Parenchyma-preserving Surgery Research Articles

A novel low-cost high-fidelity porcine model of liver metastases for simulation training in robotic parenchyma-preserving liver resection.

In the era of minimally invasive surgery (MIS), parenchyma-preserving liver resections are gaining prominence with the potential to offer improved perioperative outcomes without compromising oncological safety. The surgeon learning curve remains challenging, and simulation plays a key role in surgical training. Existing simulation models can be limited by suboptimal fidelity and high cost. We describe a novel, reproducible, high-fidelity, low-cost liver metastases model using porcine livers from adult Landrace pigs, with porcine perinephric fat used to simulate subcapsular metastases. This model was then utilised in a training session for surgical trainees performing robotic parenchyma-preserving surgery (PPS) under the guidance of expert robotic surgeons, with feedback being recorded. Trainees rated the model highly on its fidelity to human liver simulation (median score 9), tissue handling (median score 8), and overall usefulness (median score 9). Tissue handling was felt to simulate in vivo liver resection closely, while suggestions for improvement included adding simulated blood flow. This is a novel, low-cost, high-fidelity simulation model of liver metastases with high acceptability to surgical trainees, which could be readily adopted by other training centres.

Perioperative safety and prognosis following parenchyma-preserving surgery for solid pseudopapillary neoplasm of the pancreas

Background/objectivesTo evaluate perioperative safety and outcome of parenchyma-preserving pancreatectomy and risk factors of metastasis and recurrence for patients with solid pseudopapillary neoplasm (SPN).MethodsDemographic data, operative and pathological parameter, follow-up data of patients with SPN undergoing their first operation were collected in our single center from May 2016 to October 2021 and compared between regular pancreatectomy group and parenchyma-preserving surgery group. Risk factors for metastasis and recurrence were investigated.ResultsA total of 194 patients were included, 154 of whom were female and the average age of all patients was 33 years old. Most patients were asymptomatic, with the most common complaint being abdominal pain or discomfort. Of them, 62 patients underwent parenchyma-preserving pancreatectomy including middle segment pancreatectomy and enucleation, and 132 patients underwent regular pancreatectomy including pancreaticoduodenectomy, distal pancreatectomy and total pancreatectomy. Patients in the parenchyma-preserving surgery group had a shorter duration of operation, less intraoperative bleeding, and decreased risk of combined organ removal and blood transfusion, with no statistical significance yet. The two groups exhibited a similar incidence of postoperative complications including grade B and C pancreatic fistula, delayed gastric emptying, postoperative pancreatic hemorrhage, and other complications, as well as radiological intervention, relaparotomy and the length of postoperative hospital stay. There were no perioperative deaths. All the patients, except 18 of those who discontinued follow-up, were alive with a median follow-up time of 31 months. Three patients in the regular pancreatectomy group were observed to have liver metastasis, and no metastasis was observed in the parenchyma-preserving surgery group. Significant risk factors for tumor metastasis and recurrence were tumor size, angioinvasion, and nerve infiltration.ConclusionsParenchyma-preserving surgery did not significantly increase the frequency of perioperative complications or recurrence and might be preferable if comprehensive conditions allow.

25, 50 & 75 years ago.

25, 50 & 75 years ago.

Respiratory Distress Due to Giant Pulmonary Hydatid Cyst

Pulmonary echinococcosis most frequently occurs in the right and both lower lobes. Children are more likely to develop pulmonary rather than hepatic echinococcal cysts. Some evidence suggests that echinococcal cysts develop more rapidly in the lungs of children than those of adults, which may explain the more common appearance of pulmonary cysts in children. Younger patients have larger cysts owing to their greater tissue elasticity. Large pulmonary hydatid cysts are critical because they pose a higher risk of rupture. Herein, we present an eight-year-old girl presented with severe respiratory distress due to giant hydatid cyst of right lung with shift of the mediastinum at left. The lesion displaced the trachea at left. The patient was successfully treated by parenchymal-saving operation. In conclusion, Giant hydatid lung cysts represent a distinct clinical entity most frequently encountered in children and adolescents with more serious symptoms. Although non-complicated giant hydatid cysts have a good prognosis regardless of their size and can be safely treated by parenchyma-preserving surgery.

The clinicopathologic and operative characteristics of patients with small nonfunctioning pancreatic neuroendocrine tumors.

