Parent Components Research Articles

Elite Maize Lines Having Variability in Quality Parameters—A Valuable Starting Material for Grain Quality-Oriented Breeding Programs

Numerous factors, including genetic background, environmental conditions, agricultural practices, and postharvest management, affect maize grain quality. Six maize hybrids with common parental components were evaluated in micro- and production trials during five years, aiming at evaluating grain yield and grain quality traits and ascertaining the pattern of evaluated trait relationships based upon sources of variation (hybrid, year, and parental components). The parental effects were significant for the majority of analyzed quality traits, while the year effect was significant for all examined parameters. The PCAs indicated a considerable impact of the hybrids’ genetic makeup on physical parameters and kernel structure. The findings suggested the possibility of breeding simultaneously for higher protein and starch contents accompanied by a yield increase and higher protein and oil contents followed by a yield reduction. Multiple adverse interactions, which are inherently driven by the kernel structure, hamper the simultaneous breeding for higher oil and starch content. Significant quality parameter variation in the micro-trial was insufficient to provide improvement in grain quality obtained in the production trial. Although the existing variability of elite germplasm in quality parameters can be exploited, the introgression of new germplasm with high values of quality parameters per se is necessary for breeding focused on diverse applications.

Chinese adolescents’ socioeconomic status and English achievement: the mediating role of parental emotional support

Family socioeconomic status (SES) is one of the key indicators of academic achievement, including language achievement. Further investigation of SES’s mechanisms of influence and potential mediators is essential due to the concern regarding the disparities caused by SES in language achievement. This study examines the relation between SES and Chinese adolescents’ English achievement, emphasizing the role of parenting as a conduit for socioeconomic impacts on children and adolescents. The mechanism through which SES influences English achievement was examined in a sample of 1634 junior secondary school students in an urban city in mainland China. A unified model with solid fit indices, comprising both SES and parenting components, was identified through structural equation modeling. As expected, socio-economic disparities appeared to be largely associated with students’ English achievement, and this connection was partially mediated by parental emotional support. Parental emotional support, however, had varied mediating effects that affected the developmental course and shaped achievement outcomes across different SES groups. This study offers valuable insights into the joint contribution of distal SES factors and proximal interactions to achievement outcomes. Intervention efforts and future research implications are discussed.

Bidirectional effects of parenting and ADHD symptoms in young children: Effects of comorbid oppositional symptoms.

Psychosocial factors play an important role in the manifestation of attention-deficit/hyperactivity disorder (ADHD) symptoms and accompanying impairment levels in children. In a community sample of 796 children evaluated at 4, 5, and 6 years of age, bidirectional effects were examined for each of three components of parenting (parental support, hostility, scaffolding skills) and ADHD-specific symptoms that are not associated with symptoms of oppositional defiant disorder. Results indicated that (a) age 4 parenting factors were not associated with changes in ADHD-I (inattention) or ADHD-H (hyperactive-impulsive) symptoms in the subsequent year, (b) ADHD-I and ADHD-H symptoms at age 4 were not associated with changes in parenting factors at age 5, (c) age 5 ADHD-I and ADHD-H symptoms were associated with decreases in parental scaffolding skills and increases in parental hostility from ages 5 to 6 years, and (d) parental support at age 5 was associated with a decrease in ADHD-H symptoms at age 6. Findings suggest that ADHD symptoms can lead to poorer parenting attitudes and behavior, while parental support during kindergarten has a small effect on decreasing ADHD-H symptoms over time.

Development and Acceptability of Provider Training to Increase Treatment Engagement of Parents in Their Children's Behavioral Health Care Need.

BACKGROUND: Disruptive, Impulse-Control, and Conduct disorders (DIC) affect 5 million children in the United States and often require comprehensive and long-term behavioral health care for which sustained parental involvement is essential. Our research team is developing an intervention to improve parental engagement in the behavioral health care of their children with DIC. The intervention, which will be a modification of an evidence-based shared decision-making intervention called DECIDE, will include a parent component and a provider component. AIM: To determine the acceptability of the provider component of the modified DECIDE intervention. METHODS: The provider intervention is an asynchronous self-paced online training program made up of five modules: introduction, shared decision-making, perspective-taking, attributional errors, and being a responsive provider. The training was piloted with 41 providers in two public child and adolescent treatment programs. Following completion of the training, semi-structured interviews were conducted with the providers to assess the acceptability of the training. The interviews were analyzed with conventional content analysis. RESULTS: The provider training was well received by providers, and many had made practice changes based on what they had learned. Several offered recommendations for improvement, most notably the need to tailor the training based on provider role, discipline, and level of expertise. CONCLUSIONS: The feedback given by providers will be used to refine future iterations of the provider training component of the modified DECIDE intervention. Psychiatric nurses and other clinicians may draw from strategies incorporated in the training program to improve parent engagement in the treatment of children with DIC.

