Parent Artery Thrombosis Research Articles

Preliminary experience of stent salvage using Neuroform Atlas stent for procedure-related complication during coil embolization of intracranial aneurysms

ObjectivesAlthough stent-salvage technique has been well-known to rescue the situation of coil protrusion into the parent artery aggravating to make thromboembolism, the smallest profiled Neuroform Atlas stent can be expected to handle those situations easily compared to previously used intracranial stents. Thus, the purpose of this study was to report our series of stent salvage using the Neuroform Atlas stent for procedure-related complications during coil embolization of intracranial aneurysms. Patients and methodsIn March 2018, the Neuroform Atlas was approved for use in our country. Since then, we have treated 541 aneurysms in 502 patients with coil embolization. There were 15 consecutive cases (14 unruptured and 1 ruptured) with procedure-related complications, such as coil protrusion or parent artery thrombosis, rescued by the Neuroform Atlas stent. Follow-up angiography was performed in 14 of the 15 patients between 6–12 months (mean 8.2 months) after the procedure, and clinical follow-up was performed from 2 to 18 months (mean 11.2 months) after the procedure. ResultsProcedure-related complications included parent artery thrombosis due to coil herniation (n = 5) and coil protrusion floating in the parent artery (n = 10). There was no complication related to delivery or deploy of Neuroform Atlas stents. In 12 (80.0 %) of the 15 cases, the stent was deployed via the same microcatheter for coil delivery. In 3 cases of wide neck aneurysms, the stent was deployed via another microcatheter per the scheduled stent-assisted or double microcatheter techniques. Initial angiographic results showed 11 (73.3 %, 11/15) cases of complete occlusion, and 12 (85.7 %, 12/14) cases achieved complete occlusion in follow-up angiographies. ConclusionsFacing with procedure-related complications during coil embolization of intracranial aneurysms, the smallest profiled Neuroform Atlas stent might be a time-saving and feasible option for the salvage technique by using the same microcatheter to deliver coils.

LEO Baby Stent Use following Balloon-Assisted Coiling: Single- and Dual-Stent Technique--Immediate and Midterm Results of 29 Consecutive Patients.

We report our preliminary results in terms of safety and efficacy in using the low-profile LEO Baby stent for the treatment of large-neck and complex intracranial aneurysms with balloon-then-stent-assisted coiling and single- or dual-stent-assisted coiling. Clinical and radiologic data of all consecutive patients treated at our institution from September 2012 to October 2013 for an intracranial aneurysm by using a LEO Baby stent were retrospectively analyzed. Immediate and midterm clinical and anatomic follow-up of each patient is reported. Twenty-nine patients with 29 aneurysms were treated with LEO Baby stents at our institution. The mean age of patients was 48 years; 20 patients were women (71%). One patient was treated in the acute phase of a subarachnoid hemorrhage. In 8 procedures, a double-lumen-catheter balloon was used for balloon-then-stent-assisted coiling. In 3 cases, a LEO Baby stent was used in a Y-, T-, and telescopic dual-stent configuration. In 18 cases, a single LEO Baby stent was used. In 2 cases, technical failure to deploy the stent resulted in acute parent artery thrombosis. In 3 further cases, thromboembolic complications occurred intraoperatively. MR imaging and angiographic midterm follow-up showed complete aneurysm occlusion for 96% of the followed patients (27/29). Clinical outcome was favorable for all patients followed up. Results obtained in our study by using the LEO Baby stent for balloon-then-stent and single- or dual-stent-assisted coiling of complex and distally located intracranial aneurysms are encouraging. Incomplete or inadequate opening of the device is a potential cause of laminar blood flow alteration and thrombus formation.