Incidentally detected, small nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) are increasingly diagnosed on imaging modalities. This retrospective investigation evaluated the clinicopathologic characteristics and perioperative and oncologic outcomes in patients with small NF-PNETs undergoing curative resection. The medical records of 444 patients who underwent pancreatic resection for NF-PNETs at a single, large-volume institution between January 2000 and December 2018 were retrospectively reviewed. Patients were divided into those with small (≤2cm) and large (>2cm) tumors based on the largest tumor diameter on preoperative computed tomography (CT). Outcomes were also evaluated in subgroups of patients with small NF-PNET who did and did not undergo lymphadenectomy. Of the 444 patients with NF-PNETs, 195 (43.9%) had small (≤2cm) and 249 (56.1%) had large (>2cm) NF-PNETs. The rate of parenchyma-preserving surgery (14.4% vs. 7.2%, p=0.014) and the ratio of spleen preservation for left-sided pancreatectomy (65.6% vs. 38.3%, p < 0.001) were higher in the small NF-PNET group. Size on CT >2cm (p < 0.001, hazard ratio [HR]: 5.836, 95% confidence interval [CI]: 2.474-13.769), presence of perineural invasion (p < 0.001, HR: 3.025, 95% CI: 1.640-5.577), World Health Organization (WHO) Grade 2 (p=0.007, HR: 2.861, 95% CI: 1.325-6.176), and WHO Grade 3 (p < 0.001, HR: 11.537, 95% CI: 5.282-25.199) were independent predictors of disease-free survival (DFS). DFS did not differ significantly in patients with small NF-PNETs who did and did not undergo lymphadenectomy (p=0.886). Assessment of long-term oncologic outcomes suggests that surgical resection may cure small NF-PNETs. Minimally invasive surgery and organ-preserving surgery are acceptable treatment options for select patients with small NF-PNETs. The effect on survival outcomes of lymph node dissection for small NF-PNETs remains unclear.

Surgical Management of Solid Pseudopapillary Neoplasms of Pancreas: A Single-Center Experience of 60 Patients

Background: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare neoplasms, and the selection of surgical approaches is still under debate. The aim of this study was to analyze the clinicopathological characteristics and surgical outcomes of SPN patients and to compare the short-term and long-term outcomes between conventional operations and parenchyma-preserving operations. Methods: Patients who underwent pancreatic resection for SPNs between February 2010 and May 2019 in Fujian Medical University Union Hospital were identified. Clinicopathological details, perioperative data, and long-term follow-up results were retrospectively analyzed. Results: Sixty patients underwent surgical resection for SPNs during the study period: 48 females and 12 males. The mean age was 32.2 years. All patients underwent margin-negative surgical resection. The median follow-up period was 47 months (range: 3~118 months). One patient developed liver metastases 14 months after the operation and received local ablation therapy. All patients were alive during the follow-up. The incidence of postoperative pancreatic fistula was higher in the parenchyma-preserving surgery group than in the conventional surgery group (40.0 vs. 11.1%, p = 0.034). There was no significant difference in the tumor recurrence rate between the 2 groups. Eight (17.7%) and 6 patients (13.3%) in the conventional surgery group demonstrated endocrine and exocrine pancreatic insufficiency, respectively; furthermore, no patients in the parenchyma-preserving surgery group had endocrine or exocrine pancreatic insufficiency, but the incidences were not significantly different between the 2 groups. Conclusions: Margin-negative surgical resection of SPNs yields a very low rate of tumor recurrence and excellent long-term survival.

PL 01.04 What is the Optimal Management of Screen-Detected Lung Cancers

PL 01.04 What is the Optimal Management of Screen-Detected Lung Cancers

SC02.03 Surgery for Ground Glass Opacity: Sublobar Resection?

SC02.03 Surgery for Ground Glass Opacity: Sublobar Resection?