Morphological Evaluation and Phenolic Content of Wild Prunus cerasifera Ehrh. Fruits from Slovenia

Wild fruit species offer significant nutritional, environmental, and economic benefits. Among them, Prunus cerasifera Ehrh. (myrobalan) stands out for its resilience and nutrient-rich fruits, traditionally consumed fresh or dried. This study aimed to assess the morphological and biochemical diversity of 21 wild P. cerasifera accessions from Slovenia, focusing on 18 fruit and stone traits, including size, shape, color, and phenolic compounds such as total monomeric anthocyanins and total phenolic content (TPC). The objective was to identify genotypes with potential for cultivation and food production or as parental components in breeding programs. The results showed variability in fruit length (2.19–2.82 cm), width (2.18–2.99 cm), weight (67.98–150.30 g), firmness, and juiciness, with notable differences in stone characteristics. Phytochemical analysis revealed a wide range of TPC (277–1756 mg/100 g) and anthocyanin levels (0–710 mg/100 g), with higher concentrations in darker fruits. Statistical analysis compared PAM and AGNES clustering methods, finding that PAM with five clusters and AGNES with two clusters provided similar insights. The study emphasized variability in morphological and chemical traits among clusters, with specific accessions showing particularly valuable traits, such as accession RK13, which had high TPC and anthocyanins and a non-adherent stone.

The influence of flowering periods on productivity characteristics in breeding samples of soft winter wheat created with the involvement of western european ecotypes

Aim. To determine the nature of the influence of flowering periods on productivity traits in soft winter wheat lines, which were created with the involvement of late-ripening samples of the Western European ecotype. Methods. Research methods are field, laboratory, selection-genetic, statistical. Results. The nature of the manifestation of the "date of flowering" trait in hybrids F1-F3 and selection numbers selected from hybrid populations with the participation of Western European ecotypes of soft winter wheat, the correlation dependence of the date of flowering, grain yield, ear length and the duration of the "flowering-maturity" period were established. Optimums for the manifestation of indicators that determined high yield and ear length were established. Conclusions. For each hybrid population created with the participation of parental components contrasting in duration of vegetation, it is necessary to develop a specific selection plan taking into account intra-population correlations of yield, flowering dates and the duration of the "flowering-maturity" period.

Systematization of sunflower genotypes based on seed phenotypic characteristics using neural networks

In recent years, various datasets related to the phenotyping of sunflower genotypes have become increasingly accessible. However, one of the key challenges remains the efficient and accurate prediction of phenotypes based on genotypes in the context of climate change. Analyzing phenotypes at different levels of organization and detecting connections between phenotypes and genotypes require the integration and processing of large, diverse, and often noisy datasets. Machine learning offers a broad arsenal of methods and approaches for identifying predictive patterns in such data. Therefore, the research aimed to develop a methodology for the systematization of sunflower genotypes based on seed phenotypic characteristics using the data vector quantization method and neural networks. The study revealed the phenotypic characteristics of sunflower seeds from various genotypes selected by the Institute of Oilseed Crops of NAAS, grown in the southern Steppe of Ukraine, including seed length, width, thickness, seed mass, kernel mass, and seed coat cracking force. For this purpose, appropriate laboratory equipment was developed, including two modules for determining the morphological and rheological properties of seeds. The developed methodology for the systematization of sunflower genotypes based on seed phenotypic characteristics includes the following steps: measuring the characteristics of sunflower seeds from various samples (parental components); studying the mutual correlation of characteristics; conducting hierarchical cluster analysis of the data using the Ward's method; determining the optimal number of groups; performing k-means clustering using the vector quantization method; determining the correspondence of ranges of characteristics to the group; training a neural network to group the data by samples and created groups; verifying the adequacy of the neural network on test data. The developed methodology was tested, and the MLP 30-15-3 neural network for grouping data by samples and created groups of sunflower seeds was developed in the Statistica software package. The network's training efficiency was 99.4%, and such of testing and validation was 95.6% and 96.7%, respectively.

