales

Ipsilateral retinal projections and laminations of the dorsal lateral geniculate nucleus in the eastern chipmunk ( Tamias sibiricus asiaticus)

The ipsilateral retinal projections and laminations of the dorsal lateral geniculate nucleus (LGNd) were studied in the eastern chipmunk ( Tamias sibiricus asiaticus). From cyto-, myelo- and chemoarchitectures the LGNd was divided into the ventromedial and dorsolateral parts. Anterograde axonal transport of wheat germ agglutinated horseradish peroxidase (WGA-HRP) and Fink-Heimer staining after unilateral eye removal both indicated that the ipsilateral projection terminates in lamina 2 of the ventromedial part and in lamina 3b of the dorsalateral part. The remaining laminas, lamina 1 of the ventromedial part and laminas 3a and 3c of the dorsolateral part, receive afferents from the contralateral retina. It was suggested that laminas 1 and 2 of the chipmunk's LGNd correspond to laminas A and A1 of the cat's LGNd, and the lamina 3 complex to its lamina C complex.