Long-term follow-up study of 35 cases after endovascular treatment for vertebrobasilar dissecting aneurysms

ObjectiveVertebrobasilar dissecting aneurysm (VBDA) management is challenging despite the availability of multiple treatment strategies. We reviewed our experiences using endovascular treatment for VBDA patients to assess the efficacy and safety of several VBDA treatment strategies. MethodsAssisted by intra-arterial digital subtraction angiography, 35 patients in our hospital were treated using various VBDA treatment strategies, including stent-assisted coil embolization (20 patients), placement of single or multiple overlapping stents (5 patients) or coil embolization combined with proximal coil trapping of the dissected segment of the parent artery (CE+PT; 10 patients). We retrospectively reviewed the perioperative records of all 35 patients and the post-procedure angiographic and clinical outcomes of 31 available patients. ResultsOf the 25 cases with ruptured VBDAs, 14 underwent stent-assisted coil embolization, 2 underwent multiple overlapping stent placement and 9 underwent CE+PT. Perioperative complications occurred in four cases (16.0%), including one aneurysm rupture and one parent artery thrombosis during the procedure and two incidences of brainstem ischemia after the procedure. Clinical outcome evaluations were performed using the Modified Rankin Scale and resulted in the following scores: 0–2 for 22 patients (22/25, 88.0%), 5 for one patient (1/25, 4.0%) and 6 for two patients (2/25, 8.0%). No cerebral bleeding events or deaths occurred during the follow-up period. Of the 10 cases with unruptured VBDAs, six underwent stent-assisted coil embolization, three underwent single or multiple overlapping stent placement and one patient underwent CE+PT. All 10 of the patients with unruptured VBDAs had favorable clinical and radiologic outcomes without procedure-related complications. ConclusionsFor patients with ruptured VBDAs, the complication rate associated with endovascular treatment is acceptable. CE+PT is better than stent coiling in preventing aneurysmal rerupture, but is associated with a high incidence of ischemic stroke. For unruptured VBDAs, endovascular treatment is associated with good clinical outcome without perioperative complications, including rerupture and ischemic stroke. However, the high postoperative recurrent aneurysm risk suggests the necessity of long-term angiographic follow-up monitoring of VBDA patients who undergo endovascular treatments.

Initial experience of coiling cerebral aneurysms using the new Comaneci device

We present our initial patient experience with an innovative temporary bridging device, the Comaneci (Rapid Medical, Israel), to assist in the coiling of cerebral aneurysms. The Comaneci device confers the...

Treatment of ruptured blood blister-like aneurysms with flow diverter SILK stents

IntroductionBlood blister-like aneurysms (BBAs) are fragile and difficult to treat. Routine surgical and endovascular treatment methods, such as clipping, clip wrapping, primary coiling, or stent assisted coiling, have relatively high...

Resolution of Mass Effect and Compression Symptoms following Endoluminal Flow Diversion for the Treatment of Intracranial Aneurysms

Alleviation of aneurysm induced mass effect has been difficult with both conventional endovascular and surgical techniques. Our aim was to study the efficacy of endovascular flow modification on aneurysm-induced mass effect and compression syndrome, as demonstrated by cross-sectional imaging studies and clinical follow-up. Thirty aneurysms larger than 10 mm were treated by flow diversion alone and previously had undergone pre- and posttreatment cross-sectional imaging. Pretreatment MR imaging or contrast CT, follow-up angiography at 6 months, and follow-up MR imaging studies between 6 and 18 months were retrospectively analyzed. The neurologic and neuro-ophthalmologic statuses of all patients were recorded before treatment and at the time of follow-up cross-sectional imaging. At 6 months, 28 aneurysms were completely occluded, 1 had a neck remnant, and 1 had residual filling on angiography. Between 6 and 18 months, 3 aneurysms decreased in size and 27 completely collapsed as demonstrated on MR imaging. Before treatment, 6 patients had vision loss, 10 had double vision due to a third or sixth nerve palsy or both, and 1 had hemiparesis due to brain stem compression. On MR imaging follow-up, vision loss had either improved or resolved in all except 1 patient, double vision had resolved completely (7/10) or partially (3/10), and the patient with brain stem compression became asymptomatic. There was no bleeding observed in this series. One parent artery thrombosis resulted in a major infarct. Endovascular flow diversion is a highly effective technique for resolving radiologic mass effect and clinical compression syndromes.