Unveiling the potential of newly synthesized 2D TMCC monolayer for H2S gas sensing: A DFT study

The 2D monolayer of transition metal carbo-dichalcogenide (TMCC) has been recently synthesized from its bulk form. It is a unique blend of MXenes and transition metal dichalcogenides (TMDCs), offering superior properties compared to its individual parent components. TMCC has not yet been explored for its potential in gas sensing applications, motivating us to investigate its performance for detecting H2S gas molecule. The pristine monolayer of TMCC (Nb2S2C) exhibited weak H2S adsorption energy (-0.18 eV), leading to low sensitivity, poor selectivity, underscoring surface modification. The decoration strategy was incorporated by considering transition metal (TM) atoms like Ti, Co, Cu, Pd and Ag. Ti and Co decorated TMCC showed superior H2S gas sensing performance. Ti showed maximum binding energy (-5.44 eV) followed by Co (-4.91 eV). The adsorption energy of H2S on Ti and Co decorated TMCC were comparable having values of -1.08 eV and -1.09 eV respectively while showing respective practical recovery time of 6 s and 8.5 s at 350 K, respectively. The improved adsorption mechanism is due to orbital interaction and charge transfer. Work function sensitivity and thermal stability upto 400 K was assessed. The study shows Ti and Co decorated TMCC monolayer as a suitable candidate for H2S sensing, inspiring experimentalists to fabricate TMCC-based H2S sensors.

Effects of multi-component parenting and parental mental health interventions on early childhood development and parent outcomes: a systematic review and meta-analysis

Interventions supporting parents of young children often target parenting or parental mental health separately. Multi-component parenting and parental mental health interventions have the potential to improve parenting practices, mental health, and early childhood development. We aimed to examine their impact on child and parent outcomes. In this systematic review and meta-analysis, we searched MEDLINE, Embase, Web of Science Core Collection, APA PsycINFO, CINAHL Complete, the Cochrane Central Register of Controlled Trials, and the Global Health Database from inception to Jan 23, 2024. Eligible studies were randomised controlled trials of interventions explicitly targeting parenting behaviours and parental mental health antenatally or in children's first 3 years of life. Screening, extraction, and quality assessment were done independently by two authors. Primary outcomes were cognitive and social-emotional functioning in children and depressive symptoms in parents, meta-analysed as standardised mean differences (SMDs), relative to control. This study is registered with PROSPERO, CRD42022302848. We found 5843 records. After screening 2636 (45·1%) titles and abstracts, we manually identified and screened three additional articles and excluded 2177 records. After screening 462 full-length articles, 25 articles, representing a sample size of 8520 children and caregivers, were included. At baseline, mean caregiver age was 27·7 years (SD 5·9) and mean child age (excluding those enrolled during pregnancy) was 14·4 months (8·0). Interventions lasted a mean of 14 months (SD 11) and used a mean of 3·7 behaviour change techniques (2·0). Most interventions dedicated more time to parenting behaviours than to parental mental health. We found significant intervention effects on children's cognitive (SMD 0·19 [95% CI 0·04 to 0·34]; I2=69%) and social-emotional (0·26 [0·17 to 0·34]; I2=47%) outcomes but not on depressive symptoms in female caregivers (-0·18 [-0·36 to 0·002]; I2=86%) relative to control conditions. Risk of bias across studies was moderate, and we found heterogeneity across results. Multi-component parenting and mental health interventions had a positive effect on child cognitive and social-emotional outcomes, but not on depressive symptoms in parents, suggesting that other factors might contribute to positive ECD outcomes. Interventions might lack adequate focus on mental health to make a discernible impact, highlighting a need for future studies to differentiate and assess contributions of parenting and mental health components to understand independent and collective effects on family outcomes. Canadian Institutes of Health Research.