Comparative evaluation and technical aspects of pancreatodigestive anastomoses during parenchyma-preserving operations in patients with chronic pancreatitis with ductal hypertension

Actuality. The paper presents a new type of pancreatodigestive anastomosis in the form of isolated pancreaticojejunoduodenoanastomosis as the final stage of parenchyma-preserving operation – total longitudinal pancreatowirsungoduodenopapillotomy. Aim . In order to implement the isolated pancreatodigestive anastomosis in clinical practice we performed the parenchyma-preserving surgery in 71 patients with chronic pancreatitis with ductal hypertension. Methods and results. It has been studied that patients with this disease need physiological drainage of pancreatic juice and bile into the duodenum for duodenal phase of digestion. It was found that these requirements are met by developed and implemented in practice isolated pancreaticojejunoduodenostomy with evacuation of pancreatic juice and bile into the duodenum. Conclusion . This indicates that this type of surgery is an alternative to pancreatodigestive anastomosis according to Roux, for which the low drainage of pancreatic juice into jejunum bypassing the duodenum is typical.

Video-Assisted Thoracoscopic Surgery to Treat Hydatid Disease of the Thorax in Adults: Is It Feasible?

Optimal treatment of intrathoracic hydatid diseases in adults involves complete removal of the cyst with parenchyma-preserving surgery. In current practice, thoracotomy remains the standard surgical approach for pulmonary hydatid cysts, so surgical experience is limited, particularly with regard to video-assisted thoracoscopic surgery (VATS). Between June 2007 and May 2011, a selected series of 12 adult patients presenting with intrathoracic hydatid cysts underwent VATS. The cysts were completely removed using a three-trocar technique. Complete removal of the cysts was successful in all patients. All cysts were diagnosed by computerized tomography, and 6 (50%) patients had a history of hydatid disease in the liver or lung. No serious postoperative complications were observed. Patients with thoracoscopic excision were discharged after a median of 2.9 days (range, 2-6 days). No recurrences or complications were observed during a mean follow-up of 29 months. Considering the conversion and complication rates in our series, VATS should be the primary therapeutic choice for adults with thoracic hydatid cysts. Open surgical interventions in patients with large and uncomplicated cysts appear optional.

Indications for Endoscopic or Surgical Treatment of Chronic Pancreatitis

In patients suffering from chronic pancreatitis, pain as the predominant symptom remains a therapeutic challenge which often cannot be tackled conservatively. Since pancreatic duct obstruction – frequently within the pancreatic head – is an important etiological factor, treatment in these cases aims at decompressing the duct either endoscopically or surgically. Endoscopic drainage includes sphincterotomy, dilation of strictures, removal of stones, and insertion of a stent; it has a success rate of 30–100%. Surgical treatment may be accomplished by drainage or resection procedures. Drainage procedures (such as the longitudinal opening of the pancreatic duct followed by a pancreaticojejunostomy) can be performed with a low rate of postoperative complications (6–30%) and mortality (0–2%), and can achieve long-term pain relief in 65–85% of the cases. Furthermore, there are a variety of resection procedures such as pancreaticoduodenenectomy (Whipple procedure), pylorus-preserving pancreaticoduodenenectomy, different types of the duodenum-preserving pancreatic head resection (i.e. Beger, Frey, or Büchler procedures), segmentectomy, and V-shaped excision of the pancreatic duct. However, the surgical procedure of choice is controversially discussed. While it has been shown that parenchyma-preserving surgery is superior to more extensive resections, it remains unclear which of the modifications of the parenchyma-sparing procedures is suited best for which case. Recently, two randomized controlled trials have demonstrated that surgical treatment is superior to endotherapy in long-term pain reduction, physical health score results, and the number of reinterventions. Thus, in patients with chronic pancreatitis refractory to conservative medical treatment, surgery rather than endotherapy is the standard of care. Parenchyma-preserving resections should preferably be performed because they ensure lower morbidity and mortality, preserve endocrine function, and improve quality of life.

Giant viable hydatid cyst of the lung: a case report

IntroductionHydatid disease is a parasitic infestation caused by Echinococcus granulosus. The resulting large cysts in the lung are a special clinical entity called giant hydatid cysts.Case presentationAn 18-year-old Yemeni woman presented with a dry cough and mild fever, with no history of chest pain, dyspnoea or weight loss. Chest X-ray revealed a homogenous opacity almost replacing the right lung. The patient underwent surgery which revealed a large, viable hydatid cyst measuring 26 × 18 × 5 cm.ConclusionThis case report provides evidence that non-complicated hydatid cysts, even if very large, have a good prognosis and can be safely treated by parenchyma-preserving surgery.