Stent salvage using the Enterprise stent for procedure-related complication during coil embolization of ruptured intracranial aneurysms

Despite accumulated experience and improved understanding of the tools, endovascular treatment of intracranial aneurysms continues to have risks linked to the technique itself, and induces procedure-related complications. The purpose of this study was to report our series of stent salvage using the Enterprise stent for procedure-related complication during coil embolization in patients with ruptured intracranial aneurysms. Parent artery thrombosis, parent artery dissection, and coil protrusion were considered to be the procedure-related complications. There were 18 consecutive cases (3 unruptured and 15 ruptured aneurysms) with procedure-related complications rescued by the Enterprise stent from December 2008 to December 2011. Follow-up angiography was performed in 14 of the 15 patients with ruptured aneurysms between 6 and 30months (mean 14.6months) after the procedure. The procedure-related complications were parent artery dissection (n = 1), parent artery thrombosis (n = 4), and coil protrusion (n = 10). There was no complication related to delivering or deploying of the Enterprise stent. Initial radiographic results showed 8 cases of complete occlusion and 7 cases of neck remnant. There was no change in the angiographic results during the follow-up periods. Facing with procedure-related complications during coil embolization of ruptured intracranial aneurysms, the closed-cell designed Enterprise stent might be a useful option for the salvage technique by restoring blood flow and minimizing thromboembolic events.

Response to Letter Regarding Article “Flow-Diverter Stent for the Endovascular Treatment of Intracranial Aneurysms: A Prospective Study in 29 Patients With 34 Aneurysms”

Response: In response to Pierot,1 we would offer the following: We agree with the author about most comments. However, we believe that several points must be emphasized: 1. There are only 2 other series that have evaluated the use of the Silk flow-diverter stent.2,3 In both studies, the overall complication rate is quite high and is comparable to ours. Kulcsar et al3 have reported a 33% complication rate with 1 acute parent artery thrombosis and 3 delayed thromboembolic events …

Early Experience in the Treatment of Intra-Cranial Aneurysms by Endovascular Flow Diversion: A Multicentre Prospective Study

IntroductionFlow diversion is a new approach to the endovascular treatment of intracranial aneurysms which uses a high density mesh stent to induce sac thrombosis. These devices have been designed for the treatment of complex shaped and large size aneurysms. So far published safety and efficacy data on this approach is sparse.Material and MethodsOver 8 months, standardized clinical and angiographic data were collected on 70 patients treated with a flow diverter device (SILK flow diverter (SFD)) in 18 centres worldwide. Treatment and early follow up details were audited centrally. SFDs were deployed alone in 57 (81%) or with endosaccular coils in 10 (14%) aneurysms, which included: 44 (63%) saccular, 26 (37%) fusiform shapes and 18 (26%) small, 37 (53%) large, 15 (21%) giant sizes. Treatment outcome data up to 30 days were reported for all patients, with clinical (50 patients) and imaging (49 patients) follow up (median 119 days) data available.ResultsDifficulties in SFD deployment were reported in 15 (21%) and parent artery thrombosis in 8 (11%) procedures. Procedural complications caused stroke in 1 and serious extracranial bleeding in 3 patients; 2 of whom developed fatal pneumonias. Delayed worsening of symptoms occurred in 5 patients (3 transient, 1 permanent neurological deficit, and 1 death) and fatal aneurysm bleeding in 1 patient. Overall permanent morbidity rates were 2 (4%) and mortality 4 (8%). Statistical analysis revealed no significant association between complications and variables related to treated aneurysm morphology or rupture status.ConclusionThis series is the largest reporting outcome of the new treatment approach and provides data for future study design. Procedural difficulties in SFD deployment were frequent and anti-thrombosis prophylaxis appears to reduce the resulting clinical sequelae, but at the cost of morbidity due to extracranial bleeding. Delayed morbidity appears to be a consequence of the new approach and warrants care in selecting patients for treatment and future larger studies.