189 Development of the Youth-Physical Activity Towards Health in Northern Ireland (Y-PATH NI) Study

Abstract Purpose The Youth-Physical Activity Towards Health (Y-PATH) programme is an evidence-based physical literacy intervention, aimed at enhancing provision of physical education (PE). Previous research has demonstrated the effectiveness of Y-PATH at increasing children’s physical activity levels and fundamental movement skills in Ireland. As Northern Ireland (NI) has different curricular provision, this study will consult with key stakeholders (pupils, teachers, parents) to test the acceptability of Y-PATH and adapt intervention content for delivery in NI post-primary schools. Methods The development phase involved reviewing the NI PE curriculum, a cross-sectional online survey with NI pupils (n = 1541, 11-14 years), focus groups (n = 17) with pupils aged 11-16 years, and interviews with parents and teachers (n = 15). In addition, 22 pupils participated in a Youth Advisory Group and were asked to provide feedback on intervention resources and proposed data collection measures for future feasibility testing. Descriptive statistics and chi-square analyses were run for quantitative data. Qualitative data were analysed using thematic analysis, data were summarised, and themes were generated. Results Participants reported wanting to take part in more physical activity with their friends, during school time and to be given a choice of activities in their PE classes. Parents in NI indicated that they thought the Y-PATH programme would be beneficial for children and reported that they would be willing to be involved with the parent component of the intervention, while teachers noted some concerns in relation to the additional workload the intervention might entail. Feedback from the Youth Advisory Group suggested proposed outcome measures were acceptable, with detailed feedback provided on the design and functionality of Y-PATH resources, for example, the student journal. Conclusions The findings from this study suggest that the Y-PATH intervention would be suitable for schools in NI. The adapted Y-PATH NI programme will be tested in a feasibility trial and a process evaluation will determine the fidelity and acceptability of the Y-PATH intervention within the NI setting. These findings will help policymakers and researchers develop interventions that will be effective in increasing physical activity levels amongst youth. Support/Funding Source This study is funded by Northern Ireland Chest Heart and Stroke.

Spectroscopic and computational investigations of isostructural phase transitions in urea 4-carboxyanilinium nitrate having trapped disordered-nitrate ions

Urea 4-carboxyanilinium nitrate (U4-CAN) and its functional groups deuterated counterpart dU4-CAN were studied using infrared vibrational spectroscopy and computational analysis. Using the known frequencies of the parent components the infrared vibrational frequencies of U4-CAN and dU4-CAN were assigned. FTIR study was carried out to understand how the intra-and inter-molecular interactions in the parent components are affected by U4-CAN co-crystal formation. U4-CAN undergoes isostructural phase transition at 359.1 K. Hence FTIR spectra of U4-CAN were also recorded at different temperature in the range 293 K to 368 K. The interesting observation seen with temperature dependent spectra was:(i) the spectral band intensity increased with increasing temperature and (ii) the peak position of almost all bands did not change in the entire temperature range studied. This results corroborate with the reported structural data of U4-CAN were in it is found that the structural phase transition is isostructural. Hence the crystal structure in the range 293 K to 368 K has same space group and differ only in few hydrogen bond interactions. In order to carry out various theoretical calculation of U4-CAN, the crystallographically obtained structure at 293 K was optimized by density functional theory (DFT) with B3LYP/6–311 G basis set. The theoretical calculated vibration spectra were similar to the experimentally obtained FTIR data. The fingerprint plot of U4-CAN obtained using CrystalExplorer 21 software indicated that the most prominent interaction corresponds to the short O···H contact. Noncovalent interaction (NCL) study indicated that the U4-CAN complex has steric, van der Waals and hydrogen bond interactions and the NH⋅⋅⋅⋅⋅O hydrogen bond interaction between NH3+/ NH2 moieties and NO3- was the strongest. From QTAIM calculation the strongest hydrogen bond interaction in U4-CAN complex was for NH.....O and NH.....N interactions.

Mental Health Interventions in Middle Schools: A 10-Year Review of Research.

Schools can play an important role in addressing growing concerns about adolescent mental health. Mental health of high school students has predominantly been the focus in literature with less emphasis on younger adolescents. This review identified articles published in the last decade that described evaluations of middle school-based mental health interventions and randomized participants to an intervention or control condition. Fourteen interventions met the inclusion criteria. About two-thirds of interventions were based on mindfulness or cognitive behavioral therapy. Many trials utilized racially diverse, low-income samples. All interventions were delivered to groups, and three contained a parent component. Five trials increased rigor by using an active control condition. Almost two-thirds of the interventions were effective (p < .10) in reducing at least one depression, anxiety, affect, or internalizing symptom outcome compared to a control group. This article provides information about intervention characteristics, efficacy, theoretical framework, and acceptability/feasibility.