Image-guided surgery of liver metastases by three-dimensional ultrasound-based optoelectronic navigation

Vessel-oriented surgery and tumour-free resection margins are essential for resection of liver metastases to preserve liver parenchyma and improve oncological outcome. Preoperative three-dimensional models reconstructed from imaging data could facilitate surgical planning with the use of navigation technology. Thirty-three patients with central and/or impalpable liver metastases were scheduled for navigated hepatic resection. Intraoperative three-dimensional ultrasonography and an infrared-based optical tracking system were used for data registration and image-guided surgery. Postoperative three-dimensional data were compared with the preoperative virtual surgical plan to assess the accuracy of navigation, and clinical results were compared with those of a matched control group of 32 patients. Navigation was successful in 32 of 33 patients. Realization of the preoperative plan and R0 resection was achieved in 30 of these 32 patients. The median discrepancy between the planned and actual vascular dissection level was 6 (range 0-11) mm. There was a reduced rate of R1 resection in the navigated group compared with the control group (two versus four patients), and more parenchyma was preserved. Three-dimensional ultrasound-based optoelectronic navigation technology improves intraoperative orientation and enables parenchyma-preserving surgery with high precision.

Parenchyma-Preserving Surgery in the Management of Pulmonary Hydatid Cysts

Pulmonary hydatid cysts remain a significant health problem in endemic regions like Turkey. Here, we present our surgical experience in patients with pulmonary hydatid cysts. Between January 1985 and January 2001, 1118 operations were performed in 1032 patients (528 males, 504 females; mean age 32.7 years; range 1–87 years) with pulmonary hydatid cysts in our department. Posterolateral thoracotomy was performed in 1015 (98.3%), two-stage thoracotomy in 34 (3.3%), and median sternotomy in 17 (1.7%) patients. We preferred conservative surgical procedures. As a surgical procedure, cystotomy and capitonnage was performed in 626 (56%), cystotomy alone in 368 (33%), wedge resection in 81 (7%), enucleation in 29 (3%), and decortication in 11 (1%) patients. None of our patients were treated with anatomic resection. During surgery, 949 patients (92%) had unruptured and 83 patients (8%) had ruptured hydatid cyst. The morbidity ratio was 6.7%. Major complications were wound infection (2.3%), prolonged air leak (1.9%), atelectasis (1.2%), pleural effusion (0.8%), postoperative hemothorax (0.6%), and empyema (0.3%). Two patients (0.2%) died within the first month postoperatively. Mean follow-up was 31.2 months. Recurrence was detected in only 35 patients (3.3%). Treatment of pulmonary hydatid cyst is primarily surgical. Medical treatment is indicated for recurrent and multiple hydatid cysts postoperatively. Cystotomy alone, or cystotomy and capitonnage, as parenchyma-preserving surgery, is preferred. Radical surgery including pneumonectomy, lobectomy, and segmentectomy should be avoided.

Renal parenchyma-sparing surgery in carcinoma.

There is controversy regarding the role of renal-sparing surgery in patients with kidney cancer who have a functioning contralateral kidney. The present study aimed to review the recent experience of renal-sparing surgery at Royal Prince Alfred Hospital (RPAH), Sydney. Eighteen consecutive patients undergoing conservative surgery for kidney tumours at RPAH between February 1987 and January 1995, were reviewed. Eleven patients had imperative indications for conservative surgery and the remaining seven patients had elective indications. Ten patients had modified enucleation with a margin of normal parenchyma. Six patients underwent partial nephrectomy and two had wedge resections. Patients were followed up at 1, 6 and 12 months, and thence every 6-12 months. Follow-up ranged from 9 to 104 months (mean: 46.2 months, median: 48 months). Sixteen of the 18 patients were still alive at the end of the follow-up (October 1995), with no clinical evidence of local or distant metastasis. The two deaths were not related to the fact that these patients had conservative surgery. The average tumour dimensions were 43 mm x 49 mm, with an average volume of 194 mm3. All resections were complete, with margins ranging between 1.0 and 20.0 mm (mean: 8.7 mm). The survival rate in the present study is comparable to those found by other researchers. Conservative surgery is indicated in renal tumours where radical surgery would render the patient anephric. Conservative surgery, however, is controversial in a patient with a normal contralateral kidney. The present study has shown that renal parenchyma-preserving surgery for localized tumours provides a feasible treatment option.