Зміни жирнокислотного складу проростків кукурудзи за впливу мікробіологічного комплексу

Orientation of agricultural production to ecological expediency leads to interest in the use of microbial preparations that are able to increase the resistance of plants to negative environmental factors and activate germination processes. This study was conducted with the aim to investigate the influence of a microbiological complex on the sowing properties of seeds and the fatty acid composition of seedlings of different breeding samples of corn. Methods. Corn seeds of two lines 1-Ak026 and 2-Ak033 and their simple interline hybrid, which is the parent component of the three-line hybrid NUBiSe included in the State Register of plant varieties suitable for distribution in Ukraine, were used for the research. Seed inoculation was carried out with a microbial complex, which contained biological preparations Sporazyn, Avercom, and Phytovit. Seedlings from the seeds of the corresponding corn samples not treated with the microbial complex served as controls. The fatty acid composition of lipids was determined in the biological material of corn seedlings of different variants of the experiment. The Folch method was used to extract fats from plant material. Hydrolysis and methylation of fatty acids of lipids obtained from corn seedlings was carried out according to DSTU ISO 5509-2002. Fatty acids were detected and identified by gas chromatography. The quantity of fatty acids was calculated by the method of internal normalization in percentages. Results. The influence of the microbiological complex on the quantitative and qualitative composition of fatty acids of the lipid complex of corn seedlings was established, which depended on the breeding sample. In the process of research, 22 fatty acids were detected and quantitatively identified in corn seedlings. In the seedlings of lines 1-Ak033 and 2-Ak033, 20 and 19 of them were found, respectively, and in the hybrid – 18. The highest percentage content (more than 90 %) was revealed for palmitic (C16:0), oleic (C18:1n9c), and linoleic (C18:2ω6c) fatty acids. The use of the microbial complex made it possible to detect the fatty acids in line 1 and the hybrid that were not detected in the samples without inoculation. Conclusions. The study of the fatty acid composition of the microbial preparation Sporazyn revealed the highest content of unsaturated fatty acids (67.47 %) and the ratio of saturated to unsaturated (0.48). The use of microbiological preparations on corn seeds increased the activity of the germination processes, which led to the improvement of sowing properties and changes in the fatty acid composition of the lipid complex of seedlings of various breeding forms of Zea mays.

Protective Efficacy of the Epitope-Conjugated Antigen N-Tc52/TSkb20 in Mitigating Trypanosoma cruzi Infection through CD8+ T-Cells and IFNγ Responses.

Chagas disease, caused by the protozoan Trypanosoma cruzi, remains a major public health challenge affecting millions in Latin America and worldwide. Although significant progress has been made in vector control, no vaccine exists to prevent infection or mitigate disease pathogenesis. We developed a rationally designed chimeric protein vaccine, N-Tc52/TSkb20, incorporating immunodominant epitopes from two T. cruzi antigens, the amino-terminal portion of Tc52 and the TSkb20 epitope derived from trans-sialidase. The objectives of this study were to construct and characterize the antigen and evaluate its protective potential in an immunoprophylactic murine model of T. cruzi infection. The N-Tc52/TSkb20 protein was recombinantly expressed in E. coli and its identity was confirmed using mass spectrometry and Western blotting. Immunization with the chimeric protein significantly controlled parasitemia and reduced the heart, colon, and skeletal muscle parasite burdens compared to non-vaccinated mice. Protection was superior to vaccination with the individual parental antigen components. Mechanistically, the vaccine induced potent CD8+ T-cell and IFNγ responses against the incorporated epitopes and a protective IgG antibody profile. A relatively low IL-10 response favored early parasite control. These results validate the promising multi-epitope approach and support the continued development of this type of rational vaccine design strategy against Chagas disease.

Quantifying the impact of anthropogenic emissions and aquatic environmental impacts on sedimentary mercury variations in a typical urban river

In urban and industrial regions, sedimentary mercury (Hg) serves as the crucial indicator for Hg pollution, posing potential risks to ecology and human health. The physicochemical processes of Hg in aquatic environments are influenced by various factors such as anthropogenic emissions and aquatic environmental impacts, making it challenging to quantify the drivers of total mercury (THg) variations. Here, we analyzed the spatiotemporal variations, quantified driving factors, and assessed accumulation risks of sedimentary THg from the mainstream of a typical urban river (Haihe River). THg in the urban region (37−3237 ng g−1) was significantly higher (t-test, p < 0.01) than in suburban (71−2317 ng g−1) and developing regions (156−916 ng g−1). The sedimentary THg in suburban and developing regions increased from 2003 to 2018, indicating the elevated atmospheric deposition of Hg. Together with the temperature, grain size of sediments, total organic carbon (TOC), the pH and salinity of water, 40 components of parent and substituted polycyclic aromatic hydrocarbons (PAHs) were first introduced to quantify the driver of sedimentary THg based on generalized additive model. Results showed that anthropogenic emissions, including three PAHs components (31%) and TOC (63%), accounted for 94% of sedimentary THg variations. The aquatic environmental impacts accounted for 5% of sedimentary THg variations. The geo-accumulation index of THg indicated moderate to heavy accumulation in the urban region. This study demonstrates that homologous pollutants such as PAHs can be used to trace sources and variations of Hg pollution, supporting their co-regulation as international conventions regulate pollutants.

Unveiling school community perceptions of nutrition-friendly school initiatives in preschool settings in rural Sindh province, Pakistan: an exploratory study.

In 1995, the World Health Organization launched its Global School Health Initiative to expand the Health Promoting School (HPS). The objective of this study was to explore the perception of the school community in implementing nutrition-friendly school initiatives in preschool settings. This paper delineates the exploratory phase of a mixed-method study, which broadly aims to assess the adoption of the Nutrition Friendly School Initiative (NFSI) through a preschool preparedness intervention package in rural Sindh province, Pakistan. The study sites include three campuses of the Aga Khan School (Mirpur Sakro, Junior Campus Vur, and a community-based school in Sujawal). Participants were selected purposively from these campuses and constituted a committee named 'school community,' which was responsible for implementing all activities outlined in the intervention package. Data was gathered through in-depth interviews and consultative meeting with the school community. Thematic analysis was employed for data analysis. The analysis established five major themes that represent the participants' perception of school-based nutrition interventions in preschool settings. These five themes include (i) Challenges in health and nutrition for pre-school age children, (ii) Clarity in roles and responsibilities for school-based nutrition intervention, (iii) Advancing school-based nutrition activities and interventions, (iv) Recognizing resources requirements, (v) Opportunities and challenges for the way forward in school-based nutrition. Findings also suggest sustainability and scalability measures that include the aligning School Nutrition Policy with the school handbook, ways to engage with parents, a nutrition theme corner, the inclusion of a parenting component in the nutrition manual, and capacity building of the school community. Qualitative findings have guided the refinement of the intervention package, proposing additional measures for sustainability and scalability across AKES, P. The school community is hopeful that the implementation of the refined intervention package will enhance preschool preparedness toward achieving nutrition-friendly school checklist items. This study holds strong potential for replication in a public school setting and presents an opportunity to launch a school accreditation program to certify schools as Nutrition-friendly.

Interrelationships of Quality of Parental Relationship, Self-esteem, and Relational Skills among 4Ps Teenage Beneficiaries in Iligan City, Philippines

Understanding how family dynamics and self-esteem impact the social development of teenagers from low-income backgrounds is crucial for designing effective youth development programs. This study investigates the relationship between parental relationships, self-esteem, and relational skills among senior high school students who are beneficiaries of the Pantawid Pamilyang Pilipino Program (4Ps) in Mindanao, Philippines. Utilizing a descriptive-correlational design and simple random sampling, the study surveyed 171 students using standardized questionnaires. Data analysis included mean, standard deviation, Pearson correlation, and linear regression. Participants reported high parental relationship quality, self-esteem, and relational skills components such as bi-directional communication, disclosure and interpersonal closeness, and emotional experience and expression. However, assertion and conflict resolution skills were rated moderately. Parental relationships significantly correlated with self-esteem, particularly with mothers (p&lt;0.05). Both factors significantly influenced relational skills (p&lt;0.05). These findings suggest that while the 4Ps program may positively impact family relationships and self-esteem, additional support might be beneficial for developing stronger assertion and conflict resolution skills among beneficiaries, potentially leading to improved overall social development.

META-EMOTIONS: CONCEPT, STRUCTURE AND APPROACHES TO STUDY

The article examines the concept of meta-emotions or second-order emotions. The latter are understood as the emotions that the subject experiences regarding his own emotions, as well as the emotions of another person. An analysis of the development of this construct in philosophical and psychological research is presented. In this context, the relevance of introducing the concept of meta-emotions into the categorical apparatus of psychology and the empirical study of meta-emotional processes is discussed. In psychological studies of meta-emotions, two approaches have been identified that have developed to date. First, meta-emotions are considered as a component of emotional education strategies that parents implement in relation to their children. Secondly, meta-emotions are studied as part of the development of the problem of emotional intelligence, in particular based on the phenomena of meta-mood. The article also discusses the question of the structure of meta-emotions. Options are analyzed that provide a general formal description of the structure of meta-emotional activity (the object of meta-emotions, goals in the context of which meta-emotional states arise, feedback between meta-emotions and emotional goals). At the same time, the model of J. Gottman et al. is presented, in which meta-emotions act as an essential component of parents’ approaches to the emotional regulation of the child’s behavior, which are different in their productivity. Conclusions are drawn regarding the possibility of using the model of parental meta-emotions in relation to situations of educational interaction between a teacher and a student. Purpose. The article is devoted to the topic of meta-emotions, which is relevant in the current state of development of psychology and pedagogy. The subject of analysis is meta-emotions in parent-child relationships. The author aims to explore the concept, structure and modern approaches to the study of meta-emotions, as well as to analyze the model of the influence of parental meta-emotions on the child’s results in the development of emotional self-regulation skills by J. Gottman and Katz and determine the possibilities of its use in relation to the interaction between teacher and student. Methodology. The basis of the study is observation, the method of generalization of independent characteristics and twin methods. Results. The results of the work are that the author emphasizes the presence of a close relationship between the child’s ability for emotional self-regulation based on the understanding of meta-emotions by the subjects of education represented by parents or teachers. Practical implications. The results of the study can be applied in the field of psychological and pedagogical interaction between subjects of education and students based on the analysis of meta-emotions and emotional self-regulation.

Parental involvement and support of selected parents for children with special needs: a case study

The purpose of the study was to determine the extent of parental involvement with respect to guiding, communication, home training and attending meetings/conferences in the school. As well as parental support with respect to financial, psychological, and emotional aspects were used. This study made use of the descriptive methods of research. The questionnaire-checklist developed and subjected to validation of experts in the field of research and education. The subject-respondents of the study were the 40 parents and 3 Special Education teachers who were chosen through stratified random sampling. Regarding the assessment of the respondents, parental involvement components such as Guiding, Communicating, Home Training and Attending Meeting/School Conference that affected the learner’s performance were assessed often by the parents. Among the four, Attending Meeting/School Conference had a notable mean of 6.35 verbally interpreted as Often. In terms of parental support Financial, Emotional and Psychological aspects, they gained Often as elicited by the parents toward their child. Among the three, the financial aspect had the notable mean of 3.67 verbally interpreted as Often. There was no significant difference on the assessments of the two groups of respondents on the extent of parental involvement since the t-value did not exceed the 0.05 level of significance which failed to reject the null hypothesis. However, there was a significant difference on the assessment of the two groups of respondents on parental support and psychological aspect and no significant difference on financial and emotional aspect. Lastly, the School Improvement Plan and Annual Implementation Plan carried out involvement programs engaging parents and other stakeholders.

1,2,3-triazole and chiral Schiff base hybrids as potential anticancer agents: DFT, molecular docking and ADME studies

A series of novel 1,2,3-triazole and chiral Schiff base hybrids 2–6 were synthesized by Schiff base condensation reaction from pre-prepared parent component of the hybrids (1,2,3-triazole 1) and series of primary chiral amines and their chemical structure were confirmed using NMR and FTIR spectroscopies, and CHN elemental analysis. Compounds 1–6 were evaluated for their anticancer activity against two cancer PC3 (prostate) and A375 (skin) and MRC-5 (healthy) cell lines by Almar Blue assay method. The compounds exhibited significant cytotoxicity against the tested cancer cell lines. Among the tested compounds 3 and 6 showed very good activity for the inhibition of the cancer cell lines and low toxicity for the healthy cell lines. All the compounds exhibited high binding affinity for Androgen receptor modulators (PDB ID: 5t8e) and Human MIA (PDB ID: 1i1j) inhibitors compared to the reference anticancer drug (cisplatin). Structure activity relationships (SARs) of the tested compounds is in good agreement with DFT and molecular docking studies. The compounds exhibited desirable physicochemical properties for drug likeness.